PM00104 (Zalypsis®): A Marine Derived Alkylating Agent
Bradley J. Petek, Robin L. Jones
Molecules · 2014
doi:10.3390/molecules190812328 (opens in a new tab)
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Abstract
PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment.
Abstract licence: CC BY
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