New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

Three new 8-hydroxybriaranes&#8212;fragilides R&#8722;T (<b>1</b>&#8722;<b>3</b>) were obtained from a sea whip gorgonian coral <i>Junceella fragilis</i>. The structures of briaranes <b>1</b>&#8722;<b>3</b> were elucidated by using spectroscopic methods, including 1D (¹H and ¹³C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (<b>2</b> and <b>3</b>) are the only briaranes known to possess 8&#945;-hydroxy and 17&#946;-methyl groups, respectively. Briarane <b>2</b> exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

Abstract licence: CC BY

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