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No retraction, correction or concern found when last checked on Oct 18, 2026.

Mechanisms of ATP Release by Inflammatory Cells

Michel Dosch, Joël Gerber, Fadi Jebbawi and 1 more

International Journal of Molecular Sciences · 2018 · Review · CC BY

doi:10.3390/ijms19041222

Abstract

Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation. Necrosis leads to non-specific release of nucleotides, whereas specific release mechanisms include vesicular exocytosis and channel-mediated release via connexin or pannexin hemichannels. These release mechanisms allow stimulated inflammatory cells such as macrophages, neutrophils, and endothelial cells to fine-tune autocrine/paracrine responses during acute and chronic inflammation. Key effector functions of inflammatory cells are therefore regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 18, 2026. Paragraph numbers are ours, so an answer can point at one.

1. Introduction

Cellular respiration in the mitochondria converts nutrition-derived energy into adenosine 5′-triphosphate (ATP), the usable form of chemical energy in the body. Although most of the ATP (and other nucleotides) is located intracellularly, it is released into the extracellular space under specific conditions, where it is a relevant signaling molecule. The importance of ATP in inflammation has been established in the last decades. In particular, ATP released from stressed cells functions as a “danger” and “find-me” signal for phagocytes to migrate to the damaged tissue. In addition, ATP provides qualitative and quantitative information about pericellular injury to inflammatory cells via autocrine/paracrine purinergic signaling. Thus, nucleotides can define how and to what extent inflammatory cells should react through interaction with specific receptors. Such P1 and P2 receptors are conserved germline encoded pattern recognition receptors (PRRs). In other words, during inflammation, ATP is released from inflammatory cells—and parenchymal cells—to fine-tune their activation via autocrine/paracrine signaling.

Several specific properties make extracellular purines and pyrimidines efficient damage signaling molecules. First, because of their rapid release via vesicular exocytosis or pores upon cell activation. Second, because ATP is water-soluble and freely diffusible in the extracellular environment due to negatively charged phosphate residues. In addition, third, a high concentration gradient between extracellular and intracellular compartments (micromolar compared to millimolar range, respectively) creates a strong signal to noise ratio with very low background noise.

The focus of this review is on the mechanisms of ATP release from inflammatory cells. Key publications cited in this work are summarized in Table 1. Given the importance of purinergic signaling in modulating the inflammatory response, it is crucial to understand the way ATP is released into the extracellular space. Such understanding may be clinically relevant since blocking ATP release specifically may modulate the whole purinergic signaling cascade in an upstream manner and thereby offers new avenues for drug therapies.

2. Non-Specific ATP Release from Necrotic Cells

Upon inflammation, cell membrane disruption leads to non-specific release of large amounts of nucleotides due to the high intracellular nucleotide content compared to the extracellular space. ATP released from necrotic parenchymal cells in damaged tissue is then recognized by inflammatory cells. As an example, sepsis is associated with organ damage remote from primary infection site because of a systemic inflammatory reaction syndrome caused by infection. Specific and non-specific release of large amounts of ATP are observed during sepsis, which then fine-tune the activation of inflammatory cells in an autocrine/paracrine manner. Enzymatic degradation of systemic ATP by ectonucleotidases during sepsis has been shown to improve bacterial clearance and prolong survival. Application of apyrase, an ecto-ATPase, prevents the accumulation of IL1 β and other inflammasome-dependent cytokines (TNF α, IL10) in caecal ligation puncture (CLP), a peritoneal sepsis mouse model. ATP hydrolysis by apyrase additionally promotes polymorphonuclear neutrophils (PMNs) chemotaxis, leading to improved host defenses.

Furthermore, extracellular ATP serves as a “find-me” signal to attract phagocytes, that mediate the clearance of necrotic bodies. The P2Y2 receptor senses ATP but also UTP released from necrotic cells and seems to be relevant for necrosis detection by neutrophils and macrophages.

Taken together, ATP release by necrotic cells generates a pro-inflammatory microenvironment via pro-inflammatory cytokines secretion and recruitment of neutrophils to the site of necrosis.

3. Active ATP Release via Vesicular Exocytosis

Specialized cytosolic granules store and then rapidly release ATP via fusion with the plasma membrane. Storage and exocytosis of ATP depends on the vesicular nucleotide transporter (VNUT) which is also responsible for subsequent exocytosis of divalent cations. This protein is a secondary active transporter, ensuring the accumulation of cytosolic ATP inside the secretory vesicles in a chloride-dependent manner. It uses an electrochemical proton gradient (positive inside the granules) generated by V-ATPase as a driving force. VNUT protein is encoded by SCL (solute carrier) 17A9 gene, which is a member of the SCL17 family of ion transporters that are widely expressed among vertebrates and non-vertebrates. After transfer of ATP into secretory granules, the mechanism of vesicular exocytosis has been shown to depend on intracellular Ca2+ levels and SNARE (soluble N-ethylmaleimide-sensitive-factor attachment receptor) family of proteins. SNARE proteins mediate membrane fusion via the interaction of v- and t-SNARE subtypes that zipper up and form the trans-SNARE complex, an α-helical bundle, that pulls the two membranes tightly together as shown in macrophages. The mechanism of ATP release through vesicular exocytosis is summarized in Figure 1.

3.1. Vesicular ATP Release in Response to Inflammation Mediates Chronic Inflammatory Pain

Perception of pain can be a consequence of inflammation and is directly modulated by extracellular ATP. In particular, ATP is released during tissue damage and activates indirectly nociceptors on neurons, which are expressing P2 receptors. Blocking of vesicular exocytosis-mediated ATP release from neurons, microglia and immune cells using clodronate, a bisphosphonate, reduces chronic inflammatory pain in mice. Downstream, ATP-mediated nociception occurs via the activation of P2X7 on microglial cells leading to production and release of inflammatory cytokines. These results are supported by the clinical observation that bisphosphonates reduce pain when they are used to treat bone metastases from breast or prostate cancers.

