Two Furanosesterterpenoids from the Sponge Luffariella variabilis
Peni Ahmadi, Masahiro Higashi, Nicole J. de Voogd and 1 more
Marine Drugs · 2017
doi:10.3390/md15080249 (opens in a new tab)
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Abstract
Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.
Abstract licence: CC BY
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