Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy

The composition of the culture medium has great influence on the metabolite production of the marine fungus <i>Pseudallescheria boydii</i> F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (<b>1</b> and <b>2</b>), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3&#8242;-cyclohexylidenebis(1<i>H</i>-indole) (<b>3</b>) showed cytotoxic activity against various cancer cell lines.

Abstract licence: CC BY

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.