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Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis

Rolf Snijders, Linda Brom, Maurice Theunissen and 1 more

Cancers · 2023 · Review · CC BY

doi:10.3390/cancers15030591

Abstract

Simple Summary. Pain associated with cancer diagnoses is a serious concern and one of the most common symptoms reported by cancer patients. The insufficient relief of cancer pain can have a major impact on patients’ quality of life. Recent developments in oncology such as new pain management guidelines, drugs and treatment strategies may have had a positive effect on the prevalence and severity of pain. Therefore, the aim of this systematic literature review was to assess the prevalence of pain and pain severity in cancer patients throughout all phases of treatment in the 2014–2021 literature period. Our results show a decline in both the prevalence and severity of cancer pain, compared to previous research. Nevertheless, with 44.5% of cancer patients still experiencing pain, the prevalence remains high, emphasizing the need for ongoing attention regarding the management of cancer pain.

Abstract. Experiencing pain and insufficient relief can be devastating and negatively affect a patient’s quality of life. Developments in oncology such as new treatments and adjusted pain management guidelines may have influenced the prevalence of cancer pain and severity in patients. This review aims to provide an overview of the prevalence and severity of pain in cancer patients in the 2014–2021 literature period. A systematic literature search was performed using the databases PubMed, Embase, CINAHL, and Cochrane. Titles and abstracts were screened, and full texts were evaluated and assessed on methodological quality. A meta-analysis was performed on the pooled prevalence and severity rates. A meta-regression analysis was used to explore differences between treatment groups. We identified 10,637 studies, of which 444 studies were included. The overall prevalence of pain was 44.5%. Moderate to severe pain was experienced by 30.6% of the patients, a lower proportion compared to previous research. Pain experienced by cancer survivors was significantly lower compared to most treatment groups. Our results imply that both the prevalence of pain and pain severity declined in the past decade. Increased attention to the assessment and management of pain might have fostered the decline in the prevalence and severity of pain.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 18, 2026. Paragraph numbers are ours, so an answer can point at one.

1. Introduction

Each year, more than ten million people worldwide are diagnosed with cancer. Pain associated with cancer diagnoses is a serious concern and one of the most common symptoms reported by cancer patients. Experiencing pain and insufficient relief can be devastating and negatively affect a patient’s performance status and emotional well-being, leading to increased anxiety, anger, feelings of depression and even cognitive dysfunction, reducing a patient’s quality of life.

Despite increased attention to the assessment and management of pain in cancer patients, previous research concluded that no major advances have been made in the management of cancer pain in 50 years. A recent systematic literature review on the prevalence of pain during cancer treatment by Evenepoel et al. (2022) showed that pain during cancer treatment remains high during and up to three months after curative cancer treatment.

Literature indicates several reasons for the lack of improvement in the prevalence of cancer pain. Common professional barriers include a lack of knowledge and skills, clinicians’ reluctance to prescribe opioids, and poor pain assessment. Patient-related barriers include patients’ reluctance to discuss pain with clinicians, patients’ reluctance to receive treatment for their pain, adherence to analgesic prescriptions, limited knowledge on the assessment of undertreatment, and cognitive and psychological factors of patients such as depression. A systematic literature review by Makhlouf and colleagues (2020) found similar attitudinal barriers to effective cancer pain management among professionals and patients, including fear of medication addiction, tolerance of medication, and side effects of opioids.

Global trends may have influenced the prevalence of cancer pain. People worldwide are living longer, and ageing populations are associated with increased multimorbidity. Developments in oncology, including new drugs and treatment strategies, may also have influenced the prevalence of cancer pain and pain severity. Global opioid analgesics use increased between 2015 and 2019, but regional variations exist. This was probably influenced by the response to the opioid epidemic. Chen et al. (2022) performed a study on opioid use among cancer patients in the United States and showed a declining trend between 2013 and 2018. This could potentially lead to further undertreatment of cancer pain. On the other hand, the publication of new pain therapy guidelines may have improved the management of cancer pain.

Many new studies have been published on the prevalence of cancer pain since the 2016 systematic literature review of van den Beuken-van Everdingen et al. The review of Evenepoel et al. (2022) was limited to cancer patients receiving curative treatment, excluding other phases of the disease. Therefore, the aim of this systematic literature review was to assess the prevalence of cancer pain and pain severity in cancer patients throughout all phases of the disease.

2. Material and Methods

A systematic literature review was performed in accordance with the recommendations of the “Preferred Reporting Items for Systematic Reviews and Meta-analyses” (PRISMA) guidelines.

2.1. Search Strategy

A systematic electronic search of the literature published from January 2014 until December 2021 was performed on the 19th of January 2022 using the databases PubMed, Embase, CINAHL, and Cochrane. The search string was inspired by the search strings of van den Beuken-van Everdingen et al. (2016), Evenepoel et al. (2022) and Rietjens et al. (2019). Important search terms were “pain”, “symptom”, “prevalence”, and “cancer”. The search string was initially developed for PubMed and later adapted for the other databases: Embase, CINAHL, and Cochrane. More details of the search strategy can be found in Supplemental S1.

2.2. Study Selection

After identification and exclusion of duplicates, one author (R.A.H.S.) screened the titles and abstracts. Full texts of selected studies were examined by all four authors (R.A.H.S., L.B., M.T., and M.H.J.v.d.B.-v.E.) regarding the eligibility criteria. Studies that reported on the prevalence of cancer pain were eligible for inclusion. Inclusion of studies was based on the design, including original studies and secondary analyses of studies in which the patient group had not been included yet, population (studies that included patients ≥18 years, studies reporting on pain, and differentiating between cancer and noncancer patients), setting (including inpatient, outpatient, and palliative care facility (e.g., hospice, palliative care unit, and referred to a palliative care service)), while studies performed in pain clinics/including only patients with pain were excluded (Figure 1). In case of doubt about whether or not to include a study, the study in question was discussed among the authors until consensus was reached.

Corresponding authors of studies that met the inclusion criteria were contacted by e-mail to obtain missing information on the prevalence of pain. If this information remained unclear after a term of two weeks, the respective percentages of pain were estimated based on study figures.

2.3. Data Extraction

A standard extraction form was developed for consistent data extraction across the authors. General characteristics were listed for each study and included the author(s), year of publication, continent of origin, study design, method of data collection, aim of the study, and the sample size. Study population characteristics included: ethnicity, gender, age, setting (inpatient, outpatient, patient in palliative care facility), Eastern Cooperative Oncology Group performance status (ECOG), and the type of cancer (head and neck, oesophagus, bronchus/lung, breast, pancreatic, other gastro-intestinal, prostate, other urological, ovary, uterus, other gynaecological, haematological, and other). Studies that included >3 types of cancer were registered as such.

Phases of the disease trajectory were registered and used to categorise studies. Nine groups were defined. Group 1—treatment-naïve cancer patients; Group 2—including cancer patients receiving curative treatment; Group 3—including cancer patients receiving palliative treatment; Group 4—including patients with either curative or palliative treatment, or treatment intent not specified; Group 5—including patients after curative cancer treatment; Group 6—including patients for whom anti-cancer treatment is no longer feasible or wanted; Group 7—including patients in different phases of treatment; Group 8—including patients on anti-cancer treatment (Group 2, Group 3 and Group 4); Group 9—including patients with advanced, metastatic or terminal disease (Group 3 and Group 6).

With regard to the experience of pain, the main percentage of pain (%) in a study was extracted. In cases where a study reported on different types of pain (e.g., headache, abdominal pain, and joint pain) and did not report an overall percentage of pain, the highest percentage was registered. In addition, pain severity was extracted and registered as prevalence (%) of mild, moderate, moderate–severe, and severe pain. In case the severity of pain was not specified in the study and presented with Visual Analogue Scale (VAS) or Numeric Rating Scale (NRS), the rating of Serlin et al. (1995) was applied: none (0), mild (1–4), moderate (5–6), and severe (≥7). Finally, the pain recall period was extracted (point prevalent, week(s), month(s), year(s)).

2.4. Methodological Quality

The quality of the included studies was assessed by all four authors (R.A.H.S., L.B., M.T., M.H.J.v.d.B.-v.E.) using the scoring criteria presented in Table 1. These criteria were also used in the systematic literature review of van den Beuken-van Everdingen et al. (2016) and based on LeBoeuf-Yde and Lauritsen (1995), including criteria developed to assess the methodological quality for prevalence studies. The criteria relate to the representativeness of the study sample (three items); quality of the data (three items); description of the methods and results (three items); and a definition of the prevalence of pain (one item), resulting in a methodological quality score ranging from 0–20 points. Studies were included in this systematic literature review regardless of the methodological quality score.

2.5. Data Analyses

Descriptive statistics are presented for both studies with <15 points, and studies with ≥15 points on the methodological quality assessment. Details of the studies scoring <15 points on the methodological quality assessment can be found in Supplemental S2.

A meta-analysis was performed on the included studies using STATA (version 17.0, StataCorp Texas). The meta-analysis included studies with ≥15 points, a defined sample size, and pain prevalence or proportion of moderate to severe pain reported. Prevalence rates were pooled for each defined patient group with reference to pain, and pain severity (moderate–severe pain). The reciprocal of variance was chosen as a weighting factor to reflect the amount of information that each study contained as it is closely related to the study’s sample size. The 95% Confidence Interval (CI) of each prevalence rate was calculated with the formula: p ± z. √((p(1-p)/n) with p being the pain prevalence rate (p = x/n), with a z-value of 1.96 for a 95% CI. To analyse if the variation in prevalence rates between studies was due to more than chance alone, the grade of heterogeneity was assessed by performing a chi-square test (I2). If the heterogeneity test was significant (p < 0.05), extra variation was incorporated into the analysis by use of the random-effects model. If the prevalence of pain was 100%, the percentage was set as 99.9% in the analysis to avert statistical issues.

A meta-regression analysis was performed to explore if the pooled pain prevalence rates differed significantly between the patient groups. In addition, meta-regression analyses were also used to explore the association between the prevalence of pain and the type of cancer, ECOG score, age of the population, ethnicity, continent of origin, recall period, setting and method of data collection. The coefficient in the meta-regression analysis indicates how each subgroup differs from the nominated reference group; a negative coefficient in each subgroup suggests a lower prevalence of pain compared to the reference. A number of cancer types were regrouped for the analyses; pancreatic and other gastro-intestinal were regrouped as gastro-intestinal; ovary, uterus and other gynaecological were regrouped as gynaecological cancers.

