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Recent Advances in Antimicrobial Polymers: A Mini-Review

Keng-Shiang Huang, Chih-Hui Yang, Shu-Ling Huang and 3 more

International Journal of Molecular Sciences · 2016 · Review · CC BY

doi:10.3390/ijms17091578

Abstract

Human safety and well-being is threatened by microbes causing numerous infectious diseases resulting in a large number of deaths every year. Despite substantial progress in antimicrobial drugs, many infectious diseases remain difficult to treat. Antimicrobial polymers offer a promising antimicrobial strategy for fighting pathogens and have received considerable attention in both academic and industrial research. This mini-review presents the advances made in antimicrobial polymers since 2013. Antimicrobial mechanisms exhibiting either passive or active action and polymer material types containing bound or leaching antimicrobials are introduced. This article also addresses the applications of these antimicrobial polymers in the medical, food, and textile industries.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 25, 2026. Paragraph numbers are ours, so an answer can point at one.

1. Introduction

Microbes are living organisms, such as bacteria, fungi, and parasites, which are the critical sources of infections. Infectious diseases result from pathogenic microbes and kill more people than any other single cause. An antimicrobial is an agent used to kill microbes or inhibit their growth. Although numerous antimicrobial drugs have been developed to kill or inhibit microbes, many infectious diseases remain difficult to treat. Antimicrobial polymers were discovered since 1965 and have attracted considerable attention in both academic and industrial research. Table 1 shows recent review articles on antimicrobial polymers from various perspectives. These reviews focus on methods for producing antimicrobial polymers and various applications of antimicrobials. Increasing efforts develops learning from nature, green or nontoxic biocides. The medical, food, and textile industries are three major areas of applied antimicrobials. More than 27,845 patents for antimicrobial polymers have been filed in the Google Patent Search database since 2013. In addition, antimicrobial medical devices have attracted substantial attention in clinical trials. Compared with their small molecular counterparts, antimicrobial polymers demonstrate superior efficacy, reduced toxicity, minimized environmental problems, and greater resistance.

When microbes adhere to a substrate, they excrete biofilms to anchor themselves to the substrate. In biofilms, cells grow in multicellular aggregates and become embedded within a self-produced matrix of an extracellular polymeric substance. A biofilm extracellular polymeric substance is a polymeric conglomeration composed of polysaccharides and other components, such as proteins and DNA. Defective biofilms cannot offer an environment for microbes to grow. Therefore, antimicrobial applications entail strategies for preventing microbial viability or adhesion. For example, antimicrobial peptides act primarily by disrupting the bacterial cell membrane, and heparin exhibits anti-adhesive activity and hydrophilic characteristics that prevent the growth of microbes. Several reviews have described antimicrobial management. Biofilms are difficult to remove and resist many biocides. Therefore, to prevent the spread of diseases, inhibiting biofilm formation and reducing microbial attachment are a more promising antimicrobial strategy than killing microbes.

Many promising antimicrobial polymers have been reported, and the number of FDA-approved antimicrobial polymers has increased drastically in the past decade. This review describes the new developments in antimicrobial polymers over the past three years. According to the mechanism of antimicrobial activity, the activity of antimicrobial polymers can be categorized as either passive or active (Section 2). Based on the polymer material type, antimicrobial polymers can be classified as bound or leaching antimicrobials (Section 3). These antimicrobial polymers are applied in the medical, food, and textile industries (Section 4). Finally, the conclusion and prospects for future research are addressed (Section 5).

2.1. Passive Action

A passive polymer layer can reduce protein adsorption on its surface, thereby preventing the adhesion of bacteria. However, although passive surfaces repel bacteria, they do not actively interact with or kill bacteria. Due to the mainly hydrophobic and negatively-charged properties of microbes, passive polymers should be either (1) hydrophilic; (2) negatively-charged; or (3) have a low surface free energy (Figure 1). Typical passive polymers comprise (1) self-healing, slippery liquid-infused porous surface (SLIPS), such as poly(dimethyl siloxane); (2) uncharged polymers, such as poly(ethylene glycol) (PEG), poly(2-methyl-2-oxazoline), polypeptoid, polypoly(n-vinyl-pyrrolidone), and poly(dimethyl acrylamide); and (3) charged polyampholytes and zwitterionic polymers, such as phosphobetaine, sulfobetaine, and phospholipid polymers. Table 2 lists selected passive polymers and their antimicrobial applications. Among these passive polymers, PEG has been extensively studied and has demonstrated excellent antimicrobial effects in drastically reducing protein adsorption and bacterial adhesion. Due to high chain mobility, large exclusion volume, and steric hindrance effect of highly hydrated layer, PEG has been the most commonly used passive antimicrobial material, and research has shown that it exhibits high antifouling ability to prevent protein and cell adhesion effectively, consequently preventing the growth of microbes.

2.2. Active Action

Active polymers actively kill bacteria that adhere to the polymer surface. Polymers functionalized with active agents, such as cationic biocides, antimicrobial peptides, or antibiotics, can kill bacteria on contact. The mechanism of polymers killing microbes depends on the active agents (Figure 1). The most widely used active antimicrobial polymers are functionalized with positively-charged quaternary ammonium, which interacts with the cell wall and destroys the cytoplasmic membrane, resulting in the leakage of intracellular components and consequent cell death. In addition, polyethylenimine, polyguanidine, and N-halamine are representative polymers that demonstrate active antimicrobial activity. Polyethylenimine brings about bacterial cell membrane rupture by the electrostatic interaction between polyethylenimine and the cell membrane. Polyguanidine has bacterial growth inhibition through adhesion and subsequent disruption of Ca2+ salt bridges or cell death. N-halamine makes cell inhibition or inactivation by action of the oxidative halogen targeted at thio or amino groups of cell receptors. Table 3 lists active polymers and their antimicrobial applications, indicating that most of these new antimicrobials materials are based on quaternary ammonium salts.

