Mechanisms of Chromosome Congression during Mitosis

Abstract

Chromosome congression during prometaphase culminates with the establishment of a metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more than 100 years of research on this topic have attempted to explain chromosome congression based on the balance between opposing pulling and/or pushing forces that reach an equilibrium near the spindle equator. However, in mammalian cells, chromosome bi-orientation and force balance at kinetochores are not required for chromosome congression, whereas the mechanisms of chromosome congression are not necessarily involved in the maintenance of chromosome alignment after congression. Thus, chromosome congression and maintenance of alignment are determined by different principles. Moreover, it is now clear that not all chromosomes use the same mechanism for congressing to the spindle equator. Those chromosomes that are favorably positioned between both poles when the nuclear envelope breaks down use the so-called “direct congression” pathway in which chromosomes align after bi-orientation and the establishment of end-on kinetochore-microtubule attachments. This favors the balanced action of kinetochore pulling forces and polar ejection forces along chromosome arms that drive chromosome oscillatory movements during and after congression. The other pathway, which we call “peripheral congression”, is independent of end-on kinetochore microtubule-attachments and relies on the dominant and coordinated action of the kinetochore motors Dynein and Centromere Protein E (CENP-E) that mediate the lateral transport of peripheral chromosomes along microtubules, first towards the poles and subsequently towards the equator. How the opposite polarities of kinetochore motors are regulated in space and time to drive congression of peripheral chromosomes only now starts to be understood. This appears to be regulated by position-dependent phosphorylation of both Dynein and CENP-E and by spindle microtubule diversity by means of tubulin post-translational modifications. This so-called “tubulin code” might work as a navigation system that selectively guides kinetochore motors with opposite polarities along specific spindle microtubule populations, ultimately leading to the congression of peripheral chromosomes. We propose an integrated model of chromosome congression in mammalian cells that depends essentially on the following parameters: (1) chromosome position relative to the spindle poles after nuclear envelope breakdown; (2) establishment of stable end-on kinetochore-microtubule attachments and bi-orientation; (3) coordination between kinetochore- and arm-associated motors; and (4) spatial signatures associated with post-translational modifications of specific spindle microtubule populations. The physiological consequences of abnormal chromosome congression, as well as the therapeutic potential of inhibiting chromosome congression are also discussed.

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     Not in our library10.1083/jcb.200405094

101. 101.

     Akhmanova A., Hoogenraad C.C., Drabek K., Stepanova T., Dortland B., Verkerk T., Vermeulen W., Burgering B.M., De Zeeuw C.I., Grosveld F., et al. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell. 2001;104:923-935.

     Not in our library10.1016/s0092-8674(01)00288-4

102. 102.

     Perez F., Diamantopoulos G.S., Stalder R., Kreis T.E. CLIP-170 highlights growing microtubule ends in vivo. Cell. 1999;96:517-527.

     Not in our library10.1016/s0092-8674(00)80656-x

103. 103.

     Dujardin D., Wacker U.I., Moreau A., Schroer T.A., Rickard J.E., De Mey J.R. Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment. J. Cell Biol. 1998;141:849-862.

     Not in our library10.1083/jcb.141.4.849

104. 104.

     Tanenbaum M.E., Galjart N., van Vugt M.A.T.M., Medema R.H. CLIP-170 facilitates the formation of kinetochore-microtubule attachments. EMBO J. 2006;25:45-57.

     Not in our library10.1038/sj.emboj.7600916

105. 105.

     Kakeno M., Matsuzawa K., Matsui T., Akita H., Sugiyama I., Ishidate F., Nakano A., Takashima S., Goto H., Inagaki M., et al. Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment. Cell Struct. Funct. 2014;39:45-59.

     Not in our library10.1247/csf.14001

106. 106.

     Amin M.A., Kobayashi K., Tanaka K. CLIP-170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore-microtubule attachment. FEBS Lett. 2015;589:2739-2746.

     Not in our library10.1016/j.febslet.2015.07.036

107. 107.

     Bonfils C., Bec N., Lacroix B., Harricane M.C., Larroque C. Kinetic analysis of tubulin assembly in the presence of the microtubule-associated protein TOGp. J. Biol. Chem. 2007;282:5570-5581.

     Not in our library10.1074/jbc.m605641200

108. 108.

     Gard D.L., Kirschner M.W. A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end. J. Cell Biol. 1987;105:2203-2215.

     Not in our library10.1083/jcb.105.5.2203

109. 109.

     Al-Bassam J., Chang F. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Trends Cell Biol. 2011;21:604-614.

     Not in our library10.1016/j.tcb.2011.06.007

110. 110.

     Al-Bassam J., Kim H., Brouhard G., van Oijen A., Harrison S.C., Chang F. CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev. Cell. 2010;19:245-258.

     Not in our library10.1016/j.devcel.2010.07.016

111. 111.

     Gandhi S.R., Gierlinski M., Mino A., Tanaka K., Kitamura E., Clayton L., Tanaka T.U. Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis. Dev. Cell. 2011;21:920-933.

     Not in our library10.1016/j.devcel.2011.09.006

112. 112.

     Gergely F., Draviam V.M., Raff J.W. The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev. 2003;17:336-341.

     Not in our library10.1101/gad.245603

113. 113.

     Kitamura E., Tanaka K., Komoto S., Kitamura Y., Antony C., Tanaka T.U. Kinetochores generate microtubules with distal plus ends: Their roles and limited lifetime in mitosis. Dev. Cell. 2010;18:248-259.

     Not in our library10.1016/j.devcel.2009.12.018

114. 114.

     Miller M.P., Asbury C.L., Biggins S. A TOG Protein Confers Tension Sensitivity to Kinetochore-Microtubule Attachments. Cell. 2016;165:1428-1439.

     Not in our library10.1016/j.cell.2016.04.030

115. 115.

     Cassimeris L., Becker B., Carney B. TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability. Cell Motil. Cytoskeleton. 2009;66:535-545.

     Not in our library10.1002/cm.20359

116. 116.

     Maiato H., Fairley E.A., Rieder C.L., Swedlow J.R., Sunkel C.E., Earnshaw W.C. Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Cell. 2003;113:891-904.

     Not in our library10.1016/s0092-8674(03)00465-3

117. 117.

     Pereira A.L., Pereira A.J., Maia A.R., Drabek K., Sayas C.L., Hergert P.J., Lince-Faria M., Matos I., Duque C., Stepanova T., et al. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol. Biol. Cell. 2006;17:4526-4542.

     Not in our library10.1091/mbc.e06-07-0579

118. 118.

     Maiato H., Khodjakov A., Rieder C.L. Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres. Nat. Cell Biol. 2005;7:42-47.

     Not in our library10.1038/ncb1207

119. 119.

     Maffini S., Maia A.R., Manning A.L., Maliga Z., Pereira A.L., Junqueira M., Shevchenko A., Hyman A., Yates J.R., Galjart N., et al. Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux. Curr. Biol. 2009;19:1566-1572.

     Not in our library10.1016/j.cub.2009.07.059

120. 120.

     Manning A.L., Bakhoum S.F., Maffini S., Correia-Melo C., Maiato H., Compton D.A. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. Embo J. 2010;29:3531-3543.

     Not in our library10.1038/emboj.2010.230

121. 121.

     Maia A.R., Garcia Z., Kabeche L., Barisic M., Maffini S., Macedo-Ribeiro S., Cheeseman I.M., Compton D.A., Kaverina I., Maiato H. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments. J. Cell Biol. 2012;199:285-301.

     Not in our library10.1083/jcb.201203091

122. 122.

     Walczak C.E., Gayek S., Ohi R. Microtubule-depolymerizing kinesins. Annu. Rev. Cell Dev. Biol. 2013;29:417-441.