3.1. Study Selection

The electronic literature search identified 13,483 studies; PubMed yielded 3227 studies, Embase 8340 studies, CINAHL 1200 studies, and Cochrane 716 studies. After the exclusion of duplicates, titles and abstracts of 10,637 studies were screened, of which 1147 were selected for a full text evaluation. The full text assessment resulted in the inclusion of 444 studies. An overview of the reasons for exclusion is presented in Figure 1. Authors (n = 6) were e-mailed to obtain missing prevalence data, of which pain prevalence was estimated in five studies because they did not respond.

3.2. Study Characteristics

This systematic literature review includes 444 studies, of which 160 studies had <15 points on the methodological quality assessment. Of the 160 studies that scored <15 points on the methodological quality assessment, most were performed in North America (n = 46), and the least in Australia/New Zealand (n = 6). In 24 studies, the primary objective was to evaluate the prevalence of pain in cancer patients. Most studies included solely gastro-intestinal cancer patients (n = 20) and 54 studies included patients of more than three types of cancer (Supplemental S2).

This systematic literature review included 284 studies with a quality score of ≥15 points (Table 2, Table 3, Table 4, Table 5, Table 6, Table 7 and Table 8). Of the studies with a quality score of ≥15 points, most were performed in Europe (n = 97), and the least in Africa (n = 7). In 99 studies, the primary objective was to evaluate the prevalence of pain in cancer patients; 185 studies focused on another primary study objective (e.g., quality of life, predictors of depression, fatigue or sleeping problems). Most studies included solely breast cancer patients (n = 72), and 91 studies included patients of more than three types of cancer. Two hundred seventy-seven studies of the 284 with a quality score of ≥15 points were included in the meta-analysis.

3.3. Prevalence of Pain

The meta-analysis of the pooled pain prevalence rates including all groups (Group 1–Group 7) resulted in an overall pain prevalence of 44.5% (95% CI 41.1–47.9). The pooled pain prevalence rates from the group analyses are presented in Table 9. Forest plots of the meta-analysis on the pooled pain prevalence rates (effect size (ES)) can be found in Supplemental S3.

Patients in both the group after curative treatment (Group 5) and the treatment-naïve group (Group 1) experienced less pain compared with patients in the palliative treatment group and the group without feasible anti-cancer treatment, respectively Group 3, p = 0.000, and p = 0.031; and Group 6, p = 0.001, and p = 0.038. Furthermore, the prevalence of pain was significantly lower in the group after curative treatment (Group 5) compared with the group receiving curative treatment (Group 2, p = 0.005), the group receiving all kinds of treatment (Group 4, p = 0.001), and the group including patients in different phases of treatment (Group 7, p = 0.006).

3.4. Pain Severity

The meta-analysis of the pooled pain severity including all treatment groups (Group 1–Group 7) resulted in a prevalence of moderate to severe pain of 30.6% (95% CI 26.9–34.4). The results of the group analyses on the pooled moderate to severe pain prevalence rates are presented in Table 9.

Patients in both the palliative treatment group (Group 3) and the group without feasible anti-cancer treatment (Group 6) experienced more moderate to severe pain compared with patients included in the all-treatments group and the group after curative treatment, respectively; Group 4, p = 0.035 and, p = 0.023; and Group 5, p = 0.006, and p = 0.005. In addition, the prevalence of moderate to severe pain was significantly higher in the group including patients in different phases of treatment (Group 7) compared with the group including patients after curative treatment (Group 5, p = 0.030).

3.5. Determinants of Pain Prevalence

The results of the meta-regression analyses that included all treatment groups (Group 1–Group 7) are presented in Table 10. The prevalence of pain in patients with prostate cancer was significantly lower than in patients with haematological, lung, and breast cancer (p = 0.034, p = 0.039, and p = 0.036 respectively). Age, ethnicity, and performance status (ECOG) were not associated with the overall prevalence of pain (p > 0.05). Recall periods of a week(s) (p = 0.013) or a month(s) (p = 0.001) did result in lower pain rates compared with using point prevalence. Studies that used medical records for data collection showed significantly higher pain rates than studies that used a patient questionnaire (p = 0.007). The prevalence of pain in patients who stayed in a palliative care setting was significantly higher compared to the prevalence of pain in outpatients (p = 0.040). Studies from South America, Asia and Africa showed significantly higher pain rates compared to studies from Europe (p = 0.033, p = 0.016 and p = 0.000 respectively). Moreover, studies from Africa showed a significantly higher prevalence of pain compared to studies from all other continents, North America (p = 0.000), Asia (p = 0.000), South America (p = 0.014) and Australia/New Zealand (p = 0.000).

4. Discussion

The current literature on the prevalence of pain and pain severity in patients with cancer shows that both the prevalence of pain and pain severity have declined over the past decade. Pooled pain prevalence rates resulted in an overall prevalence of 44.5%. The treatment group with the lowest prevalence of pain was the group after curative treatment (35.8%). Despite the decline found, the results of this systematic literature review show that the prevalence of pain remains high, especially in advanced, metastatic and terminal cancer patients (54.6%).

The meta-analysis of moderate to severe pain resulted in an overall prevalence of 30.6%. The treatment group with the lowest proportion of moderate to severe pain was the group after curative treatment (22.8%). Moderate to severe pain was most frequently reported in the group including patients without feasible anti-cancer treatment (43.3%).

Some findings deserve attention. First, a slight decrease in the prevalence of pain was found compared with the 2016 systematic literature review by van den Beuken-van Everdingen et al. for the group after curative treatment (35.8% < 39.3%), and for the group during anti-cancer treatment (50.3% < 55.0%). A more substantial decrease was found for the advanced, metastatic or terminal disease group (54.6% < 66.4%). Our systematic review resulted in a pooled prevalence of 47.8% during curative treatment, which is higher than the 40% found by Evenepoel et al. (2022). A possible explanation can be found in different inclusion criteria. In contrast to Evenepoel et al. (2022), we did include unsolid tumours and studies conducted in nursing homes. The proportion of cancer types may also have been influential, as Evenepoel et al. (2022) included 12 studies of which ten included breast cancer patients (83%). The proportion of studies that included breast cancer patients in our review was high, but lower compared to the review of Evenepoel et al. (2022).

Second, the prevalence of moderate to severe pain decreased (30.6% < 38.0%) compared with the rate presented in the study by van den Beuken-van Everdingen and colleagues (2016). In contrast to the 2016 systematic literature review, our meta-analysis did include treatment-naïve patients, and patients after finishing curative treatment. This affects the overall prevalence of moderate to severe pain as this is lower in patients after curative treatment.

Several factors may have played a role in the decrease in the prevalence of pain and pain severity in cancer patients. In the literature review of Kwon (2014), the suggestion is made that a multidirectional interdisciplinary approach might be the best way to improve cancer pain management. Therefore, more, and better collaboration between healthcare professionals from different disciplines involved in the patients’ treatment may have led to better management of cancer pain. Shrestha et al. (2022) conducted a systematic literature review and meta-analysis on the effect of pharmacists’ involvement in cancer pain management. Their results showed that pharmacists significantly improved cancer patients’ clinical outcomes related to pain. The direct involvement of pharmacists, or in collaboration with a multidisciplinary oncology team, is highly beneficial for patients.

The observed decrease in cancer pain prevalence and pain severity may also be positively impacted by raised awareness and knowledge of healthcare professionals about cancer pain treatment and the publication of new pain therapy guidelines. However, there is still room for improvement as the literature indicates that there is a difference in knowledge between healthcare professionals and among professionals from different countries. Our results showed that the prevalence of cancer pain was significantly higher in South America, Asia and Africa than in Europe. Silbermann and colleagues have shown that the majority of patients with cancer in low-income countries are undertreated for their pain, partly due to a lack of appropriate education. Furthermore, compared with nurses, physicians have more knowledge about pain management, while both lack knowledge regarding the side effects and pharmacology of opioids. Moreover, a systematic literature review on cancer pain management showed that most oncology nurses have poor knowledge about cancer pain management.

Furthermore, in line with our results, previous research on the prevalence of undertreatment of pain in cancer patients indicate that undertreatment of pain decreased over time. In 2008 and 2014, two systematic literature reviews were published in which the prevalence of undertreatment of pain in cancer patients was 43% and 32%, respectively. In 2022, an updated review was published including studies published from 2014 to 2020 that showed a mean weighted prevalence score for undertreatment of 40.2%.

Developments in oncology, including new drugs and treatment strategies, may also have had a positive impact on the prevalence of cancer pain and pain severity. Targeted therapy and immunotherapy changed the paradigm of cancer treatment. Compared to conventional chemotherapy, these treatment strategies more subtly reduce and control tumour growth, achieving better survival outcomes and improving patients’ quality of life. The literature indicates that patients treated with immunotherapy have less cancer pain and reduced pain severity. For example, the study of Zhou and colleagues showed reduced opioid use and cancer pain scores after adoptive immunotherapy with autologous T-cell infusions. They recommend controlled clinical studies to clarify the relationship between immune cell-mediated immunotherapy and pain relief.

Strengths and Limitations

A strength of this systematic literature review is its scope, including cancer patients at all stages of the disease. This allowed us to examine differences in the prevalence of pain and pain severity between treatment groups.

However, this systematic literature review has some limitations that should be taken into account when interpreting the results. First, not every study used the criteria of Serlin et al. (1995) for defining mild, moderate or severe pain. This has led to differences in pain severity as the cut-off score for mild and moderate pain differed between these studies. Furthermore, some studies did not describe the severity of pain, or gave an overall prevalence of pain but described multiple types of pain (e.g., headache, abdominal pain, and joint pain). In these cases, the highest percentage of pain was used. Almost no studies mentioned the type of pain (nociceptive, neuropathic, mixed). Another methodological consideration relates to the meta-regression analyses of the determinants of pain. To obtain a more robust statistical analysis with more data, we chose to perform the meta-regression analyses on all studies regardless of treatment group. If a cancer type is over-represented in a treatment group with respectively low or high pain prevalence, this affects the overall prevalence of pain in that cancer type.

Although our analyses did not allow us to draw conclusions about detailed subgroups, this review provides a valuable overview of cancer pain prevalence and pain severity over the past decade.

