Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri

Our continuing studies on secondary metabolites from the stem bark of <em>Calophyllum soulattri</em> has led to the isolation of another new diprenylated xanthone, phylattrin (<strong>1</strong>), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (<strong>2</strong>), caloxanthone C (<strong>3</strong>), macluraxanthone (<strong>4</strong>), brasixanthone B (<strong>5</strong>) and trapezifolixanthone (<strong>6</strong>) while the sterols are stigmasterol (<strong>7</strong>) and <em>β</em>-sitosterol (<strong>8</strong>). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds <strong>1</strong>–<strong>7</strong> exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells.

Abstract licence: CC BY

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