No retraction, correction or concern found when last checked on Oct 24, 2026.

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

Paola Mura, Francesca Maestrelli, Marzia Cirri and 1 more

Marine Drugs · 2022 · Review · CC BY

doi:10.3390/md20050335

Abstract

Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the pharmaceutical field, in the early 1990s, CS attracted great interest, which has constantly increased over the years, due to its several beneficial and favorable features, including large availability, biocompatibility, biodegradability, non-toxicity, simplicity of chemical modifications, mucoadhesion and permeation enhancer power, joined to its capability of forming films, hydrogels and micro- and nanoparticles. Moreover, its cationic character, which renders it unique among biodegradable polymers, is responsible for the ability of CS to strongly interact with different types of molecules and for its intrinsic antimicrobial, anti-inflammatory and hemostatic activities. However, its pH-dependent solubility and susceptibility to ions presence may represent serious drawbacks and require suitable strategies to be overcome. Presently, CS and its derivatives are widely investigated for a great variety of pharmaceutical applications, particularly in drug delivery. Among the alternative routes to overcome the problems related to the classic oral drug administration, the mucosal route is becoming the favorite non-invasive delivery pathway. This review aims to provide an updated overview of the applications of CS and its derivatives in novel formulations intended for different methods of mucosal drug delivery.

References 337

1.
Song Y., Wang Y., Thakur R., Meidan V.M., Michniak B. Mucosal Drug Delivery: Membranes, Methodologies, and Applications. Crit. Rev. Ther. Drug Carrier Syst. 2004;21:195-256.
Not in our library10.1615/critrevtherdrugcarriersyst.v21.i3.20
2.
Mathias N.R., Hussain M.A. Non-Invasive Systemic Drug Delivery: Developability Considerations for Alternate Routes of Administration. J. Pharm. Sci. 2010;99:1-20.
Not in our library10.1002/jps.21793
3.
Goyal A.K., Singh R., Chauhan G., Rath G. Non-Invasive Systemic Drug Delivery through Mucosal Routes. Artif. Cells Nanomed. Biotechnol. 2018;46:539-551.
Not in our library10.1080/21691401.2018.1463230
4.
Abhang P., Momin M., Inamdar M., Kar S. Transmucosal Drug Delivery- An Overview. Drug Deliv. Lett. 2014;4:26-37.
Not in our library10.2174/22103031113039990011
5.
Liu J., Leng P., Liu Y. Oral Drug Delivery with Nanoparticles into the Gastrointestinal Mucosa. Fundam. Clin. Pharmacol. 2021;35:86-96.
Not in our library10.1111/fcp.12594
6.
Roy S., Prabhakar B. Bioadhesive Polymeric Platforms for Transmucosal Drug Delivery Systems—A Review. Trop. J. Pharm. Res. 2010;9:2043.
Not in our library10.4314/tjpr.v9i1.52043
7.
Mansuri S., Kesharwani P., Jain K., Tekade R.K., Jain N.K. Mucoadhesion: A Promising Approach in Drug Delivery System. React. Funct. Polym. 2016;100:151-172.
Not in our library10.1016/j.reactfunctpolym.2016.01.011
8.
Mahajan P., Kaur A., Aggarwal G., Harikumar S.L. Mucoadhesive Drug Delivery System: A Review. Int. J. Drug Dev. Res. 2013;5:11-20.
Not in our library10.20959/wjpps20174-8863
9.
Laffleur F. Mucoadhesive Polymers for Buccal Drug Delivery. Drug Dev. Ind. Pharm. 2014;40:591-598.
Not in our library10.3109/03639045.2014.892959
10.
Bonferoni M.C., Sandri G., Rossi S., Ferrari F., Caramella C. Chitosan and Its Salts for Mucosal and Transmucosal Delivery. Expert Opin. Drug Deliv. 2009;6:923-939.
Not in our library10.1517/17425240903114142
11.
Kumar A., Vimal A., Kumar A. Why Chitosan? From Properties to Perspective of Mucosal Drug Delivery. Int. J. Biol. Macromol. 2016;91:615-622.
Not in our library10.1016/j.ijbiomac.2016.05.054
12.
Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems · 2018
No notice
13.
Pillai C.K.S., Paul W., Sharma C.P. Chitin and Chitosan Polymers: Chemistry, Solubility and Fiber Formation. Prog. Polym. Sci. 2009;34:641-678.
Not in our library10.1016/j.progpolymsci.2009.04.001
14.
Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications · 2015
No notice
15.
Shitrit Y., Bianco-Peled H. Acrylated Chitosan for Mucoadhesive Drug Delivery Systems. Int. J. Pharm. 2017;517:247-255.
Not in our library10.1016/j.ijpharm.2016.12.023
16.
Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems · 2010
No notice
17.
Luo Y., Wang Q. Recent Development of Chitosan-Based Polyelectrolyte Complexes with Natural Polysaccharides for Drug Delivery. Int. J. Biol. Macromol. 2014;64:353-367.
Not in our library10.1016/j.ijbiomac.2013.12.017
18.
Wu D., Zhu L., Li Y., Zhang X., Xu S., Yang G., Delair T. Chitosan-Based Colloidal Polyelectrolyte Complexes for Drug Delivery: A Review. Carbohydr. Polym. 2020;238:116126.
Not in our library10.1016/j.carbpol.2020.116126
19.
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications · 2015
No notice
20.
Morin-Crini N., Lichtfouse E., Torri G., Crini G. Applications of Chitosan in Food, Pharmaceuticals, Medicine, Cosmetics, Agriculture, Textiles, Pulp and Paper, Biotechnology, and Environmental Chemistry. Environ. Chem. Lett. 2019;17:1667-1692.
Not in our library10.1007/s10311-019-00904-x
21.
Reshad R.A.I., Jishan T.A., Chowdhury N.N. Chitosan and Its Broad Applications: A Brief Review. J. Clin. Exp. Investig. 2021;12:em00779.
Not in our library10.29333/jcei/11268
22.
Zou P., Yang X., Wang J., Li Y., Yu H., Zhang Y., Liu G. Advances in Characterisation and Biological Activities of Chitosan and Chitosan Oligosaccharides. Food Chem. 2016;190:1174-1181.
Not in our library10.1016/j.foodchem.2015.06.076
23.
Younes I., Sellimi S., Rinaudo M., Jellouli K., Nasri M. Influence of Acetylation Degree and Molecular Weight of Homogeneous Chitosans on Antibacterial and Antifungal Activities. Int. J. Food Microbiol. 2014;185:57-63.
Not in our library10.1016/j.ijfoodmicro.2014.04.029
24.
Hosseinnejad M., Jafari S.M. Evaluation of Different Factors Affecting Antimicrobial Properties of Chitosan. Int. J. Biol. Macromol. 2016;85:467-475.
Not in our library10.1016/j.ijbiomac.2016.01.022
25.
Verlee A., Mincke S., Stevens C.V. Recent Developments in Antibacterial and Antifungal Chitosan and Its Derivatives. Carbohydr. Polym. 2017;164:268-283.
Not in our library10.1016/j.carbpol.2017.02.001
26.
Zhengxin M., Garrido-Maestu A., Jeong K.C. Application, Mode of Action, and in Vivo Activity of Chitosan and Its Micro- and Nanoparticles as Antimicrobial Agents: A Review. Carbohydr. Polym. 2017;176:257-265.
Not in our library10.1016/j.carbpol.2017.08.082
27.
Chang S.H., Lin Y.Y., Wu G.J., Huang C.H., Tsai G.J. Effect of Chitosan Molecular Weight on Anti-Inflammatory Activity in the RAW 264.7 Macrophage Model. Int. J. Biol. Macromol. 2019;131:167-175.
Not in our library10.1016/j.ijbiomac.2019.02.066
28.
Jitprasertwong P., Khamphio M., Petsrichuang P., Eijsink V.G.H., Poolsri W., Muanprasat C., Rangnoi K., Yamabhai M. Anti-Inflammatory Activity of Soluble Chito-Oligosaccharides (CHOS) on VitD3-Induced Human THP-1 Monocytes. PLoS ONE. 2021;16:e0246381.
Not in our library10.1371/journal.pone.0246381
29.
Anticancer and Anti-Inflammatory Properties of Chitin and Chitosan Oligosaccharides · 2015
No notice
30.
Fong D., Hoemann C.D. Chitosan Immunomodulatory Properties: Perspectives on the Impact of Structural Properties and Dosage. Future Sci. OA. 2018;4:FSO225.
Not in our library10.4155/fsoa-2017-0064
31.
Je J.Y., Kim S.K. Antioxidant Activity of Novel Chitin Derivative. Bioorg. Med. Chem. Lett. 2006;16:1884-1887.
Not in our library10.1016/j.bmcl.2005.12.077
32.
Zhang J., Zhang W., Mamadouba B., Xia W. A Comparative Study on Hypolipidemic Activities of High and Low Molecular Weight Chitosan in Rats. Int. J. Biol. Macromol. 2012;51:504-508.
Not in our library10.1016/j.ijbiomac.2012.06.018
33.
Huang L., Chen J., Cao P., Pan H., Ding C., Xiao T., Zhang P., Guo J., Su Z. Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats. Mar. Drugs. 2015;13:2732-2756.
Not in our library10.3390/md13052732
34.
De Lima J.M., Sarmento R.R., de Souza J.R., Brayner F.A., Feitosa A.P.S., Padilha R., Alves L.C., Porto I.J. Evaluation of Hemagglutination Activity of Chitosan Nanoparticles Using Human Erythrocytes. BioMed Res. Int. 2015;2015:247965.
Not in our library10.1155/2015/247965
35.
Tang F., Lv L., Lu F., Rong B., Li Z., Lu B., Yu K., Liu J., Dai F., Wu D., et al. Preparation and Characterization of N -Chitosan as a Wound Healing Accelerator. Int. J. Biol. Macromol. 2016;93:1295-1303.
Not in our library10.1016/j.ijbiomac.2016.09.101
36.
Shen S., Chen X., Shen Z., Chen H. Marine Polysaccharides for Wound Dressings Application: An Overview. Pharmaceutics. 2021;13:1666.
Not in our library10.3390/pharmaceutics13101666
37.
Elgadir M.A., Uddin M.S., Ferdosh S., Adam A., Chowdhury A.J.K., Sarker M.Z.I. Impact of Chitosan Composites and Chitosan Nanoparticle Composites on Various Drug Delivery Systems: A Review. J. Food Drug Anal. 2015;23:619-629.
Not in our library10.1016/j.jfda.2014.10.008
38.
Shariatinia Z. Pharmaceutical Applications of Chitosan. Adv. Colloid Interface Sci. 2019;263:131-194.
Not in our library10.1016/j.cis.2018.11.008
39.
Mansouri S., Lavigne P., Corsi K., Benderdour M., Beaumont E., Fernandes J.C. Chitosan-DNA Nanoparticles as Non-Viral Vectors in Gene Therapy: Strategies to Improve Transfection Efficacy. Eur. J. Pharm. Biopharm. 2004;57:1-8.
Not in our library10.1016/s0939-6411(03)00155-3
40.
Dastidar D.G., Ghosh D. Silver Nanoparticle Decorated Chitosan Scaffoldfor Wound Healing and Tissue Regeneration. Macromolecules. 2018;105:1241-1249.
Not in our library
41.
de Moraes Crizel T., de Oliveira Rios A.D., Alves V., Bandarra N., Moldão-Martins M., Hickmann Flôres S. Active Food Packaging Prepared with Chitosan and Olive Pomace. Food Hydrocoll. 2018;74:139-150.
Not in our library10.1016/j.foodhyd.2017.08.007
42.
Chopra S., Mahdi S., Kaur J., Iqbal Z., Talegaonkar S., Ahmad F.J. Advances and Potential Applications of Chitosan Derivatives as Mucoadhesive Biomaterials in Modern Drug Delivery. J. Pharm. Pharmacol. 2006;58:1021-1032.
Not in our library10.1211/jpp.58.8.0002
43.
Riva R., Ragelle H., des Rieux A., Duhem N., Jérôme C., Préat V., Jayakumar R., Prabaharan M., Muzzarelli R.A.A. Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering. Chitosan for Biomaterials II. 2011;Volume 244:19-44.
Not in our library
44.
Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications · 2015
No notice
45.
You J., Xie S., Cao J., Ge H., Xu M., Zhang L., Zhou J. Quaternized Chitosan/Poly (Acrylic Acid) Polyelectrolyte Complex Hydrogels with Tough, Self-Recovery, and Tunable Mechanical Properties. Macromolecules. 2016;49:1049-1059.
Not in our library10.1021/acs.macromol.5b02231
46.
Potaś J., Szymańska E., Winnicka K. Challenges in Developing of Chitosan–Based Polyelectrolyte Complexes as a Platform for Mucosal and Skin Drug Delivery. Eur. Polym. J. 2020;140:110020.
Not in our library10.1016/j.eurpolymj.2020.110020
47.
An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery · 2017
No notice
48.