5. Conclusions

In conclusion, this systematic literature review shows that both the prevalence of pain and pain severity have declined in the past decade. The development of new treatment strategies and increased attention on assessment and management of pain may have facilitated the decreases in the prevalence and severity of pain. However, with more than half of the patients experiencing pain, the prevalence in advanced, metastatic and terminal patients remains high. To further decrease the prevalence of pain and pain severity, ongoing attention and improved educational programs on cancer pain management are needed.

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    Alt-Epping B., Seidel W., Vogt J., Mehnert A., Thomas M., van Oorschot B., Wolff H., Schliephake H., Canis M., Dröge L.H., et al. Symptoms and Needs of Head and Neck Cancer Patients at Diagnosis of Incurability-Prevalences, Clinical Implications, and Feasibility of a Prospective Longitudinal Multicenter Cohort Study. Oncol. Res. Treat. 2016;39:186-192.

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    Andersen K.G., Aasvang E.K., Kroman N., Kehlet H. Intercostobrachial nerve handling and pain after axillary lymph node dissection for breast cancer. Acta. Anaesthesiol. Scand. 2014;58:1240-1248.

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    Bibby A.C., Halford P., De Fonseka D., Morley A.J., Smith S., Maskell N.A. The Prevalence and Clinical Relevance of Nonexpandable Lung in Malignant Pleural Mesothelioma. A Prospective, Single-Center Cohort Study of 229 Patients. Ann. Am. Thorac. Soc. 2019;16:1273-1279.

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    Efficace F., Gaidano G., Breccia M., Criscuolo M., Cottone F., Caocci G., Bowen D., Lübbert M., Angelucci E., Stauder R., et al. Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes. Br. J. Haematol. 2015;168:361-370.

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    Esser P., Kuba K., Scherwath A., Schirmer L., Schulz-Kindermann F., Dinkel A., Balck F., Koch U., Kröger N., Götze H., et al. Posttraumatic stress disorder symptomatology in the course of allogeneic HSCT: A prospective study. J. Cancer Surviv. 2017;11:203-210.

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    Gjeilo K.H., Oksholm T., Follestad T., Wahba A., Rustøen T. Trajectories of Pain in Patients Undergoing Lung Cancer Surgery: A Longitudinal Prospective Study. J. Pain Symptom Manag. 2020;59:818-828.e1.

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    Godby R.C., Dai C., Al-Obaidi M., Giri S., Young-Smith C., Kenzik K., McDonald A.M., Paluri R.K., Gbolahan O.B., Bhatia S., et al. Depression among older adults with gastrointestinal malignancies. J. Geriatr. Oncol. 2021;12:599-604.

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    Hong J., Wei Z., Wang W. Preoperative psychological distress, coping and quality of life in Chinese patients with newly diagnosed gastric cancer. J. Clin. Nurs. 2015;24:2439-2447.

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    Kirchheiner K., Nout R.A., Czajka-Pepl A., Ponocny-Seliger E., Sturdza A.E., Dimopoulos J.C., Dörr W., Pötter R. Health related quality of life and patient reported symptoms before and during definitive radio(chemo)therapy using image-guided adaptive brachytherapy for locally advanced cervical cancer and early recovery—A mono-institutional prospective study. Gynecol. Oncol. 2015;136:415-423.

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    Kuon J., Vogt J., Mehnert A., Alt-Epping B., van Oorschot B., Sistermanns J., Ahlborn M., Ritterbusch U., Stevens S., Kahl C., et al. Symptoms and Needs of Patients with Advanced Lung Cancer: Early Prevalence Assessment. Oncol. Res. Treat. 2019;42:650-659.

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    Lunde S., Petersen K.K., Kugathasan P., Arendt-Nielsen L., Søgaard-Andersen E. Chronic Postoperative Pain after Robot-Assisted Laparoscopic Hysterectomy for Endometrial Cancer. J. Gynecol. Surg. 2019;35:140-146.

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    Ravn Munkvold B.K., Sagberg L.M., Jakola A.S., Solheim O. Preoperative and Postoperative Headache in Patients with Intracranial Tumors. World Neurosurg. 2018;115:e322-e330.

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    Roy S., Pathy S., Mohanti B.K., Raina V., Jaiswal A., Kumar R., Kalaivani M. Accelerated hypofractionated radiotherapy with concomitant chemotherapy in locally advanced squamous cell carcinoma of lung: Evaluation of response, survival, toxicity and quality of life from a Phase II randomized study. Br. J. Radiol. 2016;89:20150966.

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    Russo M., Villani V., Taga A., Genovese A., Terrenato I., Manzoni G.C., Servadei F., Torelli P., Pace A. Headache as a presenting symptom of glioma: A cross-sectional study. Cephalalgia. 2018;38:730-735.

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    Salwey L., L’Huillier V., Zaid M., Vené Y., Tavernier L., Mauvais O. Neuropathic pain at diagnosis of head and neck squamous cell carcinoma. Eur. Ann. Otorhinolaryngol. Head Neck Dis. 2020;137:377-380.

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    Tang M.H., Castle D.J., Choong P.F.M. Identifying the prevalence, trajectory, and determinants of psychological distress in extremity sarcoma. Sarcoma. 2015;2015:745163.

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    Thomas S., Walsh D., Shrotriya S., Aktas A., Hullihen B., Estfan B., Budd G.T., Hjermstad M.J., O’Connor B. Symptoms, Quality of Life, and Daily Activities in People with Newly Diagnosed Solid Tumors Presenting to a Medical Oncologist. Am. J. Hosp. Care. 2017;34:611-621.

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    Wang Y.J., Chan Y.N., Jheng Y.W., Wu C.J., Lin M.W., Tseng L.M., Tsai Y.F., Liu L.C. Chemotherapy-induced peripheral neuropathy in newly diagnosed breast cancer survivors treated with taxane: A prospective longitudinal study. Support. Care Cancer. 2021;29:2959-2971.

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    Williams G.R., Al-Obaidi M., Dai C., Harmon C., Buford T.W., Gbolahan O., Pergolotti M., Bhatia S., Giri S. Fatigue is independently associated with functional status limitations in older adults with gastrointestinal malignancies—Results from the CARE registry. Support. Care Cancer. 2021;29:6793-6800.

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    Yao H.H.I., Crump R.T., Charbonneau C., Khan A., Barton C., Brotherhood H., Jiang J., Carlson K.V., Baverstock R.J. Baseline patient reported outcomes data shows high prevalence of overactive bladder, sexual dysfunction, depression and anxiety in Canadian men with newly diagnosed localized prostate cancer. Transl. Androl. Urol. 2020;9:2046-2053.

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    Berliere M., Piette N., Bernard M., Lacroix C., Gerday A., Samartzi V., Coyette M., Roelants F., Docquier M.A., Touil N., et al. Hypnosis sedation reduces the duration of different side effects of cancer treatments in breast cancer patients receiving neoadjuvant chemotherapy. Cancers. 2021;13:4147.

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    Bretschneider C.E., Doll K.M., Bensen J.T., Gehrig P.A., Wu J.M., Geller E.J. Prevalence of pelvic floor disorders in women with suspected gynecological malignancy: A survey-based study. Int. Urogynecol. J. 2016;27:1409-1414.

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    Browall M., Brandberg Y., Nasic S., Rydberg P., Bergh J., Rydén A., Xie H., Eriksson I., Wengström Y., Rydén A., et al. A prospective exploration of symptom burden clusters in women with breast cancer during chemotherapy treatment. Support. Care Cancer. 2017;25:1423-1429.

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    Calderon C., Carmona-Bayonas A., Hernández R., Ghanem I., Castelo B., Martinez de Castro E., Ferreira E., Ciria L., Muñiz M., Jimenez-Fonseca P. Effects of pessimism, depression, fatigue, and pain on functional health-related quality of life in patients with resected non-advanced breast cancer. Breast. 2019;44:108-112.

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    Choo S.B., Saifulbahri A., Zullkifli S.N., Fadzil M.L., Redzuan A.M., Abdullah N., Bustamam R.S.A., Ahmad H.Z., Shah N.M. Adjuvant endocrine therapy side-effects among postmenopausal breast cancer patients in Malaysia. Climacteric. 2019;22:175-181.

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    de Menezes Couceiro T.C., Valença M.M., Raposo M.C.F., de Orange F.A., Amorim M.M.R. Prevalence of Post-Mastectomy Pain Syndrome and Associated Risk Factors: A Cross-Sectional Cohort Study. Pain Manag. Nurs. 2014;15:731-737.

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    Dylke E.S., Kilbreath S. Current rehabilitation processes do not prevent long-term impairments after treatment for breast cancer in Australia. Aust. Fam. Physician. 2015;44:405-409.

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    El-Aqoul A., Obaid A., Yacoub E., Al-Najar M., Ramadan M., Darawad M. Factors Associated with Inadequate Pain Control among Postoperative Patients with Cancer. Pain Manag. Nurs. 2018;19:130-138.

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    Fenlon D., Powers C., Simmonds P., Clough J., Addington-Hall J. The JACS prospective cohort study of newly diagnosed women with breast cancer investigating joint and muscle pain, aches, and stiffness: Pain and quality of life after primary surgery and before adjuvant treatment. BMC Cancer. 2014;14:467.

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    Reduced symptom burden with the support of an interactive app during neoadjuvant chemotherapy for breast cancer – A randomized controlled trial · 2020
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    Hagiwara Y., Ohashi Y., Uesaka K., Boku N., Fukutomi A., Okamura Y., Konishi M., Matsumoto I., Kaneoka Y., Shimizu Y., et al. Health-related quality of life of adjuvant chemotherapy with S-1 versus gemcitabine for resected pancreatic cancer: Results from a randomised phase III trial (JASPAC 01). Eur. J. Cancer. 2018;93:79-88.

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    Haryani H., Hsu Y.Y., Warsini S., Wang S.T. Measuring the Symptom Experience of Patients with Cancer in Indonesia: Cross-Cultural Adaptation and Validation of the Memorial Symptom Assessment Scale—Indonesian Version. J. Pain Symptom Manag. 2018;56:920-927.

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    Ho R.T.H., Kwan T.T.C., Cheung I.K.M., Chan C.K.P., Lo P.H.Y., Yip P.S.F., Luk M.Y., Chan C.L.W. Association of fatigue with perceived stress in Chinese women with early stage breast cancer awaiting adjuvant radiotherapy. Stress Health. 2015;31:214-221.