3. Bound or Leaching Antimicrobials

Several recent comprehensive state-of-the-art reviews summarize the progress of and research on antimicrobial polymers. Antimicrobial polymers can be divided into three types: polymeric biocides, biocidal polymers, and biocide-releasing polymers. Recently, synergistic combination has been commonly used to provide multiple functional antimicrobials for fighting pathogens.

3.1. Polymeric Biocides

Polymeric biocides are polymers that covalently link bioactive repeating units with antimicrobial activity such as amino, carboxyl, or hydroxyl groups. The polymerization process may either enhance or reduce the antimicrobial activity of bioactive functional groups. Table 4 lists examples of polymeric biocides synthesized from antimicrobial monomers.

3.2. Biocidal Polymers

Requiring no bioactive repeating units, the antimicrobial site of biocidal polymers is embodied by the entire macromolecule. Many biocidal polymers contain cationic biocides, such as quaternary ammonium, phosphonium, tertiary sulfonium, and guanidinium. Microbes generally have a negative charge at the outer membrane of the cell. Cationic polymers can lead to the destabilization of the cell surface and the ultimately induction of bacterial death. The antimicrobial activity of cationic polymers relate to the charge density of cationic groups.

Table 5 lists examples of biocidal polymers in relevant literature. Due to its properties of nontoxicity, biodegradability, and biocompatibility, chitosan is the most representative natural material exhibiting inherent antimicrobial activity. The antimicrobial activity of chitosan depends heavily on pH value. With a pH value of less than pKa, electrostatic interaction occurs between protonated amino groups and the cell wall. When the pH is higher than the pKa value, the antimicrobial activity of chitosan derives from hydrophobic interaction and chelation effects. Other natural antimicrobial polymers include heparin, poly-ε-lysine, and gramicidin A. Antimicrobial peptides have been recognized as promising candidates for the new generation of antibacterial surfaces. Thus far, more than 1000 antimicrobial peptides have been found. In addition to directly killing microbes by disrupting cell membranes and inhibiting cellular processes, the antimicrobial mechanisms of peptides can also exert immunomodulatory effects resulting in microbial clearance through stimulation of the noninflammatory host immune response. The challenges of microbial peptides for therapeutic use include unwanted side effects, high production costs, deficient stability, and adaptive antimicrobial resistance.

3.3. Biocide-Releasing Polymers

Biocide-releasing polymers can be realized by (1) polymerization of biocide-releasing molecules to polymeric backbone; or (2) polymer/biocide-releasing molecules composites. The polymer in biocide-releasing systems is used as a carrier for biocides. Polymers exhibit antibacterial properties through the incorporation of antibiotic and/or antiseptic compounds. The controlled release system of biocide-release polymers has numerous advantages such as maintaining a high local biocide concentration close to microbes and facilitating the delivery of biocides with short in vivo half-lives. This type of antimicrobial polymer demonstrates great potential for use in the medical industry. Numerous biodegradable polymer devices have been developed as antibiotic carriers for various applications. Table 6 shows various biocide-releasing polymer systems, including new polymer composites that exhibit antimicrobial activity.

A chitosan-agarose hybrid material and nanocomposite ionogels decorated with silver were produced using an ionic liquid, 1-butyl-3-methylimidazolium chloride. The prepared antimicrobial composite ionogels were biocompatible and demonstrated favorable electrical conductivity, as well as thermal and conformational stability. A resorbable antibiotic-eluting polymer composite bone void filler was developed to exhibit both osteoconductive and antimicrobial properties for reducing the rates of orthopedic device-related infections. Synergistic combinations of iron-sequestering polymers and conventional antibiotics may drastically reduce the minimum inhibitory concentrations of antibiotics and offer a promising early intervention or adjuvant to antibiotics. Incorporating crystal violet and di(octyl)­phosphinic-acid-capped zinc oxide nanoparticles into medical-grade silicone can provide a dual-mechanism antimicrobial polymer as a strategy for reducing the risk of infection.

In addition, antimicrobial polymers can be classified as surface-bound or solution-based polymers. Surface-bound polymers have direct antimicrobial activity on the polymer surface. However, solution-based polymers need to be used in solutions to have antimicrobial activity. In general, biocidal polymers are surface-bound polymers, while biocide-releasing polymers are solution-based polymers to release biocides in solutions. Depending on the property of bioactive repeating units, polymeric biocides can be surface-bound or solution-based polymers.

4. Applications

The major areas of applied antimicrobial polymers are the medical, food, and textile industries. The recent advances in these three areas are addressed as follows.

4.1. Medical Industry

The surfaces of all medical devices provide an environment for microbial growth, and are susceptible to microbial infection. Despite continual improvements in materials and techniques, most hospital-acquired infections originate from medical devices. An innovative antimicrobial copolymer of 4-vinyl-n-hexylpyridinium bromide (VP) and dimethyl(2-methacryloyloxyethyl) phosphonate (DMMEP) was developed to reduce biofilm formation and to improve the long-term use of medical devices. Coating a copolymer (VP:DMMEP 30:70) on titanium drastically reduces the adhesion of various pathogenic bacteria (e.g., Streptococcus sanguinis, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis). Furthermore, soft tissue cells (human gingival or dermis fibroblasts) are minimally affected by such a coating.