Hasnain M.S., Nayak A.K. Chitosan as Mucoadhesive Polymer in Drug Delivery. Chitosan in Drug Delivery. 2022;225-246.
Not in our library
49.
Collado-González M., González Espinosa Y., Goycoolea F.M. Interaction Between Chitosan and Mucin: Fundamentals and Applications. Biomimetics. 2019;4:32.
Not in our library10.3390/biomimetics4020032
50.
Sogias I.A., Williams A.C., Khutoryanskiy V.V. Why Is Chitosan Mucoadhesive? Biomacromolecules. 2008;9:1837-1842.
Not in our library10.1021/bm800276d
51.
Menchicchi B., Fuenzalida J.P., Bobbili K.B., Hensel A., Swamy M.J., Goycoolea F.M. Structure of Chitosan Determines Its Interactions with Mucin. Biomacromolecules. 2014;15:3550-3558.
Not in our library10.1021/bm5007954
52.
Collado-González M., Montalbán M.G., Peña-García J., Pérez-Sánchez H., Víllora G., Díaz Baños F.G. Chitosan as Stabilizing Agent for Negatively Charged Nanoparticles. Carbohydr. Polym. 2017;161:63-70.
Not in our library10.1016/j.carbpol.2016.12.043
53.
Sogias I.A., Khutoryanskiy V.V., Williams A.C. Exploring the Factors Affecting the Solubility of Chitosan in Water. Macromol. Chem. Phys. 2010;211:426-433.
Not in our library10.1002/macp.200900385
54.
Kulkarni A.D., Patel H.M., Surana S.J., Vanjari Y.H., Belgamwar V.S., Pardeshi C.V. N,N,N-Trimethyl Chitosan: An Advanced Polymer with Myriad of Opportunities in Nanomedicine. Carbohydr. Polym. 2017;157:875-902.
Not in our library10.1016/j.carbpol.2016.10.041
55.
Federer C., Kurpiers M., Bernkop-Schnürch A. Thiolated Chitosans: A Multi-Talented Class of Polymers for Various Applications. Biomacromolecules. 2021;22:24-56.
Not in our library10.1021/acs.biomac.0c00663
56.
Jain S., Nuwal K., Mahmood A., Piplani M., Chander S., Dubey S.K., Singhvi G. Thiolated Chitosan as an Improved Bioadhesive Polymer in Drug Delivery. Chitosan in Drug Delivery. 2022;247-276.
Not in our library
57.
Biocompatibility of Chitosan Carriers with Application in Drug Delivery · 2012
No notice
58.
Shukla S.K., Mishra A.K., Arotiba O.A., Mamba B.B. Chitosan-Based Nanomaterials: A State-of-the-Art Review. Int. J. Biol. Macromol. 2013;59:46-58.
Not in our library10.1016/j.ijbiomac.2013.04.043
59.
Biomedical Applications of Chitosan and Its Derivative Nanoparticles · 2018
No notice
60.
Matica A., Menghiu G., Ostafe V. Biodegradability of chitosan based products. N. Front. Chem. 2017;26:75-86.
Not in our library
61.
Shikov A.N., Flisyuk E.V., Obluchinskaya E.D., Pozharitskaya O.N. Pharmacokinetics of Marine-Derived Drugs. Mar. Drugs. 2020;18:557.
Not in our library10.3390/md18110557
62.
Bernkop-Schnürch A., Dünnhaupt S. Chitosan-Based Drug Delivery Systems. Eur. J. Pharm. Biopharm. 2012;81:463-469.
Not in our library10.1016/j.ejpb.2012.04.007
63.
Sonaje K., Chuang E.Y., Lin K.J., Yen T.C., Su F.Y., Tseng M.T., Sung H.W. Opening of Epithelial Tight Junctions and Enhancement of Paracellular Permeation by Chitosan: Microscopic, Ultrastructural, and Computed-Tomographic Observations. Mol. Pharm. 2012;9:1271-1279.
Not in our library10.1021/mp200572t
64.
Peers S., Montembault A., Ladavière C. Chitosan Hydrogels for Sustained Drug Delivery. J. Control. Release. 2020;326:150-163.
Not in our library10.1016/j.jconrel.2020.06.012
65.
Tan H., Chu C.R., Payne K.A., Marra K.G. Injectable in Situ Forming Biodegradable Chitosan–Hyaluronic Acid Based Hydrogels for Cartilage Tissue Engineering. Biomaterials. 2009;30:2499-2506.
Not in our library10.1016/j.biomaterials.2008.12.080
66.
Jamal A., Shahzadi L., Ahtzaz S., Zahid S., Chaudhry A.A., Rehman I., Yar M. Identification of Anti-Cancer Potential of Doxazocin: Loading into Chitosan Based Biodegradable Hydrogels for on-Site Delivery to Treat Cervical Cancer. Mater. Sci. Eng. C. 2018;82:102-109.
Not in our library10.1016/j.msec.2017.08.054
67.
Valmikinathan C.M., Mukhatyar V.J., Jain A., Karumbaiah L., Dasari M., Bellamkonda R.V. Photocrosslinkable Chitosan Based Hydrogels for Neural Tissue Engineering. Soft Matter. 2012;8:1964-1976.
Not in our library10.1039/c1sm06629c
68.
Liu L., Gao Q., Lu X., Zhou H. In Situ Forming Hydrogels Based on Chitosan for Drug Delivery and Tissue Regeneration. Asian J. Pharm. Sci. 2016;11:673-683.
Not in our library10.1016/j.ajps.2016.07.001
69.
Zahir-Jouzdani F., Wolf J.D., Atyabi F., Bernkop-Schnürch A. In Situ Gelling and Mucoadhesive Polymers: Why Do They Need Each Other? Expert Opin. Drug Deliv. 2018;15:1007-1019.
Not in our library10.1080/17425247.2018.1517741
70.
Berillo D., Zharkinbekov Z., Kim Y., Raziyeva K., Temirkhanova K., Saparov A. Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery. Pharmaceutics. 2021;13:2050.
Not in our library10.3390/pharmaceutics13122050
71.
“The Good, the Bad and the Ugly” of Chitosans · 2016
No notice
72.
Marques C., Som C., Schmutz M., Borges O., Borchard G. How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. Front. Bioeng. Biotechnol. 2020;8:165.
Not in our library10.3389/fbioe.2020.00165
73.
Targhotra M., Chauhan M.K. An Overview on Various Approaches and Recent Patents on Buccal Drug Delivery Systems. Curr. Pharm. Des. 2020;26:5030-5039.
Not in our library10.2174/1381612826666200614182013
74.
Sandri G., Ruggeri M., Rossi S., Bonferoni M.C., Vigani B., Ferrari F. (Trans)Buccal Drug Delivery. Nanotechnology for Oral Drug Delivery. 2020;225-250.
Not in our library
75.
Bruschi M.L., de Souza Ferreira S.B., Bassi da Silva J. Mucoadhesive and Mucus-Penetrating Polymers for Drug Delivery. Nanotechnology for Oral Drug Delivery. 2020;77-141.
Not in our library
76.
Shahiwala A. Applications of Polymers in Buccal Drug Delivery. Applications of Polymers in Drug Delivery. 2021;43-76.
Not in our library
77.
Şenel S. Potential Applications of Chitosan in Oral Mucosal Delivery. J. Drug Deliv. Sci. Technol. 2010;20:23-32.
Not in our library10.1016/s1773-2247(10)50003-0
78.
Laffleur F., Röttges S. Mucoadhesive Approach for Buccal Application: Preactivated Chitosan. Eur. Polym. J. 2019;113:60-66.
Not in our library10.1016/j.eurpolymj.2019.01.049
79.
Laffleur F., Röttges S. Buccal Adhesive Chitosan Conjugate Comprising Pilocarpine for Xerostomia. Int. J. Biol. Macromol. 2019;135:1043-1051.
Not in our library10.1016/j.ijbiomac.2019.05.219
80.
Kaundal A., Kumar P., Chaudhry A.A. A Review on Mucoadhesive Buccal Tablets Prepared Using Natural and Synthetic Polymers. World J. Pharm. Pharmacol. Sci. 2015;4:475-500.
Not in our library
81.
Fontinele de Sà L.L., Carvalho Nogueira N., da Silva F., Figueiras A. Design of Buccal Mucoadhesive Tablets: Understanding and Development. J. App. Pharm. Sci. 2018;8:150-163.
Not in our library10.7324/japs.2018.8223
82.
Fathima N., Das P., Kuchana V. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Carvedilol Using Natural Binders. Int. J. Res. Pharm. Chem. 2015;5:699-707.
Not in our library
83.
Abruzzo A., Cerchiara T., Bigucci F., Gallucci M.C., Luppi B. Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride. J. Pharm. Sci. 2015;104:4365-4372.
Not in our library10.1002/jps.24688
84.
Jacob S., Nair A.B., Boddu S.H.S., Gorain B., Sreeharsha N., Shah J. An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems. Pharmaceutics. 2021;13:1206.
Not in our library10.3390/pharmaceutics13081206
85.
Timur S.S., Yüksel S., Akca G., Şenel S. Localized Drug Delivery with Mono and Bilayered Mucoadhesive Films and Wafers for Oral Mucosal Infections. Int. J. Pharm. 2019;559:102-112.
Not in our library10.1016/j.ijpharm.2019.01.029
86.
Eleftheriadis G.K., Ritzoulis C., Bouropoulos N., Tzetzis D., Andreadis D.A., Boetker J., Rantanen J., Fatouros D.G. Unidirectional Drug Release from 3D Printed Mucoadhesive Buccal Films Using FDM Technology: In Vitro and Ex Vivo Evaluation. Eur. J. Pharm. Biopharm. 2019;144:180-192.
Not in our library10.1016/j.ejpb.2019.09.018
87.
Ashri L.Y., Abou El Ela A.E.S.F., Ibrahim M.A., Alshora D.H., Naguib M.J. Optimization and Evaluation of Chitosan Buccal Films Containing Tenoxicam for Treating Chronic Periodontitis: In Vitro and in Vivo Studies. J. Drug Deliv. Sci. Technol. 2020;57:101720.
Not in our library10.1016/j.jddst.2020.101720
88.
Abouhussein D., El Nabarawi M.A., Shalaby S.H., El-Bary A.A. Cetylpyridinium Chloride Chitosan Blended Mucoadhesive Buccal Films for Treatment of Pediatric Oral Diseases. J. Drug Deliv. Sci. Technol. 2020;57:101676.
Not in our library10.1016/j.jddst.2020.101676
89.
Soe M.T., Pongjanyakul T., Limpongsa E., Jaipakdee N. Modified Glutinous Rice Starch-Chitosan Composite Films for Buccal Delivery of Hydrophilic Drug. Carbohydr. Polym. 2020;245:116556.
Not in our library10.1016/j.carbpol.2020.116556
90.
Mura P., Corti G., Cirri M., Maestrelli F., Mennini N., Bragagni M. Development of Mucoadhesive Films for Buccal Administration of Flufenamic Acid: Effect of Cyclodextrin Complexation. J. Pharm. Sci. 2010;99:3019-3029.
Not in our library10.1002/jps.22068
91.
Jug M., Maestrelli F., Mura P. Native and Polymeric β-Cyclodextrins in Performance Improvement of Chitosan Films Aimed for Buccal Delivery of Poorly Soluble Drugs. J. Incl. Phenom. Macrocycl. Chem. 2012;74:87-97.
Not in our library10.1007/s10847-011-0086-4
92.
Pilicheva B., Uzunova Y., Bodurov I., Viraneva A., Exner G., Sotirov S., Yovcheva T., Marudova M. Layer-by-Layer Self-Assembly Films for Buccal Drug Delivery: The Effect of Polymer Cross-Linking. J. Drug Deliv. Sci. Technol. 2020;59:101897.
Not in our library10.1016/j.jddst.2020.101897
93.
Wang S., Gao Z., Liu L., Li M., Zuo A., Guo J. Preparation, in Vitro and in Vivo Evaluation of Chitosan-Sodium Alginate-Ethyl Cellulose Polyelectrolyte Film as a Novel Buccal Mucosal Delivery Vehicle. Eur. J. Pharm. Sci. 2022;168:106085.
Not in our library10.1016/j.ejps.2021.106085
94.
Boateng J.S., Areago D. Composite Sodium Alginate and Chitosan Based Wafers for Buccal Delivery of Macromolecules. Austin J. Anal. Pharm. Chem. 2014;1:1022.
Not in our library
95.
Vaidya A., Mitragotri S. Ionic Liquid-Mediated Delivery of Insulin to Buccal Mucosa. J. Control. Release. 2020;327:26-34.
Not in our library10.1016/j.jconrel.2020.07.037
96.
Escalona-Rayo C.F., Serrano-Castañeda P., López-Cervantes M., Escobar-Chávez J.J. Optimization of Unidirectional Mucoadhesive Buccal Patches Based on Chitosan and Pluronic® F-127 for Metoprolol Controlled Release: In Vitro and Ex Vivo Evaluations. J. Pharm. Innov. 2020;15:556-568.
