Benzyl 2-β-Glucopyranosyloxybenzoate, a New Phenolic Acid Glycoside from Sarcandra glabra

From the whole plant of <em>Sarcandra glabra</em>,<strong> </strong>a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (<strong>1</strong>), together with seven known compounds including eleutheroside B<sub>1</sub> (<strong>2</strong>), 5-<em>O</em>-caffeoylshikimic acid (<strong>3</strong>), (–)-(7<em>S</em>, 8<em>R</em>)-dihydrodehydro-diconiferyl alcohol (<strong>4</strong>), (–)-(7<em>S</em>, 8<em>R</em>)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-<em>O</em>-â-D-glucopyranoside (<strong>5</strong>–<strong>7</strong>), and (–)-(7<em>S</em>, 8<em>R</em>)-5-methoxydihydrodehydrodiconiferyl alcohol 4-<em>O</em>-β-D-glucopyranoside (<strong>8</strong>) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound<strong> 2</strong> was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC<sub>50</sub> value of 2.53 and 1.85 µM, respectively.

Abstract licence: CC BY

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