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    Hong J.S., Tian J. Prevalence of anxiety and depression and their risk factors in Chinese cancer patients. Support. Care Cancer. 2014;22:453-459.

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    Jarden M., Møller T., Christensen K.B., Buchardt A.S., Kjeldsen L., Adamsen L. Longitudinal symptom burden in adult patients with acute leukaemia participating in the PACE-AL randomised controlled exercise trial—An explorative analysis. Eur. J. Cancer Care. 2021;30:e13462.

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    Jensen N.B.K., Pötter R., Kirchheiner K., Fokdal L., Lindegaard J.C., Kirisits C., Mazeron R., Mahantshetty U., Jürgenliemk-Schulz I.M., Segedin B., et al. Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: Physician- and patient reported outcome from the EMBRACE study. Radiother. Oncol. 2018;127:431-439.

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    Khan Q.J., Kimler B.F., Reddy P.S., Sharma P., Klemp J.R., Nydegger J.L., Yeh H.W., Fabian C.J. Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial. Breast Cancer Res. Treat. 2017;166:491-500.

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    Kim Y.S., Do H., Lee J.W., Jeong J., Shin Y.W., Yi K., Kim J., Lee S.B., Sohn G., Yang N., et al. Patient reporting pain intensity immediately after surgery can be associated with underlying depression in women with breast cancer. Psychooncology. 2016;25:308-315.

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    Kirkham A.A., Eves N.D., Shave R.E., Bland K.A., Bovard J., Gelmon K.A., Virani S.A., McKenzie D.C., Stöhr E.J., Waburton D.E.R., et al. The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: A RCT. Breast Cancer Res. Treat. 2018;167:719-729.

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    Lewis L., Williams A.M., Athifa M., Brown D., Budgeon C.A., Bremner A.P. Evidence-Based Self-care Guidelines for People Receiving Chemotherapy: Do They Reduce Symptom Burden and Psychological Distress? Cancer Nurs. 2015;38:e1-e8.

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    Lewis S., Pandey S., Salins N., Deodhar J., Patil V., Gupta T., Laskar S.G., Budrukkar A., Murthy V., Joshi A., et al. Distress Screening in Head and Neck Cancer Patients Planned for Cancer-Directed Radiotherapy. Laryngoscope. 2021;131:2023-2029.

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    McFarland D.C., Shaffer K.M., Tiersten A., Holland J. Prevalence of physical problems detected by the distress thermometer and problem list in patients with breast cancer. Psychooncology. 2018;27:1394-1403.

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    Moloney N., Sung J.M.W., Kilbreath S., Dylke E. Prevalence and risk factors associated with pain 21 months following surgery for breast cancer. Support. Care Cancer. 2016;24:4533-4539.

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    Nogueira de Oliveira Martins T., dos Santos L.F., do Nascimento Petter G., da Silva Ethur J.N., Medeiros Braz M., Foletto Pivetta H.M. Immediate breast reconstruction versus non-reconstruction after mastectomy: A study on quality of life, pain and functionality. Fisioter. Pesqui. 2017;24:412-419.

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    Okamoto A., Yamasaki M., Yokota I., Mori M., Matsuda M., Yamaguchi Y., Yamakita S., Ueno H., Sawa T., Taguchi T., et al. Classification of acute pain trajectory after breast cancer surgery identifies patients at risk for persistent pain: A prospective observational study. J. Pain Res. 2018;11:2197-2206.

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    Ribas Y., Bonet M., Torres L., Núñez M., Esther Jovell-Fernández E., Aranda E., Andreyev H.J. Bowel dysfunction in survivors of gynaecologic malignancies. Support. Care Cancer. 2020;28:5501-5510.

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    Røhrl K., Guren M.G., Miaskowski C., Cooper B.A., Diep L.M., Rustøen T. No Differences in Symptom Burden Between Colorectal Cancer Patients Receiving Curative Versus Palliative Chemotherapy. J. Pain Symptom Manag. 2016;52:539-547.

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  80. 80.

    Shaulov A., Rodin G., Popovic G., Caraiscos V.B., Le L.W., Rydall A., Schimmer A.D., Zimmermann C. Pain in patients with newly diagnosed or relapsed acute leukemia. Support. Care Cancer. 2019;27:2789-2797.

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    Tran B.T., Pham N.H., Nguyen T.X., Choi K.S., Sohn D.K., Kim S.Y., Suh J.K., Nguyen T.D., Phan V.S., Tran D.T., et al. Measurement of health-related quality of life among colorectal cancer patients using the vietnamese value set of the eq-5d-5l. Patient Prefer. Adherence. 2020;14:2427-2437.

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    Xu Y., Hu X., Zhou L., Zhao Y. Effect of sequencing of preoperative systemic therapy on patients with locally advanced breast cancer. Breast J. 2020;26:1987-1994.

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    Yi M., Hwang E. Pain and Menopause Symptoms of Breast Cancer Patients with Adjuvant Hormonal Therapy in Korea: Secondary Analysis. Asia Pac. J. Oncol. Nurs. 2018;5:262-269.

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    Agarwal S., Garg R., Minhas V., Bhatnagar S., Mishra S., Kumar V., Bharati S.J., Gupta N., Khan M.A. To assess the Prevalence and Predictors of Cancer-related Fatigue and its Impact on Quality of Life in Advanced Cancer Patients Receiving Palliative Care in a Tertiary Care Hospital: A Cross-sectional Descriptive Study. Indian J. Palliat. Care. 2020;26:523-527.

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    Al-Zahrani O., Eldali A., Al-Shahri M.Z. Prevalence and severity of pain in cancer patients in an outpatient palliative care setting in Saudi Arabia. Qatar Med. J. 2014;1:38-45.

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    Blank A.T., Lerman D.M., Shaw S., Dadrass F., Zhang Y., Liu W., Hung M., Jones K.B., Randall R.L. PROMIS(®) scores in operative metastatic bone disease patients: A multicenter, prospective study. J. Surg. Oncol. 2018;118:532-535.

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    Bouché O., Le Cesne A., Rios M., Chaigneau L., Italiano A., Duffaud F., Lecomte T., Arsène D., Manfredi S., Aparicio T., et al. EPigist: An observational real-life study on patients with metastatic gastrointestinal stromal tumors receiving imatinib. PLoS ONE. 2018;13:e0204117.

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    Bullock A., Stuart K., Jacobus S., Abrams T., Wadlow R., Goldstein M., Miksad R. Capecitabine and oxaliplatin as first and second line treatment for locally advanced and metastatic pancreatic ductal adenocarcinoma. J. Gastrointest. Oncol. 2017;8:945-952.

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    Green A.K., Corty R.W., Wood W.A., Meeneghan M., Reeder-Hayes K.E., Basch E., Milowsky M.I., Dusetzina S.B. Comparative effectiveness of mitoxantrone plus prednisone versus prednisone alone in metastatic castrate-resistant prostate cancer after docetaxel failure. Oncologist. 2015;20:516-522.

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    Iwase S., Kawaguchi T., Tokoro A., Yamada K., Kanai Y., Matsuda Y., Kashiwaya Y., Okuma K., Inada S., Ariyoshi K., et al. Assessment of cancer-related fatigue, pain, and quality of life in cancer patients at palliative care team referral: A multicenter observational study (JORTC PAL-09). PLoS ONE. 2015;10:e0134022.

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    Jespersen E., Nielsen L.K., Larsen R.F., Möller S., Jarlbæk L. Everyday living with pain-reported by patients with multiple myeloma. Scand. J. Pain. 2021;21:127-134.

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    King M.T., Stockler M.R., O’Connell R.L., Buizen L., Joly F., Lanceley A., Hilpert F., Okamoto A., Aotani E., Bryce J., et al. Measuring what matters MOST: Validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer. Qual. Life Res. 2018;27:59-74.

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    Koldenhof J.J., Witteveen P.O., De Vos R., Walraven M., Tillier C.N., Verheul H.M.W., Teunissen S.C.C.M. Symptoms from treatment with sunitinib or sorafenib: A multicenter explorative cohort study to explore the influence of patient-reported outcomes on therapy decisions. Support. Care Cancer. 2014;22:2371-2380.

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    Lavdaniti M., Fradelos E.C., Troxoutsou K., Zioga E., Mitsi D., Alikari V., Zyga S. Symptoms in Advanced Cancer Patients in a Greek Hospital: A Descriptive Study. Asian Pac. J. Cancer Prev. 2018;19:1047-1052.

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    LeBlanc T.W., Nickolich M., Rushing C.N., Samsa G.P., Locke S.C., Abernethy A.P. What bothers lung cancer patients the most? A prospective, longitudinal electronic patient-reported outcomes study in advanced non-small cell lung cancer. Support. Care Cancer. 2015;23:3455-3463.

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    Lechner B., Chow S., Chow R., Zhang L., Tsao M., Danjoux C., Barnes E., DeAngelis C., Vuong S., Ganesh V., et al. The incidence of neuropathic pain in bone metastases patients referred for palliative radiotherapy. Radiother. Oncol. 2016;118:557-561.

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    Madsen M., Grønbæk H., Finnerup N.B., Dam G. A descriptive cross-sectional study of pain in patients with neuroendocrine tumors. Scand. J. Gastroenterol. 2017;52:431-436.

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    McFarland D.C., Shaffer K.M., Polizzi H., Mascarenhas J., Kremyanskaya M., Holland J., Hoffman R. Prevalence of Physical Problems Detected by the Distress Thermometer and Problem List in Patients with Myeloproliferative Disorders. J. Natl. Compr. Cancer Netw. 2017;15:1503-1508.

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    Mercadante S., Aielli F., Masedu F., Valenti M., Verna L., Porzio G. Age differences in the last week of life in advanced cancer patients followed at home. Support. Care Cancer. 2016;24:1889-1895.

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    Sampogna F., Paradisi A., Iemboli M.L., Ricci F., Sonego G., Abeni D. Comparison of quality of life between melanoma and non-melanoma skin cancer patients. Eur. J. Dermatol. 2019;29:185-191.

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    Selvy M., Kerckhove N., Pereira B., Barreau F., Nguyen D., Busserolles J., Giraudet F., Cabrespine A., Chaleteix C., Soubrier M., et al. Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study. Front. Pharmacol. 2021;12:637593.

