Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
Xiao Jia Yin, Guan Hong Xu, Xu Sun and 4 more
Molecules · 2010
doi:10.3390/molecules15064261 (opens in a new tab)
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Abstract
This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC.
Abstract licence: CC BY
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