Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
Mudassir Shah, Chunxiao Sun, Zichao Sun and 5 more
Marine Drugs · 2020
doi:10.3390/md18020071 (opens in a new tab)
We email you when a new notice or a question about this paper appears.
Abstract
Three new polyketides, ketidocillinones A−C (<b>1</b>−<b>3</b>), were discovered from the extract of an Antarctica sponge-derived fungus <i>Penicillium</i> sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound <b>3</b> was established by using ECD calculation. Compounds <b>1</b>−<b>3</b> can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (<b>2</b> and <b>3</b>) exhibited potent antibacterial activity against <i>Pseudomonas aeurigenosa</i>, <i>Mycobacterium phlei</i>, and MRCNS (methicillin-resistant coagulase-negative <i>staphylococci</i>) with MIC values ranging from 1.56 to 25.00 µg/mL.
Abstract licence: CC BY
References25
25 more references, whose wording the paper’s licence keeps private.
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.