Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer’s disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

Abstract licence: CC BY

1. 11.

   Marine Peptides: Bioactivities and Applications · 2015

2. 15.

   β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease · 2015

3. 73.

   Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012 · 2015

4. 89.

   Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives · 2013

5. 93.

   Acetylcholinesterase Inhibitors: Pharmacology and Toxicology · 2013

6. 96.

   Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action · 2013

7. 103.

   Zinc homeostasis and neurodegenerative disorders · 2013

8. 110.

   Marine Polysaccharides in Pharmaceutical Applications: An Overview · 2010

9. 113.

   The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies · 2011

10. 128.

    Chemical Methods for Peptide and Protein Production · 2013

11. 157.

    Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective · 2018

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