3.2. Vesicular Exocytosis-Mediated ATP Release in Response to Infection

Pathogen associated molecular patterns (PAMPs) released during infection induce active ATP release from inflammatory cells. In response to unspecific (ionomycin) or Toll-like receptors 4 (lipopolysaccharides, LPS) and 2 (Pam3CSK4) stimuli, vesicular exocytosis-mediated ATP release was observed for microglia, bone marrow and peritoneal macrophages, and THP-1 monocytes. Only blockade of vesicular exocytosis by N-ethylmaleimide (NEM), but not hemichannel blockers (carbenoxolone, probenecid or flufenamic acid) inhibited LPS-induced ATP release by RAW264.7 macrophages. However, other studies observed nucleotide release via connexin-43 and pannexin-1 under similar conditions. These discrepancies might underline parallel contribution of both vesicular exocytosis and hemichannels in LPS-induced ATP release by monocytes/macrophages. Differences might further depend on particular experimental settings, including cell types tested and kinetics of ATP measurements. Once in the extracellular space, ATP released through vesicular exocytosis regulates THP-1 monocytes activation in an autocrine manner via P2Y11 activation. In addition to LPS, viruses and their products can also mediate vesicular ATP release. In particular, vesicular stomatitis virus (VSV) infected macrophages release ATP via both vesicular exocytosis and hemichannel pannexin-1.

Vesicular release of ATP, which is Ca2+-dependent, can further induce changes in cytosolic calcium concentration by the activation of P2Y receptors in an autocrine manner. Indeed, treatment of monocytes using NEM or P2Y receptors antagonists blocks intracellular Ca2+ increase following lysosomes disruption, which play a critical role for monocytes functions, including responses to LPS, for chemotaxis, phagocytosis, and cytokines production.

3.3. Vesicular Exocytosis Mediated ATP Release in Response to Hypoxia

It is accepted that hypoxia leads to inflammation by inducing production of inflammatory cytokines through activation of hypoxia-inducible factors (HIF). HIFs amplify the NFκB pathway, among others by increased expression and signaling of Toll-like receptors (TLRs). Alternatively, hypoxia induces inflammation through ATP release. Indeed, hypoxia induces ATP release from endothelial cells by vesicular exocytosis, a mechanism dependent on phosphoinositide 3-kinases (PI3K) and Rho-associated protein kinase (ROCK). Released ATP induces venous dilation via increase in prostaglandins and nitric oxide (NO). In this study, autocrine purinergic signaling decreased in endothelial cells upon hypoxia limiting P2 receptor-mediated [Ca2+]i increase and self-regenerating ATP release via vesicular exocytosis in a negative feedback loop.

4.1. Connexins and Pannexins—Structural and Functional Differences

In addition to vesicular exocytosis, inflammatory cells release nucleotides in the extracellular space via connexin hemichannels or pannexin channels, mainly connexin-43 and pannexin-1. One critical remaining challenge in the field is to distinguish their respective contributions. The main functional difference between these two types of hemichannels is that connexin proteins can form both gap junctions and hemichannels, while pannexin proteins only form (hemi)channels. Even though pannexins do not share sequence homology with connexins, both proteins display N- and C-terminal domains in the cytoplasm, four membrane spanning segments and extracellular and intracellular loop domains. Connexins and pannexins are both four-pass transmembrane proteins that assemble to form a hexameric structure called connexon and pannexon respectively. While connexins contain six Cys residues in their extracellular loops, pannexins contain four and a consensus sequence for glycosylation. Connexons and pannexons mediate the release of small molecules in the extracellular space, including ATP, glutamate, prostaglandins and others typically below 1–2 kDa, as well as the influx of ions such as Na+ and Ca2+. Importantly, both channels were shown to be permeable to ATP in opened state and to mediate its release. In addition to connexin-43 and connexin-37 (see below), other connexin isoforms, including connexins-26 and -36, were shown to mediate ATP release into extracellular space. Epithelial cells from the colonic mucosa release ATP via connexin-26 upon Shigella flexneri infection, the intracellular causative agent of bacillary dysentery that elicit an intense inflammatory reaction. Connexin-26 opening and subsequent ATP release are dependent on actin and phospholipase-C. This mechanism contributes to bacterial invasion and spreading. Connexin-36 mediates ATP release from depolarizing neurons. Other connexin channels release ATP in other cells than inflammatory cells and in other contexts than inflammation.

Gating of both connexons and pannexons is regulated by changes in transmembrane voltage (Vm), extracellular or intracellular calcium concentrations, mechanical strain or post-translational modifications. The specific mechanisms for each channel subtype are detailed below in Section 4.2 and Section 4.7 respectively.

