Separation Technique for the Determination of Highly Polar Metabolites in Biological Samples
Yusuke Iwasaki, Takahiro Sawada, Kentaro Hatayama and 6 more
Metabolites · 2012
doi:10.3390/metabo2030496 (opens in a new tab)
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Abstract
Metabolomics is a new approach that is based on the systematic study of the full complement of metabolites in a biological sample. Metabolomics has the potential to fundamentally change clinical chemistry and, by extension, the fields of nutrition, toxicology, and medicine. However, it can be difficult to separate highly polar compounds. Mass spectrometry (MS), in combination with capillary electrophoresis (CE), gas chromatography (GC), or high performance liquid chromatography (HPLC) is the key analytical technique on which emerging "omics" technologies, namely, proteomics, metabolomics, and lipidomics, are based. In this review, we introduce various methods for the separation of highly polar metabolites.
Abstract licence: CC BY
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