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    Steel J.L., Geller D.A., Kim K.H., Butterfield L.H., Spring M., Grady J., Sun W., Marsh W., Antoni M., Dew M.A., et al. Web-based collaborative care intervention to manage cancer-related symptoms in the palliative care setting. Cancer. 2016;122:1270-1282.

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    Walling A.M., Weeks J.C., Kahn K.L., Tisnado D., Keating N.L., Dy S.M., Arora N.K., Mack J.W., Pantoja P.M., Malin J.L. Symptom prevalence in lung and colorectal cancer patients. J. Pain Symptom Manag. 2015;49:192-202.

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    Zhou T., Yang K., Thapa S., Liu H., Wang B., Yu S. Differences in Symptom Burden among Cancer Patients with Different Stages of Cachexia. J. Pain Symptom Manag. 2017;53:919-926.

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    Abu-Saad Huijer H., Sagherian K., Tamim H. Validation of the Arabic Version of the Memorial Symptom Assessment Scale among Lebanese Cancer Patients. J. Pain Symptom Manag. 2015;50:559-565.

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    Bernardes C.M., Beesley V., Martin J., Sabesan S., Baade P., Meiklejohn J.A., Garvey G., Valery P.C. Unmet supportive care needs among people with cancer: A cross-cultural comparison between Indigenous and Non-Indigenous Australians. Eur. J. Cancer Care. 2019;28:e13080.

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    Chan A., Lim E., Ng T., Shih V., Quek R., Cheung Y.T. Symptom burden and medication use in adult sarcoma patients. Support. Care Cancer. 2015;23:1709-1717.

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    Chen F., Leng Y., Zhang L., Xu J., Zhang D., Qin Y., Li J., Zheng Y. The Correlation of Symptom Clusters and Functional Performance in Adult Acute Leukemia Patients under Chemotherapy. Cancer Nurs. 2021;44:E287-E295.

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    Cheng H.L., Molassiotis A., Leung A.K.T., Wong K.H. Docetaxel-Induced Peripheral Neuropathy in Breast Cancer Patients Treated with Adjuvant or Neo-Adjuvant Chemotherapy. Breast Care. 2021;16:269-275.

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    Damm M., Weniger M., Kölsch A.K., Lampert C., Ceyhan G.O., Beer S., Schorn S., Moir J., Michl P., Rosendahl J. The quality of pain management in pancreatic cancer: A prospective multi-center study. Pancreatology. 2020;20:1511-1518.

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    Kuperus J.M., Busman R.D., Kuipers S.K., Broekhuizen H.T., Noyes S.L., Brede C.M., Tobert C.M., Lane B.R. Comparison of Side Effects and Tolerability Between Intravesical Bacillus Calmette-Guerin, Reduced-Dose BCG and Gemcitabine for Non-Muscle Invasive Bladder Cancer. Urology. 2021;156:191-198.

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    Matsumoto Y., Yoshida Y., Kiba S., Yamashiro S., Nogami H., Ohashi N., Kajitani R., Munechika T., Nagano H., Komono A., et al. Acute chemotherapy-induced peripheral neuropathy due to oxaliplatin administration without cold stimulation. Support. Care Cancer. 2020;28:5405-5410.

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    Schumacher O., Galvao D.A., Taaffe D.R., Spry N., Joseph D., Tang C., Chee R., Newton R.U. Effect of Exercise Adjunct to Radiation and Androgen Deprivation Therapy on Patient-Reported Treatment Toxicity in Men with Prostate Cancer: A Secondary Analysis of 2 Randomized Controlled Trials. Pract. Radiat. Oncol. 2021;11:215-225.

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    Stamm S.L., Spichiger E., Pabst T., Bachnick S., Jeitziner M.M. Symptom prevalence and health-related quality of life in patients undergoing autologous stem cell transplantation—A longitudinal observational study. Eur. J. Oncol. Nurs. 2021;53:101997.

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    Turner J.P., Shakib S., Singhal N., Hogan-Doran J., Prowse R., Johns S., Thynne T., Bell J.S. Statin use and pain in older people with cancer: A cross-sectional study. J. Am. Geriatr. Soc. 2014;62:1900-1905.

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    van der Baan F.H., Koldenhof J.J., de Nijs E.J., Echteld M.A., Zweers D., Hesselmann G.M., Vervoort S.C., Vos J.B., de Graaf E., Witteveen P.O., et al. Validation of the Dutch version of the Edmonton Symptom Assessment System. Cancer Med. 2020;9:6111-6121.

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    Wang D., Fu J. Symptom clusters and quality of life in China patients with lung cancer undergoing chemotherapy. Afr. Health Sci. 2014;14:49-55.

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    Yahaya N.A., Subramanian P., Bustam A.Z., Taib N.A. Symptom experiences and coping strategies among multi- ethnic solid tumor patients undergoing chemotherapy in Malaysia. Asian Pac. J. Cancer Prev. 2015;16:723-730.

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    Zhong B.L., Li S.H., Lv S.Y., Tian S.L., Liu Z.D., Li X.B., Zhuang H.Q., Tao R., Zhang W., Zhuo C.J. Suicidal ideation among Chinese cancer inpatients of general hospitals: Prevalence and correlates. Oncotarget. 2017;8:25141-25150.

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    Adams E., Boulton M.G., Horne A., Rose P.W., Durrant L., Collingwood M., Oskrochi R., Davidson S.E., Watson E.K. The effects of pelvic radiotherapy on cancer survivors: Symptom profile, psychological morbidity and quality of life. Clin. Oncol. (R. Coll. Radiol.). 2014;26:10-17.

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    Ahmed A., Bhatnagar S., Rana S.P.S., Ahmad S.M., Joshi S., Mishra S. Prevalence of phantom breast pain and sensation among postmastectomy patients suffering from breast cancer: A prospective study. Pain Pract. 2014;14:E17-E28.

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    Al Maqbali M. Sleep disturbance among Arabic breast cancer survivors. Support. Care Cancer. 2021;29:5179-5186.

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    Andersen K.G., Duriaud H.M., Jensen H.E., Kroman N., Kehlet H. Predictive factors for the development of persistent pain after breast cancer surgery. Pain. 2015;156:2413-2422.

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    Asplund D., Prytz M., Bock D., Haglind E., Angenete E. Persistent perineal morbidity is common following abdominoperineal excision for rectal cancer. Int. J. Color. Dis. 2015;30:1563-1570.

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    Baden M., Lu L., Drummond F.J., Gavin A., Sharp L. Pain, fatigue and depression symptom cluster in survivors of prostate cancer. Support. Care Cancer. 2020;28:4813-4824.

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    Bao T., Seidman A., Li Q., Seluzicki C., Blinder V., Meghani S.H., Farrar J.T., Mao J.J. Living with chronic pain: Perceptions of breast cancer survivors. Breast Cancer Res. Treat. 2018;169:133-140.

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    Bennedsgaard K., Ventzel L., Themistocleous A.C., Bennett D.L., Jensen A.B., Jensen A.R., Andersen N.T., Jensen T.S., Tankisi H., Finnerup N.B. Long-term symptoms of polyneuropathy in breast and colorectal cancer patients treated with and without adjuvant chemotherapy. Cancer Med. 2020;9:5114-5123.

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    Boehmer U., Potter J., Clark M.A., Ozonoff A., Winter M., Berklein F., Ward K.C., Hartshorn K. Assessing the relationship between symptoms and health care utilization in colorectal cancer survivors of different sexual orientations. Support. Care Cancer. 2021;29:5821-5830.

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    Bøhn S.K.H., Thorsen L., Kiserud C.E., Fosså S.D., Lie H.C., Loge J.H., Wisløff T., Haugnes H.S., Reinertsen K.V. Chronic fatigue and associated factors among long-term survivors of cancers in young adulthood. Acta Oncol. 2019;58:753-762.

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    Bonhof C.S., Trompetter H.R., Vreugdenhil G., van de Poll-Franse L.V., Mols F. Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: Results from the population-based PROFILES registry. Support. Care Cancer. 2020;28:5933-5941.

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    Bovbjerg D.H., Keefe F.J., Soo M.S., Manculich J., Van Denburg A., Zuley M.L., Ahrendt G.M., Skinner C.S., Edmond S.N., Shelby R.A. Persistent breast pain in post-surgery breast cancer survivors and women with no history of breast surgery or cancer: Associations with pain catastrophizing, perceived breast cancer risk, breast cancer worry, and emotional distress. Acta Oncol. 2019;58:763-768.

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    Bulley C., Coutts F., Blyth C., Jack W., Chetty U., Barber M., Tan C.W. A morbidity Screening Tool for identifying fatigue, pain, upper limb dysfunction and lymphedema after breast cancer treatment: A validity study. Eur. J. Oncol. Nurs. 2014;18:218-227.

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    Cameron K.E., Kole M.B., Sammel M.D., Ginsberg J.P., Gosiengfiao Y., Mersereau J.E., Su H.I., Gracia C.R. Acute Menopausal Symptoms in Young Cancer Survivors Immediately following Chemotherapy. Oncology. 2018;94:200-206.

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    Capelan M., Battisti N.M.L., McLoughlin A., Maidens V., Snuggs N., Slyk P., Peckitt C., Ring A., Battisti N.M.L. The prevalence of unmet needs in 625 women living beyond a diagnosis of early breast cancer. Br. J. Cancer. 2017;117:1113-1120.

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    Chiang D.L.C., Rice D.A., Helsby N.A., Somogyi A.A., Kluger M.T. The Prevalence, Impact, and Risk Factors for Persistent Pain After Breast Cancer Surgery in a New Zealand Population. Pain Med. 2019;20:1803-1814.

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    Cui L., Fan P., Qiu C., Hong Y. Single institution analysis of incidence and risk factors for post-mastectomy pain syndrome. Sci. Rep. 2018;8:11494.

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    De Groef A., Van Kampen M., Vervloesem N., De Geyter S., Christiaens M.R., Neven P., Vos L., De Vrieze T., Geraerts I., Devoogdt N. Myofascial techniques have no additional beneficial effects to a standard physical therapy programme for upper limb pain after breast cancer surgery: A randomized controlled trial. Clin. Rehabil. 2017;31:1625-1635.