4.2. Structure and General Functions of Connexin Hemichannels

Connexin proteins contribute to various cellular and physiological functions by forming gap junctions or unopposed hemichannels, which allow intercellular communication. For convenience, connexins are classified according to the molecular weight of their subunits. To date, 21 connexin isoforms are identified in the human and 20 in the mouse genome, among which connexin-43 is the most widely expressed. Under homeostatic conditions, hemichannels are more likely to be in closed rather than in an open state to avoid the loss of vital ionic, energetic, and metabolic gradients. However, connexin hemichannels are opened by electrical, chemical and mechanical stimuli as shown in Figure 2A. The regulation of the opened/closed state of connexin-43 was shown to be dependent on the interaction between its cytoplasmic loop and cytoplasmic tail. In particular, interactions between the last nine amino acids at the end of the cytoplasmic tail of the connexin-43 protein and the L2 domain, located on the cytoplasmic loop, determine opening of the hemichannel. This mechanism is further dependent on intracellular calcium concentrations and positive cell membrane voltage changes. In addition, connexin-43 phosphorylation at multiple serine residues induces conformational changes that determine hemichannel oligomerization and subsequently the formation of hemichannels or gap junctions. Trafficking to or within the plasma membrane, hemichannel opening and ultimately connexin degradation are also related to phosphorylation events. Reactive oxygen species, typically released in large amounts during inflammation, modulate connexin hemichannels via oxidation of several potentially oxidizable amino acids and nitric oxide-mediated S-nitrosylation of cysteine residues. Especially, redox-mediated regulation of connexin proteins can lead to connexin-43 hemichannels opening. There are specific inhibitors targeting the extra- and intra-cellular mechanisms. These include mimetic peptides derived from highly conserved regions, including Gap26 and Gap27 that target the first and second extracellular loop of connexin-43, respectively. Gap19 is a nonapeptide that targets the L2 domain with the advantage to block specifically connexin-43 hemichannels and not gap junctions.

4.3. Connexin-Mediated ATP Release in Response to Pathogen Associated Molecular Patterns

In monocytes and macrophages, TLRs activation is associated with connexin-43 expression. LPS from Escherichia coli, a TLR4 agonist, and Pam3CSK4, a TLR2 agonist, lead to connexin-43 expression in an ERK/AP-1 dependent manner in a macrophages cell line (RAW 264.7), as presented in Figure 2B. This results in the release of UDP and ATP from macrophages that activate purinergic receptors such as P2Y6 by UDP and P2X7 by ATP. In an autocrine loop, UDP induces MCP-1 release from macrophages via P2Y6 activation, a mechanism that seems to protect from Escherichia coli bacteremia. In parallel, ATP activates P2X7 and increases inflammatory cytokine levels and bacterial load. Systemic pharmacological blockade of connexin-43 by Gap 27 led to increased levels of inflammatory cytokines IL6 and IL10 in the peritoneal lavage after caecal ligation and puncture. However, outcome of peritoneal sepsis upon connexin-43 blockade was not assessed in this study.

PMNs play a critical role in the acute phase of the inflammatory reaction to PAMPs beside monocytes/macrophages. PMNs have been shown to release ATP via connexin-43 upon activation with N-formyl Met-Leu-Phe (fMLP), a potent PMNs chemotactic factor, and LPS. This was tested by treating PMNs using Gap19 and in PMNs partly or totally deleted for connexin-43. Mechanistically, the ATP released through connexin-43 by PMNs in response to LPS stimulation activates P2X1 receptors leading to intracellular calcium increase and eventually to myosin light chain activation. This mechanism serves as a “stop signal” for neutrophils in order to halt their migration at the infectious foci.

Endothelial cells are another important cell type in the regulation of inflammation to PAMPs via connexin-43-mediated ATP release. Indeed, ATP release through connexin-43 hemichannels occurs from endothelial cells in response to TLR2 agonists, more precisely peptidoglycans derived from Staphylococcus epidermidis, a process that further initiate an inflammatory reaction. In addition, human microvascular endothelial cells (HMVEC) were shown to release ATP through connexin-43 hemichannels in response to foreign material. The implantation of foreign material is a potential trigger of sterile inflammation, a process called foreign body reaction, and purinergic signaling contributes to the early inflammatory events of this reaction.

4.4. Connexin-Mediated ATP Release in Atherosclerosis

Purinergic signaling plays a critical role in the pathophysiology of atherosclerosis. In this context, inflammation-induced adhesion of monocytes to the endothelium is a crucial event that is modulated by connexin-43-mediated ATP release from monocytes. Released ATP is rapidly converted to adenosine (ADO) by ecto-ATPases, which decreases the adhesion of circulating monocytes to endothelium, a process that prevents the formation of atherosclerosis. In an older study, a macrophage cell line (H36.12j cells) transfected with connexin-37, another connexin isoform, released higher levels of ATP. These results are of interest in atherosclerosis pathogenesis, since deletion of connexin-37 gene in apolipoprotein E-deficient mice (Apoe−/−, a mouse model of atherosclerosis) leads to increased aortic lesions compared to conventional Apoe−/− mice. Investigations using purinergic agents for the treatment of atherosclerosis are in progress with potential for new therapeutic targets.

4.5. Hypoxia Regulates Connexin-Dependent ATP Release

Connexin-43 expression and subsequent ATP release in vascular endothelial cells were shown to decrease under hypoxic conditions. Specifically, hypoxia resulted in connexin-43/ser368 phosphorylation, a process that induces a conformational change in the channel associated with decreased channel permeability. Conversely, during intestinal neuro-inflammation, hypoxia induces damage and oxidative stress in the gut. Connexin-43-mediated ATP release by local glial cells upon hypoxia increases damage by inducing neuro-inflammation, which kills enteric neurons and contributes to the development of motility disorders. As shown above, alterations of hypoxia regulate ATP release via vesicular exocytosis and connexin hemichannels and seem to be highly context-dependent as well as insufficiently understood.

4.6. Regulation of Pannexin Channels

Pannexin proteins are orthologues of invertebrate innexins and consist of 3 members, including pannexin-1, -2 and -3. Pannexin-1 and -3 are widely expressed, whereas pannexin-2 is mainly expressed in the brain. Here, the focus is on pannexin-1 due to its function in inflammation. Like connexin hemichannels, pannexin channels are likely to stay closed under homeostatic conditions. Concretely, the C-terminal tails of pannexin-1 proteins maintain the channel closed, presumably by directly plugging up the pore from the intracellular side as shown in Figure 3A,B. The cleavage of the C-terminal tail of pannexin-1 proteins by activated caspases, including caspase-3 and -7 during apoptosis and caspase-11 during pyroptosis and endotoxic shock, plays a critical role in pannexin-1 channel activation. The cleavage of successive C-terminal tails inside the pannexon is associated with a progressive opening of pannexin-1 channel and an increase of the permeability to ions and larger molecules including nucleotides.