     Not in our library10.1146/annurev-cellbio-101512-122345

123. 123.

     Desai A., Verma S., Mitchison T.J., Walczak C.E. Kin I kinesins are microtubule-destabilizing enzymes. Cell. 1999;96:69-78.

     Not in our library10.1016/s0092-8674(00)80960-5

124. 124.

     Manning A.L., Ganem N.J., Bakhoum S.F., Wagenbach M., Wordeman L., Compton D.A. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol. Biol. Cell. 2007;18:2970-2979.

     Not in our library10.1091/mbc.e07-02-0110

125. 125.

     Walczak C.E. The Kin I kinesins are microtubule end-stimulated ATPases. Mol. Cell. 2003;11:286-288.

     Not in our library10.1016/s1097-2765(03)00067-4

126. 126.

     Ganem N.J., Compton D.A. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J. Cell Biol. 2004;166:473-478.

     Not in our library10.1083/jcb.200404012

127. 127.

     Walczak C.E., Mitchison T.J., Desai A. XKCM1: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell. 1996;84:37-47.

     Not in our library10.1016/s0092-8674(00)80991-5

128. 128.

     Kline-Smith S.L., Walczak C.E. The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells. Mol. Biol. Cell. 2002;13:2718-2731.

     Not in our library10.1091/mbc.e01-12-0143

129. 129.

     Wordeman L., Wagenbach M., von Dassow G. MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover. J. Cell Biol. 2007;179:869-879.

     Not in our library10.1083/jcb.200707120

130. 130.

     Bakhoum S.F., Thompson S.L., Manning A.L., Compton D.A. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat. Cell Biol. 2009;11:27-35.

     Not in our library10.1038/ncb1809

131. 131.

     Gaetz J., Kapoor T.M. Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles. J. Cell Biol. 2004;166:465-471.

     Not in our library10.1083/jcb.200404015

132. 132.

     Ganem N.J., Upton K., Compton D.A. Efficient mitosis in human cells lacking poleward microtubule flux. Curr. Biol. 2005;15:1827-1832.

     Not in our library10.1016/j.cub.2005.08.065

133. 133.

     Gupta M.L., Carvalho P., Roof D.M., Pellman D. Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nat. Cell Biol. 2006;8:913-923.

     Not in our library10.1038/ncb1457

134. 134.

     Mayr M.I., Hümmer S., Bormann J., Grüner T., Adio S., Woehlke G., Mayer T.U. The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr. Biol. 2007;17:488-498.

     Not in our library10.1016/j.cub.2007.02.036

135. 135.

     Varga V., Helenius J., Tanaka K., Hyman A.A., Tanaka T.U., Howard J. Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat. Cell Biol. 2006;8:957-962.

     Not in our library10.1038/ncb1462

136. 136.

     Varga V., Leduc C., Bormuth V., Diez S., Howard J. Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization. Cell. 2009;138:1174-1183.

     Not in our library10.1016/j.cell.2009.07.032

137. 137.

     Du Y., English C.A., Ohi R. The kinesin-8 Kif18A dampens microtubule plus-end dynamics. Curr. Biol. 2010;20:374-380.

     Not in our library10.1016/j.cub.2009.12.049

138. 138.

     Stumpff J., Du Y., English C.A., Maliga Z., Wagenbach M., Asbury C.L., Wordeman L., Ohi R. A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A. Mol. Cell. 2011;43:764-775.

     Not in our library10.1016/j.molcel.2011.07.022

139. 139.

     Gandhi R., Bonaccorsi S., Wentworth D., Doxsey S., Gatti M., Pereira A. The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly. Mol. Biol. Cell. 2004;15:121-131.

     Not in our library10.1091/mbc.e03-05-0342

140. 140.

     Goshima G., Wollman R., Stuurman N., Scholey J.M., Vale R.D. Length control of the metaphase spindle. Curr. Biol. 2005;15:1979-1988.

     Not in our library10.1016/j.cub.2005.09.054

141. 141.

     Rischitor P.E., Konzack S., Fischer R. The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae. Eukaryotic Cell. 2004;3:632-645.

     Not in our library10.1128/ec.3.3.632-645.2004

142. 142.

     Straight A.F., Sedat J.W., Murray A.W. Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J. Cell Biol. 1998;143:687-694.

     Not in our library10.1083/jcb.143.3.687

143. 143.

     West R.R., Malmstrom T., McIntosh J.R. Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis. J. Cell Sci. 2002;115:931-940.

     Not in our library10.1242/jcs.115.5.931

144. 144.

     Stumpff J., von Dassow G., Wagenbach M., Asbury C., Wordeman L. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev. Cell. 2008;14:252-262.

     Not in our library10.1016/j.devcel.2007.11.014

145. 145.

     Jaqaman K., King E.M., Amaro A.C., Winter J.R., Dorn J.F., Elliott H.L., McHedlishvili N., McClelland S.E., Porter I.M., Posch M., et al. Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. J. Cell Biol. 2010;188:665-679.

     Not in our library10.1083/jcb.200909005

146. 146.

     Stumpff J., Wagenbach M., Franck A., Asbury C.L., Wordeman L. Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension. Dev. Cell. 2012;22:1017-1029.

     Not in our library10.1016/j.devcel.2012.02.013

147. 147.

     Thein K.H., Kleylein-Sohn J., Nigg E.A., Gruneberg U. Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. J. Cell Biol. 2007;178:345-354.

     Not in our library10.1083/jcb.200701163

148. 148.

     Schmidt J.C., Kiyomitsu T., Hori T., Backer C.B., Fukagawa T., Cheeseman I.M. Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores. J. Cell Biol. 2010;191:269-280.

     Not in our library10.1083/jcb.201006129

149. 149.

     Dunsch A.K., Linnane E., Barr F.A., Gruneberg U. The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J. Cell Biol. 2011;192:959-968.

     Not in our library10.1083/jcb.201008023

150. 150.

     Logarinho E., Maffini S., Barisic M., Marques A., Toso A., Meraldi P., Maiato H. CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment. Nat. Cell Biol. 2012;14:295-303.

     Not in our library10.1038/ncb2423

151. 151.

     Wu G., Lin Y.-T., Wei R., Chen Y., Shan Z., Lee W.-H. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Mol. Cell. Biol. 2008;28:3652-3662.

     Not in our library10.1128/mcb.01923-07

152. 152.

     Hoar K., Chakravarty A., Rabino C., Wysong D., Bowman D., Roy N., Ecsedy J.A. MLN8054, a Small-Molecule Inhibitor of Aurora A, Causes Spindle Pole and Chromosome Congression Defects Leading to Aneuploidy. Mol. Cell. Biol. 2007;27:4513-4525.

     Not in our library10.1128/mcb.02364-06

153. 153.

     Sasai K., Parant J.M., Brandt M.E., Carter J., Adams H.P., Stass S.A., Killary A.M., Katayama H., Sen S. Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality. Oncogene. 2008;27:4122-4127.

     Not in our library10.1038/onc.2008.47

154. 154.
     Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules. · 2013

     Not checked
155. 155.
     Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. · 2011

     Not checked
156. 156.

     Tanudji M., Shoemaker J., L’Italien L., Russell L., Chin G., Schebye X.M. Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay. Mol. Biol. Cell. 2004;15:3771-3781.

     Not in our library10.1091/mbc.e03-07-0482

157. 157.

     Maia A.F., Feijão T., Vromans M.J.M., Sunkel C.E., Lens S.M.A. Aurora B kinase cooperates with CENP-E to promote timely anaphase onset. Chromosoma. 2010;119:405-413.

     Not in our library10.1007/s00412-010-0265-x

158. 158.