Not in our library10.1007/s12247-019-09401-8
97.
Rohani Shirvan A., Hemmatinejad N., Bahrami S.H., Bashari A. Fabrication of Multifunctional Mucoadhesive Buccal Patch for Drug Delivery Applications. J. Biomed. Mater. Res. A. 2021;109:2640-2656.
Not in our library10.1002/jbm.a.37257
98.
Kundu A., Hasnain M.S., Nayak A.K. Chitosan-Based Hydrogels in Drug Delivery. Chitosan in Drug Delivery. 2022;361-387.
Not in our library
99.
Xu J., Strandman S., Zhu J.X.X., Barralet J., Cerruti M. Genipin-Crosslinked Catechol-Chitosan Mucoadhesive Hydrogels for Buccal Drug Delivery. Biomaterials. 2015;37:395-404.
Not in our library10.1016/j.biomaterials.2014.10.024
100.
Xiao Y., Gong T., Jiang Y., Wang Y., Wen Z.T., Zhou S., Bao C., Xu X. Fabrication and Characterization of a Glucose-Sensitive Antibacterial Chitosan–Polyethylene Oxide Hydrogel. Polymer. 2016;82:1-10.
Not in our library10.1016/j.polymer.2015.11.016
101.
Liu J., Xiao Y., Wang X., Huang L., Chen Y., Bao C. Glucose-Sensitive Delivery of Metronidazole by Using a Photo-Crosslinked Chitosan Hydrogel Film to Inhibit Porphyromonas Gingivalis Proliferation. Int. J. Biol. Macromol. 2019;122:19-28.
Not in our library10.1016/j.ijbiomac.2018.09.202
102.
Chang P.C., Chao Y.C., Hsiao M.H., Chou H.S., Jheng Y.H., Yu X.H., Lee N., Yang C., Liu D.M. Inhibition of Periodontitis Induction Using a Stimuli-Responsive Hydrogel Carrying Naringin. J. Periodontol. 2017;88:190-196.
Not in our library10.1902/jop.2016.160189
103.
Ortiz A.C., Morales J.O., Muttil P., Kunda N.K. Buccal Delivery of Nanoparticles. Mucosal Delivery of Drugs and Biologics in Nanoparticles. 2020;Volume 41:107-124.
Not in our library
104.
Morantes S.J., Buitrago D.M., Ibla J.F., García Y.M., Lafaurie G.I., Parraga J.E. Composites of Hydrogels and Nanoparticles. Biopolymer-Based Composites. 2017;107-138.
Not in our library
105.
Batista P., Castro P., Madureira A., Sarmento B., Pintado M. Development and Characterization of Chitosan Microparticles-in-Films for Buccal Delivery of Bioactive Peptides. Pharmaceuticals. 2019;12:32.
Not in our library10.3390/ph12010032
106.
dos Santos T.C., Rescignano N., Boff L., Reginatto F.H., Simões C.M.O., Machado de Campos A.M., Mijangos C.U. Manufacture and Characterization of Chitosan/PLGA Nanoparticles Nanocomposite Buccal Films. Carbohydr. Polym. 2017;6:638-644.
Not in our library10.1016/j.carbpol.2017.06.014
107.
Rahbarian M., Mortazavian E., Dorkoosh F.A., Rafiee Tehrani M. Preparation, Evaluation and Optimization of Nanoparticles Composed of Thiolated Triethyl Chitosan: A Potential Approach for Buccal Delivery of Insulin. J. Drug Deliv. Sci. Technol. 2018;44:254-263.
Not in our library10.1016/j.jddst.2017.12.016
108.
Mahdizadeh Barzoki Z., Emam-Djomeh Z., Mortazavian E., Rafiee-Tehrani N., Behmadi H., Rafiee-Tehrani M., Moosavi-Movahedi A.A. Determination of Diffusion Coefficient for Released Nanoparticles from Developed Gelatin/Chitosan Bilayered Buccal Films. Int. J. Biol. Macromol. 2018;112:1005-1013.
Not in our library10.1016/j.ijbiomac.2018.01.215
109.
Sinha S., Garg V., Sonali, Singh R.P., Dutt R. Chitosan-Alginate Core-Shell-Corona Shaped Nanoparticles of Dimethyl Fumarate in Orodispersible Film to Improve Bioavailability in Treatment of Multiple Sclerosis: Preparation, Characterization and Biodistribution in Rats. J. Drug Deliv. Sci. Technol. 2021;64:102645.
Not in our library10.1016/j.jddst.2021.102645
110.
Calixto G.M.F., Victorelli F.D., Dovigo L.N., Chorilli M. Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery. AAPS Pharm. Sci. Technol. 2018;19:820-836.
Not in our library10.1208/s12249-017-0890-2
111.
Kassem M.A.A., ElMeshad A.N., Fares A.R. Lyophilized Sustained Release Mucoadhesive Chitosan Sponges for Buccal Buspirone Hydrochloride Delivery: Formulation and In Vitro Evaluation. AAPS Pharm. Sci. Technol. 2015;16:537-547.
Not in our library10.1208/s12249-014-0243-3
112.
Freag M.S., Saleh W.M., Abdallah O.Y. Laminated Chitosan-Based Composite Sponges for Transmucosal Delivery of Novel Protamine-Decorated Tripterine Phytosomes: Ex-Vivo Mucopenetration and in-Vivo Pharmacokinetic Assessments. Carbohydr. Polym. 2018;188:108-120.
Not in our library10.1016/j.carbpol.2018.01.095
113.
Chen J., Duan H., Pan H., Yang X., Pan W. Two Types of Core/Shell Fibers Based on Carboxymethyl Chitosan and Sodium Carboxymethyl Cellulose with Self-Assembled Liposome for Buccal Delivery of Carvedilol across TR146 Cell Culture and Porcine Buccal Mucosa. Int. J. Biol. Macromol. 2019;128:700-709.
Not in our library10.1016/j.ijbiomac.2019.01.143
114.
Touitou E., Illum L. Nasal Drug Delivery. Drug Deliv. Transl. Res. 2013;3:1-3.
Not in our library10.1007/s13346-012-0111-1
115.
Erdő F., Bors L.A., Farkas D., Bajza Á., Gizurarson S. Evaluation of Intranasal Delivery Route of Drug Administration for Brain Targeting. Brain Res. Bull. 2018;143:155-170.
Not in our library10.1016/j.brainresbull.2018.10.009
116.
Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa · 2018
No notice
117.
Davis S.S., Illum L. Absorption Enhancers for Nasal Drug Delivery. Clin. Pharmacokinet. 2003;42:1107-1128.
Not in our library10.2165/00003088-200342130-00003
118.
Laffleur F., Bauer B. Progress in Nasal Drug Delivery Systems. Int. J. Pharm. 2021;607:120994.
Not in our library10.1016/j.ijpharm.2021.120994
119.
Casettari L., Illum L. Chitosan in Nasal Delivery Systems for Therapeutic Drugs. J. Controll. Release. 2014;190:189-200.
Not in our library10.1016/j.jconrel.2014.05.003
120.
Yu S., Xu X., Feng J., Liu M., Hu K. Chitosan and Chitosan Coating Nanoparticles for the Treatment of Brain Disease. Int. J. Pharm. 2019;560:282-293.
Not in our library10.1016/j.ijpharm.2019.02.012
121.
Ojeda-Hernández D.D., Canales-Aguirre A.A., Matias-Guiu J., Gomez-Pinedo U., Mateos-Díaz J.C. Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System. Front. Bioeng. Biotechnol. 2020;8:389.
Not in our library10.3389/fbioe.2020.00389
122.
Ali A., Ahmed S. A Review on Chitosan and Its Nanocomposites in Drug Delivery. Int. J. Biol. Macromol. 2018;109:273-286.
Not in our library10.1016/j.ijbiomac.2017.12.078
123.
Patil S., Babbar A., Mathur R., Mishra A., Sawant K. Mucoadhesive Chitosan Microspheres of Carvedilol for Nasal Administration. J. Drug Target. 2010;18:321-331.
Not in our library10.3109/10611861003663523
124.
Gungor S., Okyar A., Erturk-Toker S., Baktir G., Ozsoy Y. Ondansetron-Loaded Chitosan Microspheres for Nasal Antiemetic Drug Delivery: An Alternative Approach to Oral and Parenteral Routes. Drug Dev. Ind. Pharm. 2010;36:806-813.
Not in our library10.3109/03639040903517906
125.
Pandey J., Shankar R., Kumar M., Shukla K., Kumari B. Development of Nasal Mucoadhesive Microspheres of Granisetron: A Potential Drug. Drug Res. 2020;70:367.
Not in our library10.1055/a-1193-4781
126.
Chitosan Derivatives and Their Application in Biomedicine · 2020
No notice
127.
Yang W., Dong Z., Li Y., Zhang Y., Fu H., Xie Y. Therapeutic Efficacy of Chitosan Nanoparticles Loaded with BCG-Polysaccharide Nucleic Acid and Ovalbumin on Airway Inflammation in Asthmatic Mice. Eur. J. Clin. Microbiol. Infect. Dis. 2021;40:1623-1631.
Not in our library10.1007/s10096-021-04183-9
128.
Lv Y., Zhang J., Wang C. Self-Assembled Chitosan Nanoparticles for Intranasal Delivery of Recombinant Protein Interleukin-17 Receptor C (IL-17RC): Preparation and Evaluation in Asthma Mice. Bioengineered. 2021;12:3029-3039.
Not in our library10.1080/21655979.2021.1940622
129.
Xu J., Xu B., Shou D., Xia X., Hu Y. Preparation and Evaluation of Vancomycin-Loaded N-Trimethyl Chitosan Nanoparticles. Polymers. 2015;7:1850-1870.
Not in our library10.3390/polym7091488
130.
Bartos C., Varga P., Szabó-Révész P., Ambrus R. Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration. Pharmaceutics. 2021;13:608.
Not in our library10.3390/pharmaceutics13050608
131.
Jin H., Zhao Z., Lan Q., Zhou H., Mai Z., Wang Y., Ding X., Zhang W., Pi J., Evans C.E., et al. Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury. Front. Pharmacol. 2021;11:592238.
Not in our library10.3389/fphar.2020.592238
132.
Cho C.S., Islam M.A., Firdous J., Choi Y.J., Yun C.H. Design and Application of Chitosan Microspheres as Oral and Nasal Vaccine Carriers: An Updated Review. Int. J. Nanomed. 2012;7:6077.
Not in our library10.2147/ijn.s38330
133.
Cui Z., Han D., Sun X., Zhang M., Feng X., Sun C., Gu J., Tong C., Lei L., Han W. Mannose-Modified Chitosan Microspheres Enhance OprF-OprI-Mediated Protection of Mice against Pseudomonas Aeruginosa Infection via Induction of Mucosal Immunity. Appl. Microbiol. Biotechnol. 2015;99:667-680.
Not in our library10.1007/s00253-014-6147-z
134.
Li Z., Xiong F., He J., Dai X., Wang G. Surface-Functionalized, PH-Responsive Poly (Lactic-Co-Glycolic Acid)-Based Microparticles for Intranasal Vaccine Delivery: Effect of Surface Modification with Chitosan and Mannan. Eur. J. Pharm. Biopharm. 2016;109:24-34.
Not in our library10.1016/j.ejpb.2016.08.012
135.
Pawar D., Jaganathan K.S. Mucoadhesive Glycol Chitosan Nanoparticles for Intranasal Delivery of Hepatitis B Vaccine: Enhancement of Mucosal and Systemic Immune Response. Drug Deliv. 2016;23:185-194.
Not in our library10.3109/10717544.2014.908427
136.
Chowdhury M.Y.E., Kim T.H., Uddin M.B., Kim J.H., Hewawaduge C.Y., Ferdowshi Z., Sung M.H., Kim C.J., Lee J.S. Mucosal Vaccination of Conserved SM2, HA2 and Cholera Toxin Subunit A1 (CTA1) Fusion Protein with Poly Gamma-Glutamate/Chitosan Nanoparticles (PC NPs) Induces Protection against Divergent Influenza Subtypes. Vet. Microbiol. 2017;201:240-251.
Not in our library10.1016/j.vetmic.2017.01.020
137.
Mehrabi M., Mohamadpour Dounighi N., Montazeri H., Vakili-Ghartavol R., Rashti A. Chitosan Based Nanoparticles in Mucosal Vaccine Delivery. Arch. Razi Inst. 2018;73:165-176.
Not in our library10.22092/ari.2017.109235.1101
138.
Jearanaiwitayakul T., Seesen M., Chawengkirttikul R., Limthongkul J., Apichirapokey S., Sapsutthipas S., Phumiamorn S., Sunintaboon P., Ubol S. Intranasal Administration of RBD Nanoparticles Confers Induction of Mucosal and Systemic Immunity against SARS-CoV-2. Vaccines. 2021;9:768.
Not in our library10.3390/vaccines9070768
139.