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    Dieterich M., Allmendinger S., Gerber B., Reimer T., Hartmann S., Stachs A., Stubert J. Prevalence, Clinical Significance and Risk Factors for Developing Scar Pain and Sensibility Disorders in Breast Cancer Patients after Breast-Conserving Therapy and Mastectomy. Breast Care. 2021;16:507-515.

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    Drury A., Payne S., Brady A.M. The cost of survival: An exploration of colorectal cancer survivors’ experiences of pain. Acta Oncol. 2017;56:205-211.

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    Dualé C., Ouchchane L., Schoeffler P., Dubray C. Neuropathic aspects of persistent postsurgical pain: A French multicenter survey with a 6-month prospective follow-up. J. Pain. 2014;15:e1-e24.

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    Efficace F., Breccia M., Avvisati G., Cottone F., Intermesoli T., Borlenghi E., Carluccio P., Rodeghiero F., Fabbiano F., Luppi M., et al. Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia. Leukemia. 2019;33:1598-1607.

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    Engvall K., Gréen H., Fredriksson M., Åvall-Lundqvist E. Persistent neuropathy among early-stage breast cancer survivors in a population-based cohort. Br. J. Cancer. 2021;125:445-457.

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    Ezendam N.P.M., Pijlman B., Bhugwandass C., Pruijt J.F.M., Mols F., Vos M.C., Pijnenborg J.M.A., Van De Poll-Franse L.V. Chemotherapy-induced peripheral neuropathy and its impact on health-related quality of life among ovarian cancer survivors: Results from the population-based PROFILES registry. Gynecol. Oncol. 2014;135:510-517.

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    Farrukh N., Hageman L., Chen Y., Wu J., Ness E., Kung M., Francisco L., Parman M., Landier W., Arora M., et al. Pain in older survivors of hematologic malignancies after blood or marrow transplantation: A BMTSS report. Cancer. 2020;126:2003-2012.

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    Feddern M.L., Jensen T.S., Laurberg S. Chronic pain in the pelvic area or lower extremities after rectal cancer treatment and its impact on quality of life: A population-based cross-sectional study. Pain. 2015;156:1765-1771.

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    Ferreira A.R., Di Meglio A., Pistilli B., Gbenou A.S., El-Mouhebb M., Dauchy S., Charles C., Joly F., Everhard S., Lambertini M., et al. Differential impact of endocrine therapy and chemotherapy on quality of life of breast cancer survivors: A prospective patient-reported outcomes analysis. Ann. Oncol. 2019;30:1784-1795.

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    Gallaway M.S., Townsend J.S., Shelby D., Puckett M.C. Pain among Cancer Survivors. Prev. Chronic Dis. 2020;17:E54.

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    Gong Y., Tan Q., Qin Q., Wei C. Prevalence of postmastectomy pain syndrome and associated risk factors: A large single-institution cohort study. Medicine. 2020;99:e19834.

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    Götze H., Taubenheim S., Dietz A., Lordick F., Mehnert A. Comorbid conditions and health-related quality of life in long-term cancer survivors-associations with demographic and medical characteristics. J. Cancer Surviv. 2018;12:712-720.

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    Hammer S.M., Brown J.C., Segal S., Chu C.S., Schmitz K.H. Cancer-related impairments influence physical activity in uterine cancer survivors. Med. Sci. Sports Exerc. 2014;46:2195-2201.

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    Hamood R., Hamood H., Merhasin I., Keinan-Boker L.A. Feasibility study to assess the validity of administrative data sources and self-reported information of breast cancer survivors. Isr. J. Health Policy Res. 2016;5:50.

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    Hamood R., Hamood H., Merhasin I., Keinan-Boker L. Chronic pain and other symptoms among breast cancer survivors: Prevalence, predictors, and effects on quality of life. Breast Cancer Res. Treat. 2018;167:157-169.

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    Haviland J.S., Mannino M., Griffin C., Porta N., Sydenham M., Bliss J.M., Yarnold J.R. Late normal tissue effects in the arm and shoulder following lymphatic radiotherapy: Results from the UK START (Standardisation of Breast Radiotherapy) trials. Radiother. Oncol. 2017;126:155-162.

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    Henderson J.R., Tao A., Kirwan C.C., Barr L. Immediate breast reconstruction does not increase postmastectomy pain. Ann. Surg. Oncol. 2014;21:113-117.

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    Henry M., Alias A., Cherba M., Woronko C., Rosberger Z., Hier M., Zeitouni A., Kost K., Mlynarek A., Richardson K., et al. Immediate post-treatment supportive care needs of patients newly diagnosed with head and neck cancer. Support. Care Cancer. 2020;28:5557-5567.

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    Hope-Stone L., Brown S.L., Heimann H., Damato B., Salmon P. Phantom Eye Syndrome: Patient Experiences after Enucleation for Uveal Melanoma. Ophthalmology. 2015;122:1585-1590.

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    Huang I.C., Alberts N.M., Buckley M.G., Li Z., Ehrhardt M.J., Brinkman T.M., Allen J., Krull K.R., Klosky J.L., Greene W.L., et al. Change in pain status and subsequent opioid and marijuana use among long-term adult survivors of childhood cancer. JNCI Cancer Spectr. 2020;4:pkaa070.

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    Janah A., Bouhnik A.D., Touzani R., Bendiane M.K., Peretti-Watel P. Underprescription of Step III Opioids in French Cancer Survivors with Chronic Pain: A Call for Integrated Early Palliative Care in Oncology. J. Pain Symptom Manag. 2020;59:836-847.

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    Jansen F., Eerenstein S.E.J., Lissenberg-Witte B.I., van Uden-Kraan C.F., Leemans C.R., Leeuw I.M.V.D. Unmet supportive care needs in patients treated with total laryngectomy and its associated factors. Head Neck. 2018;40:2633-2641.

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    Jardim L.C., Flores P.T., do Carmo dos Santos Araújo M., Chiesa J., de Moraes C.M.B., Antoniazzi R.P. Oral health–related quality of life in breast cancer survivors. Support. Care Cancer. 2020;28:65-71.

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    Jariwala P., Kaur N.A. descriptive study on prevalence of arm/shoulder problems and its impact on quality of life in breast cancer survivors. Indian J. Cancer. 2021;58:201-206.

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    Johannsdottir I.M.R., Hamre H., Fosså S.D., Loge J.H., Drolsum L., Lund M.B., Nordsletten L., Kiserud C. Adverse Health Outcomes and Associations with Self-Reported General Health in Childhood Lymphoma Survivors. J. Adolesc. Young Adult Oncol. 2017;6:470-476.

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    Johannsen M., Christensen S., Zachariae R., Jensen A.B. Socio-demographic, treatment-related, and health behavioral predictors of persistent pain 15 months and 7–9 years after surgery: A nationwide prospective study of women treated for primary breast cancer. Breast Cancer Res. Treat. 2015;152:645-658.

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    Juhl A.A., Christiansen P., Damsgaard T.E. Persistent pain after breast cancer treatment: A questionnaire-based study on the prevalence, associated treatment variables, and pain type. J. Breast Cancer. 2016;19:447-454.

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    Karlson C.W., Alberts N.M., Liu W., Brinkman T.M., Annett R.D., Mulrooney D.A., Schulte F., Leisenring W.M., Gibson T.M., Howell R.M., et al. Longitudinal pain and pain interference in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer. 2020;126:2915-2923.

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    Kaur N., Gupta A., Sharma A.K., Jain A. Survivorship issues as determinants of quality of life after breast cancer treatment: Report from a limited resource setting. Breast. 2018;41:120-126.

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    Kelada L., Wakefield C.E., Heathcote L.C., Jaaniste T., Signorelli C., Fardell J.E., Donoghoe M., McCarthy M.C., Gabriel M., Cohn R.J. Perceived cancer-related pain and fatigue, information needs, and fear of cancer recurrence among adult survivors of childhood cancer. Patient Educ. Couns. 2019;102:2270-2278.

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    Kibar S., Dalyan Aras M., Ünsal Delialioğlu S. The risk factors and prevalence of upper extremity impairments and an analysis of effects of lymphoedema and other impairments on the quality of life of breast cancer patients. Eur. J. Cancer Care. 2017;26:e12433.

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    Kjær T.K., Johansen C., Andersen E., Karlsen R., Nielsen A.L., Frederiksen K., Rørth M., Ibfelt E., Dalton S.O. Influence of social factors on patient-reported late symptoms: Report from a controlled trial among long-term head and neck cancer survivors in Denmark. Head Neck. 2016;38:e1713-e1721.

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    Poursadegh M., Poursadegh F., Esmaeili M., Bakhshaee M. Epidemiological survey of sinonasal malignancy in North-East Iran. Iran. J. Otorhinolaryngol. 2015;27:225-229.

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    Rudd P., Gorman D., Meja S., Mtonga P., Jere Y., Chidothe I., Msusa A.T., Bates M.J., Brown E., Masamba L. Cervical cancer in southern Malawi: A prospective analysis of presentation, management, and outcomes. Malawi Med. J. 2017;29:124-129.

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    Shen C., Dasari A., Xu Y., Zhou S., Gu D., Chu Y., Halperin D.M., Shih Y.T., Yao J.C. Pre-existing Symptoms and Healthcare Utilization Prior to Diagnosis of Neuroendocrine Tumors: A SEER-Medicare Database Study. Sci. Rep. 2018;8:16863.

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    Antony A., Joel J.J., Shetty J., Umar N.F. Identification and analysis of adverse drug reactions associated with cancer chemotherapy in hospitalized patients. Int. J. Pharm. Pharm. Sci. 2016;8:448-451.

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    Berger A., Kumar G., LeVan T., Meza J. Symptom Clusters And Quality Of Life Over 1 Year In Breast Cancer Patients Receiving Adjuvant Chemotherapy. Asia Pac. J. Oncol. Nurs. 2020;7:134-140.

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    Bianchini C., Malagò M., Crema L., Aimoni C., Matarazzo T., Bortolazzi S., Ciorba A., Pelucchi S., Pastore A. Post-operative pain management in head and neck cancer patients: Predictive factors and efficacy of therapy. Acta Otorhinolaryngol. Ital. 2016;36:91-96.

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    Dervis E., Ayer M., Belli A.A., Barut S.G. Cutaneous adverse reactions of imatinib therapy in patients with chronic myeloid leukemia: A six-year follow up. Eur. J. Dermatol. 2016;26:133-137.