Antimicrobial peptides and synthetic mimics of antimicrobial peptides are a new generation of antimicrobial agents with high antimicrobial, broad spectrum activity against a variety of pathogens and modulation of the immune response. Antimicrobial wound-dressings composed of cotton gauze containing antimicrobial peptides incorporated with polycation (chitosan) and polyanion (alginic acid sodium salt) exert a high antimicrobial effect (in the range of 4–6 log reduction) for Staphylococcus aureus and Klebsiella pneumonia. These dressings have also been proven to be noncytotoxic to normal human dermal fibroblasts.

A novel controlled release zinc oxide/gentamicin-chitosan composite gel was developed. By slowly releasing the antibiotic, this composite gel demonstrated highly effective antimicrobial properties, inhibiting Staphylococcus aureus and Pseudomonas aeruginosa growth under both planktonic and surface-attached conditions. When used in a wound dressing, it maintained a moist environment at the wound interface and provided a cooling sensation and soothing effect. Moreover, this system is fully scalable to any other soluble drug because the entire solution remains trapped in the ZnO-chitosan composite gel.

The infection of catheter-associated urinary tract is the commonest hospital-acquired infection. Impregnation of urinary catheters with a combination of rifampicin, sparfloxacin and triclosan was developed. The release of the drugs from the silicone catheter segments were more than one month. The antimicrobial catheters could prevent colonization of Proteus mirabilis, Staphylococcus aureus, and Escherichia coli for 7–12 weeks. The impregnated catheters might reduce catheter-associated urinary tract infection in both short-term and long-term urinary catheter use.

4.2. Food Industry

Food safety and quality have attracted increasing attention because of concerns about consumer health. The advent of new technologies has been addressed by the food industry to reduce the risks to consumer health. In particular, substantial progress in food packaging has been achieved using antimicrobial polymers.

Nisin is the only bacteriocin approved as a food preservative because of its favorable properties of negligible toxicity and antibacterial effectiveness. Nisin-loaded chitosan/poly(l-lactic acid) antimicrobial films were developed for applications in food packaging. The diffusion process of antimicrobial nisin from the manufactured film is spontaneous and endothermic. The well-controlled release of nisin from the film demonstrates high antimicrobial activity against Staphylococcus aureus.

Antimicrobial packing films were developed by compounding low-density polyethylene and its blend of ethylene vinyl acetate with potassium sorbate. A new approach to incorporating preservatives into a polyolefin matrix by using glycerol mono-oleate as a dispersant was reported to obtain uniform dispersions of the preservatives in the packing films, thereby significantly improving the thermal stability with no viscosity reduction.

A cellulose acetate film incorporated with a solution of bacteriophages was developed for food packaging. This film showed antimicrobial activity against Salmonella Typhimurium ATCC 14028, and the bacteriophages could remain viable for 14 days.

4.3. Textile Industry

Textiles are favorable substrates for microbial growth under appropriate conditions of temperature and moisture. Antimicrobial agents have yielded new opportunities for additional applications involving textile fibers. The market for antimicrobial textiles has grown dramatically over the past two decades.

Ag:ZnO/chitosan nanocomposite coatings were developed using a modified sol-gel method with 3-glycidyloxypropyltrimethoxysilane and tetraethoxysilane as functionalization agents and were applied to antimicrobial fabrics. This prepared hybrid nanocomposite demonstrated high antimicrobial activity and exhibited higher thermal stability than that of chitosan. Composite coatings on the textile blend of cotton/polyester (50%/50%) exerted the most advanced effect.

Natural fibers contributing to the reduction of environmental pollution as well as the burden of waste disposal have recently received considerable attention and become highly valuable materials. A new type of textile consisting of mulberry fibers uniformly laden with titania nanorods was prepared using sol-gel electrospinning and facile dip-coating methods. The mulberry fiber-TiO2 composite textile exhibited improved antimicrobial activity compared with pure mulberry textile. Furthermore, the advantages of this unique natural-synthetic composite textile are its anti-yellowing and self-cleaning properties, which are due to the scattering effect of UV radiation by titania nanorods.

For fabricating ecofriendly antimicrobial textile material, the impregnation of polypropylene (PP) and corona-modified PP nonwoven material with thymol by super-critical solvent impregnation with carbon dioxide as a working fluid was proposed. The thymol impregnation yield was approximately 7% for both PP and corona-modified PP nonwoven fabrics, providing antimicrobial activity against S. aureus, E. coli, and Candida albicans. Nevertheless, the higher rate of thymol release from the corona-modified material was due to the higher fiber surface hydrophilicity.

5. Conclusions

Recently, antimicrobial polymers have received considerable attention in both academic and industrial research. This mini-review summarizes the advances made in antimicrobial polymers since 2013. Passive antimicrobial polymers preventing bacterial adhesion and growth provide a more promising strategy than that of killing microbes directly by using active antimicrobial polymers. Among three bound or leaching polymers–polymeric biocides, biocidal polymers, and biocide-releasing polymers–the biocide-releasing system demonstrates the most potential because of the controlled release characteristics. Despite the substantial progress of antimicrobial polymers, the precise mechanisms underlying antimicrobial interaction with microbes necessitates further clarification. In particular, biofilm-associated mechanisms will require an intensive effort to design a promising antimicrobial agent. Combining diverse antimicrobial mechanisms may contribute to a more effective antimicrobial polymer. Further challenges are developments of long-acting or reusable antimicrobial polymers, a broad range of antimicrobial activity, and an activity-controlled system on demand sites.