Gao Y., Wu Y. Recent Advances of Chitosan-Based Nanoparticles for Biomedical and Biotechnological Applications. Int. J. Biol. Macromol. 2022;203:379-388.
Not in our library10.1016/j.ijbiomac.2022.01.162
140.
Wang Z.B., Shan P., Li S.Z., Zhou Y., Deng X., Li J.L., Zhang Y., Gao J.S., Xu J. The Mechanism of Action of Acid-Soluble Chitosan as an Adjuvant in the Formulation of Nasally Administered Vaccine against HBV. RSC Adv. 2016;6:96785-96797.
Not in our library10.1039/c6ra14419e
141.
Singh B., Maharjan S., Sindurakar P., Cho K.H., Choi Y.J., Cho C.S. Needle-Free Immunization with Chitosan-Based Systems. Int. J. Mol. Sci. 2018;19:3639.
Not in our library10.3390/ijms19113639
142.
Malik A., Gupta M., Gupta V., Gogoi H., Bhatnagar R. Novel Application of Trimethyl Chitosan as an Adjuvant in Vaccine Delivery. Int. J. Nanomed. 2018;13:7959-7970.
Not in our library10.2147/ijn.s165876
143.
Shim S., Yoo H.S. The Application of Mucoadhesive Chitosan Nanoparticles in Nasal Drug Delivery. Mar. Drugs. 2020;18:605.
Not in our library10.3390/md18120605
144.
Boroumand H., Badie F., Mazaheri S., Seyedi Z.S., Nahand J.S., Nejati M., Baghi H.B., Abbasi-Kolli M., Badehnoosh B., Ghandali M., et al. Chitosan-Based Nanoparticles Against Viral Infections. Front. Cell. Infect. Microbiol. 2021;11:643953.
Not in our library10.3389/fcimb.2021.643953
145.
Aderibigbe B.A., Naki T. Chitosan-Based Nanocarriers for Nose to Brain Delivery. Appl. Sci. 2019;9:2219.
Not in our library10.3390/app9112219
146.
Tzeyung A., Md S., Bhattamisra S., Madheswaran T., Alhakamy N., Aldawsari H., Radhakrishnan A. Fabrication, Optimization, and Evaluation of Rotigotine-Loaded Chitosan Nanoparticles for Nose-To-Brain Delivery. Pharmaceutics. 2019;11:26.
Not in our library10.3390/pharmaceutics11010026
147.
Manek E., Darvas F., Petroianu G.A. Use of Biodegradable, Chitosan-Based Nanoparticles in the Treatment of Alzheimer’s Disease. Molecules. 2020;25:4866.
Not in our library10.3390/molecules25204866
148.
Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics · 2021
No notice
149.
Liu S., Yang S., Ho P.C. Intranasal Administration of Carbamazepine-Loaded Carboxymethyl Chitosan Nanoparticles for Drug Delivery to the Brain. Asian J. Pharm. Sci. 2018;13:72-81.
Not in our library10.1016/j.ajps.2017.09.001
150.
Sunena, Singh S.K., Mishra D.N. Nose to Brain Delivery of Galantamine Loaded Nanoparticles: In-Vivo Pharmacodynamic and Biochemical Study in Mice. Curr. Drug Deliv. 2018;16:51-58.
Not in our library10.2174/1567201815666181004094707
151.
Cortés H., Alcalá-Alcalá S., Caballero-Florán I.H., Bernal-Chávez S.A., Ávalos-Fuentes A., González-Torres M., González-Del Carmen M., Figueroa-González G., Reyes-Hernández O.D., Floran B., et al. A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier. Membranes. 2020;10:212.
Not in our library10.3390/membranes10090212
152.
Bruinsmann F., Pigana S., Aguirre T., Souto G., Pereira G., Bianchera A., Fasiolo L., Colombo G., Marques M., Pohlmann A., et al. Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery. Pharmaceutics. 2019;11:86.
Not in our library10.3390/pharmaceutics11020086
153.
Chatzitaki A.T., Jesus S., Karavasili C., Andreadis D., Fatouros D.G., Borges O. Chitosan-Coated PLGA Nanoparticles for the Nasal Delivery of Ropinirole Hydrochloride: In Vitro and Ex Vivo Evaluation of Efficacy and Safety. Int. J. Pharm. 2020;589:119776.
Not in our library10.1016/j.ijpharm.2020.119776
154.
El-Enin H.A.A., Elkomy M.H., Naguib I.A., Ahmed M.F., Alsaidan O.A., Alsalahat I., Ghoneim M.M., Eid H.M. Lipid Nanocarriers Overlaid with Chitosan for Brain Delivery of Berberine via the Nasal Route. Pharmaceuticals. 2022;15:281.
Not in our library10.3390/ph15030281
155.
Gartziandia O., Egusquiaguirre S.P., Bianco J., Pedraz J.L., Igartua M., Hernandez R.M., Préat V., Beloqui A. Nanoparticle Transport across in Vitro Olfactory Cell Monolayers. Int. J. Pharm. 2016;499:81-89.
Not in our library10.1016/j.ijpharm.2015.12.046
156.
Nimi T., Manohar D. An overview on in situ nasal gel for drug delivery. J. Pharm. Sci. Res. 2019;11:2585-2589.
Not in our library
157.
Ravi P.R., Aditya N., Patil S., Cherian L. Nasal in-Situ Gels for Delivery of Rasagiline Mesylate: Improvement in Bioavailability and Brain Localization. Drug Deliv. 2015;22:903-910.
Not in our library10.3109/10717544.2013.860501
158.
Abouhussein D.M.N., Khattab A., Bayoumi N.A., Mahmoud A.F., Sakr T.M. Brain Targeted Rivastigmine Mucoadhesive Thermosensitive In Situ Gel: Optimization, In Vitro Evaluation, Radiolabeling, In Vivo Pharmacokinetics and Biodistribution. J. Drug Deliv. Sci. Technol. 2018;43:129-140.
Not in our library10.1016/j.jddst.2017.09.021
159.
Bahmanpour A., Ghaffari M., Milan P.B., Moztarzadeh F., Mozafari M. Synthesis and Characterization of Thermosensitive Hydrogel Based on Quaternized Chitosan for Intranasal Delivery of Insulin. Biotechnol. Appl. Biochem. 2021;68:247-256.
Not in our library10.1002/bab.1917
160.
Taymouri S., Minaiyan M., Ebrahimi F., Tavakoli N. In-vitro and In-vivo Evaluation of Chitosan-based Thermosensitive Gel Containing Lorazepam NLCs for the Treatment of Status Epilepticus. IET Nanobiotechnol. 2020;14:148-154.
Not in our library10.1049/iet-nbt.2019.0156
161.
Gholizadeh H., Messerotti E., Pozzoli M., Cheng S., Traini D., Young P., Kourmatzis A., Caramella C., Ong H.X. Application of a Thermosensitive In Situ Gel of Chitosan-Based Nasal Spray Loaded with Tranexamic Acid for Localised Treatment of Nasal Wounds. AAPS Pharm. Sci. Technol. 2019;20:299.
Not in our library10.1208/s12249-019-1517-6
162.
Su Y., Sun B., Gao X., Liu S., Hao R., Han B. Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of MiRNA-146a to Treat Allergic Rhinitis. Pharmaceutics. 2020;12:907.
Not in our library10.3390/pharmaceutics12100907
163.
Nanoemulsions for “Nose-to-Brain” Drug Delivery · 2019
No notice
164.
Ahmad E., Feng Y., Qi J., Fan W., Ma Y., He H., Xia F., Dong X., Zhao W., Lu Y., et al. Evidence of Nose-to-Brain Delivery of Nanoemulsions: Cargoes but Not Vehicles. Nanoscale. 2017;9:1174-1183.
Not in our library10.1039/c6nr07581a
165.
Bahadur S., Pardhi D.M., Rautio J., Rosenholm J.M., Pathak K. Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders. Pharmaceutics. 2020;12:1230.
Not in our library10.3390/pharmaceutics12121230
166.
Bahadur S., Pathak K. Buffered Nanoemulsion for Nose to Brain Delivery of Ziprasidone Hydrochloride: Preformulation and Pharmacodynamic Evaluation. Curr. Drug Deliv. 2012;9:596-607.
Not in our library10.2174/156720112803529792
167.
Sood S., Jain K., Gowthamarajan K. Optimization of Curcumin Nanoemulsion for Intranasal Delivery Using Design of Experiment and Its Toxicity Assessment. Colloids Surf. B Biointerfaces. 2014;113:330-337.
Not in our library10.1016/j.colsurfb.2013.09.030
168.
Abdou E.M., Kandil S.M., Miniawy H.M.F.E. Brain Targeting Efficiency of Antimigrain Drug Loaded Mucoadhesive Intranasal Nanoemulsion. Int. J. Pharm. 2017;529:667-677.
Not in our library10.1016/j.ijpharm.2017.07.030
169.
Fachel F.N.S., Michels L.R., Azambuja J.H., Lenz G.S., Gelsleichter N.E., Endres M., Scholl J.N., Schuh R.S., Barschak A.G., Figueiró F., et al. Chitosan-Coated Rosmarinic Acid Nanoemulsion Nasal Administration Protects against LPS-Induced Memory Deficit, Neuroinflammation, and Oxidative Stress in Wistar Rats. Neurochem. Int. 2020;141:104875.
Not in our library10.1016/j.neuint.2020.104875
170.
Shukr M.H., Farid O.A.A. Brain Targeting of Agomelatine Egg Lecithin Based Chitosan Coated Nanoemulsion. Pharm. Dev. Technol. 2021;26:464-475.
Not in our library10.1080/10837450.2021.1888980
171.
Ahmed S., Gull A., Aqil M., Danish A.M., Sultana Y. Poloxamer-407 Thickened Lipid Colloidal System of Agomelatine for Brain Targeting: Characterization, Brain Pharmacokinetic Study and Behavioral Study on Wistar Rats. Colloids Surf. B Biointerfaces. 2019;181:426-436.
Not in our library10.1016/j.colsurfb.2019.05.016
172.
Ahmad N., Ahmad R., Ahmad F.J., Ahmad W., Alam M.A., Amir M., Ali A. Poloxamer-Chitosan-Based Naringenin Nanoformulation Used in Brain Targeting for the Treatment of Cerebral Ischemia. Saudi J. Biol. Sci. 2020;27:500-517.
Not in our library10.1016/j.sjbs.2019.11.008
173.
Gaudana R., Ananthula H.K., Parenky A., Mitra A.K. Ocular Drug Delivery. AAPS J. 2010;12:348-360.
Not in our library10.1208/s12248-010-9183-3
174.
Zhang J., Jiao J., Niu M., Gao X., Zhang G., Yu H., Yang X., Liu L. Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective. Int. J. Nanomed. 2021;16:6497-6530.
Not in our library10.2147/ijn.s329831
175.
Irimia T., Dinu-Pîrvu C.E., Ghica M., Lupuleasa D., Muntean D.L., Udeanu D., Popa L. Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review. Mar. Drugs. 2018;16:373.
Not in our library10.3390/md16100373
176.
Pontillo A.R.N., Detsi A. Nanoparticles for Ocular Drug Delivery: Modified and Non-Modified Chitosan as a Promising Biocompatible Carrier. Nanomedicine. 2019;14:1889-1909.
Not in our library10.2217/nnm-2019-0040
177.
Paliwal R., Paliwal S.R., Sulakhiya K., Kurmi B.D., Kenwat R., Mamgain A. Chitosan-Based Nanocarriers for Ophthalmic Applications. Polysaccharide Carriers for Drug Delivery. 2019;79-104.
Not in our library
178.
Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments · 2020
No notice
179.
Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting · 2019
No notice
180.
Advances in Chitosan-Based Nanoparticles for Drug Delivery · 2021
No notice
181.
Manchanda S., Sahoo P.K. Topical Delivery of Acetazolamide by Encapsulating in Mucoadhesive Nanoparticles. Asian J. Pharm. Sci. 2017;12:550-557.
Not in our library10.1016/j.ajps.2017.04.005
182.
Shinde U.A., Joshi P.N., Jain D.D., Singh K. Preparation and Evaluation of N-Trimethyl Chitosan Nanoparticles of Flurbiprofen for Ocular Delivery. Curr. Eye Res. 2019;44:575-582.
Not in our library10.1080/02713683.2019.1567793
183.
Zhao R., Li J., Wang J., Yin Z., Zhu Y., Liu W. Development of Timolol-Loaded Galactosylated Chitosan Nanoparticles and Evaluation of Their Potential for Ocular Drug Delivery. AAPS Pharm. Sci. Technol. 2017;18:997-1008.
Not in our library10.1208/s12249-016-0669-x
184.
Yu A., Shi H., Liu H., Bao Z., Dai M., Lin D., Lin D., Xu X., Li X., Wang Y. Mucoadhesive Dexamethasone-Glycol Chitosan Nanoparticles for Ophthalmic Drug Delivery. Int. J. Pharm. 2020;575:118943.
Not in our library10.1016/j.ijpharm.2019.118943
185.