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    Prevalence and Correlates of Unmet Supportive Needs of Nigerian Patients With Cancer · 2019
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    Frowen J., Hughes R., Skeat J. The prevalence of patient-reported dysphagia and oral complications in cancer patients. Support. Care Cancer. 2020;28:1141-1150.

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    Germano F., Melone P., Testi D., Arcuri L., Marmiroli L., Petrone A., Arcuri C. Oral complications of head and neck radiotherapy: Prevalence and management. Minerva Stomatol. 2015;64:189-202.

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    Kartin P.T., Tasci S., Soyuer S., Elmali F. Effect of an oral mucositis protocol on quality of life of patients with head and neck cancer treated with radiation therapy. Clin. J. Oncol. Nurs. 2014;18:e118-e125.

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    Rahnama M., Madej-Czerwonka B., Jastrzębska-Jamrogiewicz I., Jamrogiewicz R. Analysis of the influence of parenteral cancer chemotherapy on the health condition of oral mucosa. Contemp. Oncol. 2015;19:77-82.

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    Sahora K., Crippa S., Zamboni G., Ferrone C., Warshaw A.L., Lillemoe K., Mino-Kenudson M., Falconi M., Fernandez-del Castillo C. Intraductal papillary mucinous neoplasms of the pancreas with concurrent pancreatic and periampullary neoplasms. Eur. J. Surg. Oncol. 2016;42:197-204.

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    Takayama Y., Kaneoka Y., Maeda A., Takahashi T., Kiriyama M., Seita K. Assessment of perioperative symptoms of patients with gastric cancer using the edmonton symptom assessment system revised japanese version (Esas-r-j). J. Med. Investig. 2021;68:90-95.

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    Wagland R., Richardson A., Ewings S., Armes J., Lennan E., Hankins M., Griffiths P. Prevalence of cancer chemotherapy-related problems, their relation to health-related quality of life and associated supportive care: A cross-sectional survey. Support. Care Cancer. 2016;24:4901-4911.

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    Wang Y., Lu Q., Zhang L., Zhuang B., Zhang T., Jin S., Sun Y., Xiao S., Zheng B., Fang Y., et al. Nutrition Impact Symptom Clusters in Patients with Head and Neck Cancer Receiving Concurrent Chemoradiotherapy. J. Pain Symptom Manag. 2021;62:277-285.

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    Yanque O. Uterine leiomyosarcoma: A 10-year review in a referral hospital in Peru, 2005–2014. S. Afr. J. Obstet. Gynaecol. 2018;24:87-89.

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    Ahmadi Z., Wysham N.G., Lundström S., Janson C., Currow D.C., Ekström M. End-of-life care in oxygen-dependent ILD compared with lung cancer: A national population-based study. Thorax. 2016;71:510-516.

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    Alsirafy S.A., Abd El-Aal H.H., Farag D.E., Radwan R.H., El-Sherief W.A., Fawzy R. High Symptom Burden among Patients with Newly Diagnosed Incurable Cancer in a Developing Country. J. Pain. Symptom Manag. 2016;51:e1-e5.

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    Bischoff K.E., O’Riordan D.L., Fazzalaro K., Kinderman A., Pantilat S.Z. Identifying Opportunities to Improve Pain among Patients with Serious Illness. J. Pain Symptom Manag. 2018;55:881-889.

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    Cuyun Carter G., Kaltenboeck A., Ivanova J., Liepa A.M., San Roman A., Koh M., Rajan N., Cheng R., Birnbaum H., Chen J.S. Treatment patterns in patients with advanced gastric cancer in Taiwan. Asia Pac. J. Clin. Oncol. 2017;13:185-194.

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    End of Life Care for Patients Dying of Stroke: A Comparative Registry Study of Stroke and Cancer. · 2016
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    Family L., Xu H., Cannavale K., Mehta B., Pourmoussa A., Xu L., Chao C. Symptom burdens related to chemotherapy-induced anemia in stage IV cancer. J. Community Support. Oncol. 2018;16:e260-e271.

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    Hasegawa T., Goto N., Matsumoto N., Sasaki Y., Ishiguro T., Kuzuya N., Sugiyama Y. Prevalence of unmet needs and correlated factors in advanced-stage cancer patients receiving rehabilitation. Support. Care Cancer. 2016;24:4761-4767.

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    Langlais B.T., Geyer H., Scherber R., Mesa R.A., Dueck A.C. Quality of life and symptom burden among myeloproliferative neoplasm patients: Do symptoms impact quality of life? Leuk. Lymphoma. 2019;60:402-408.

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    Multiple myeloma in Nigeria: a multi-centre epidemiological and biomedical study · 2015
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    Pimentel L.E., Yennurajalingam S., Chisholm G., Edwards T., Guerra-Sanchez M., De La Cruz M., Tanco K., Vidal M., Bruera E. The frequency and factors associated with the use of a dedicated Supportive Care Center Telephone Triaging Program in patients with advanced cancer at a comprehensive cancer center. J. Pain Symptom Manag. 2015;49:939-944.

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    Richter J., Sanchez L., Biran N., Wang C.K., Tanenbaum K., DeVincenzo V., Grunman B., Vesole D.H., Siegel D.S., Pecora A., et al. Prevalence and Survival Impact of Self-Reported Symptom and Psychological Distress among Patients with Multiple Myeloma. Clin. Lymphoma Myeloma Leuk. 2021;21:e284-e289.

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    Sandgren A., Strang P. Palliative care needs in hospitalized cancer patients: A 5-year follow-up study. Support. Care Cancer. 2018;26:181-186.

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    Scharf M., Petry V., Daniel H., Rinke A., Gress T.M. Bone Metastases in Patients with Neuroendocrine Neoplasm: Frequency and Clinical, Therapeutic, and Prognostic Relevance. Neuroendocrinology. 2018;106:30-37.

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    Spence W., Ghosh S., Palen M., Liska A., Ha V., Wong R., Huang F. Symptom burden among Northern Alberta radiotherapy patients with advanced cancer: Mapping needs and gaps. Support. Care Cancer. 2020;28:4963-4969.

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    Unseld M., Fischöder S., Jachs M., Drimmel M., Siebenhüner A., Bianconi D., Kieler M., Puhr H., Minichsdorfer C., Winder T., et al. Different toxicity profiles predict third line treatment efficacy in metastatic colorectal cancer patients. J. Clin. Med. 2020;9:1772.

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    Wangnamthip S., Euasobhon P., Siriussawakul A., Jirachaipitak S., Laurujisawat J., Vimolwattanasarn K. Effective Pain Management for Inpatients at Siriraj Hospital: A Retrospective Study. J. Med. Assoc. Thai. 2016;99:565-571.

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    Yanamandra U., Saini N., Chauhan P., Sharma T., Khadwal A., Prakash G., Varma N., Lad D., Varma S., Malhotra P. AYA-Myeloma: Real-World, Single-Center Experience Over Last 5 Years. J. Adolesc. Young Adult Oncol. 2018;7:120-124.

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    Yi Y.S., Ban W.H., Sohng K.Y. Effect of COPD on symptoms, quality of life and prognosis in patients with advanced non-small cell lung cancer. BMC Cancer. 2018;18:1053.

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    Abid H., Kober K.M., Smoot B., Paul S.M., Hammer M., Levine J.D., Lee K., Wright F., Cooper B.A., Conley Y.P., et al. Common and Distinct Characteristics Associated with Trajectories of Morning and Evening Energy in Oncology Patients Receiving Chemotherapy. J. Pain Symptom Manag. 2017;53:887-900.e2.

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    Agyemang-Yeboah F., Yorke J., Obirikorang C., Batu E.N., Acheampong E., Frempong E.A., Anto E.O., Amankwaa B. Patterns and presentations of colorectal cancer at Komfo-Anokye teaching hospital Kumasi, Ghana. Pan Afr. Med. J. 2017;28:121.

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    Allgar V.L., Chen H., Richfield E., Currow D., Macleod U., Johnson M.J. Psychometric Properties of the Needs Assessment Tool-Progressive Disease Cancer in U.K. Primary Care. J. Pain Symptom Manag. 2018;56:602-612.

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    Alsughayer L.Y., Altamimi L.A., Alsaleh F.S., Alsaghan L., Alfurayh I., Abdel-Aziz N.M., Alsaleh K.A., Alosaimi F.D. Prevalence and determinants of distress among oncology patients at a tertiary care medical city in Riyadh, Saudi Arabia. Saudi Med. J. 2021;42:761-768.

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    Bell S.G., Dalton L., McNeish B.L., Fang F., Henry N.L., Kidwell K.M., McLean K. Aromatase inhibitor use, side effects and discontinuation rates in gynecologic oncology patients. Gynecol. Oncol. 2020;159:509-514.

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    Crossnohere N.L., Richardson D.R., Reinhart C., O’Donoghue B., Love S.M., Smith B.D., Bridges J.F.P. Side effects from acute myeloid leukemia treatment: Results from a national survey. Curr. Med. Res. Opin. 2019;35:1965-1970.

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    Hirpara D.H., Gupta V., Davis L.E., Zhao H., Hallet J., Mahar A.L., Sutradhar R., Doherty M., Louie A.V., Kidane B., et al. Severe symptoms persist for Up to one year after diagnosis of stage I-III lung cancer: An analysis of province-wide patient reported outcomes. Lung Cancer. 2020;142:80-89.

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    Jazieh A.M., AlSumai T.S., Ali Y.Z., Sheblaq N.R., Alkaiyat M. The pattern of bone involvement, management, and outcomes in patients with nonsmall cell lung cancer: A retrospective study. Ann. Thorac. Med. 2018;13:150-155.

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    Kawazoe H., Mori N., Ido S., Uozumi R., Tsuneoka K., Takeuchi A., Matsuo M., Yamauchi M., Nakai M., Sumikawa S., et al. Liquid Formulation of Gemcitabine Increases Venous Pain in Patients with Cancer: A Retrospective Study. Clin. Ther. 2020;42:712-719.

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    Kebebew T., Mavhandu-Mudzusi A.H., Mosalo A. A cross-sectional assessment of symptom burden among patients with advanced cervical cancer. BMC Palliat. Care. 2021;20:190.