Altogether, various triggers lead to opening and activation of pannexin-1 channels, including mechanical stress and increased intracellular calcium or extracellular potassium. Ligand-gated receptors activate pannexin-1 channel for ATP release as well, including ATP-gated ionotropic P2X7 receptor, protease activated receptor 1 (PAR-1) receptors following thrombin stimulation, H1 receptors in response to histamine and B2 receptors in response to bradykinin. Also redox potential changes could play a role.

In an autocrine negative feedback loop, pannexin-1 channels can be inhibited by ATP as shown in Figure 3B. In particular, ATP released through pannexin-1 channels interacts with P2X7 receptors and mediates the internalization of pannexin-1 channels in a concentration- and time-dependent manner in Neuro2a cells. In contrast to connexin-43, phosphorylation of pannexin-1 proteins as a mean to modulate channel functions have not been studied in depth yet. However, one study is showing that NO attenuates pannexin-1 channel function by phosphorylation of a serine residue through a cGMP-PKG dependent pathway in HEK-293 cells.

4.7. Pannexin-1 Mediated ATP Release from Apoptotic Cells

In contrast to necrotic cells, apoptotic cells release ATP in a controlled manner, via pannexin-1 channels. The role of ATP and UTP as damage associated molecular patterns, “danger signals” that guide inflammatory cells to the site of injury, is a well-established concept. In particular, it has been shown that ATP and UTP released during apoptosis attract monocytes to remove cellular debris. These “find-me” nucleotides are specifically released from apoptotic cells via pannexin-1 channels after caspases-3 and -7 mediated cleavage as shown in Figure 3B. ATP released from apoptotic cells is not only important for phagocyte recruitment, but also for the secretion of IL1 β by macrophages via activation of Nlrp3 inflammasome.

4.8.1. Neutrophils

Proper chemotaxis of neutrophils requires an excitatory signal at the front edge and an inhibitory signal at the rear of the cell. ATP released via pannexin-1 channels mediates neutrophil activation at the front edge via P2Y2 receptor autocrine stimulation. In addition, pannexin-1 channels also provide inhibitory signals at the rear of the cell by releasing ATP, which is further degraded to adenosine by CD39 and CD73. Finally, adenosine signals via adenosine A2a receptors that redistribute to the rear of the neutrophil and block chemoattractant receptor signaling.

4.8.2. Monocytes/Macrophages

In macrophages, synthesis and secretion of IL1 β is dependent of pannexin-1 mediated ATP release. The process requires endogenous ATP secretion via pannexin-1 channels by macrophages in response to LPS and the consequential interaction with P2X7 receptor for the assembly of oligomerized Nlrp3 inflammasome. Pro-IL1 β is then further cleaved by caspase-1, which is activated by assembled inflammasome complexes. Treatment using an unspecific inhibitor (carbenoxolone) in THP-1 monocyte cell line identified that the pannexin-1/endogenous ATP/P2X7 axis is sufficient to induce synthesis and secretion of IL1 β in response to TLR2 stimulation. Conversely, TLR4-dependent IL1 β release from THP-1 monocytes is not solely dependent on pannexin-1.

Sepsis is a systemic inflammatory reaction syndrome caused by infection and is associated with organ damage remote from primary infection site. In particular, the liver is likely to be damaged in the case of high grade sepsis. Opened pannexin-1 channels release ATP in the extracellular space, increasing damage and lethality during sepsis. In this context, ATP released from macrophages during peritonitis-induced sepsis has deleterious pro-inflammatory consequences ending with liver damage, when not degraded by CD39 ectonucleotidases. In addition, ATP released via pannexin-1 channels from macrophages has been shown to mediate pyroptosis in a P2X7-dependent manner. Pyroptosis is a pro-inflammatory form of programmed cell death associated with endotoxic shock. In the study from Yang et al., the authors show that caspase-11 activation by intra- but not extracellular LPS leads to the assembly of the non-canonical inflammasome, which cleaves and truncates C-terminal tails and therefore activates pannexin-1 proteins.

4.8.3. Dendritic Cells

ATP is also released from dendritic cells (DCs) via pannexin-1 channels. This process corresponds to an autocrine amplification loop in DCs: ATP present at the injury site interacts with P2X7 receptors on DCs, leading to activation of pannexin-1 channels and mediating further ATP release. The whole process aims to accelerate the speed of migration to the injury site and the reorganization of the cytoskeleton of DCs.

4.8.4. Pannexin-Mediated Intravascular Crosstalk

Pannexin-1 channels have been shown to modulate the function of platelets and endothelial cells during inflammation. In particular, it has been shown that platelet activation, e.g., via shear stress, is mediated by ATP released through pannexin-1 channels. In another study, collagen-induced platelet aggregation was reduced upon pannexin-1 channels blockade using different pharmacological strategies (probenecid, mefloquine and a specific peptide targeting pannexin-1) as well as genetically modified Panx1−/− platelets in vitro. Subsequent activation of P2X1 via pannexin-1 leads then to increased platelet aggregation. Vascular endothelium critically modulates the migration of leucocytes to the site of injury. It has recently been shown that TNF α released upon inflammation induces pannexin-1 opening and ATP release from vascular endothelial cells. Apart from TNF α, thrombin was shown to induce pannexin-1 mediated ATP release from endothelial cells in a PAR-1-dependent manner. Extracellular ATP further induces the activation of vascular endothelial cells in a P2Y receptor-dependent manner leading to increased vascular cell adhesion molecule-1 (VCAM-1) expression. This step is critical for adhesion and diapedesis of leucocytes, and indeed, purinergic signaling was shown to be critical for macrophage chemotaxis in this context.