Chhonker Y.S., Prasad Y.D., Chandasana H., Vishvkarma A., Mitra K., Shukla P.K., Bhatta R.S. Amphotericin-B Entrapped Lecithin/Chitosan Nanoparticles for Prolonged Ocular Application. Int. J. Biol. Macromol. 2015;72:1451-1458.
Not in our library10.1016/j.ijbiomac.2014.10.014
186.
Cross-linked chitosan-dextran sulphate vehicle system for controlled release of ciprofloxaxin drug: An ophthalmic application · 2017
Not checked
187.
Taghe S., Mirzaeei S. Preparation and Characterization of Novel, Mucoadhesive Ofloxacin Nanoparticles for Ocular Drug Delivery. Braz. J. Pharm. Sci. 2019;55:e17105.
Not in our library10.1590/s2175-97902019000117105
188.
Silva B., Marto J., Braz B.S., Delgado E., Almeida A.J., Gonçalves L. New Nanoparticles for Topical Ocular Delivery of Erythropoietin. Int. J. Pharm. 2020;576:119020.
Not in our library10.1016/j.ijpharm.2020.119020
189.
Pandit J., Sultana Y., Aqil M. Chitosan-Coated PLGA Nanoparticles of Bevacizumab as Novel Drug Delivery to Target Retina: Optimization, Characterization, and in Vitro Toxicity Evaluation. Artif. Cells Nanomed. Biotechnol. 2017;45:1397-1407.
Not in our library10.1080/21691401.2016.1243545
190.
Dandamudi M., McLoughlin P., Behl G., Rani S., Coffey L., Chauhan A., Kent D., Fitzhenry L. Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery. Pharmaceutics. 2021;13:1590.
Not in our library10.3390/pharmaceutics13101590
191.
Xing Y., Zhu L., Zhang K., Li T., Huang S. Nanodelivery of Triamcinolone Acetonide with PLGA-Chitosan Nanoparticles for the Treatment of Ocular Inflammation. Artif. Cells Nanomed. Biotechnol. 2021;49:308-316.
Not in our library10.1080/21691401.2021.1895184
192.
Selvaraj K., Kuppusamy G., Krishnamurthy J., Mahalingam R., Singh S.K., Gulati M. Repositioning of Itraconazole for the Management of Ocular Neovascularization Through Surface-Modified Nanostructured Lipid Carriers. ASSAY Drug Dev. Technol. 2019;17:178-190.
Not in our library10.1089/adt.2018.898
193.
Li J., Jin X., Yang Y., Zhang L., Liu R., Li Z. Trimethyl Chitosan Nanoparticles for Ocular Baicalein Delivery: Preparation, Optimization, in Vitro Evaluation, in Vivo Pharmacokinetic Study and Molecular Dynamics Simulation. Int. J. Biol. Macromol. 2020;156:749-761.
Not in our library10.1016/j.ijbiomac.2020.04.115
194.
Shahab M.S., Rizwanullah M., Alshehri S., Imam S.S. Optimization to Development of Chitosan Decorated Polycaprolactone Nanoparticles for Improved Ocular Delivery of Dorzolamide: In Vitro, Ex Vivo and Toxicity Assessments. Int. J. Biol. Macromol. 2020;163:2392-2404.
Not in our library10.1016/j.ijbiomac.2020.09.185
195.
Tan G., Yu S., Pan H., Li J., Liu D., Yuan K., Yang X., Pan W. Bioadhesive Chitosan-Loaded Liposomes: A More Efficient and Higher Permeable Ocular Delivery Platform for Timolol Maleate. Int. J. Biol. Macromol. 2017;94:355-363.
Not in our library10.1016/j.ijbiomac.2016.10.035
196.
Li J., Cheng T., Tian Q., Cheng Y., Zhao L., Zhang X., Qu Y. A More Efficient Ocular Delivery System of Triamcinolone Acetonide as Eye Drop to the Posterior Segment of the Eye. Drug Deliv. 2019;26:188-198.
Not in our library10.1080/10717544.2019.1571122
197.
Khalil M., Hashmi U., Riaz R., Rukh Abbas S. Chitosan Coated Liposomes (CCL) Containing Triamcinolone Acetonide for Sustained Delivery: A Potential Topical Treatment for Posterior Segment Diseases. Int. J. Biol. Macromol. 2020;143:483-491.
Not in our library10.1016/j.ijbiomac.2019.10.256
198.
Wu Y., Liu Y., Li X., Kebebe D., Zhang B., Ren J., Lu J., Li J., Du S., Liu Z. Research Progress of In-Situ Gelling Ophthalmic Drug Delivery System. Asian J. Pharm. Sci. 2019;14:1-15.
Not in our library10.1016/j.ajps.2018.04.008
199.
Al-Kinani A.A., Zidan G., Elsaid N., Seyfoddin A., Alani A.W.G., Alany R.G. Ophthalmic Gels: Past, Present and Future. Adv. Drug Deliv. Rev. 2018;126:113-126.
Not in our library10.1016/j.addr.2017.12.017
200.
Gupta S. Carbopol/Chitosan Based PH Triggered In Situ Gelling System for Ocular Delivery of Timolol Maleate. Sci. Pharm. 2010;78:959-976.
Not in our library10.3797/scipharm.1001-06
201.
Tsai C.Y., Woung L.C., Yen J.C., Tseng P.C., Chiou S.H., Sung Y.J., Liu K.T., Cheng Y.H. Thermosensitive Chitosan-Based Hydrogels for Sustained Release of Ferulic Acid on Corneal Wound Healing. Carbohydr. Polym. 2016;135:308-315.
Not in our library10.1016/j.carbpol.2015.08.098
202.
Cheng Y., Chang Y., Ko Y., Liu C.J. Sustained Release of Levofloxacin from Thermosensitive Chitosan-based Hydrogel for the Treatment of Postoperative Endophthalmitis. J. Biomed. Mater. Res. B Appl. Biomater. 2020;108:8-13.
Not in our library10.1002/jbm.b.34359
203.
Deepthi S., Jose J. Novel Hydrogel-Based Ocular Drug Delivery System for the Treatment of Conjunctivitis. Int. Ophthalmol. 2019;39:1355-1366.
Not in our library10.1007/s10792-018-0955-6
204.
Kashikar V., Gonjari I. In Situ Gelling Systems of Ofloxacin: Comparative Performance of in Vivo Precorneal Drainage and Pharmacokinetic Study. Asian J. Pharm. 2013;7:15.
Not in our library10.4103/0973-8398.110931
205.
Gupta H., Velpandian T., Jain S. Ion- and pH-activated novel in-situ gel system for sustained ocular drug delivery. J. Drug Target. 2010;18:499-505.
Not in our library10.3109/10611860903508788
206.
Gupta H., Aqil M., Khar R., Ali A., Bhatnagar A., Mittal G. An Alternative in Situ Gel-Formulation of Levofloxacin Eye Drops for Prolong Ocular Retention. J. Pharm. Bioallied Sci. 2015;7:9.
Not in our library10.4103/0975-7406.149810
207.
Ameeduzzafar, Imam S.S., Bukhari S.N.A., Ali A. Preparation and Evaluation of Novel Chitosan: Gelrite Ocular System Containing Besifloxacin for Topical Treatment of Bacterial Conjunctivitis: Scintigraphy, Ocular Irritation and Retention Assessment. Artif. Cells Nanomed. Biotechnol. 2018;46:959-967.
Not in our library10.1080/21691401.2017.1349779
208.
Ameeduzzafar, Imam S.S., Bukhari S.N.A., Ahmad J., Ali A. Formulation and Optimization of Levofloxacin Loaded Chitosan Nanoparticle for Ocular Delivery: In-Vitro Characterization, Ocular Tolerance and Antibacterial Activity. Int. J. Biol. Macromol. 2018;108:650-659.
Not in our library10.1016/j.ijbiomac.2017.11.170
209.
Fabiano A., Bizzarri R., Zambito Y. Thermosensitive Hydrogel Based on Chitosan and Its Derivatives Containing Medicated Nanoparticles for Transcorneal Administration of 5-Fluorouracil. Int. J. Nanomed. 2017;12:633-643.
Not in our library10.2147/ijn.s121642
210.
Fabiano A., Piras A.M., Guazzelli L., Storti B., Bizzarri R., Zambito Y. Impact of Different Mucoadhesive Polymeric Nanoparticles Loaded in Thermosensitive Hydrogels on Transcorneal Administration of 5-Fluorouracil. Pharmaceutics. 2019;11:623.
Not in our library10.3390/pharmaceutics11120623
211.
Ahmed T., Aljaeid B. A Potential in Situ Gel Formulation Loaded with Novel Fabricated Poly (Lactide-Co-Glycolide) Nanoparticles for Enhancing and Sustaining the Ophthalmic Delivery of Ketoconazole. Int. J. Nanomed. 2017;12:1863-1875.
Not in our library10.2147/ijn.s131850
212.
Cheng Y.H., Ko Y.C., Chang Y.F., Huang S.H., Liu C.J. Thermosensitive Chitosan-Gelatin-Based Hydrogel Containing Curcumin-Loaded Nanoparticles and Latanoprost as a Dual-Drug Delivery System for Glaucoma Treatment. Exp. Eye Res. 2019;179:179-187.
Not in our library10.1016/j.exer.2018.11.017
213.
Almeida H., Lobão P., Frigerio C., Fonseca J., Silva R., Quaresma P., Lobo J.M.S., Amaral M.H. Development of Mucoadhesive and Thermosensitive Eyedrops to Improve the Ophthalmic Bioavailability of Ibuprofen. J. Drug Deliv. Sci. Technol. 2016;35:69-80.
Not in our library10.1016/j.jddst.2016.04.010
214.
Tan G., Yu S., Li J., Pan W. Development and characterization of nanostructured lipid carriers based chitosan thermosensitive hydrogel for delivery of dexamethasone. Int. J. Biol. Macromol. 2017;103:941-947.
Not in our library10.1016/j.ijbiomac.2017.05.132
215.
Abdel-Rashid R.S., Helal D.A., Omar M.M., El Sisi A.M. Nanogel Loaded with Surfactant Based Nanovesicles for Enhanced Ocular Delivery of Acetazolamide. Int. J. Nanomed. 2019;14:2973-2983.
Not in our library10.2147/ijn.s201891
216.
Hua S. Physiological and Pharmaceutical Considerations for Rectal Drug Formulations. Front. Pharmacol. 2019;10:1196.
Not in our library10.3389/fphar.2019.01196
217.
Melo M., Nunes R., Sarmento B., das Neves J. Rectal Administration of Nanosystems: From Drug Delivery to Diagnostics. Mater. Today Chem. 2018;10:128-141.
Not in our library10.1016/j.mtchem.2018.09.001
218.
Xu J., Tam M., Samaei S., Lerouge S., Barralet J., Stevenson M.M., Cerruti M. Mucoadhesive Chitosan Hydrogels as Rectal Drug Delivery Vessels to Treat Ulcerative Colitis. Acta Biomater. 2017;48:247-257.
Not in our library10.1016/j.actbio.2016.10.026
219.
El-Leithy E.S., Shaker D.S., Ghorab M.K., Abdel-Rashid R.S. Evaluation of Mucoadhesive Hydrogels Loaded with Diclofenac Sodium–Chitosan Microspheres for Rectal Administration. AAPS Pharm. Sci. Technol. 2010;11:1695-1702.
Not in our library10.1208/s12249-010-9544-3
220.
Feng C., Li J., Kong M., Liu Y., Cheng X.J., Li Y., Park H.J., Chen X.G. Surface Charge Effect on Mucoadhesion of Chitosan Based Nanogels for Local Anti-Colorectal Cancer Drug Delivery. Colloids Surf. B Biointerfaces. 2015;128:439-447.
Not in our library10.1016/j.colsurfb.2015.02.042
221.
Amini-Fazl M.S., Mohammadi R., Kheiri K. 5-Fluorouracil Loaded Chitosan/Polyacrylic Acid/Fe3O4 Magnetic Nanocomposite Hydrogel as a Potential Anticancer Drug Delivery System. Int. J. Biol. Macromol. 2019;132:506-513.
Not in our library10.1016/j.ijbiomac.2019.04.005
222.
Bialik M., Kuras M., Sobczak M., Oledzka E. Achievements in Thermosensitive Gelling Systems for Rectal Administration. Int. J. Mol. Sci. 2021;22:5500.
Not in our library10.3390/ijms22115500
223.
Patil S.D., Havaldar V., Mali K.K., Dias R.J. Formulation and Characterization of Mucoadhesive Liquid Suppositories Containing Chitosan Based Candesartan Celixitil Loaded Microspheres. Int. J. Sci. Eng. Res. 2017;8:2277-2295.
Not in our library
224.
He W., Du Y., Dai W., Wu Y., Zhang M. Effects OfN-Trimethyl Chitosan Chloride as an Absorption Enhancer on Properties of Insulin Liquid Suppository in Vitro and in Vivo. J. Appl. Polym. Sci. 2006;99:1140-1146.
