Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
Philippe Barthélémy, Eric Amigues, Amit Patwa and 1 more
Molecules · 2013
doi:10.3390/molecules181012241 (opens in a new tab)
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Abstract
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower glim) compared to the first generation of GNFs.
Abstract licence: CC BY
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