4-Methylenesterols from a Sponge Theonella swinhoei

Three new 4-methylenesterols, theonellasterol K (<strong>1</strong>), acetyltheonellasterol (<strong>2</strong>) and acetyldehydroconicasterol (<strong>3</strong>), along with two known sterols, theonellasterol (<strong>4</strong>) and theonellasterone (<strong>5</strong>), were isolated from the sponge <em>Theonella swinhoei</em>. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound <strong>1</strong> exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4<strong> </strong>cancer cell lines.

Abstract licence: CC BY

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