Not in our library10.1002/app.22317
225.
du Plessis L.H., Kotzé A.F., Junginger H.E. Nasal and Rectal Delivery of Insulin with Chitosan and N-Trimethyl Chitosan Chloride. Drug Deliv. 2010;17:399-407.
Not in our library10.3109/10717541003762888
226.
Palma E., Costa N., Molinaro R., Francardi M., Paolino D., Cosco D., Fresta M. Improvement of the Therapeutic Treatment of Inflammatory Bowel Diseases Following Rectal Administration of Mesalazine-Loaded Chitosan Microparticles vs Asamax®. Carbohydr. Polym. 2019;212:430-438.
Not in our library10.1016/j.carbpol.2019.02.049
227.
Jhundoo H.D., Siefen T., Liang A., Schmidt C., Lokhnauth J., Béduneau A., Pellequer Y., Larsen C.C., Lamprecht A. Anti-Inflammatory Activity of Chitosan and 5-Amino Salicylic Acid Combinations in Experimental Colitis. Pharmaceutics. 2020;12:1038.
Not in our library10.3390/pharmaceutics12111038
228.
Tanphaichitr N., Srakaew N., Alonzi R., Kiattiburut W., Kongmanas K., Zhi R., Li W., Baker M., Wang G., Hickling D. Potential Use of Antimicrobial Peptides as Vaginal Spermicides/Microbicides. Pharmaceuticals. 2016;9:13.
Not in our library10.3390/ph9010013
229.
Johal H.S., Garg T., Rath G., Goyal A.K. Advanced Topical Drug Delivery System for the Management of Vaginal Candidiasis. Drug Deliv. 2016;23:550-563.
Not in our library10.3109/10717544.2014.928760
230.
El-Hammadi M.M., Arias J.L. Nanomedicine for Vaginal Drug Delivery. Theory and Applications of Nonparenteral Nanomedicines. 2021;235-257.
Not in our library
231.
Valamla B., Thakor P., Phuse R., Dalvi M., Kharat P., Kumar A., Panwar D., Singh S.B., Giorgia P., Mehra N.K. Engineering Drug Delivery Systems to Overcome the Vaginal Mucosal Barrier: Current Understanding and Research Agenda of Mucoadhesive Formulations of Vaginal Delivery. J. Drug Deliv. Sci. Technol. 2022;70:103162.
Not in our library10.1016/j.jddst.2022.103162
232.
Osmałek T., Froelich A., Jadach B., Tatarek A., Gadziński P., Falana A., Gralińska K., Ekert M., Puri V., Wrotyńska-Barczyńska J., et al. Recent Advances in Polymer-Based Vaginal Drug Delivery Systems. Pharmaceutics. 2021;13:884.
Not in our library10.3390/pharmaceutics13060884
233.
Lalan M.S., Patel V.N., Misra A. Polymers in Vaginal Drug Delivery: Recent Advancements. Applications of Polymers in Drug Delivery. 2021;281-303.
Not in our library
234.
Dedeloudi A., Siamidi A., Pavlou P., Vlachou M. Recent Advances in the Excipients Used in Modified Release Vaginal Formulations. Materials. 2022;11:327.
Not in our library10.3390/ma15010327
235.
Araujo V.H.S., de Souza M.P.C., Carvalho G.C., Duarte J.L., Chorilli M. Chitosan-Based Systems Aimed at Local Application for Vaginal Infections. Carbohydr. Polym. 2021;261:117919.
Not in our library10.1016/j.carbpol.2021.117919
236.
Nayak R., Kar B., Ghosh G., Rath G. Current Trends in Chitosan Based Nanopharmaceuticals for Topical Vaginal Therapies. Int. J. Biol. Macromol. 2021;193:2140-2152.
Not in our library10.1016/j.ijbiomac.2021.11.045
237.
Fitaihi R.A., Aleanizy F.S., Elsamaligy S., Mahmoud H.A., Bayomi M.A. Role of Chitosan on Controlling the Characteristics and Antifungal Activity of Bioadhesive Fluconazole Vaginal Tablets. Saudi Pharm. J. 2018;26:151-161.
Not in our library10.1016/j.jsps.2017.12.016
238.
Cazorla-Luna R., Martín-Illana A., Notario-Pérez F., Bedoya L.-M., Bermejo P., Ruiz-Caro R., Veiga M.-D. Dapivirine Bioadhesive Vaginal Tablets Based on Natural Polymers for the Prevention of Sexual Transmission of HIV. Polymers. 2019;11:483.
Not in our library10.3390/polym11030483
239.
Paczkowska M., Chanaj-Kaczmarek J., Romaniuk-Drapała A., Rubiś B., Szymanowska D., Kobus-Cisowska J., Szymańska E., Winnicka K., Cielecka-Piontek J. Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment. J. Clin. Med. 2020;9:1208.
Not in our library10.3390/jcm9041208
240.
Sánchez M.T., Ruiz M.A., Castán H., Morales M.E. A Novel Double-Layer Mucoadhesive Tablet Containing Probiotic Strain for Vaginal Administration: Design, Development and Technological Evaluation. Eur. J. Pharm. Sci. 2018;112:63-70.
Not in our library10.1016/j.ejps.2017.11.006
241.
Lupo N., Fodor B., Muhammad I., Yaqoob M., Matuszczak B., Bernkop-Schnürch A. Entirely S-Protected Chitosan: A Promising Mucoadhesive Excipient for Metronidazole Vaginal Tablets. Acta Biomater. 2017;64:106-115.
Not in our library10.1016/j.actbio.2017.10.014
242.
Abilova G.K., Kaldybekov D.B., Irmukhametova G.S., Kazybayeva D.S., Iskakbayeva Z.A., Kudaibergenov S.E., Khutoryanskiy V.V. Chitosan/Poly(2-Ethyl-2-Oxazoline) Films with Ciprofloxacin for Application in Vaginal Drug Delivery. Materials. 2020;13:1709.
Not in our library10.3390/ma13071709
243.
Calvo N.L., Svetaz L.A., Alvarez V.A., Quiroga A.D., Lamas M.C., Leonardi D. Chitosan-Hydroxypropyl Methylcellulose Tioconazole Films: A Promising Alternative Dosage Form for the Treatment of Vaginal Candidiasis. Int. J. Pharm. 2019;556:181-191.
Not in our library10.1016/j.ijpharm.2018.12.011
244.
Calvo N.L., Tejada G., Svetaz L.A., Quiroga A.D., Alvarez V.A., Lamas M.C., Leonardi D. Development and Optimization of a New Tioconazole Vaginal Mucoadhesive Film Using an Experimental Design Strategy. Physicochemical and Biological Characterization. J. Pharm. Biomed. Anal. 2021;205:114303.
Not in our library10.1016/j.jpba.2021.114303
245.
Martín-Illana A., Chinarro E., Cazorla-Luna R., Notario-Perez F., Veiga-Ochoa M.D., Rubio J., Tamayo A. Optimized Hydration Dynamics in Mucoadhesive Xanthan-Based Trilayer Vaginal Films for the Controlled Release of Tenofovir. Carbohydr. Polym. 2022;278:118958.
Not in our library10.1016/j.carbpol.2021.118958
246.
Martín-Illana A., Cazorla-Luna R., Notario-Pérez F., Rubio J., Ruiz-Caro R., Tamayo A., Veiga M.D. Eudragit® L100/Chitosan Composite Thin Bilayer Films for Intravaginal PH-Responsive Release of Tenofovir. Int. J. Pharm. 2022;616:121554.
Not in our library10.1016/j.ijpharm.2022.121554
247.
Tentor F., Siccardi G., Sacco P., Demarchi D., Marsich E., Almdal K., Bose Goswami S., Boisen A. Long Lasting Mucoadhesive Membrane Based on Alginate and Chitosan for Intravaginal Drug Delivery. J. Mater. Sci. Mater. Med. 2020;31:25.
Not in our library10.1007/s10856-020-6359-y
248.
dos Santos A.M., Carvalho S.G., Araujo V.H.S., Carvalho G.C., Gremião M.P.D., Chorilli M. Recent Advances in Hydrogels as Strategy for Drug Delivery Intended to Vaginal Infections. Int. J. Pharm. 2020;590:119867.
Not in our library10.1016/j.ijpharm.2020.119867
249.
Tian B., Hua S., Tian Y., Liu J. Chemical and Physical Chitosan Hydrogels as Prospective Carriers for Drug Delivery: A Review. J. Mater. Chem. B. 2020;8:10050-10064.
Not in our library10.1039/d0tb01869d
250.
Campos L.M., de Oliveira Lemos A.S., da Cruz L.F., de Freitas Araújo M.G., de Mello Botti G.C.R., Júnior J.L.R., Rocha V.N., Denadai Â.M.L., da Silva T.P., Tavares G.D., et al. Development and in Vivo Evaluation of Chitosan-Gel Containing Mitracarpus Frigidus Methanolic Extract for Vulvovaginal Candidiasis Treatment. Biomed. Pharmacother. 2020;130:110609.
Not in our library10.1016/j.biopha.2020.110609
251.
Yang I.H., Lin I.E., Chen T.C., Chen Z.Y., Kuan C.Y., Lin J.N., Chou Y.C., Lin F.H. Synthesis, Characterization, and Evaluation of BDDE Crosslinked Chitosan-TGA Hydrogel Encapsulated with Genistein for Vaginal Atrophy. Carbohydr. Polym. 2021;260:117832.
Not in our library10.1016/j.carbpol.2021.117832
252.
Abd Ellah N.H., Abdel-Aleem J.A., Abdo M.N., Abou-Ghadir O.F., Zahran K.M., Hetta H.F. Efficacy of Ketoconazole Gel-Flakes in Treatment of Vaginal Candidiasis: Formulation, in Vitro and Clinical Evaluation. Int. J. Pharm. 2019;567:118472.
Not in our library10.1016/j.ijpharm.2019.118472
253.
Malli S., Bories C., Pradines B., Loiseau P.M., Ponchel G., Bouchemal K. In Situ Forming Pluronic® F127/Chitosan Hydrogel Limits Metronidazole Transmucosal Absorption. Eur. J. Pharm. Biopharm. 2017;112:143-147.
Not in our library10.1016/j.ejpb.2016.11.024
254.
Argenta D.F., Bernardo B.d.C., Chamorro A.F., Matos P.R., Caon T. Thermosensitive Hydrogels for Vaginal Delivery of Secnidazole as an Approach to Overcome the Systemic Side-Effects of Oral Preparations. Eur. J. Pharm. Sci. 2021;159:105722.
Not in our library10.1016/j.ejps.2021.105722
255.
Velázquez N.S., Turino L.N., Luna J.A., Mengatto L.N. Progesterone Loaded Thermosensitive Hydrogel for Vaginal Application: Formulation and in Vitro Comparison with Commercial Product. Saudi Pharm. J. 2019;27:1096-1106.
Not in our library10.1016/j.jsps.2019.09.006
256.
Shaker D.S., Ismail S., Hamed S., El-Shishtawy E.M. Butoconazole Nitrate Vaginal Sponge: Drug Release and Antifungal Efficacy. J. Drug Deliv. Sci. Technol. 2018;48:274-287.
Not in our library10.1016/j.jddst.2018.09.011
257.
Maestrelli F., Jug M., Cirri M., Kosalec I., Mura P. Characterization and Microbiological Evaluation of Chitosan-Alginate Microspheres for Cefixime Vaginal Administration. Carbohydr. Polym. 2018;192:176-183.
Not in our library10.1016/j.carbpol.2018.03.054
258.
Cirri M., Maestrelli F., Scuota S., Bazzucchi V., Mura P. Development and Microbiological Evaluation of Chitosan and Chitosan-Alginate Microspheres for Vaginal Administration of Metronidazole. Int. J. Pharm. 2021;598:120375.
Not in our library10.1016/j.ijpharm.2021.120375
259.
Moreno M.A., Gómez-Mascaraque L.G., Arias M., Zampini I.C., Sayago J.E., Ramos L.L.P., Schmeda-Hirschmann G., López-Rubio A., Isla M.I. Electrosprayed Chitosan Microcapsules as Delivery Vehicles for Vaginal Phytoformulations. Carbohydr. Polym. 2018;201:425-437.
Not in our library10.1016/j.carbpol.2018.08.084
260.
Meng J., Agrahari V., Ezoulin M.J., Purohit S.S., Zhang T., Molteni A., Dim D., Oyler N.A., Youan B.B.C. Spray-Dried Thiolated Chitosan-Coated Sodium Alginate Multilayer Microparticles for Vaginal HIV Microbicide Delivery. AAPS J. 2017;19:692-702.
Not in our library10.1208/s12248-016-0007-y
261.
Szymanska E., Czarnomysy R., Jacyna J., Basa A., Wilczewska A.Z., Markuszewski M., Winnicka K. Could Spray-Dried Microbeads with Chitosan Glutamate Be Considered as Promising Vaginal Microbicide Carriers? The Effect of Process Variables on the in Vitro Functional and Physicochemical Characteristics. Int. J. Pharm. 2019;568:118558.