     Wu Q., He R., Zhou H., Yu A.C.H., Zhang B., Teng J., Chen J. Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Cell Res. 2012;22:1390-1401.

     Not in our library10.1038/cr.2012.61

159. 159.

     Oshimori N., Li X., Ohsugi M., Yamamoto T. Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. EMBO J. 2009;28:2066-2076.

     Not in our library10.1038/emboj.2009.161

160. 160.

     Kim K., Rhee K. The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole. J. Cell Sci. 2011;124:338-347.

     Not in our library10.1242/jcs.078329

161. 161.

     Kimura M., Yoshioka T., Saio M., Banno Y., Nagaoka H., Okano Y. Mitotic catastrophe and cell death induced by depletion of centrosomal proteins. Cell Death Dis. 2013;4:e603.

     Not in our library10.1038/cddis.2013.108

162. 162.

     Mimori-Kiyosue Y., Grigoriev I., Sasaki H., Matsui C., Akhmanova A., Tsukita S., Vorobjev I. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Genes Cells. 2006;11:845-857.

     Not in our library10.1111/j.1365-2443.2006.00990.x

163. 163.

     Hauf S., Cole R.W., LaTerra S., Zimmer C., Schnapp G., Walter R., Heckel A., van Meel J., Rieder C.L., Peters J.-M. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 2003;161:281-294.

     Not in our library10.1083/jcb.200208092

164. 164.

     Johnson V.L., Scott M.I.F., Holt S.V., Hussein D., Taylor S.S. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J. Cell Sci. 2004;117:1577-1589.

     Not in our library10.1242/jcs.01006

165. 165.

     Dai J., Sultan S., Taylor S.S., Higgins J.M.G. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev. 2005;19:472-488.

     Not in our library10.1101/gad.1267105

166. 166.

     Dai J., Sullivan B.A., Higgins J.M.G. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. Dev. Cell. 2006;11:741-750.

     Not in our library10.1016/j.devcel.2006.09.018

167. 167.

     Dai J., Kateneva A.V., Higgins J.M.G. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. J. Cell Sci. 2009;122:4168-4176.

     Not in our library10.1242/jcs.054122

168. 168.

     Fielding A.B., Dobreva I., McDonald P.C., Foster L.J., Dedhar S. Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. J. Cell Biol. 2008;180:681-689.

     Not in our library10.1083/jcb.200710074

169. 169.

     Fang L., Seki A., Fang G. SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition. Cell Cycle. 2009;8:2819-2827.

     Not in our library10.4161/cc.8.17.9514

170. 170.

     Martin-Lluesma S., Stucke V.M., Nigg E.A. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science. 2002;297:2267-2270.

     Not in our library10.1126/science.1075596

171. 171.

     Joseph J., Liu S.-T., Jablonski S.A., Yen T.J., Dasso M. The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr. Biol. 2004;14:611-617.

     Not in our library10.1016/j.cub.2004.03.031

172. 172.

     Li L., Yang L., Scudiero D.A., Miller S.A., Yu Z.X., Stukenberg P.T., Shoemaker R.H., Kotin R.M. Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells. Gene Ther. 2007;14:814-827.

     Not in our library10.1038/sj.gt.3302933

173. 173.

     Sundin L.J., Guimaraes G.J., Deluca J.G. The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis. Mol. Biol. Cell. 2011;22:759-768.

     Not in our library10.1091/mbc.e10-08-0671

174. 174.

     Xu P., Virshup D.M., Lee S.H. B56-PP2A regulates motor dynamics for mitotic chromosome alignment. J. Cell Sci. 2014;127:4567-4573.

     Not in our library10.1242/jcs.154609

175. 175.

     DeLuca J.G., Moree B., Hickey J.M., Kilmartin J.V., Salmon E.D. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J. Cell Biol. 2002;159:549-555.

     Not in our library10.1083/jcb.200208159

176. 176.
     NuMA is required for proper spindle assembly and chromosome alignment in prometaphase · 2009

     Not checked
177. 177.
     Shugoshin Prevents Dissociation of Cohesin from Centromeres During Mitosis in Vertebrate Cells · 2005

     No notice
178. 178.

     Raaijmakers J.A., Tanenbaum M.E., Medema R.H. Systematic dissection of dynein regulators in mitosis. J. Cell Biol. 2013;201:201-215.

     Not in our library10.1083/jcb.201208098

179. 179.

     Barisic M., Sohm B., Mikolcevic P., Wandke C., Rauch V., Ringer T., Hess M., Bonn G., Geley S. Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. Mol. Biol. Cell. 2010;21:1968-1981.

     Not in our library10.1091/mbc.e09-04-0356

180. 180.

     Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Wetzel W., Schulze-Osthoff K., Nurnberg B., Piekorz R.P. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J. Biol. Chem. 2007;282:29273-29283.

     Not in our library10.1074/jbc.m704151200

181. 181.

     Lin C.H., Hu C.K., Shih H.M. Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J. Cell Biol. 2010;189:1097-1105.

     Not in our library10.1083/jcb.200911120

182. 182.

     Cheeseman L.P., Harry E.F., McAinsh A.D., Prior I.A., Royle S.J. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. J. Cell Sci. 2013;126:2102-2113.

     Not in our library10.1242/jcs.124834

183. 183.

     Royle S.J., Bright N.A., Lagnado L. Clathrin is required for the function of the mitotic spindle. Nature. 2005;434:1152-1157.

     Not in our library10.1038/nature03502

184. 184.

     Krauss S.W., Spence J.R., Bahmanyar S., Barth A.I.M., Go M.M., Czerwinski D., Meyer A.J. Downregulation of protein 4.1R, a mature centriole protein, disrupts centrosomes, alters cell cycle progression, and perturbs mitotic spindles and anaphase. Mol. Cell. Biol. 2008;28:2283-2294.

     Not in our library10.1128/mcb.02021-07

185. 185.

     Hanisch A., Silljé H.H.W., Nigg E.A. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J. 2006;25:5504-5515.

     Not in our library10.1038/sj.emboj.7601426

186. 186.

     Sivakumar S., Daum J.R., Tipton A.R., Rankin S., Gorbsky G.J. The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol. Biol. Cell. 2014;25:594-605.

     Not in our library10.1091/mbc.e13-07-0421

187. 187.

     Gaitanos T.N., Santamaria A., Jeyaprakash A.A., Wang B., Conti E., Nigg E.A. Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J. 2009;28:1442-1452.

     Not in our library10.1038/emboj.2009.96

188. 188.

     Welburn J.P.I., Grishchuk E.L., Backer C.B., Wilson-Kubalek E.M., Yates J.R., Cheeseman I.M. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev. Cell. 2009;16:374-385.

     Not in our library10.1016/j.devcel.2009.01.011

189. 189.

     Daum J.R., Wren J.D., Daniel J.J., Sivakumar S., McAvoy J.N., Potapova T.A., Gorbsky G.J. Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis. Curr. Biol. 2009;19:1467-1472.

     Not in our library10.1016/j.cub.2009.07.017

190. 190.

     Raaijmakers J.A., Tanenbaum M.E., Maia A.F., Medema R.H. RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. J. Cell Sci. 2009;122:2436-2445.

     Not in our library10.1242/jcs.051912

191. 191.

     Tokai-Nishizumi N., Ohsugi M., Suzuki E., Yamamoto T. The chromokinesin Kid is required for maintenance of proper metaphase spindle size. Mol. Biol. Cell. 2005;16:5455-5463.

     Not in our library10.1091/mbc.e05-03-0244

192. 192.

     Huang Y., Yao Y., Xu H.-Z., Wang Z.-G., Lu L., Dai W. Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. Cell Cycle. 2009;8:2643-2649.

     Not in our library10.4161/cc.8.16.9366

193. 193.