5. Conclusions

Purinergic signaling is now accepted as one of the key players during inflammation. We review here the mechanisms mediating ATP release into the extracellular space from inflammatory cells. These mechanisms are critical in various processes, including the recruitment of inflammatory cells to the damaged or infected sites, fine-tuning of cell activation and immune responses or the establishment of adverse effects during chronic inflammation such as scarring and pain. To specifically modulate ATP release mechanisms would represent a novel therapeutic option for many diseases where specific treatment strategies are still lacking.

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    Not in our library10.1016/j.immuni.2015.10.009

  32. 32.

    Molica F., Morel S., Meens M.J., Denis J.F., Bradfield P.F., Penuela S., Zufferey A., Monyer H., Imhof B.A., Chanson M., et al. Functional role of a polymorphism in the Pannexin1 gene in collagen-induced platelet aggregation. Thromb. Haemost. 2015;114:325-336.

    Not in our library10.1160/th14-11-0981

  33. 33.

    Calder B.W., Matthew Rhett J., Bainbridge H., Fann S.A., Gourdie R.G., Yost M.J. Inhibition of connexin 43 hemichannel-mediated ATP release attenuates early inflammation during the foreign body response. Tissue Eng. Part A. 2015;21:1752-1762.

    Not in our library10.1089/ten.tea.2014.0651

  34. 34.

    Csóka B., Németh Z.H., Törő G., Idzko M., Zech A., Koscsó B., Spolarics Z., Antonioli L., Cseri K., Erdélyi K., et al. Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing. FASEB J. 2015;29:3626-3637.

    Not in our library10.1096/fj.15-272450

  35. 35.

    Ren H., Teng Y., Tan B., Zhang X., Jiang W., Liu M., Du B., Qian M. Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infect. Immun. 2014;82:5076-5085.

    Not in our library10.1128/iai.02546-14

  36. 36.

    Taylor K.A., Wright J.R., Vial C., Evans R.J., Mahaut-Smith M.P. Amplification of human platelet activation by surface pannexin-1 channels. J. Thromb. Haemost. 2014;12:987-998.

    Not in our library10.1111/jth.12566

  37. 37.

    Sakaki H., Tsukimoto M., Harada H., Moriyama Y., Kojima S. Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLoS ONE. 2013;8:e59778.

    Not in our library10.1371/journal.pone.0059778

  38. 38.

    Burnstock G. Purinergic signalling and disorders of the central nervous system. Nat. Rev. Drug Discov. 2008;7:575-590.

    Not in our library10.1038/nrd2605

  39. 39.

    Moalem G., Tracey D.J. Immune and inflammatory mechanisms in neuropathic pain. Brain Res. Rev. 2006;51:240-264.

    Not in our library10.1016/j.brainresrev.2005.11.004

  40. 40.

    Marchand F., Perretti M., McMahon S.B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 2005;6:521-532.

    Not in our library10.1038/nrn1700

  41. 41.

    Cook S.P., Vulchanova L., Hargreaves K.M., Elde R., McCleskey E.W. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature. 1997;387:505-508.

    Not in our library10.1038/387505a0

  42. 42.

    Chessell I.P., Hatcher J.P., Bountra C., Michel A.D., Hughes J.P., Green P., Egerton J., Murfin M., Richardson J., Peck W.L., et al. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005;114:386-396.

    Not in our library10.1016/j.pain.2005.01.002

  43. 43.

    Coleman R., Body J.J., Aapro M., Hadji P., Herrstedt J., Group E.G.W. Bone health in cancer patients: ESMO Clinical Practice Guidelines. Ann. Oncol. 2014;25(Suppl. 3):iii124-iii137.

    Not in our library10.1093/annonc/mdu103

  44. 44.

    Sivaramakrishnan V., Bidula S., Campwala H., Katikaneni D., Fountain S.J. Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes. J. Cell Sci. 2012;125:4567-4575.

    Not in our library10.1242/jcs.107318

  45. 45.

    McLeish K.R., Dean W.L., Wellhausen S.R., Stelzer G.T. Role of intracellular calcium in priming of human peripheral blood monocytes by bacterial lipopolysaccharide. Inflammation. 1989;13:681-692.

    Not in our library10.1007/bf00914312

  46. 46.

    Gouwy M., Struyf S., Noppen S., Schutyser E., Springael J.Y., Parmentier M., Proost P., Van Damme J. Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol. Pharmacol. 2008;74:485-495.

    Not in our library10.1124/mol.108.045146

  47. 47.

    Badolato R., Johnston J.A., Wang J.M., McVicar D., Xu L.L., Oppenheim J.J., Kelvin D.J. Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. J. Immunol. 1995;155:4004-4010.

    Not in our library

  48. 48.

    Hishikawa T., Cheung J.Y., Yelamarty R.V., Knutson D.W. Calcium transients during Fc receptor-mediated and nonspecific phagocytosis by murine peritoneal macrophages. J. Cell Biol. 1991;115:59-66.

    Not in our library10.1083/jcb.115.1.59

  49. 49.

    MacIntyre J.P., Pope B.L. The involvement of protein kinase C, calcium, and 5-lipoxygenase in the production of tumor necrosis factor by a cloned interleukin-3 dependent cell line with natural cytotoxic activity. Int. J. Immunopharmacol. 1991;13:175-184.

    Not in our library10.1016/0192-0561(91)90096-p

  50. 50.

    Eltzschig H.K., Carmeliet P. Hypoxia and inflammation. N. Engl. J. Med. 2011;364:656-665.

    Not in our library10.1056/nejmra0910283

  51. 51.
    Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia · 2007
    No notice
  52. 52.

    Eltzschig H.K., Ibla J.C., Furuta G.T., Leonard M.O., Jacobson K.A., Enjyoji K., Robson S.C., Colgan S.P. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: Role of ectonucleotidases and adenosine A2B receptors. J. Exp. Med. 2003;198:783-796.

