Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Two new succinimide-containing derivatives, cladosporitins A (<b>1</b>) and B (<b>2</b>), were isolated from the fermentation cultures of the mangrove-derived fungus <i>Cladosporium</i> sp. HNWSW-1, along with a new pyrone, clapone (<b>3</b>), as well as the previously reported talaroconvolutin A (<b>4</b>) and anthraquinone (<b>5</b>). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound <b>2</b> showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC₅₀ values of 29.4 &#177; 0.35 &#956;M, 25.6 &#177; 0.47 &#956;M, and 41.7 &#177; 0.71 &#956;M, respectively, whereas compound <b>4</b> exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC₅₀ values of 14.9 &#177; 0.21 &#956;M and 26.7 &#177; 1.1 &#956;M, respectively. In addition, compounds <b>4</b> and <b>5</b> displayed inhibitory activity against &#945;-glycosidase, with IC₅₀ values of 78.2 &#177; 2.1 &#956;M and 49.3 &#177; 10.6 &#956;M, respectively.

Abstract licence: CC BY

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.