Not in our library10.1016/j.ijpharm.2019.118558
262.
Rossi S., Vigani B., Puccio A., Bonferoni M., Sandri G., Ferrari F. Chitosan Ascorbate Nanoparticles for the Vaginal Delivery of Antibiotic Drugs in Atrophic Vaginitis. Mar. Drugs. 2017;15:319.
Not in our library10.3390/md15100319
263.
Amaral A.C., Saavedra P.H.V., Oliveira Souza A.C., de Melo M.T., Tedesco A.C., Morais P.C., Soares Felipe M.S., Bocca A.L. Miconazole Loaded Chitosan-Based Nanoparticles for Local Treatment of Vulvovaginal Candidiasis Fungal Infections. Colloids Surf. B Biointerfaces. 2019;174:409-415.
Not in our library10.1016/j.colsurfb.2018.11.048
264.
Fernandes Costa A., Evangelista Araujo D., Santos Cabral M., Teles Brito I., Borges de Menezes Leite L., Pereira M., Correa Amaral A. Development, Characterization, and in Vitro–in Vivo Evaluation of Polymeric Nanoparticles Containing Miconazole and Farnesol for Treatment of Vulvovaginal Candidiasis. Med. Mycol. 2019;57:52-62.
Not in our library10.1093/mmy/myx155
265.
Facchinatto W.M., Galante J., Mesquita L., Silva D.S., Martins dos Santos D., Moraes T.B., Campana-Filho S.P., Colnago L.A., Sarmento B., das Neves J. Clotrimazole-Loaded N-(2-Hydroxy)-Propyl-3-Trimethylammonium, O-Palmitoyl Chitosan Nanoparticles for Topical Treatment of Vulvovaginal Candidiasis. Acta Biomater. 2021;125:312-321.
Not in our library10.1016/j.actbio.2021.02.029
266.
Malli S., Bories C., Bourge M., Loiseau P., Bouchemal K. Surface-Dependent Endocytosis of Poly (Isobutylcyanoacrylate) Nanoparticles by Trichomonas Vaginalis. Int. J. Pharm. 2018;548:276-287.
Not in our library10.1016/j.ijpharm.2018.07.006
267.
Arias L.S., Pessan J.P., de Souza Neto F.N., Lima B.H.R., de Camargo E.R., Ramage G., Delbem A.C.B., Monteiro D.R. Novel Nanocarrier of Miconazole Based on Chitosan-Coated Iron Oxide Nanoparticles as a Nanotherapy to Fight Candida Biofilms. Colloids Surf. B Biointerfaces. 2020;192:111080.
Not in our library10.1016/j.colsurfb.2020.111080
268.
Martínez-Pérez B., Quintanar-Guerrero D., Tapia-Tapia M., Cisneros-Tamayo R., Zambrano-Zaragoza M.L., Alcalá-Alcalá S., Mendoza-Muñoz N., Piñón-Segundo E. Controlled-Release Biodegradable Nanoparticles: From Preparation to Vaginal Applications. Eur. J. Pharm. Sci. 2018;115:185-195.
Not in our library10.1016/j.ejps.2017.11.029
269.
Marciello M., Rossi S., Caramella C., Remuñán-López C. Freeze-Dried Cylinders Carrying Chitosan Nanoparticles for Vaginal Peptide Delivery. Carbohydr. Polym. 2017;170:43-51.
Not in our library10.1016/j.carbpol.2017.04.051
270.
Deshkar S., Sikchi S., Thakre A., Kale R. Poloxamer Modified Chitosan Nanoparticles for Vaginal Delivery of Acyclovir. Pharm. Nanotechnol. 2021;9:141-156.
Not in our library10.2174/2211738508666210108121541
271.
Arumugam G., Rajendran R. Callophycin A Loaded Chitosan and Spicules Based Nanocomposites as an Alternative Strategy to Overcome Vaginal Candidiasis. Int. J. Biol. Macromol. 2020;161:656-665.
Not in our library10.1016/j.ijbiomac.2020.06.119
272.
Ulubayram K., Calamak S., Shahbazi R., Eroglu I. Nanofibers Based Antibacterial Drug Design, Delivery and Applications. Curr. Pharm. Des. 2015;21:1930-1943.
Not in our library10.2174/1381612821666150302151804
273.
Zupančič Š., Potrč T., Baumgartner S., Kocbek P., Kristl J. Formulation and Evaluation of Chitosan/Polyethylene Oxide Nanofibers Loaded with Metronidazole for Local Infections. Eur. J. Pharm. Sci. 2016;95:152-160.
Not in our library10.1016/j.ejps.2016.10.030
274.
Meng J., Agrahari V., Ezoulin M.J., Zhang C., Purohit S.S., Molteni A., Dim D., Oyler N.A., Youan B.B.C. Tenofovir Containing Thiolated Chitosan Core/Shell Nanofibers: In Vitro and in Vivo Evaluations. Mol. Pharm. 2016;13:4129-4140.
Not in our library10.1021/acs.molpharmaceut.6b00739
275.
dos Santos T.C., Hernández R., Rescignano N., Boff L., Reginatto F.H., Simões C.M.O., de Campos A.M., Mijangos C. Nanocomposite Chitosan Hydrogels Based on PLGA Nanoparticles as Potential Biomedical Materials. Eur. Polym. J. 2018;99:456-463.
Not in our library10.1016/j.eurpolymj.2017.12.039
276.
Peers S., Montembault A., Ladavière C. Chitosan Hydrogels Incorporating Colloids for Sustained Drug Delivery. Carbohydr. Polym. 2022;275:118689.
Not in our library10.1016/j.carbpol.2021.118689
277.
Yang T.T., Cheng Y.Z., Qin M., Wang Y.H., Yu H.L., Wang A.L., Zhang W.F. Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery. BioMed. Res. Int. 2017;2017:3564060.
Not in our library10.1155/2017/3564060
278.
Algharib S.A., Dawood A., Zhou K., Chen D., Li C., Meng K., Maa M.K., Ahmed S., Huang L., Xie S. Designing, Structural Determination and Biological Effects of Rifaximin Loaded Chitosan- Carboxymethyl Chitosan Nanogel. Carbohydr. Polym. 2020;248:116782.
Not in our library10.1016/j.carbpol.2020.116782
279.
Frank L.A., Chaves P.S., D’Amore C.M., Contri R.V., Frank A.G., Beck R.C.R., Pohlmann A.R., Buffon A., Guterres S.S. The Use of Chitosan as Cationic Coating or Gel Vehicle for Polymeric Nanocapsules: Increasing Penetration and Adhesion of Imiquimod in Vaginal Tissue. Eur. J. Pharm. Biopharm. 2017;114:202-212.
Not in our library10.1016/j.ejpb.2017.01.021
280.
Zhang Y., Miyamoto Y., Ihara S., Yang J.Z., Zuill D.E., Angsantikul P., Zhang Q., Gao W., Zhang L., Eckmann L. Composite Thermoresponsive Hydrogel with Auranofin-Loaded Nanoparticles for Topical Treatment of Vaginal Trichomonad Infection. Adv. Ther. 2019;2:1900157.
Not in our library10.1002/adtp.201900157
281.
dos Santos M.K., Kreutz T., Danielli L.J., De Marchi J.G.B., Pippi B., Koester L.S., Fuentefria A.M., Limberger R.P. A chitosan hydrogel-thickened nanoemulsion containing Pelargonium graveolens essential oil for treatment of vaginal candidia-sis. J. Drug Deliv. Sci. Technol. 2020;56:101527.
Not in our library10.1016/j.jddst.2020.101527
282.
Tuğcu-Demiröz F., Saar S., Kara A.A., Yıldız A., Tunçel E., Acartürk F. Development and Characterization of Chitosan Nanoparticles Loaded Nanofiber Hybrid System for Vaginal Controlled Release of Benzydamine. Eur. J. Pharm. Sci. 2021;161:105801.
Not in our library10.1016/j.ejps.2021.105801
283.
Andersen T., Mishchenko E., Flaten G., Sollid J., Mattsson S., Tho I., Škalko-Basnet N. Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes. Mar. Drugs. 2017;15:64.
Not in our library10.3390/md15030064
284.
Berginc K., Suljaković S., Škalko-Basnet N., Kristl A. Mucoadhesive Liposomes as New Formulation for Vaginal Delivery of Curcumin. Eur. J. Pharm. Biopharm. 2014;87:40-46.
Not in our library10.1016/j.ejpb.2014.02.006
285.
Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate · 2017
Not checked
286.
Rodero C.F., Fioramonti Calixto G.M., Cristina dos Santos K., Sato M.R., Aparecido dos Santos Ramos M., Miró M.S., Rodríguez E., Vigezzi C., Bauab T.M., Sotomayor C.E., et al. Curcumin-Loaded Liquid Crystalline Systems for Controlled Drug Release and Improved Treatment of Vulvovaginal Candidiasis. Mol. Pharm. 2018;15:4491-4504.
Not in our library10.1021/acs.molpharmaceut.8b00507
287.
Victorelli F.D., Calixto G.M.F., dos Santos K.C., Buzzá H.H., Chorilli M. Curcumin-Loaded Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems as a Potential Platform in the Treatment of Cervical Cancer. J. Mol. Liq. 2021;325:115080.
Not in our library10.1016/j.molliq.2020.115080
288.
Othman S.I., Alturki A.M., Abu-Taweel G.M., Altoom N.G., Allam A.A., Abdelmonem R. Chitosan for Biomedical Applications, Promising Antidiabetic Drug Delivery System, and New Diabetes Mellitus Treatment Based on Stem Cell. Int. J. Biol. Macromol. 2021;190:417-432.
Not in our library10.1016/j.ijbiomac.2021.08.154
289.
Padhi S., Behera A., Hasnain M.S., Nayak A.K. Uses of Chitosan in Drug Delivery. Chitosan in Biomedical Applications. 2022;139-162.
Not in our library
290.
de Souza M.P.C., Sábio R.M., Ribeiro T.C., Santos A.M.D., Meneguin A.B., Chorilli M. Highlighting the Impact of Chitosan on the Development of Gastroretentive Drug Delivery Systems. Int. J. Biol. Macromol. 2020;159:804-822.
Not in our library10.1016/j.ijbiomac.2020.05.104
291.
Modi J., Joshi G., Sawant K. Chitosan Based Mucoadhesive Nanoparticles of Ketoconazole for Bioavailability Enhancement: Formulation, Optimization, in Vitro and Ex Vivo Evaluation. Drug Dev. Ind. Pharm. 2013;39:540-547.
Not in our library10.3109/03639045.2012.666978
292.
Arora S., Gupta S., Narang R.K., Budhiraja R.D. Amoxicillin Loaded Chitosan–Alginate Polyelectrolyte Complex Nanoparticles as Mucopenetrating Delivery System for H. Pylori. Sci. Pharm. 2011;79:5.
Not in our library10.3797/scipharm.1011-05
293.
Praveen R., Prasad Verma P.R., Venkatesan J., Yoon D.H., Kim S.K., Singh S.K. In Vitro and in Vivo Evaluation of Gastro-Retentive Carvedilol Loaded Chitosan Beads Using GastroplusTM. Int. J. Biol. Macromol. 2017;102:642-650.
Not in our library10.1016/j.ijbiomac.2017.04.067
294.
Darbasizadeh B., Motasadizadeh H., Foroughi-Nia B., Farhadnejad H. Tripolyphosphate-Crosslinked Chitosan/Poly (Ethylene Oxide) Electrospun Nanofibrous Mats as a Floating Gastro-Retentive Delivery System for Ranitidine Hydrochloride. J. Pharm. Biomed. Anal. 2018;153:63-75.
Not in our library10.1016/j.jpba.2018.02.023
295.
Das S.S., Kar S., Singh S.K., Verma P.R.P., Hussain A., Beg S. Chitosan-Based Systems for Oral Drug Delivery Applications. Chitosan in Drug Delivery. 2022;23-53.
Not in our library
296.
Calinescu C., Mondovi B., Federico R., Ispas-Szabo P., Mateescu M.A. Carboxymethyl Starch: Chitosan Monolithic Matrices Containing Diamine Oxidase and Catalase for Intestinal Delivery. Int. J. Pharm. 2012;428:48-56.
Not in our library10.1016/j.ijpharm.2012.02.032
297.
Millotti G., Laffleur F., Perera G., Vigl C., Pickl K., Sinner F., Bernkop-Schnürch A. In Vivo Evaluation of Thiolated Chitosan Tablets for Oral Insulin Delivery. J. Pharm. Sci. 2014;103:3165-3170.
Not in our library10.1002/jps.24102
298.
Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors · 2020
No notice
299.
Giacomello E., Sava G., Vita F., Delhom N., Mahl P., Bergamo A. Chitosan-Coated Alginate Micro-Particles Delivery of Active Principles through Conventional Pelleted Food–A Study in Tilapia (Oreochromis Niloticus). Int. J. Biol. Macromol. 2020;165:82-92.
Not in our library10.1016/j.ijbiomac.2020.09.162
300.