     Liu X.-S., Zhao X.-D., Wang X., Yao Y.-X., Zhang L.-L., Shu R.-Z., Ren W.-H., Huang Y., Huang L., Gu M.-M., et al. Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E. Genes Cancer. 2010;1:26-39.

     Not in our library10.1177/1947601909358184

194. 194.

     Tanenbaum M.E., Macurek L., van der Vaart B., Galli M., Akhmanova A., Medema R.H. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 2011;21:1356-1365.

     Not in our library10.1016/j.cub.2011.07.017

195. 195.

     Stout J.R., Yount A.L., Powers J.A., Leblanc C., Ems-McClung S.C., Walczak C.E. Kif18B interacts with EB1 and controls astral microtubule length during mitosis. Mol. Biol. Cell. 2011;22:3070-3080.

     Not in our library10.1091/mbc.e11-04-0363

196. 196.

     Walczak C.E., Zong H., Jain S., Stout J.R. Spatial regulation of astral microtubule dynamics by Kif18B in PtK cells. Mol. Biol. Cell. 2016;27:3021-3030.

     Not in our library10.1091/mbc.e16-04-0254

197. 197.

     Kline-Smith S.L., Khodjakov A., Hergert P., Walczak C.E. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol. Biol. Cell. 2004;15:1146-1159.

     Not in our library10.1091/mbc.e03-08-0581

198. 198.

     Silljé H.H.W., Nagel S., Körner R., Nigg E.A. HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr. Biol. 2006;16:731-742.

     Not in our library10.1016/j.cub.2006.02.070

199. 199.

     Wong J., Fang G. HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J. Cell Biol. 2006;173:879-891.

     Not in our library10.1083/jcb.200511132

200. 200.

     Ye F., Tan L., Yang Q., Xia Y., Deng L.-W., Murata-Hori M., Liou Y.-C. HURP regulates chromosome congression by modulating kinesin Kif18A function. Curr. Biol. 2011;21:1584-1591.

     Not in our library10.1016/j.cub.2011.08.024

201. 201.

     McHedlishvili N., Wieser S., Holtackers R., Mouysset J., Belwal M., Amaro A.C., Meraldi P. Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation. J. Cell Sci. 2012;125:906-918.

     Not in our library10.1242/jcs.091967

202. 202.

     Raemaekers T., Ribbeck K., Beaudouin J., Annaert W., Van Camp M., Stockmans I., Smets N., Bouillon R., Ellenberg J., Carmeliet G. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. J. Cell Biol. 2003;162:1017-1029.

     Not in our library10.1083/jcb.200302129

203. 203.

     Li C., Xue C., Yang Q., Low B.C., Liou Y.C. NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force. Nat. Commun. 2016;7:10597.

     Not in our library10.1038/ncomms10597

204. 204.

     Ma N., Matsunaga S., Morimoto A., Sakashita G., Urano T., Uchiyama S., Fukui K. The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles. J. Cell Sci. 2011;124:394-404.

     Not in our library10.1242/jcs.063347

205. 205.

     Meraldi P., Sorger P.K. A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J. 2005;24:1621-1633.

     Not in our library10.1038/sj.emboj.7600641

206. 206.

     Ditchfield C., Johnson V.L., Tighe A., Ellston R., Haworth C., Johnson T., Mortlock A., Keen N., Taylor S.S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 2003;161:267-280.

     Not in our library10.1083/jcb.200208091

207. 207.
     BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression · 2013

     Not checked
208. 208.

     Elowe S., Dulla K., Uldschmid A., Li X., Dou Z., Nigg E.A. Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1. J. Cell Sci. 2010;123:84-94.

     Not in our library10.1242/jcs.056507

209. 209.

     Itoh G., Sugino S., Ikeda M., Mizuguchi M., Kanno S.-i., Amin M.A., Iemura K., Yasui A., Hirota T., Tanaka K. Nucleoporin Nup188 is required for chromosome alignment in mitosis. Cancer Sci. 2013;104:871-879.

     Not in our library10.1111/cas.12159

210. 210.

     Holt S.V., Vergnolle M.A.S., Hussein D., Wozniak M.J., Allan V.J., Taylor S.S. Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint. J. Cell Sci. 2005;118:4889-4900.

     Not in our library10.1242/jcs.02614

211. 211.

     Serio G., Margaria V., Jensen S., Oldani A., Bartek J., Bussolino F., Lanzetti L. Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores. Proc. Natl. Acad. Sci. USA. 2011;108:17337-17342.

     Not in our library10.1073/pnas.1103516108

212. 212.

     Yang Z., Guo J., Chen Q., Ding C., Du J., Zhu X. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 2005;25:4062-4074.

     Not in our library10.1128/mcb.25.10.4062-4074.2005

213. 213.

     De Luca M., Lavia P., Guarguaglini G. A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle. 2006;5:296-303.

     Not in our library10.4161/cc.5.3.2392

214. 214.

     Sumara I., Giménez-Abián J.F., Gerlich D., Hirota T., Kraft C., de la Torre C., Ellenberg J., Peters J.-M. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr. Biol. 2004;14:1712-1722.

     Not in our library10.1016/j.cub.2004.09.049

215. 215.

     Neumann B., Held M., Liebel U., Erfle H., Rogers P., Pepperkok R., Ellenberg J. High-throughput RNAi screening by time-lapse imaging of live human cells. Nat. Methods. 2006;3:385-390.

     Not in our library10.1038/nmeth876

216. 216.

     Nishino M., Kurasawa Y., Evans R., Lin S.-H., Brinkley B.R., Yu-Lee L.-Y. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Curr. Biol. 2006;16:1414-1421.

     Not in our library10.1016/j.cub.2006.05.052

217. 217.

     Chuang C., Pan J., Hawke D.H., Lin S.H., Yu-Lee L.Y. NudC deacetylation regulates mitotic progression. PLoS ONE. 2013;8:e73841.

     Not in our library10.1371/journal.pone.0073841

218. 218.

     Gambe A.E., Matsunaga S., Takata H., Ono-Maniwa R., Baba A., Uchiyama S., Fukui K. A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 2009;583:1951-1956.

     Not in our library10.1016/j.febslet.2009.05.033

219. 219.

     Ma N., Matsunaga S., Takata H., Ono-Maniwa R., Uchiyama S., Fukui K. Nucleolin functions in nucleolus formation and chromosome congression. J. Cell Sci. 2007;120:2091-2105.

     Not in our library10.1242/jcs.008771

220. 220.

     Zhang L., Iyer J., Chowdhury A., Ji M., Xiao L., Yang S., Chen Y., Tsai M.-Y., Dong J. KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis. J. Biol. Chem. 2012;287:34069-34077.

     Not in our library10.1074/jbc.m112.385518

221. 221.

     Jang C.-Y., Wong J., Coppinger J.A., Seki A., Yates J.R., Fang G. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J. Cell Biol. 2008;181:255-267.

     Not in our library10.1083/jcb.200711032

222. 222.

     Jang C.-Y., Fang G. DDA3 associates with MCAK and controls chromosome congression. Biochem. Biophys. Res. Commun. 2011;407:610-614.

     Not in our library10.1016/j.bbrc.2011.03.081

223. 223.

     Park S.J. Huntingtin-interacting protein 1-related is required for accurate congression and segregation of chromosomes. BMB Rep. 2010;43:795-800.

     Not in our library10.5483/bmbrep.2010.43.12.795

224. 224.

     Amin M.A., Matsunaga S., Uchiyama S., Fukui K. Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells. Biochem. J. 2008;415:345-351.

     Not in our library10.1042/bj20081411

225. 225.

     Frémont S., Gérard A., Galloux M., Janvier K., Karess R.E., Berlioz-Torrent C. Beclin-1 is required for chromosome congression and proper outer kinetochore assembly. EMBO Rep. 2013;14:364-372.