    Not in our library10.1084/jem.20030891

  53. 53.

    Thompson L.F., Eltzschig H.K., Ibla J.C., Van De Wiele C.J., Resta R., Morote-Garcia J.C., Colgan S.P. Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia. J. Exp. Med. 2004;200:1395-13405.

    Not in our library10.1084/jem.20040915

  54. 54.

    Spaans F., de Vos P., Bakker W.W., van Goor H., Faas M.M. Danger signals from ATP and adenosine in pregnancy and preeclampsia. Hypertension. 2014;63:1154-1160.

    Not in our library10.1161/hypertensionaha.114.03240

  55. 55.

    Lohman A.W., Isakson B.E. Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS Lett. 2014;588:1379-1388.

    Not in our library10.1016/j.febslet.2014.02.004

  56. 56.

    Sosinsky G.E., Boassa D., Dermietzel R., Duffy H.S., Laird D.W., MacVicar B., Naus C.C., Penuela S., Scemes E., Spray D.C., et al. Pannexin channels are not gap junction hemichannels. Channels. 2011;5:193-197.

    Not in our library10.4161/chan.5.3.15765

  57. 57.

    Scemes E., Spray D.C., Meda P. Connexins, pannexins, innexins: Novel roles of “hemi-channels”. Pflugers Arch. 2009;457:1207-1226.

    Not in our library10.1007/s00424-008-0591-5

  58. 58.

    D’hondt C., Ponsaerts R., De Smedt H., Bultynck G., Himpens B. Pannexins, distant relatives of the connexin family with specific cellular functions? Bioessays. 2009;31:953-974.

    Not in our library10.1002/bies.200800236

  59. 59.

    Penuela S., Gehi R., Laird D.W. The biochemistry and function of pannexin channels. Biochim. Biophys. Acta. 2013;1828:15-22.

    Not in our library10.1016/j.bbamem.2012.01.017

  60. 60.

    Baroja-Mazo A., Barberà-Cremades M., Pelegrín P. The participation of plasma membrane hemichannels to purinergic signaling. Biochim. Biophys. Acta. 2013;1828:79-93.

    Not in our library10.1016/j.bbamem.2012.01.002

  61. 61.

    Kang J., Kang N., Lovatt D., Torres A., Zhao Z., Lin J., Nedergaard M. Connexin 43 hemichannels are permeable to ATP. J. Neurosci. 2008;28:4702-4711.

    Not in our library10.1523/jneurosci.5048-07.2008

  62. 62.

    Bao L., Locovei S., Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 2004;572:65-68.

    Not in our library10.1016/j.febslet.2004.07.009

  63. 63.

    Wang N., De Bock M., Decrock E., Bol M., Gadicherla A., Vinken M., Rogiers V., Bukauskas F.F., Bultynck G., Leybaert L. Paracrine signaling through plasma membrane hemichannels. Biochim. Biophys. Acta. 2013;1828:35-50.

    Not in our library10.1016/j.bbamem.2012.07.002

  64. 64.

    Tran Van Nhieu G., Clair C., Bruzzone R., Mesnil M., Sansonetti P., Combettes L. Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells. Nat. Cell Biol. 2003;5:720-726.

    Not in our library10.1038/ncb1021

  65. 65.

    Schock S.C., Leblanc D., Hakim A.M., Thompson C.S. ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro. Biochem. Biophys. Res. Commun. 2008;368:138-144.

    Not in our library10.1016/j.bbrc.2008.01.054

  66. 66.

    Retamal M.A., Schalper K.A., Shoji K.F., Orellana J.A., Bennett M.V., Sáez J.C. Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J. Membr. Biol. 2007;218:49-63.

    Not in our library10.1007/s00232-007-9043-y

  67. 67.

    Lopez W., Ramachandran J., Alsamarah A., Luo Y., Harris A.L., Contreras J.E. Mechanism of gating by calcium in connexin hemichannels. Proc. Natl. Acad. Sci. USA. 2016;113:E7986-E7995.

    Not in our library10.1073/pnas.1609378113

  68. 68.

    Locovei S., Wang J., Dahl G. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett. 2006;580:239-244.

    Not in our library10.1016/j.febslet.2005.12.004

  69. 69.

    Kar R., Batra N., Riquelme M.A., Jiang J.X. Biological role of connexin intercellular channels and hemichannels. Arch. Biochem. Biophys. 2012;524:2-15.

    Not in our library10.1016/j.abb.2012.03.008

  70. 70.

    Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Güldenagel M., Deutsch U., Söhl G. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 2002;383:725-737.

    Not in our library10.1515/bc.2002.076

  71. 71.

    Dourado M., Wong E., Hackos D.H. Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface. PLoS ONE. 2014;9:e99596.

    Not in our library10.1371/journal.pone.0099596

  72. 72.

    Wang N., De Bock M., Decrock E., Bol M., Gadicherla A., Bultynck G., Leybaert L. Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening. Neuropharmacology. 2013;75:506-516.

    Not in our library10.1016/j.neuropharm.2013.08.021

  73. 73.

    Iyyathurai J., Wang N., D’hondt C., Jiang J.X., Leybaert L., Bultynck G. The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity. Cell. Mol. Life Sci. 2017.

    Not in our library10.1007/s00018-017-2722-7

  74. 74.

    Leybaert L., Lampe P.D., Dhein S., Kwak B.R., Ferdinandy P., Beyer E.C., Laird D.W., Naus C.C., Green C.R., Schulz R. Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol. Rev. 2017;69:396-478.

    Not in our library10.1124/pr.115.012062

  75. 75.

    Solan J.L., Lampe P.D. Key connexin 43 phosphorylation events regulate the gap junction life cycle. J. Membr. Biol. 2007;217:35-41.

