The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
Hyeyoun Chang, Zhenying Cai, Thomas M. Roberts
Biomolecules · 2019
doi:10.3390/biom9110713 (opens in a new tab)
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Abstract
In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.
Abstract licence: CC BY
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