References 92

  1. 1.

    Ross A.G.P., Olds G.R., Cripps A.W., Farrar J.J., McManus D.P. Enteropathogens and chronic illness in returning travelers. N. Engl. J. Med. 2013;368:1817-1825.

    Not in our library10.1056/nejmra1207777

  2. 2.

    Lin Y.S., Lee M.Y., Yang C.H., Huang K.S. Biomedical devices for pathogen detection using microfluidic chips. Curr. Proteom. 2014;11:116-120.

    Not in our library10.2174/157016461102140917122234

  3. 3.

    Chan C.F., Huang K.S., Lee M.Y., Yang C.H., Wang C.Y., Lin Y.S. Applications of nanoparticles for antimicrobial activity and drug delivery. Curr. Org. Chem. 2014;18:204-215.

    Not in our library10.2174/13852728113176660144

  4. 4.

    Sun D., Shahzad M.B., Li M., Wang G., Xu D. Antimicrobial materials with medical applications. Mater. Technol. 2015;30:B90-B95.

    Not in our library10.1179/1753555714y.0000000239

  5. 5.

    Siedenbiedel F., Tiller J.C. Antimicrobial polymers in solution and on surfaces: Overview and functional principles. Polymers. 2012;4:46-71.

    Not in our library10.3390/polym4010046

  6. 6.

    Jain A., Duvvuri L.S., Farah S., Beyth N., Domb A.J., Khan W. Antimicrobial polymers. Adv. Healthc. Mater. 2014;3:1969-1985.

    Not in our library10.1002/adhm.201400418

  7. 7.

    Islam M.R., Gao Y.F., Li X., Zhang Q.M., Wei M., Serpe M.J. Stimuli-responsive polymeric materials for human health applications. Chin. Sci. Bull. 2014;59:4237-4255.

    Not in our library10.1007/s11434-014-0545-6

  8. 8.

    Francolini I., Donelli G., Crisante F., Taresco V., Piozzi A. Antimicrobial polymers for anti-biofilm medical devices: State-of-art and perspectives. Adv. Exp. Med. Biol. 2015;831:93-117.

    Not in our library10.1007/978-3-319-09782-4_7

  9. 9.

    Strempel N., Strehmel J., Overhage J. Potential application of antimicrobial peptides in the treatment of bacterial biofilm infections. Curr. Pharm. Des. 2015;21:67-84.

    Not in our library10.2174/1381612820666140905124312

  10. 10.

    Alves D., Olívia Pereira M. Mini-review: Antimicrobial peptides and enzymes as promising candidates to functionalize biomaterial surfaces. Biofouling. 2014;30:483-499.

    Not in our library10.1080/08927014.2014.889120

  11. 11.

    Gour N., Ngo K.X., Vebert-Nardin C. Anti-infectious surfaces achieved by polymer modification. Macromol. Mater. Eng. 2014;299:648-668.

    Not in our library10.1002/mame.201300285

  12. 12.
    Antimicrobial Polymers with Metal Nanoparticles · 2015
    No notice
  13. 13.

    Hui F., Debiemme-Chouvy C. Antimicrobial N-halamine polymers and coatings: A review of their Synthesis, characterization, and applications. Biomacromolecules. 2013;14:585-601.

    Not in our library10.1021/bm301980q

  14. 14.

    Sedlarik V., Chamy R., Rosenkranz F. Antimicrobial modifications of polymers. Biodegradation—Life of Science. 2013;187-204.

    Not in our library

  15. 15.

    Beyth N., Farah S., Domb A.J., Weiss E.I. Antibacterial dental resin composites. React. Funct. Polym. 2014;75:81-88.

    Not in our library10.1016/j.reactfunctpolym.2013.11.011

  16. 16.

    Carmona-Ribeiro A.M., de Melo Carrasco L.D. Novel formulations for antimicrobial peptides. Int. J. Mol. Sci. 2014;15:18040-18083.

    Not in our library10.3390/ijms151018040

  17. 17.

    Kargupta R., Bok S., Darr C.M., Crist B.D., Gangopadhyay K., Gangopadhyay S., Sengupta S. Coatings and surface modifications imparting antimicrobial activity to orthopedic implants. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2014;6:475-495.

    Not in our library10.1002/wnan.1273

  18. 18.
    Antimicrobial Activity of Chitosan Derivatives Containing N-Quaternized Moieties in Its Backbone: A Review · 2014
    No notice
  19. 19.

    Deka S.R., Sharma A.K., Kumar P. Cationic polymers and their self-assembly for antibacterial applications. Curr. Top. Med. Chem. 2015;15:1179-1195.

    Not in our library10.2174/1568026615666150330110602

  20. 20.
    Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts · 2015
    No notice
  21. 21.

    Desrousseaux C., Sautou V., Descamps S., Traore O. Modification of the surfaces of medical devices to prevent microbial adhesion and biofilm formation. J. Hosp. Infect. 2013;85:87-93.

    Not in our library10.1016/j.jhin.2013.06.015

  22. 22.