Nisar S., Pandit A.H., Nadeem M., Pandit A.H., Rizvi M.M.A., Rattan S. γ-Radiation Induced L-Glutamic Acid Grafted Highly Porous, PH-Responsive Chitosan Hydrogel Beads: A Smart and Biocompatible Vehicle for Controlled Anti-Cancer Drug Delivery. Int. J. Biol. Macromol. 2021;182:37-50.
Not in our library10.1016/j.ijbiomac.2021.03.134
301.
Jing H., Huang X., Du X., Mo L., Ma C., Wang H. Facile Synthesis of PH-Responsive Sodium Alginate/Carboxymethyl Chitosan Hydrogel Beads Promoted by Hydrogen Bond. Carbohydr. Polym. 2022;278:118993.
Not in our library10.1016/j.carbpol.2021.118993
302.
Kim J.U., Shahbaz H.M., Lee H., Kim T., Yang K., Roh Y.H., Park J. Optimization of Phytic Acid-Crosslinked Chitosan Microspheres for Oral Insulin Delivery Using Response Surface Methodology. Int. J. Pharm. 2020;588:119736.
Not in our library10.1016/j.ijpharm.2020.119736
303.
Jafari Z., Rad A.S., Baharfar R., Asghari S., Esfahani M.R. Synthesis and Application of Chitosan/Tripolyphosphate/Graphene Oxide Hydrogel as a New Drug Delivery System for Sumatriptan Succinate. J. Mol. Liq. 2020;315:113835.
Not in our library10.1016/j.molliq.2020.113835
304.
Yang J., Chen J., Pan D., Wan Y., Wang Z. PH-Sensitive Interpenetrating Network Hydrogels Based on Chitosan Derivatives and Alginate for Oral Drug Delivery. Carbohydr. Polym. 2013;92:719-725.
Not in our library10.1016/j.carbpol.2012.09.036
305.
Wang Y., Wang J., Yuan Z., Han H., Li T., Li L., Guo X. Chitosan Cross-Linked Poly (Acrylic Acid) Hydrogels: Drug Release Control and Mechanism. Colloids Surf. B Biointerfaces. 2017;152:252-259.
Not in our library10.1016/j.colsurfb.2017.01.008
306.
Lv X., Zhang W., Liu Y., Zhao Y., Zhang J., Hou M. Hygroscopicity Modulation of Hydrogels Based on Carboxymethyl Chitosan/Alginate Polyelectrolyte Complexes and Its Application as PH-Sensitive Delivery System. Carbohydr. Polym. 2018;198:86-93.
Not in our library10.1016/j.carbpol.2018.06.058
307.
Wang M., Zang Y., Hong K., Zhao X., Yu C., Liu D., An Z., Wang L., Yue W., Nie G. Preparation of PH-Sensitive Carboxymethyl Cellulose/Chitosan/Alginate Hydrogel Beads with Reticulated Shell Structure to Deliver Bacillus Subtilis Natto. Int. J. Biol. Macromol. 2021;192:684-691.
Not in our library10.1016/j.ijbiomac.2021.10.019
308.
Sun X., Shen J., Yu D., Ouyang X. Preparation of PH-Sensitive Fe3O4@C/Carboxymethyl Cellulose/Chitosan Composite Beads for Diclofenac Sodium Delivery. Int. J. Biol. Macromol. 2019;127:594-605.
Not in our library10.1016/j.ijbiomac.2019.01.191
309.
Karzar Jeddi M., Mahkam M. Magnetic Nano Carboxymethyl Cellulose-Alginate/Chitosan Hydrogel Beads as Biodegradable Devices for Controlled Drug Delivery. Int. J. Biol. Macromol. 2019;135:829-838.
Not in our library10.1016/j.ijbiomac.2019.05.210
310.
Lemos T.S.A., de Souza J.F., Fajardo A.R. Magnetic Microspheres Based on Pectin Coated by Chitosan towards Smart Drug Release. Carbohydr. Polym. 2021;265:118013.
Not in our library10.1016/j.carbpol.2021.118013
311.
Huang J., Wang Q., Chu L., Xia Q. Liposome-Chitosan Hydrogel Bead Delivery System for the Encapsulation of Linseed Oil and Quercetin: Preparation and in Vitro Characterization Studies. LWT. 2020;117:108615.
Not in our library10.1016/j.lwt.2019.108615
312.
Manna S., Banerjee A., Jana S., Bhowmik M. Chitosan-Based Nanoengineered Drug Delivery System. Micro–and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications. 2022;77-95.
Not in our library
313.
Leichner C., Jelkmann M., Prüfert F., Laffleur F., Bernkop-Schnürch A. Intestinal Enzyme Delivery: Chitosan/Tripolyphosphate Nanoparticles Providing a Targeted Release behind the Mucus Gel Barrier. Eur. J. Pharm. Biopharm. 2019;144:125-131.
Not in our library10.1016/j.ejpb.2019.09.012
314.
Joyce P., Wignall A., Peressin K., Wright L., Williams D.B., Prestidge C.A. Chitosan Nanoparticles Facilitate Improved Intestinal Permeation and Oral Pharmacokinetics of the Mast Cell Stabiliser Cromoglycate. Int. J. Pharm. 2022;612:121382.
Not in our library10.1016/j.ijpharm.2021.121382
315.
He M., Zhong C., Hu H., Jin Y., Chen Y., Lou K., Gao F. Cyclodextrin/Chitosan Nanoparticles for Oral Ovalbumin Delivery: Preparation, Characterization and Intestinal Mucosal Immunity in Mice. Asian J. Pharm. Sci. 2019;14:193-203.
Not in our library10.1016/j.ajps.2018.04.001
316.
Lin C., Kuo T.C., Lin J.C., Ho Y.C., Mi F.L. Delivery of Polysaccharides from Ophiopogon Japonicus (OJPs) Using OJPs/Chitosan/Whey Protein Co-Assembled Nanoparticles to Treat Defective Intestinal Epithelial Tight Junction Barrier. Int. J. Biol. Macromol. 2020;160:558-570.
Not in our library10.1016/j.ijbiomac.2020.05.151
317.
Majumdar S., Mandal T., Dasgupta Mandal D. Comparative Performance Evaluation of Chitosan Based Polymeric Microspheres and Nanoparticles as Delivery System for Bacterial β-Carotene Derived from Planococcus Sp. TRC1. Int. J. Biol. Macromol. 2022;195:384-397.
Not in our library10.1016/j.ijbiomac.2021.11.167
318.
Ghobadi-Oghaz N., Asoodeh A., Mohammadi M. Fabrication, Characterization and in Vitro Cell Exposure Study of Zein-Chitosan Nanoparticles for Co-Delivery of Curcumin and Berberine. Int. J. Biol. Macromol. 2022;204:576-586.
Not in our library10.1016/j.ijbiomac.2022.02.041
319.
Karimi Jabali M., Allafchian A.R., Jalali S.A.H., Shakeripour H., Mohammadinezhad R., Rahmani F. Design of a PDNA Nanocarrier with Ascorbic Acid Modified Chitosan Coated on Superparamagnetic Iron Oxide Nanoparticles for Gene Delivery. Colloids Surf. Physicochem. Eng. Asp. 2022;632:127743.
Not in our library10.1016/j.colsurfa.2021.127743
320.
Arévalo-Pérez R., Maderuelo C., Lanao J.M. Recent Advances in Colon Drug Delivery Systems. J. Control. Release. 2020;327:703-724.
Not in our library10.1016/j.jconrel.2020.09.026
321.
McConnell E.L., Murdan S., Basit A.W. An Investigation into the Digestion of Chitosan (Noncrosslinked and Crosslinked) by Human Colonic Bacteria. J. Pharm. Sci. 2008;97:3820-3829.
Not in our library10.1002/jps.21271
322.
Kulkarni N., Jain P., Shindikar A., Suryawanshi P., Thorat N. Advances in the Colon-Targeted Chitosan Based Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease. Carbohydr. Polym. 2022;288:119351.
Not in our library10.1016/j.carbpol.2022.119351
323.
Kurakula M., Gorityala S., Moharir K. Recent Trends in Design and Evaluation of Chitosan-Based Colon Targeted Drug Delivery Systems: Update 2020. J. Drug Deliv. Sci. Technol. 2021;64:102579.
Not in our library10.1016/j.jddst.2021.102579
324.
Padhi S., Behera A., Hasnain M.S., Nayak A.K. Chitosan in Colon-Targeted Drug Delivery. Chitosan in Drug Delivery. 2022;107-132.
Not in our library
325.
Hoang H.T., Jo S.H., Phan Q.T., Park H., Park S.H., Oh C.W., Lim K.T. Dual PH-/Thermo-Responsive Chitosan-Based Hydrogels Prepared Using “Click” Chemistry for Colon-Targeted Drug Delivery Applications. Carbohydr. Polym. 2021;260:117812.
Not in our library10.1016/j.carbpol.2021.117812
326.
Maestrelli F., Cirri M., Mennini N., Bragagni M., Zerrouk N., Mura P. Influence of Cross-Linking Agent Type and Chitosan Content on the Performance of Pectinate-Chitosan Beads Aimed for Colon-Specific Drug Delivery. Drug Dev. Ind. Pharm. 2012;38:1142-1151.
Not in our library10.3109/03639045.2011.641566
327.
Mennini N., Furlanetto S., Cirri M., Mura P. Quality by Design Approach for Developing Chitosan-Ca-Alginate Microspheres for Colon Delivery of Celecoxib-Hydroxypropyl-β-Cyclodextrin-PVP Complex. Eur. J. Pharm. Biopharm. 2012;80:67-75.
Not in our library10.1016/j.ejpb.2011.08.002
328.
Jin M., Li S., Wu Y., Li D., Han Y. Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice. Nanomaterials. 2021;11:1884.
Not in our library10.3390/nano11081884
329.
Wang Q.S., Wang G.F., Zhou J., Gao L.N., Cui Y.L. Colon Targeted Oral Drug Delivery System Based on Alginate-Chitosan Microspheres Loaded with Icariin in the Treatment of Ulcerative Colitis. Int. J. Pharm. 2016;515:176-185.
Not in our library10.1016/j.ijpharm.2016.10.002
330.
Tekie F.S.M., Soleimani M., Zakerian A., Dinarvand M., Amini M., Dinarvand R., Arefian E., Atyabi F. Glutathione Responsive Chitosan-Thiolated Dextran Conjugated MiR-145 Nanoparticles Targeted with AS1411 Aptamer for Cancer Treatment. Carbohydr. Polym. 2018;201:131-140.
Not in our library10.1016/j.carbpol.2018.08.060
331.
Cardoso V.M.d.O., de Brito N.A.P., Ferreira N.N., Boni F.I., Ferreira L.M.B., Carvalho S.G., Gremião M.P.D. Design of Mucoadhesive Gellan Gum and Chitosan Nanoparticles Intended for Colon-Specific Delivery of Peptide Drugs. Colloids Surf. Physicochem. Eng. Asp. 2021;628:127321.
Not in our library10.1016/j.colsurfa.2021.127321
332.
Pandey S., Mishra A., Raval P., Patel H., Gupta A., Shah D. Chitosan–Pectin Polyelectrolyte Complex as a Carrier for Colon Targeted Drug Delivery. J. Young Pharm. 2013;5:160-166.
Not in our library10.1016/j.jyp.2013.11.002
333.
Kavianinia I., Plieger P.G., Cave N.J., Gopakumar G., Dunowska M., Kandile N.G., Harding D.R.K. Design and Evaluation of a Novel Chitosan-Based System for Colon-Specific Drug Delivery. Int. J. Biol. Macromol. 2016;85:539-546.
Not in our library10.1016/j.ijbiomac.2016.01.003
334.
Leonida M., Ispas-Szabo P., Mateescu M.A. Self-Stabilized Chitosan and Its Complexes with Carboxymethyl Starch as Excipients in Drug Delivery. Bioact. Mater. 2018;3:334-340.
Not in our library10.1016/j.bioactmat.2018.04.001
335.
Ma Y., Thurecht K.J., Coombes A.G.A. Development of Enteric-Coated, Biphasic Chitosan/HPMC Microcapsules for Colon-Targeted Delivery of Anticancer Drug-Loaded Nanoparticles. Int. J. Pharm. 2021;607:121026.
Not in our library10.1016/j.ijpharm.2021.121026
336.
Wu D., Zhu L., Li Y., Wang H., Xu S., Zhang X., Wu R., Yang G. Superparamagnetic Chitosan Nanocomplexes for Colorectal Tumor-Targeted Delivery of Irinotecan. Int. J. Pharm. 2020;584:119394.
Not in our library10.1016/j.ijpharm.2020.119394
337.
Almeida A., Linares V., Mora-Castaño G., Casas M., Caraballo I., Sarmento B. 3D Printed Systems for Colon-Specific Delivery of Camptothecin-Loaded Chitosan Micelles. Eur. J. Pharm. Biopharm. 2021;167:48-56.
Not in our library10.1016/j.ejpb.2021.07.005

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.