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    Kokkonen K., Tasmuth T., Lehto J.T., Kautiainen H., Elme A., Jaaskelainen A.S., Saarto T. Cancer patients’ symptom burden and health-related quality of life (HRQoL) at Tertiary Cancer Center from 2006 to 2013: A cross-sectional study. Anticancer Res. 2019;39:271-277.

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    Kolb N.A., Smith A.G., Singleton J.R., Beck S.L., Howard D., Dittus K., Karafiath S., Mooney K. Chemotherapy-related neuropathic symptom management: A randomized trial of an automated symptom-monitoring system paired with nurse practitioner follow-up. Support. Care Cancer. 2018;26:1607-1615.

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    Ladaninejad S., Ilali E., Mousavinasab N., Taraghi Z. The Relationship between Depressive Symptoms and Demographic-Medical Characteristics among Elder People with Cancer. Asia Pac. J. Oncol. Nurs. 2019;6:424-430.

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    Lim J.S., Koh C.E., Liu H., Solomon M.J., Johnstone C.S.H. The Price We Pay for Radical Curative Pelvic Exenterations: Prevalence and Management of Pain. Dis. Colon Rectum. 2018;61:314-319.

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    Risk factors for chemotherapy‐induced peripheral neuropathy in patients receiving taxane‐ and platinum‐based chemotherapy · 2019
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    Motah M., Gams Massi D., Fouda Bekolo F., Akweseh Nju N., Ndoumbe A., Moumi M., Sango A., Shu P., Eyenga V. Epidemiological profile of brain tumors in Cameroon: A retrospective study. Egypt. J. Neurol. Psychiatr. Neurosurg. 2021;57:126.

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    Neves Duarte Lisboa I., Dantas De Sá Tinôco J., Dias Fernandes M.I.D.C., Da Silva R.R., Student N., Barbosa Da Silva J., Freire Delgado M., Oliveira Lopes M.V., Brandão De Carvalho Lira A.L. Constipation in Chemotherapy Patients: A Diagnostic Accuracy Study. Asian Pac. J. Cancer Prev. 2021;22:3017-3021.

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    Association among presence of cancer pain, inadequate pain control, and psychotropic drug use. · 2017
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    Porta-Sales J., Nabal-Vicuna M., Vallano A., Espinosa J., Planas-Domingo J., Verger-Fransoy E., Julià-Torras J., Serna J., Pascual-López A., Rodríguez D., et al. Have We Improved Pain Control in Cancer Patients? A Multicenter Study of Ambulatory and Hospitalized Cancer Patients. J. Palliat. Med. 2015;18:923-932.

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    Pozzar R.A., Hammer M.J., Paul S.M., Cooper B.A., Kober K.M., Conley Y.P., Levine J.D., Miaskowski C. Distinct sleep disturbance profiles among patients with gynecologic cancer receiving chemotherapy. Gynecol. Oncol. 2021;163:419-426.

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    Santos I., Mendes L., Mansinho H., Santos C.A. Nutritional status and functional status of the pancreatic cancer patients and the impact of adjacent symptoms. Clin. Nutr. 2021;40:5486-5493.

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    Williams L.A., Bohac C., Hunter S., Cella D. Patient and health care provider perceptions of cancer-related fatigue and pain. Support. Care Cancer. 2016;24:4357-4363.

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    Beyaz S.G., Ergönenç J.Ş., Ergönenç T., Sönmez Ö.U., Erkorkmaz Ü., Altintoprak F. Postmastectomy pain: A cross-sectional study of prevalence, pain characteristics, and effects on quality of life. Chin. Med. J. 2016;129:66-71.

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    Cardoso L.R., Rizzo C.C., de Oliveira C.Z., dos Santos C.R., Carvalho A.L. Myofascial pain syndrome after head and neck cancer treatment: Prevalence, risk factors, and influence on quality of life. Head Neck. 2015;37:1733-1737.

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    Cox-Martin E., Anderson-Mellies A., Borges V., Bradley C. Chronic pain, health-related quality of life, and employment in working-age cancer survivors. J. Cancer Surviv. 2020;14:179-187.

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    Fuchs H., Hölscher A.H., Leers J., Bludau M., Brinkmann S., Schröder W., Alakus H., Mönig S., Gutschow C.A. Long-term quality of life after surgery for adenocarcinoma of the esophagogastric junction: Extended gastrectomy or transthoracic esophagectomy? Gastric Cancer. 2016;19:312-317.

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    Huang I.C., Hudson M.M., Robison L.L., Krull K.R. Differential Impact of Symptom Prevalence and Chronic Conditions on Quality of Life in Cancer Survivors and Non-Cancer Individuals: A Population Study. Cancer Epidemiol. Biomark. Prev. 2017;26:1124-1132.

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    Jefford M., Ward A.C., Lisy K., Lacey K., Emery J.D., Glaser A.W., Cross H., Krishnasamy M., McLachlan S.A., Bishop J. Patient-reported outcomes in cancer survivors: A population-wide cross-sectional study. Support. Care Cancer. 2017;25:3171-3179.

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    Jiang C., Wang H., Wang Q., Luo Y., Sidlow R., Han X. Prevalence of Chronic Pain and High-Impact Chronic Pain in Cancer Survivors in the United States. JAMA Oncol. 2019;5:1224-1226.

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    Kimberg C.I., Klosky J.L., Zhang N., Brinkman T.M., Ness K.K., Srivastava D.K., Robison L.L., Hudson M.M., Krull K.R. Predictors of health care utilization in adult survivors of childhood cancer exposed to central nervous system-directed therapy. Cancer. 2015;121:774-782.

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    Lang A.E., Murphy M., Dickerson C.R., Stavness I., Soo Y.K. Shoulder Dysfunction in Breast Cancer Survivors: Can Treatment Type or Musculoskeletal Factors Identify Those at Higher Risk? Rehabil. Oncol. 2021;39:143-151.

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    Maass S., Boerman L.M., Brandenbarg D., Verhaak P.F.M., Maduro J.H., de Bock G.H., Berendsen A.J. Symptoms in long-term breast cancer survivors: A cross-sectional study in primary care. Breast. 2020;54:133-138.

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    Maguire R., Drummond F.J., Hanly P., Gavin A., Sharp L. Problems sleeping with prostate cancer: Exploring possible risk factors for sleep disturbance in a population-based sample of survivors. Support. Care Cancer. 2019;27:3365-3373.

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    Mahmood N.G., Mahmood R.A., Ibrahim R.H. The postmastectomy pain syndrome among women in city of mosul-iraq. Teikyo Med. J. 2021;44:1625-1630.

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    McDonough A.L., Lei Y., Kwak A.H., Haggett D.E., Jimenez R.B., Johnston K.T., Moy B., Spring L.M., Peppercorn J. Implementation of a Brief Screening Tool to Identify Needs of Breast Cancer Survivors. Clin. Breast Cancer. 2021;21:e88-e95.

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    Mehdizadeh O.B., Dhar S.I., Evangelista L., Nativ-Zeltzer N., Bewley A.F., Belafsky P.C. Prevalence of profound laryngeal sensory neuropathy in head and neck cancer survivors with feeding tube-dependent oropharyngeal dysphagia. Head Neck. 2020;42:898-904.

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    Moreno P.I., Ramirez A.G., San Miguel-Majors S.L., Castillo L., Fox R.S., Gallion K.J., Munoz E., Estabrook R., Perez A., Lad T., et al. Unmet supportive care needs in Hispanic/Latino cancer survivors: Prevalence and associations with patient-provider communication, satisfaction with cancer care, and symptom burden. Support. Care Cancer. 2019;27:1383-1394.

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    Mustafa Ali M., Moeller M., Rybicki L., Moore H.C.F. Prevalence and correlates of patient-reported symptoms and comorbidities in breast cancer survivors at a tertiary center. J. Cancer Surviv. 2017;11:743-750.

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    Oancea S.C., Brinkman T.M., Ness K.K., Krull K.R., Smith W.A., Srivastava D.K., Robison L.L., Hudson M.M., Gurney J.G. Emotional distress among adult survivors of childhood cancer. J. Cancer Surviv. 2014;8:293-303.

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    Olsson I.T., Lubas M.M., Li C., Mandrell B.N., Banerjee P., Howell C.R., Ness K.K., Srivastava D., Robison L.L., Hudson M.M., et al. Insomnia and neurocognitive functioning in adult survivors of childhood cancer. JNCI Cancer Spectr. 2020;4:pkaa008.

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    Pezdirec M., Strojan P., Boltezar I.H. Swallowing disorders after treatment for head and neck cancer. Radiol. Oncol. 2019;53:225-230.

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    Romero A., Torà-Rocamora I., Baré M., Barata T., Domingo L., Ferrer J., Torà N., Comas M., Merenciano C., Macià F., et al. Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs. BMC Cancer. 2016;16:735.

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    Salani R., Preston M.M., Hade E.M., Johns J., Fowler J.M., Paskett E.P., Katz M.L. Swelling among women who need education about leg lymphedema: A descriptive study of lymphedema in women undergoing surgery for endometrial cancer. Int. J. Gynecol. Cancer. 2014;24:1507-1512.

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    Soares E.W.S., Nagai H.M., Bredt L.C., da Cunha Jr A.D., Andrade R.J., Soares G.V.S. Morbidity after conventional dissection of axillary lymph nodes in breast cancer patients. World J. Surg. Oncol. 2014;12:67.

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    Wulff-Burchfield E., Dietrich M.S., Ridner S., Murphy B.A. Late systemic symptoms in head and neck cancer survivors. Support. Care Cancer. 2019;27:2893-2902.

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    Yen H.J., Eissa H.M., Bhatt N.S., Huang S., Ehrhardt M.J., Bhakta N., Ness K.K., Krull K.R., Srivastava D.K., Robison L.L., et al. Patient-reported outcomes in survivors of childhood hematologic malignancies with hematopoietic stem cell transplant. Blood. 2020;135:1847-1858.

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    Bandeali S., des Ordons A.R., Sinnarajah A. Comparing the physical, psychological, social, and spiritual needs of patients with non-cancer and cancer diagnoses in a tertiary palliative care setting. Palliat. Support. Care. 2020;18:513-518.

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    Covarrubias-Gómez A., Hernández-Martínez E.E., Ruiz-Ramírez S., López Collada-Estrada M. Assessment of pain and other symptoms in Mexican patients with advanced illness. J. Pain Palliat. Care Pharmacother. 2014;28:394-398.

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