    Veerachamy S., Yarlagadda T., Manivasagam G., Yarlagadda P.K. Bacterial adherence and biofilm formation on medical implants: A review. Proc. Inst. Mech. Eng. Part H J. Eng. Med. 2014;228:1083-1099.

    Not in our library10.1177/0954411914556137

  23. 23.

    Brooks B.D., Brooks A.E. Therapeutic strategies to combat antibiotic resistance. Adv. Drug Deliv. Rev. 2014;78:14-27.

    Not in our library10.1016/j.addr.2014.10.027

  24. 24.

    Draenert R., Seybold U., Grutzner E., Bogner J.R. Novel antibiotics: Are we still in the pre–post-antibiotic era? Infection. 2015;43:145-151.

    Not in our library10.1007/s15010-015-0749-y

  25. 25.

    Dryden M.S. Alternative clinical indications for novel antibiotics licensed for skin and soft tissue infection? Curr. Opin. Infect. Dis. 2015;28:117-124.

    Not in our library10.1097/qco.0000000000000142

  26. 26.

    Lee B., Boucher H.W. Targeting antimicrobial-resistant bacterial respiratory tract pathogens: It is time to “get smart”. Curr. Opin. Pulm. Med. 2015;21:293-303.

    Not in our library10.1097/mcp.0000000000000157

  27. 27.

    Roca I., Akova M., Baquero F., Carlet J., Cavaleri M., Coenen S., Cohen J., Findlay D., Gyssens I., Heuer O.E., et al. The global threat of antimicrobial resistance: Science for intervention. New Microbes New Infect. 2015;6:22-29.

    Not in our library10.1016/j.nmni.2015.02.007

  28. 28.

    Yu Q., Wu Z., Chen H. Dual-function antibacterial surfaces for biomedical applications. Acta Biomater. 2015;16:1-13.

    Not in our library10.1016/j.actbio.2015.01.018

  29. 29.

    Holban A.M., Iordanskii A., Grumezescu A.M., Bychkova A., Andronescu E., Mogoantă L., Mogoșanu G.D., Iordache F. Prosthetic devices with nanostructurated surfaces for increased resistance to microbial colonization. Curr. Pharm. Biotechnol. 2015;16:112-120.

    Not in our library10.2174/138920101602150112150303

  30. 30.
    Anti-fouling Coatings of Poly(dimethylsiloxane) Devices for Biological and Biomedical Applications · 2015
    Corrected
  31. 31.

    Liu L., Li W., Liu Q. Recent development of antifouling polymers: Structure, evaluation, and biomedical applications in nano/micro-structures. WIREs Nanomed. Nanobiotechnol. 2014;6:599-614.

    Not in our library10.1002/wnan.1278

  32. 32.

    Ye Q., Zhou F., Zhou F. Antifouling surfaces based on polymer brushes. Antifouling Surfaces and Materials. 2015;55-81.

    Not in our library

  33. 33.

    Yu K., Mei Y., Hadjesfandiari N., Kizhakkedathu J.N. Engineering biomaterials surfaces to modulate the host response. Colloids Surf. B Biointerfaces. 2014;124:69-79.

    Not in our library10.1016/j.colsurfb.2014.08.009

  34. 34.

    Zhou R., Ren P.F., Yang H.C., Xu Z.K. Fabrication of antifouling membrane surface by poly(sulfobetaine methacrylate)/polydopamine co-deposition. J. Membr. Sci. 2014;466:18-25.

    Not in our library10.1016/j.memsci.2014.04.032

  35. 35.

    Hippiusa C., Bütünb V., Erel-Goktepec I. Bacterial anti-adhesive properties of a monolayer of zwitterionic block copolymer micelles. Mater. Sci. Eng. C. 2014;41:354-362.

    Not in our library10.1016/j.msec.2014.04.023

  36. 36.

    Pidhatika B., Rakhmatullina E. The synthesis of polymeric dual-functional antimicrobial surface based on poly(2-methyl-2-oxazoline). Indones. J. Biotechnol. 2014;19:12-22.

    Not in our library

  37. 37.

    Jones A., Abhyuday M., Sharma S. Protein-based bioplastics and their antibacterial potential. J. Appl. Polym. Sci. 2015;132.

    Not in our library10.1002/app.41931

  38. 38.

    Shahzad M., Millhouse E., Culshaw S., Edwards C.A., Ramage G., Combet E. Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation. Food Funct. 2015;6:719-729.

    Not in our library10.1039/c4fo01087f

  39. 39.

    Duday D., Vreuls C., Moreno M., Frache G., Boscher N.D., Zocchi G., Archambeau C., van de Weerdt C., Martial J., Choquet P. Atmospheric pressure plasma modified surfaces for immobilization of antimicrobial nisin peptides. Surf. Coat. Technol. 2013;218:152-161.

    Not in our library10.1016/j.surfcoat.2012.12.045

  40. 40.

    Liu G., Wu G., Jin C., Kong Z. Preparation and antimicrobial activity of terpene-based polyurethane coatings with carbamate group-containing quaternary ammonium salts. Prog. Org. Coat. 2015;80:150-155.

    Not in our library10.1016/j.porgcoat.2014.12.005

  41. 41.

    Taresco V., Crisante F., Francolini I., Martinelli A., D’Ilario L., Ricci-Vitiani L., Buccarelli M., Pietrelli L., Piozzi A. Antimicrobial and antioxidant amphiphilic random copolymers to address medical device-centered infections. Acta Biomater. 2015;22:131-140.