     Not in our library10.1038/embor.2013.23

226. 226.

     Ritchie K., Seah C., Moulin J., Isaac C., Dick F., Bérubé N.G. Loss of ATRX leads to chromosome cohesion and congression defects. J. Cell Biol. 2008;180:315-324.

     Not in our library10.1083/jcb.200706083

227. 227.

     Santamaria A., Nagel S., Sillje H.H.W., Nigg E.A. The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Curr. Biol. 2008;18:723-729.

     Not in our library10.1016/j.cub.2008.04.041

228. 228.

     Dunsch A.K., Hammond D., Lloyd J., Schermelleh L., Gruneberg U., Barr F.A. Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. J. Cell Biol. 2012;198:1039-1054.

     Not in our library10.1083/jcb.201202112

229. 229.

     Kukkonen-Macchi A., Sicora O., Kaczynska K., Oetken-Lindholm C., Pouwels J., Laine L., Kallio M.J. Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death. J. Cell Sci. 2011;124:216-227.

     Not in our library10.1242/jcs.068254

230. 230.

     Archinti M., Lacasa C., Teixidó-Travesa N., Lüders J. SPICE—A previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. J. Cell Sci. 2010;123:3039-3046.

     Not in our library10.1242/jcs.069963

231. 231.

     Li Y., Yu W., Liang Y., Zhu X. Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Cell Res. 2007;17:701-712.

     Not in our library10.1038/cr.2007.65

232. 232.

     Yang Z., Tulu U.S., Wadsworth P., Rieder C.L. Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Curr. Biol. 2007;17:973-980.

     Not in our library10.1016/j.cub.2007.04.056

233. 233.

     Shrestha R.L., Tamura N., Fries A., Levin N., Clark J., Draviam V.M. TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes. Open Biol. 2014;4:130108.

     Not in our library10.1098/rsob.130108

234. 234.

     Carleton M., Mao M., Biery M., Warrener P., Kim S., Buser C., Marshall C.G., Fernandes C., Annis J., Linsley P.S. RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure. Mol. Cell. Biol. 2006;26:3853-3863.

     Not in our library10.1128/mcb.26.10.3853-3863.2006

235. 235.

     Prendergast L., van Vuuren C., Kaczmarczyk A., Doering V., Hellwig D., Quinn N., Hoischen C., Diekmann S., Sullivan K.F. Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State. PLoS Biol. 2011;9:e1001082.

     Not in our library10.1371/journal.pbio.1001082

236. 236.

     Kaczmarczyk A., Sullivan K.F. CENP-W Plays a Role in Maintaining Bipolar Spindle Structure. PLoS ONE. 2014;9:e106464.

     Not in our library10.1371/journal.pone.0106464

237. 237.

     Chun Y., Kim R., Lee S. Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells. PLoS ONE. 2016;11:e0149127.

     Not in our library10.1371/journal.pone.0149127

238. 238.

     Foltz D.R., Jansen L.E., Black B.E., Bailey A.O., Yates J.R., Cleveland D.W. The human CENP-A centromeric nucleosome-associated complex. Nat. Cell Biol. 2006;8:458-469.

     Not in our library10.1038/ncb1397

239. 239.

     McClelland S.E., Borusu S., Amaro A.C., Winter J.R., Belwal M., McAinsh A.D., Meraldi P. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J. 2007;26:5033-5047.

     Not in our library10.1038/sj.emboj.7601927

240. 240.

     McAinsh A.D., Meraldi P., Draviam V.M., Toso A., Sorger P.K. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J. 2006;25:4033-4049.

     Not in our library10.1038/sj.emboj.7601293

241. 241.

     Bancroft J., Auckland P., Samora C.P., McAinsh A.D. Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. J. Cell Sci. 2015;128:171-184.

     Not in our library10.1242/jcs.163659

242. 242.

     Hua S., Wang Z., Jiang K., Huang Y., Ward T., Zhao L., Dou Z., Yao X. CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment. J. Biol. Chem. 2011;286:1627-1638.

     Not in our library10.1074/jbc.m110.174946

243. 243.
     The pseudo GTPase CENP-M drives human kinetochore assembly · 2014

     No notice
244. 244.

     Zhu M., Wang F., Yan F., Yao P.Y., Du J., Gao X., Wang X., Wu Q., Ward T., Li J., et al. Septin 7 Interacts with Centromere-associated Protein E and Is Required for Its Kinetochore Localization. J. Biol. Chem. 2008;283:18916-18925.

     Not in our library10.1074/jbc.m710591200

245. 245.

     Milev M.P., Hasaj B., Saint-Dic D., Snounou S., Zhao Q., Sacher M. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. J. Cell Biol. 2015;209:221-234.

     Not in our library10.1083/jcb.201501090

246. 246.

     Liu X., Zheng H., Qu C.-K. Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability. Cancer Res. 2012;72:5296-5306.

     Not in our library10.1158/0008-5472.can-12-1495

247. 247.

     Liu X., Zheng H., Li X., Wang S., Meyerson H.J., Yang W., Neel B.G., Qu C.-K. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proc. Natl. Acad. Sci. USA. 2016;113:984-989.

     Not in our library10.1073/pnas.1508535113

248. 248.

     Porter I.M., McClelland S.E., Khoudoli G.A., Hunter C.J., Andersen J.S., McAinsh A.D., Blow J.J., Swedlow J.R. Bod1, a novel kinetochore protein required for chromosome biorientation. J. Cell Biol. 2007;179:187-197.

     Not in our library10.1083/jcb.200704098

249. 249.

     Porter I.M., Schleicher K., Porter M., Swedlow J.R. Bod1 regulates protein phosphatase 2A at mitotic kinetochores. Nat. Commun. 2013;4:2677.

     Not in our library10.1038/ncomms3677

250. 250.

     He J., Zhang Z., Ouyang M., Yang F., Hao H., Lamb K.L., Yang J., Yin Y., Shen W.H. PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nat. Commun. 2016;7:12335.

     Not in our library10.1038/ncomms12355

251. 251.

     Park Y.Y., Nam H.-J., Do M., Lee J.-H. The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles. Exp. Mol. Med. 2016;48:e250.

     Not in our library10.1038/emm.2016.61

252. 252.

     Vigneron S., Brioudes E., Burgess A., Labbé J.C., Lorca T., Castro A. RSK2 is a kinetochore-associated protein that participates in the spindle assembly checkpoint. Oncogene. 2010;29:3566-3574.

     Not in our library10.1038/onc.2010.105

253. 253.

     Willard F.S., Crouch M.F. MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: A role for the MAP kinase pathway in regulating mitotic exit. Cell. Signal. 2001;13:653-664.

     Not in our library10.1016/s0898-6568(01)00185-1

254. 254.

     Hashizume C., Moyori A., Kobayashi A., Yamakoshi N., Endo A., Wong R.W. Nucleoporin Nup62 maintains centrosome homeostasis. Cell Cycle. 2013;12:3804-3816.

     Not in our library10.4161/cc.26671

255. 255.

     Wu Z., Jin Z., Zhang X., Shen N., Wang J., Zhao Y., Mei L. Nup62, associated with spindle microtubule rather than spindle matrix, is involved in chromosome alignment and spindle assembly during mitosis. Cell Biol. Int. 2016;40:968-975.

     Not in our library10.1002/cbin.10633

256. 256.

     Kwon H.J., Park J.E., Song H., Jang C.-Y. DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics. J. Cell Sci. 2016;129:2719-2725.

     Not in our library10.1242/jcs.180109

257. 257.

     Kim S., Jang C.-Y. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. Biochem. Biophys. Res. Commun. 2016;470:484-491.

