Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Bioassay directed isolation of secondary metabolites from the rhizomes of <i>Zingiber montanum</i> (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (<i>E</i>)-8(17),12-labdadiene-15,16-dial (<b>1</b>), zerumbol (<b>2</b>),<b> </b>zerumbone (<b>3</b>), buddledone A (<b>4</b>), furanodienone (<b>5</b>), germacrone (<b>6</b>), borneol (<b>7</b>),<b> </b>and<b> </b>camphor (<b>8</b>) by analysing one-dimensional (1D) (¹H and ¹³C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds <b>1</b> and <b>2</b> revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant<i> Staphylococcus aureus </i>(MRSA).

Abstract licence: CC BY

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