    Not in our library10.1016/j.actbio.2015.04.023

  42. 42.

    Yuen J.W., Chung T.W., Loke A.Y. Methicillin-resistant Staphylococcus aureus (MRSA) contamination in bedside surfaces of a hospital ward and the potential effectiveness of enhanced disinfection with an antimicrobial polymer surfactant. Int. J. Environ. Res. Public Health. 2015;12:3026-3041.

    Not in our library10.3390/ijerph120303026

  43. 43.

    Zhou F., Qin X., Li Y., Ren L., Zhao Y., Yuan X. Fluorosilicone multi-block copolymers tethering quaternary ammonium salt groups for antimicrobial purpose. Appl. Surf. Sci. 2015;347:231-241.

    Not in our library10.1016/j.apsusc.2015.04.079

  44. 44.

    Zhang A.Q., Liu Q.Q., Lei Y.F., Hong S.H., Lin Y.L. Synthesis and antimicrobial activities of acrylamide polymers containing quaternary ammonium salts on bacteria and phytopathogenic fungi. React. Funct. Polym. 2015;88:39-46.

    Not in our library10.1016/j.reactfunctpolym.2015.02.005

  45. 45.

    Babu P.N.K., Ramadevi B., Poornachandra Y., Ganesh Kumar C. Synthesis, antimicrobial, and anticancer evaluation of novel 2-(3-methylindolyl) benzimidazole derivatives. Med. Chem. Res. 2014;23:3970-3978.

    Not in our library10.1007/s00044-014-0974-4

  46. 46.

    Cheng X., Li R., Du J., Sheng J., Ma K., Ren X., Huang T.S. Antimicrobial activity of hydrophobic cotton coated with N-halamine. Polym. Adv. Technol. 2015;26:99-103.

    Not in our library10.1002/pat.3426

  47. 47.

    Li X., Liu Y., Jiang Z., Li R., Ren X., Huang T.S. Synthesis of an N-halamine monomer and its application in antimicrobial cellulose via an electron beam irradiation process. Cellulose. 2015;22:3609-3617.

    Not in our library

  48. 48.

    Li C., Liu Y., Zeng Q.Y., Ao N.J. Preparation and antimicrobial activity of quaternary phosphonium modified epoxidized natural rubber. Mater. Lett. 2013;93:145-148.

    Not in our library10.1016/j.matlet.2012.11.045

  49. 49.

    Lim K., Chua R.R., Saravanan R., Basu A., Mishra B., Tambyah P.A., Ho B., Leong S.S. Immobilization studies of an engineered arginine–tryptophan-rich peptide on a silicone surface with antimicrobial and antibiofilm activity. ACS Appl. Mater. Interfaces. 2013;5:6412-6422.

    Not in our library10.1021/am401629p

  50. 50.

    Lim K., Chua R.R., Bow H., Tambyah P.A., Hadinoto K., Leong S.S. Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties. Acta Biomater. 2015;15:127-138.

    Not in our library10.1016/j.actbio.2014.12.015

  51. 51.

    Locock K.E., Michl T.D., Valentin J.D., Vasilev K., Hayball J.D., Qu Y., Traven A., Griesser H.J., Meagher L., Haeussler M. Guanylated polymethacrylates: A class of potent antimicrobial polymers with low hemolytic activity. Biomacromolecules. 2013;14:4021-4031.

    Not in our library10.1021/bm401128r

  52. 52.

    Mogosanua G.D., Grumezescu A.M. Natural and synthetic polymers for wounds and burns dressing. Int. J. Pharm. 2014;463:127-136.

    Not in our library10.1016/j.ijpharm.2013.12.015

  53. 53.

    Radulescu M., Ficai D., Oprea O., Ficai A., Andronescu E., Holban A.M. Antimicrobial chitosan based formulations with impact on different biomedical applications. Curr. Pharm. Biotechnol. 2015;16:128-136.

    Not in our library10.2174/138920101602150112151157

  54. 54.

    Xing K., Zhu X., Peng X., Qin S. Chitosan antimicrobial and eliciting properties for pest control in agriculture: A review. Agron. Sustain. Dev. 2015;35:569-588.

    Not in our library10.1007/s13593-014-0252-3

  55. 55.

    Thoma L.M., Boles B.R., Kuroda K. Cationic methacrylate polymers as topical antimicrobial agents against Staphylococcus aureus nasal colonization. Biomacromolecules. 2014;15:2933-2943.

    Not in our library10.1021/bm500557d

  56. 56.

    Hassan E.A., Hassan M.L., Moorefield C.N., Newkome G.R. New supramolecular metallo-terpyridine carboxymethyl cellulose derivatives with antimicrobial properties. Carbohydr. Polym. 2015;116:2-8.

    Not in our library10.1016/j.carbpol.2014.06.056

  57. 57.

    Melendez-Ortiz H.I., Alvarez-Lorenzo C., Burillo G., Magariños B., Concheiro A., Bucio E. Radiation-grafting of n-vinylimidazole onto silicone rubber for antimicrobial properties. Radiat. Phys. Chem. 2015;110:59-66.

    Not in our library10.1016/j.radphyschem.2015.01.025

  58. 58.

    Mohamed M.F., Hammac G.K., Guptill L., Seleem M.N. Antibacterial activity of novel cationic peptides against clinical isolates of multi-drug resistant Staphylococcus pseudintermedius from infected dogs. PLoS ONE. 2014;9:1578.

