Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
Yoichi Nakao, Takeru Shiroiwa, Shigeki Matsunaga and 4 more
Marine Drugs · 2004
doi:10.3390/md202055 (opens in a new tab)
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Abstract
Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
Abstract licence: CC BY
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