    Not in our library10.1007/s00232-007-9035-y

  76. 76.

    Solan J.L., Lampe P.D. Connexin43 phosphorylation: Structural changes and biological effects. Biochem. J. 2009;419:261-272.

    Not in our library10.1042/bj20082319

  77. 77.

    Bao X., Reuss L., Altenberg G.A. Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368. J. Biol. Chem. 2004;279:20058-20066.

    Not in our library10.1074/jbc.m311137200

  78. 78.

    García I.E., Sánchez H.A., Martínez A.D., Retamal M.A. Redox-mediated regulation of connexin proteins; focus on nitric oxide. Biochim. Biophys. Acta. 2018;1860:91-95.

    Not in our library10.1016/j.bbamem.2017.10.006

  79. 79.

    Retamal M.A., Cortés C.J., Reuss L., Bennett M.V., Sáez J.C. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents. Proc. Natl. Acad. Sci. USA. 2006;103:4475-4480.

    Not in our library10.1073/pnas.0511118103

  80. 80.

    Wang N., De Vuyst E., Ponsaerts R., Boengler K., Palacios-Prado N., Wauman J., Lai C.P., De Bock M., Decrock E., Bol M., Vinken M., et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res. Cardiol. 2013;108:309.

    Not in our library10.1007/s00395-012-0309-x

  81. 81.

    Eltzschig H.K., Eckle T., Mager A., Küper N., Karcher C., Weissmüller T., Boengler K., Schulz R., Robson S.C., Colgan S.P. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ. Res. 2006;99:1100-1108.

    Not in our library10.1161/01.res.0000250174.31269.70

  82. 82.

    Robertson J., Lang S., Lambert P.A., Martin P.E. Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells. Biochem. J. 2010;432:133-143.

    Not in our library10.1042/bj20091753

  83. 83.

    Rhett J.M., Fann S.A., Yost M.J. Purinergic signaling in early inflammatory events of the foreign body response: Modulating extracellular ATP as an enabling technology for engineered implants and tissues. Tissue Eng. Part B Rev. 2014;20:392-402.

    Not in our library10.1089/ten.teb.2013.0554

  84. 84.

    Burnstock G. Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells. Pharmacol. Rep. 2008;60:12-20.

    Not in our library

  85. 85.

    Ferrari D., Vitiello L., Idzko M., la Sala A. Purinergic signaling in atherosclerosis. Trends Mol. Med. 2015;21:184-192.

    Not in our library10.1016/j.molmed.2014.12.008

  86. 86.

    Yuan D., Wang Q., Wu D., Yu M., Zhang S., Li L., Tao L., Harris A.L. Monocyte-endothelial adhesion is modulated by Cx43-stimulated ATP release from monocytes. Biochem. Biophys. Res. Commun. 2012;420:536-541.

    Not in our library10.1016/j.bbrc.2012.03.027

  87. 87.

    Tabas I., Lichtman A.H. Monocyte-Macrophages and T Cells in Atherosclerosis. Immunity. 2017;47:621-634.

    Not in our library10.1016/j.immuni.2017.09.008

  88. 88.

    Wong C.W., Christen T., Roth I., Chadjichristos C.E., Derouette J.P., Foglia B.F., Chanson M., Goodenough D.A., Kwak B.R. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat. Med. 2006;12:950-954.

    Not in our library10.1038/nm1441

  89. 89.
    ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia · 2008
    No notice
  90. 90.

    Chekeni F.B., Elliott M.R., Sandilos J.K., Walk S.F., Kinchen J.M., Lazarowski E.R., Armstrong A.J., Penuela S., Laird D.W., Salvesen G.S., et al. Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis. Nature. 2010;467:863-867.

    Not in our library10.1038/nature09413

  91. 91.

    Sandilos J.K., Chiu Y.H., Chekeni F.B., Armstrong A.J., Walk S.F., Ravichandran K.S., Bayliss D.A. Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. J. Biol. Chem. 2012;287:11303-11311.

    Not in our library10.1074/jbc.m111.323378

  92. 92.
    A quantized mechanism for activation of pannexin channels · 2017
    No notice
  93. 93.

    Silverman W.R., de Rivero Vaccari J.P., Locovei S., Qiu F., Carlsson S.K., Scemes E., Keane R.W., Dahl G. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J. Biol. Chem. 2009;284:18143-18151.

    Not in our library10.1074/jbc.m109.004804

  94. 94.

    Gulbransen B.D., Bashashati M., Hirota S.A., Gui X., Roberts J.A., MacDonald J.A., Muruve D.A., McKay D.M., Beck P.L., Mawe G.M., et al. Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nat. Med. 2012;18:600-604.

    Not in our library10.1038/nm.2679

  95. 95.

    Pelegrin P., Surprenant A. The P2X(7) receptor-pannexin connection to dye uptake and IL-1β release. Purinergic Signal. 2009;5:129-137.

    Not in our library10.1007/s11302-009-9141-7

  96. 96.

    Iglesias R., Locovei S., Roque A., Alberto A.P., Dahl G., Spray D.C., Scemes E. P2X7 receptor-Pannexin1 complex: Pharmacology and signaling. Am. J. Physiol. Cell Physiol. 2008;295:C752-C760.

    Not in our library10.1152/ajpcell.00228.2008

  97. 97.

    Gödecke S., Roderigo C., Rose C.R., Rauch B.H., Gödecke A., Schrader J. Thrombin-induced ATP release from human umbilical vein endothelial cells. Am. J. Physiol. Cell Physiol. 2012;302:C915-C923.

    Not in our library10.1152/ajpcell.00283.2010

  98. 98.

    Pinheiro A.R., Paramos-de-Carvalho D., Certal M., Costa M.A., Costa C., Magalhães-Cardoso M.T., Ferreirinha F., Sévigny J., Correia-de-Sá P. Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation. J. Biol. Chem. 2013;288:27571-27583.