    Not in our library10.1371/journal.pone.0116259

  59. 59.

    Lopez-Meza J.E., Ochoa-Zarzosa A., Barboza-Corona J.E., Bideshi D.K. Antimicrobial peptides: Current and potential applications in biomedical therapies. BioMed Res. Int. 2015;2015.

    Not in our library10.1155/2015/367243

  60. 60.

    Aquino R.P., Auriemma G., Mencherini T., Russo P., Porta A., Adami R., Liparoti S., Della Porta G., Reverchon E., del Gaudio P. Design and production of gentamicin/dextrans microparticles by supercritical assisted atomisation for the treatment of wound bacterial infections. Int. J. Pharm. 2013;440:188-194.

    Not in our library10.1016/j.ijpharm.2012.07.074

  61. 61.

    Hornyák I., Madácsi E., Kalugyer P., Vácz G., Horváthy D.B., Szendrői M., Han W., Lacza Z. Increased release time of antibiotics from bone allografts through a novel biodegradable coating. BioMed Res. Int. 2014;2014.

    Not in our library10.1155/2014/459867

  62. 62.

    Su L.C., Xie Z., Zhang Y., Nguyen K.T., Yang J. Study on the antimicrobial properties of citrate-based biodegradable polymers. Front. Bioeng. Biotechnol. 2014;2.

    Not in our library10.3389/fbioe.2014.00023

  63. 63.

    Macha I.J., Cazalbou S., Ben-Nissan B., Harvey K.L., Milthorpe B. Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery. Mar. Drugs. 2015;13:666-680.

    Not in our library10.3390/md13010666

  64. 64.

    Trivedi T.J., Rao K.S., Kumar A. Facile preparation of agarose-chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol-gel transition. Green Chem. 2014;16:320-330.

    Not in our library10.1039/c3gc41317a

  65. 65.

    Brooks B.D., Sinclair K.D., Grainger D.W., Brooks A.E. A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model. PLoS ONE. 2015;10:1578.

    Not in our library10.1371/journal.pone.0118696

  66. 66.

    El-Gendy N., Qian J., Eshelman K., Rivera M., Berkland C. Antibiotic activity of iron-sequestering polymers. Biomacromolecules. 2015;16:1480-1488.

    Not in our library10.1021/bm5016392

  67. 67.

    Noimark S., Weiner J., Noor N., Allan E., Williams C.K., Shaffer M.S., Parkin I.P. Dual-mechanism antimicrobial polymer–ZnO nanoparticle and crystal violet-encapsulated silicone. Adv. Funct. Mater. 2015;25:1367-1373.

    Not in our library10.1002/adfm.201402980

  68. 68.

    Filatova L.Y., Donovan D.M., Becker S.C., Lebedev D.N., Priyma A.D., Koudriachova H.V., Kabanov A.V., Klyachko N.L. Physicochemical characterization of the staphylolytic LysK enzyme in complexes with polycationic polymers as a potent antimicrobial. Biochimie. 2013;95:1689-1696.

    Not in our library10.1016/j.biochi.2013.04.013

  69. 69.

    Garcia-Arguelles S., Serrano M.C., Gutierrez M.C., Ferrer M.L., Yuste L., Rojo F., del Monte F. Deep eutectic solvent-assisted synthesis of biodegradable polyesters with antibacterial properties. Langmuir. 2013;29:9525-9534.

    Not in our library10.1021/la401353r

  70. 70.

    Ramos A.I., Braga T.M., Fernandes J.A., Silva P., Ribeiro-Claro P.J., Paz F.A., Lopes M.D., Braga S.S. Analysis of the microcrystalline inclusion compounds of triclosan with β-cyclodextrin and its tris-o-methylated derivative. J. Pharm. Biomed. Anal. 2013;80:34-43.

    Not in our library10.1016/j.jpba.2013.02.033

  71. 71.

    Lyutakov O., Hejna O., Solovyev A., Kalachyova Y., Svorcik V. Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material. RSC Adv. 2014;4:50624-50630.

    Not in our library10.1039/c4ra08385g

  72. 72.

    Lyutakov O., Goncharova I., Rimpelova S., Kolarova K., Svanda J., Svorcik V. Silver release and antimicrobial properties of PMMA films doped with silver ions, nano-particles and complexes. Mater. Sci. Eng. C Mater. Biol. Appl. 2015;49:534-540.

    Not in our library10.1016/j.msec.2015.01.022

  73. 73.

    Punitha N., Ramesh P.S., Geetha D. Spectral, morphological and antibacterial studies of β-cyclodextrin stabilized silver-Chitosan nanocomposites. Spectrochim. Acta Part A Mol. Biomol. Spectr. 2015;136:1710-1717.

    Not in our library10.1016/j.saa.2014.10.071

  74. 74.

    Rodriguez L.C., Palmer K., Montagner F., Rodrigues D.C. A novel chlorhexidine-releasing composite bone cement: Characterization of antimicrobial effectiveness and cement strength. J. Bioact. Compat. Polym. 2015;30:34-47.

    Not in our library10.1177/0883911514566130

  75. 75.

    Tran P.A., Hocking D.M., O’Connor A.J. In situ formation of antimicrobial silver nanoparticles and the impregnation of hydrophobic polycaprolactone matrix for antimicrobial medical device applications. Mater. Sci. Eng. C Mater. Biol. Appl. 2015;47:63-69.