     Not in our library10.1016/j.bbrc.2016.01.144

258. 258.

     Koliou X., Fedonidis C., Kalpachidou T., Mangoura D. Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression. J. Neurochem. 2016;136:78-91.

     Not in our library10.1111/jnc.13401

259. 259.

     O’Regan L., Sampson J., Richards M.W., Knebel A., Roth D., Hood F.E., Straube A., Royle S.J., Bayliss R., Fry A.M. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J. Cell Biol. 2015;209:349-358.

     Not in our library10.1083/jcb.201409151

260. 260.

     de Souza E.E., Hehnly H., Perez A.M., Meirelles G.V., Smetana J.H.C., Doxsey S., Kobarg J. Human Nek7-interactor RGS2 is required for mitotic spindle organization. Cell Cycle. 2015;14:656-667.

     Not in our library10.4161/15384101.2014.994988

261. 261.

     Foley E.A., Maldonado M., Kapoor T.M. Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Nat. Cell Biol. 2011;13:1265-1271.

     Not in our library10.1038/ncb2327

262. 262.

     Kitajima T.S., Sakuno T., Ishiguro K.-i., Iemura S.-i., Natsume T., Kawashima S.A., Watanabe Y. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature. 2006;441:46-52.

     Not in our library10.1038/nature04663

263. 263.

     Jaramillo-Lambert A., Hao J., Xiao H., Li Y., Han Z., Zhu W. Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres. J. Biol. Chem. 2013;288:1480-1488.

     Not in our library10.1074/jbc.m112.429266

264. 264.

     Lee M.H., Lin L., Equilibrina I., Uchiyama S., Matsunaga S., Fukui K. ASURA (PHB2) Is Required for Kinetochore Assembly and Subsequent Chromosome Congression. Acta Histochem. Cytochem. 2011;44:247-258.

     Not in our library10.1267/ahc.11033

265. 265.

     Oh H.J., Kim M.J., Song S.J., Kim T., Lee D., Kwon S.-H., Choi E.-J., Lim D.-S. MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr. Biol. 2010;20:416-422.

     Not in our library10.1016/j.cub.2009.12.054

266. 266.

     Shimizu H., Nagamori I., Yabuta N., Nojima H. GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression. J. Cell Sci. 2009;122:3145-3152.

     Not in our library10.1242/jcs.052795

267. 267.

     Zhuo X., Guo X., Zhang X., Jing G., Wang Y., Chen Q., Jiang Q., Liu J., Zhang C. Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. J. Cell Biol. 2015;210:727-735.

     Not in our library10.1083/jcb.201502044

268. 268.

     Pfarr C.M., Coue M., Grissom P.M., Hays T.S., Porter M.E., McIntosh J.R. Cytoplasmic dynein is localized to kinetochores during mitosis. Nature. 1990;345:263-265.

     Not in our library10.1038/345263a0

269. 269.

     Steuer E.R., Wordeman L., Schroer T.A., Sheetz M.P. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature. 1990;345:266-268.

     Not in our library10.1038/345266a0

270. 270.

     Maiato H., Lince-Faria M. The perpetual movements of anaphase. Cell Mol. Life Sci. 2010;67:2251-2269.

     Not in our library10.1007/s00018-010-0327-5

271. 271.

     King J.M., Hays T.S., Nicklas R.B. Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension. J. Cell Biol. 2000;151:739-748.

     Not in our library10.1083/jcb.151.4.739

272. 272.

     Wojcik E., Basto R., Serr M., Scaerou F., Karess R., Hays T. Kinetochore dynein: Its dynamics and role in the transport of the Rough deal checkpoint protein. Nat. Cell Biol. 2001;3:1001-1007.

     Not in our library10.1038/ncb1101-1001

273. 273.

     Lombillo V.A., Nislow C., Yen T.J., Gelfand V.I., McIntosh J.R. Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro. J. Cell Biol. 1995;128:107-115.

     Not in our library10.1083/jcb.128.1.107

274. 274.

     Lombillo V.A., Stewart R.J., McIntosh J.R. Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization. Nature. 1995;373:161-164.

     Not in our library10.1038/373161a0

275. 275.

     Schneider B. Über die umordunug der chromosomen bei der mitose. Z. Zellf Mikr Anat. 1933;17:255-312.

     Not in our library10.1007/bf00374044

276. 276.
     Cine-Micrographic studies on mitosis in endosperm. I. [Badania kinematograficzne nad mitozą w endospermie. I.] · 2017

     Not checked
277. 277.

     Bajer A., Molè-Bajer J. Cine-micrographic studies on mitosis in endosperm. II. Chromosoma. 1956;7:558-607.

     Not in our library10.1007/bf00329742

278. 278.

     Uretz R.B., Bloom W., Zirkle R.E. Irradiation of parts of individual cells. II. Effects of an ultraviolet microbeam focused on parts of chromosomes. Science. 1954;120:197-199.

     Not in our library10.1126/science.120.3110.197

279. 279.

     Bloom W., Zirkle R.E., Uretz R.B. Irradiation of parts of individual cells. III. Effects of chromosomal and extrachromosomal irradiation on chromosome movements. Ann. N. Y. Acad. Sci. 1955;59:503-513.

     Not in our library10.1111/j.1749-6632.1955.tb45966.x

280. 280.

     Zirkle R.E. Partial-cell irradiation. Adv. Biol. Med. Phys. 1957;5:103-146.

     Not in our library10.1016/b978-1-4832-3111-2.50007-9

281. 281.

     Rickards G.K. Prophase chromosome movements in living house cricket spermatocytes and their relationship to prometaphase, anaphase and granule movements. Chromosoma. 1975;49:407-455.

     Not in our library10.1007/bf00285133

282. 282.

     Roos U.P. Light and electron microscopy of rat kangaroo cells in mitosis. III. Patterns of chromosome behavior during prometaphase. Chromosoma. 1976;54:363-385.

     Not in our library10.1007/bf00292816

283. 283.

     Rieder C.L., Alexander S.P. Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J. Cell Biol. 1990;110:81-95.

     Not in our library10.1083/jcb.110.1.81

284. 284.

     Merdes A., De Mey J. The mechanism of kinetochore-spindle attachment and polewards movement analyzed in PtK2 cells at the prophase-prometaphase transition. Eur. J. Cell Biol. 1990;53:313-325.

     Not in our library

285. 285.

     Wordeman L., Steuer E.R., Sheetz M.P., Mitchison T. Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes. J. Cell Biol. 1991;114:285-294.

     Not in our library10.1083/jcb.114.2.285

286. 286.

     Vorozhko V.V., Emanuele M.J., Kallio M.J., Stukenberg P.T., Gorbsky G.J. Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma. 2008;117:169-179.

     Not in our library10.1007/s00412-007-0135-3

287. 287.

     Mitchison T.J., Kirschner M.W. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J. Cell Biol. 1985;101:766-777.

     Not in our library10.1083/jcb.101.3.766

288. 288.

     Hyman A.A., Mitchison T.J. Two different microtubule-based motor activities with opposite polarities in kinetochores. Nature. 1991;351:206-211.

     Not in our library10.1038/351206a0

289. 289.

     Yen T.J., Compton D.A., Wise D., Zinkowski R.P., Brinkley B.R., Earnshaw W.C., Cleveland D.W. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 1991;10:1245-1254.

     Not in our library10.1002/j.1460-2075.1991.tb08066.x

290. 290.

     Yen T.J., Li G., Schaar B.T., Szilak I., Cleveland D.W. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature. 1992;359:536-539.

     Not in our library10.1038/359536a0

291. 291.

     Yao X., Anderson K.L., Cleveland D.W. The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules. J. Cell Biol. 1997;139:435-447.