    Not in our library10.1074/jbc.m113.460865

  99. 99.

    Pinheiro A.R., Paramos-de-Carvalho D., Certal M., Costa C., Magalhães-Cardoso M.T., Ferreirinha F., Costa M.A., Correia-de-Sá P. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun. Signal. 2013;11:70.

    Not in our library10.1186/1478-811x-11-70

  100. 100.

    Retamal M.A. Connexin and Pannexin hemichannels are regulated by redox potential. Front. Physiol. 2014;5:80.

    Not in our library10.3389/fphys.2014.00080

  101. 101.

    Boyce A.K.J., Swayne L.A. P2X7 receptor cross-talk regulates ATP-induced pannexin 1 internalization. Biochem. J. 2017;474:2133-2144.

    Not in our library10.1042/bcj20170257

  102. 102.

    Qiu F., Dahl G. A permeant regulating its permeation pore: Inhibition of pannexin 1 channels by ATP. Am. J. Physiol. Cell Physiol. 2009;296:C250-255.

    Not in our library10.1152/ajpcell.00433.2008

  103. 103.

    Whyte-Fagundes P., Zoidl G. Mechanisms of pannexin1 channel gating and regulation. Biochim. Biophys. Acta. 2018;1860:65-71.

    Not in our library10.1016/j.bbamem.2017.07.009

  104. 104.

    Poornima V., Vallabhaneni S., Mukhopadhyay M., Bera A.K. Nitric oxide inhibits the pannexin 1 channel through a cGMP-PKG dependent pathway. Nitric Oxide. 2015;47:77-84.

    Not in our library10.1016/j.niox.2015.04.005

  105. 105.

    Ayna G., Krysko D.V., Kaczmarek A., Petrovski G., Vandenabeele P., Fésüs L. ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages. PLoS ONE. 2012;7:e40069.

    Not in our library10.1371/journal.pone.0040069

  106. 106.

    Lauber K., Blumenthal S.G., Waibel M., Wesselborg S. Clearance of apoptotic cells: Getting rid of the corpses. Mol Cell. 2004;14:277-287.

    Not in our library10.1016/s1097-2765(04)00237-0

  107. 107.

    Qu Y., Misaghi S., Newton K., Gilmour L.L., Louie S., Cupp J.E., Dubyak G.R., Hackos D., Dixit V.M. Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J. Immunol. 2011;186:6553-6561.

    Not in our library10.4049/jimmunol.1100478

  108. 108.

    Bao Y., Chen Y., Ledderose C., Li L., Junger W.G. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J. Biol. Chem. 2013;288:22650-22657.

    Not in our library10.1074/jbc.m113.476283

  109. 109.

    Chen Y., Yao Y., Sumi Y., Li A., To U.K., Elkhal A., Inoue Y., Woehrle T., Zhang Q., Hauser C., et al. Purinergic signaling: A fundamental mechanism in neutrophil activation. Sci. Signal. 2010;3:ra45.

    Not in our library10.1126/scisignal.2000549

  110. 110.

    Chen Y., Corriden R., Inoue Y., Yip L., Hashiguchi N., Zinkernagel A., Nizet V., Insel P.A., Junger W.G. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006;314:1792-1795.

    Not in our library10.1126/science.1132559

  111. 111.

    Riteau N., Baron L., Villeret B., Guillou N., Savigny F., Ryffel B., Rassendren F., Le Bert M., Gombault A., Couillin I. ATP release and purinergic signaling: A common pathway for particle-mediated inflammasome activation. Cell Death Dis. 2012;3:e403.

    Not in our library10.1038/cddis.2012.144

  112. 112.

    Pelegrin P., Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor. EMBO J. 2006;25:5071-5082.

    Not in our library10.1038/sj.emboj.7601378

  113. 113.
    ATP release and purinergic signaling in NLRP3 inflammasome activation · 2013
    No notice
  114. 114.

    Connors B.W. Tales of a dirty drug: Carbenoxolone, gap junctions, and seizures. Epilepsy Curr. 2012;12:66-68.

    Not in our library10.5698/1535-7511-12.2.66

  115. 115.

    Yan J., Li S. The role of the liver in sepsis. Int. Rev. Immunol. 2014;33:498-510.

    Not in our library10.3109/08830185.2014.889129

  116. 116.

    Savio L.E.B., de Andrade Mello P., Figliuolo V.R., de Avelar Almeida T.F., Santana P.T., Oliveira S.D.S., Silva C.L.M., Feldbrügge L., Csizmadia E., Minshall R.D., et al. CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. J. Hepatol. 2017;67:716-726.

    Not in our library10.1016/j.jhep.2017.05.021

  117. 117.

    Martinon F., Tschopp J. Inflammatory caspases and inflammasomes: Master switches of inflammation. Cell Death Differ. 2007;14:10-22.

    Not in our library10.1038/sj.cdd.4402038

  118. 118.

    Zerr M., Hechler B., Freund M., Magnenat S., Lanois I., Cazenave J.P., Léon C., Gachet C. Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation. Circulation. 2011;123:2404-2413.

    Not in our library10.1161/circulationaha.110.002139

  119. 119.

    Riegel A.K., Faigle M., Zug S., Rosenberger P., Robaye B., Boeynaems J.M., Idzko M., Eltzschig H.K. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood. 2011;117:2548-2555.

    Not in our library10.1182/blood-2010-10-313957

  120. 120.

    Kronlage M., Song J., Sorokin L., Isfort K., Schwerdtle T., Leipziger J., Robaye B., Conley P.B., Kim H.C., Sargin S., et al. Autocrine purinergic receptor signaling is essential for macrophage chemotaxis. Sci. Signal. 2010;3:ra55.

    Not in our library10.1126/scisignal.2000588

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