    Not in our library10.1016/j.msec.2014.11.016

  76. 76.

    Winkel A., Dempwolf W., Gellermann E., Sluszniak M., Grade S., Heuer W., Eisenburger M., Menzel H., Stiesch M. Introducing a semi-coated model to investigate antibacterial effects of biocompatible polymers on titanium surfaces. Int. J. Mol. Sci. 2015;16:4327-4342.

    Not in our library10.3390/ijms16024327

  77. 77.

    Fu T., Li Y., Thaker H.D., Scott R.W., Tew G.N. Expedient synthesis of SMAMPs via click chemistry. ACS Med. Chem. Lett. 2013;4:841-845.

    Not in our library10.1021/ml400155a

  78. 78.

    Kuroda K., Caputo G.A. Antimicrobial polymers as synthetic mimics of host-defense peptides. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2013;5:49-66.

    Not in our library10.1002/wnan.1199

  79. 79.

    Thaker H.D., Cankaya A., Scott R.W., Tew G.N. Role of amphiphilicity in the design of synthetic mimics of antimicrobial peptides with Gram-negative activity. ACS Med. Chem. Lett. 2013;4:481-485.

    Not in our library10.1021/ml300307b

  80. 80.

    Takahashi H., Palermo E.F., Yasuhara K., Caputo G.A., Kuroda K. Molecular design, structures, and activity of antimircobial peptide-mimetic polymers. Marcomol. Biosci. 2013;13:1285-1299.

    Not in our library10.1002/mabi.201300126

  81. 81.

    Liu R., Chen X., Chakraborty S., Lemke J.J., Hayouka Z., Chow C., Welch R.A., Weisblum B., Masters K.S., Gellman S.H. Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern. J. Am. Chem. Soc. 2014;136:4410-4418.

    Not in our library10.1021/ja500367u

  82. 82.

    Choi H., Chakraborty S., Liu R., Gellman S.H., Weisshaar J.C. Single-cell, time-resolved antimicrobial effects of a highly cationic, random nylon-3 copolymer on live Escherichia coli. ACS Chem. Biol. 2016;11:113-120.

    Not in our library10.1021/acschembio.5b00547

  83. 83.

    Gomes A.P., Mano J.F., Queiroz J.A., Gouveia I.C. Incorporation of antimicrobial peptides on functionalized cotton gauzes for medical applications. Carbohydr. Polym. 2015;127:451-461.

    Not in our library10.1016/j.carbpol.2015.03.089

  84. 84.

    Vasile B.S., Oprea O., Voicu G., Ficai A., Andronescu E., Teodorescu A., Holban A. Synthesis and characterization of a novel controlled release zinc oxide/gentamicin-chitosan composite with potential applications in wounds care. Int. J. Pharm. 2014;463:161-169.

    Not in our library10.1016/j.ijpharm.2013.11.035

  85. 85.

    Fisher L.E., Hook A.L., Ashraf W., Yousef A., Barrett D.A., Scurr D.J., Chen X., Smith E.F., Fay M., Parmenter C.D., et al. Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity. J. Control. Release. 2015;202:57-64.

    Not in our library10.1016/j.jconrel.2015.01.037

  86. 86.

    Gharsallaoui A., Joly C., Oulahal N., Degraeve P. Nisin as a food preservative: Part 2: Antimicrobial polymer materials containing nisin. Crit. Rev. Food Sci. Nutr. 2016;56:1275-1289.

    Not in our library10.1080/10408398.2013.763766

  87. 87.

    Wang H., Liu H., Chu C., She Y., Jiang S., Zhai L., Jiang S., Li X. Diffusion and antibacterial properties of nisin-loaded chitosan/poly (l-lactic acid) towards development of active food packaging film. Food Bioprocess Technol. 2015;8:1657-1667.

    Not in our library10.1007/s11947-015-1522-z

  88. 88.

    Kuplennik N., Tchoudakov R., Zelas Z.B., Sadovski A., Fishman A., Narkis M. Antimicrobial packaging based on linear low-density polyethylene compounded with potassium sorbate. LWT Food Sci. Technol. 2015;62:278-286.

    Not in our library10.1016/j.lwt.2015.01.002

  89. 89.

    Gouvêa D.M., Mendonça R.C., Soto M.L., Cruz R.S. Acetate cellulose film with bacteriophages for potential antimicrobial use in food packaging. LWT Food Sci. Technol. 2015;63:85-91.

    Not in our library10.1016/j.lwt.2015.03.014

  90. 90.

    Busila M., Musat V., Textorbc T., Mahltigd B. Synthesis and characterization of antimicrobial textile finishing based on Ag:ZnO nanoparticles/chitosan biocomposites. RSC Adv. 2015;5:21562-21571.

    Not in our library10.1039/c4ra13918f

  91. 91.

    Jang Y.S., Amna T., Hassan M.S. Nanotitania/mulberry fibers as novel textile with anti-yellowing and intrinsic antimicrobial properties. Ceram. Int. 2015;41:6274-6280.

    Not in our library10.1016/j.ceramint.2015.01.050

  92. 92.

    Markovic D., Milovanovic S., Radeti M., Jokic B., Zizovic I. Impregnation of corona modified polypropylene non-woven materialwith thymol in supercritical carbon dioxide for antimicrobialapplication. J. Supercrit. Fluids. 2015;101:215-221.

    Not in our library10.1016/j.supflu.2015.03.022

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