     Not in our library10.1083/jcb.139.2.435

292. 292.

     Cooke C.A., Schaar B., Yen T.J., Earnshaw W.C. Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase. Chromosoma. 1997;106:446-455.

     Not in our library10.1007/s004120050266

293. 293.

     Wood K.W., Sakowicz R., Goldstein L.S., Cleveland D.W. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell. 1997;91:357-366.

     Not in our library10.1016/s0092-8674(00)80419-5

294. 294.

     Yao X., Abrieu A., Zheng Y., Sullivan K.F., Cleveland D.W. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat. Cell Biol. 2000;2:484-491.

     Not in our library10.1038/35019518

295. 295.

     Schaar B.T., Chan G.K., Maddox P., Salmon E.D., Yen T.J. CENP-E function at kinetochores is essential for chromosome alignment. J. Cell Biol. 1997;139:1373-1382.

     Not in our library10.1083/jcb.139.6.1373

296. 296.

     Yucel J.K., Marszalek J.D., McIntosh J.R., Goldstein L.S., Cleveland D.W., Philp A.V. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J. Cell Biol. 2000;150:1-11.

     Not in our library10.1083/jcb.150.1.1

297. 297.

     McEwen B.F., Chan G.K., Zubrowski B., Savoian M.S., Sauer M.T., Yen T.J. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol. Biol. Cell. 2001;12:2776-2789.

     Not in our library10.1091/mbc.12.9.2776

298. 298.

     Putkey F.R., Cramer T., Morphew M.K., Silk A.D., Johnson R.S., McIntosh J.R., Cleveland D.W. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev. Cell. 2002;3:351-365.

     Not in our library10.1016/s1534-5807(02)00255-1

299. 299.

     Cleveland D.W., Mao Y., Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell. 2003;112:407-421.

     Not in our library10.1016/s0092-8674(03)00115-6

300. 300.

     Kapoor T.M., Lampson M.A., Hergert P., Cameron L., Cimini D., Salmon E.D., McEwen B.F., Khodjakov A. Chromosomes can congress to the metaphase plate before biorientation. Science. 2006;311:388-391.

     Not in our library10.1126/science.1122142

301. 301.

     Espeut J., Gaussen A., Bieling P., Morin V., Prieto S., Fesquet D., Surrey T., Abrieu A. Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E. Mol. Cell. 2008;29:637-643.

     Not in our library10.1016/j.molcel.2008.01.004

302. 302.

     Kim Y., Heuser J.E., Waterman C.M., Cleveland D.W. CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J. Cell Biol. 2008;181:411-419.

     Not in our library10.1083/jcb.200802189

303. 303.

     Gudimchuk N., Vitre B., Kim Y., Kiyatkin A., Cleveland D.W., Ataullakhanov F.I., Grishchuk E.L. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nat. Cell Biol. 2013;15:1079-1088.

     Not in our library10.1038/ncb2831

304. 304.

     Vitre B., Gudimchuk N., Borda R., Kim Y., Heuser J.E., Cleveland D.W., Grishchuk E.L. Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E. Mol. Biol. Cell. 2014;25:2272-2281.

     Not in our library10.1091/mbc.e14-01-0698

305. 305.

     Cai S., O’Connell C.B., Khodjakov A., Walczak C.E. Chromosome congression in the absence of kinetochore fibres. Nat. Cell Biol. 2009;11:832-838.

     Not in our library10.1038/ncb1890

306. 306.

     Roos U.P. Light and electron microscopy of rat kangaroo cells in mitosis. II. Kinetochore structure and function. Chromosoma. 1973;41:195-220.

     Not in our library10.1007/bf00319696

307. 307.

     Magidson V., Paul R., Yang N., Ault J.G., O’Connell C.B., Tikhonenko I., McEwen B.F., Mogilner A., Khodjakov A. Adaptive changes in the kinetochore architecture facilitate proper spindle assembly. Nat. Cell Biol. 2015;17:1134-1144.

     Not in our library10.1038/ncb3223

308. 308.

     Maddox P.S., Oegema K., Desai A., Cheeseman I.M. Holoer than thou: Chromosome segregation and kinetochore function in C. elegans. Chromosome Res. 2004;12:641-653.

     Not in our library10.1023/b:chro.0000036588.42225.2f

309. 309.

     Powers J., Rose D.J., Saunders A., Dunkelbarger S., Strome S., Saxton W.M. Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes. J. Cell Biol. 2004;166:991-1001.

     Not in our library10.1083/jcb.200403036

310. 310.

     Rieder C.L., Cole R.W., Khodjakov A., Sluder G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 1995;130:941-948.

     Not in our library10.1083/jcb.130.4.941

311. 311.

     Brenner S.L., Liaw L.H., Berns M.W. Laser microirradiation of kinetochores in mitotic PtK2 cells: Chromatid separation and micronucleus formation. Cell Biophys. 1980;2:139-152.

     Not in our library10.1007/bf02795840

312. 312.

     Brinkley B.R., Zinkowski R.P., Mollon W.L., Davis F.M., Pisegna M.A., Pershouse M., Rao P.N. Movement and segregation of kinetochores experimentally detached from mammalian chromosomes. Nature. 1988;336:251-254.

     Not in our library10.1038/336251a0

313. 313.

     Wise D.A., Brinkley B.R. Mitosis in cells with unreplicated genomes (MUGs): Spindle assembly and behavior of centromere fragments. Cell Motil Cytoskeleton. 1997;36:291-302.

     Not in our library10.1002/(sici)1097-0169(1997)36:3<291::aid-cm9>3.0.co;2-a

314. 314.

     O’Connell C.B., Loncarek J., Hergert P., Kourtidis A., Conklin D.S., Khodjakov A. The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes. J. Cell Biol. 2008;183:29-36.

     Not in our library10.1083/jcb.200801038

315. 315.

     Khodjakov A., Cole R.W., McEwen B.F., Buttle K.F., Rieder C.L. Chromosome fragments possessing only one kinetochore can congress to the spindle equator. J. Cell Biol. 1997;136:229-240.

     Not in our library10.1083/jcb.136.2.229

316. 316.

     Barisic M., Maiato H. Dynein prevents erroneous kinetochore-microtubule attachments in mitosis. Cell Cycle. 2015;14:3356-3361.

     Not in our library10.1080/15384101.2015.1089369

317. 317.

     Iemura K., Tanaka K. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. Nat. Commun. 2015;6:6447.

     Not in our library10.1038/ncomms7447

318. 318.

     Nousiainen M., Silljé H.H.W., Sauer G., Nigg E.A., Körner R. Phosphoproteome analysis of the human mitotic spindle. Proc. Natl. Acad. Sci. USA. 2006;103:5391-5396.

     Not in our library10.1073/pnas.0507066103

319. 319.

     Liao H., Li G., Yen T.J. Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein. Science. 1994;265:394-398.

     Not in our library10.1126/science.8023161

320. 320.

     Zecevic M., Catling A.D., Eblen S.T., Renzi L., Hittle J.C., Yen T.J., Gorbsky G.J., Weber M.J. Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E. J. Cell Biol. 1998;142:1547-1558.

     Not in our library10.1083/jcb.142.6.1547

321. 321.

     Kim Y., Holland A.J., Lan W., Cleveland D.W. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell. 2010;142:444-455.

     Not in our library10.1016/j.cell.2010.06.039

322. 322.

     Whyte J., Bader J.R., Tauhata S.B., Raycroft M., Hornick J., Pfister K.K., Lane W.S., Chan G.K., Hinchcliffe E.H., Vaughan P.S., et al. Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J. Cell Biol. 2008;183:819-834.

     Not in our library10.1083/jcb.200804114

323. 323.

