Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
Chuan-Xin Yu, Bainian Feng, Wen-Hua Fan and 5 more
Molecules · 2013
doi:10.3390/molecules18089163 (opens in a new tab)
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Abstract
The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
Abstract licence: CC BY
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