     Bader J.R., Kasuboski J.M., Winding M., Vaughan P.S., Hinchcliffe E.H., Vaughan K.T. Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis. J Biol. Chem. 2011;286:20769-20777.

     Not in our library10.1074/jbc.m111.226605

324. 324.

     Kardon J.R., Reck-Peterson S.L., Vale R.D. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc. Natl. Acad. Sci. USA. 2009;106:5669-5674.

     Not in our library10.1073/pnas.0900976106

325. 325.

     McKenney R.J., Huynh W., Tanenbaum M.E., Bhabha G., Vale R.D. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014;345:337-341.

     Not in our library10.1126/science.1254198

326. 326.

     Zhang X.-D., Goeres J., Zhang H., Yen T.J., Porter A.C.G., Matunis M.J. SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Mol. Cell. 2008;29:729-741.

     Not in our library10.1016/j.molcel.2008.01.013

327. 327.

     Ashar H.R., James L., Gray K., Carr D., Black S., Armstrong L., Bishop W.R., Kirschmeier P. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J. Biol. Chem. 2000;275:30451-30457.

     Not in our library10.1074/jbc.m003469200

328. 328.

     Schafer-Hales K., Iaconelli J., Snyder J.P., Prussia A., Nettles J.H., El-Naggar A., Khuri F.R., Giannakakou P., Marcus A.I. Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function. Mol. Cancer Ther. 2007;6:1317-1328.

     Not in our library10.1158/1535-7163.mct-06-0703

329. 329.

     Crespo N.C., Ohkanda J., Yen T.J., Hamilton A.D., Sebti S.M. The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. J. Biol. Chem. 2001;276:16161-16167.

     Not in our library10.1074/jbc.m006213200

330. 330.

     Crespo N.C., Delarue F., Ohkanda J., Carrico D., Hamilton A.D., Sebti S.M. The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. Cell Death Differ. 2002;9:702-709.

     Not in our library10.1038/sj.cdd.4401023

331. 331.

     Hussein D., Taylor S.S. Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J. Cell Sci. 2002;115:3403-3414.

     Not in our library10.1242/jcs.115.17.3403

332. 332.

     Brown K.D., Coulson R.M., Yen T.J., Cleveland D.W. Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. J. Cell Biol. 1994;125:1303-1312.

     Not in our library10.1083/jcb.125.6.1303

333. 333.

     Gurden M.D.J., Holland A.J., van Zon W., Tighe A., Vergnolle M.A., Andres D.A., Spielmann H.P., Malumbres M., Wolthuis R.M.F., Cleveland D.W., et al. Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell Sci. 2010;123:321-330.

     Not in our library10.1242/jcs.062075

334. 334.

     Holland A.J., Reis R.M., Niessen S., Pereira C., Andres D.A., Spielmann H.P., Cleveland D.W., Desai A., Gassmann R. Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol. Biol. Cell. 2015;26:1845-1856.

     Not in our library10.1091/mbc.e14-11-1560

335. 335.

     Moudgil D.K., Westcott N., Famulski J.K., Patel K., Macdonald D., Hang H., Chan G.K.T. A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores. J. Cell Biol. 2015;208:881-896.

     Not in our library10.1083/jcb.201412085

336. 336.

     Hewitt L., Tighe A., Santaguida S., White A.M., Jones C.D., Musacchio A., Green S., Taylor S.S. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J. Cell Biol. 2010;190:25-34.

     Not in our library10.1083/jcb.201002133

337. 337.

     Jelluma N., Brenkman A.B., van den Broek N.J.F., Cruijsen C.W.A., van Osch M.H.J., Lens S.M.A., Medema R.H., Kops G.J.P.L. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008;132:233-246.

     Not in our library10.1016/j.cell.2007.11.046

338. 338.

     Maure J.-F., Kitamura E., Tanaka T.U. Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism. Curr. Biol. 2007;17:2175-2182.

     Not in our library10.1016/j.cub.2007.11.032

339. 339.
     Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression. · 2014

     Not checked
340. 340.

     Maciejowski J., George K.A., Terret M.-E., Zhang C., Shokat K.M., Jallepalli P.V. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J. Cell Biol. 2010;190:89-100.

     Not in our library10.1083/jcb.201001050

341. 341.

     Santaguida S., Tighe A., D’Alise A.M., Taylor S.S., Musacchio A. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J. Cell Biol. 2010;190:73-87.

     Not in our library10.1083/jcb.201001036

342. 342.

     Abrieu A., Magnaghi-Jaulin L., Kahana J.A., Peter M., Castro A., Vigneron S., Lorca T., Cleveland D.W., Labbe J.C. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Cell. 2001;106:83-93.

     Not in our library10.1016/s0092-8674(01)00410-x

343. 343.

     Verhey K.J., Gaertig J. The tubulin code. Cell Cycle. 2007;6:2152-2160.

     Not in our library10.4161/cc.6.17.4633

344. 344.

     Janke C. The tubulin code: Molecular components, readout mechanisms, and functions. J. Cell Biol. 2014;206:461-472.

     Not in our library10.1083/jcb.201406055

345. 345.

     Barisic M., Silva e Sousa R., Tripathy S.K., Magiera M.M., Zaytsev A.V., Pereira A.L., Janke C., Grishchuk E.L., Maiato H. Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Science. 2015;348:799-803.

     Not in our library10.1126/science.aaa5175

346. 346.

     Barisic M., Maiato H. The Tubulin Code: A Navigation System for Chromosomes during Mitosis. Trends Cell Biol. 2016;26:766-775.

     Not in our library10.1016/j.tcb.2016.06.001

347. 347.

     Park I.Y., Powell R.T., Tripathi D.N., Dere R., Ho T.H., Blasius T.L., Chiang Y.C., Davis I.J., Fahey C.C., Hacker K.E., et al. Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell. 2016;166:950-962.

     Not in our library10.1016/j.cell.2016.07.005

348. 348.

     Hammond J.W., Huang C.F., Kaech S., Jacobson C., Banker G., Verhey K.J. Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons. Mol. Biol. Cell. 2010;21:572-583.

     Not in our library10.1091/mbc.e09-01-0044

349. 349.

     Konishi Y., Setou M. Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Nat. Neurosci. 2009;12:559-567.

     Not in our library10.1038/nn.2314

350. 350.

     Maas C., Belgardt D., Lee H.K., Heisler F.F., Lappe-Siefke C., Magiera M.M., van Dijk J., Hausrat T.J., Janke C., Kneussel M. Synaptic activation modifies microtubules underlying transport of postsynaptic cargo. Proc. Natl. Acad. Sci. USA. 2009;106:8731-8736.

     Not in our library10.1073/pnas.0812391106

351. 351.

     Reed N.A., Cai D., Blasius T.L., Jih G.T., Meyhofer E., Gaertig J., Verhey K.J. Microtubule acetylation promotes kinesin-1 binding and transport. Curr. Biol. 2006;16:2166-2172.

     Not in our library10.1016/j.cub.2006.09.014

352. 352.

     Kaul N., Soppina V., Verhey K.J. Effects of alpha-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system. Biophys. J. 2014;106:2636-2643.

     Not in our library10.1016/j.bpj.2014.05.008

353. 353.

     Sirajuddin M., Rice L.M., Vale R.D. Regulation of microtubule motors by tubulin isotypes and post-translational modifications. Nat. Cell Biol. 2014;16:335-344.

     Not in our library10.1038/ncb2920

354. 354.

     Bobinnec Y., Moudjou M., Fouquet J.P., Desbruyeres E., Edde B., Bornens M. Glutamylation of centriole and cytoplasmic tubulin in proliferating non-neuronal cells. Cell Motil. Cytoskeleton. 1998;39:223-232.

     Not in our library10.1002/(sici)1097-0169(1998)39:3<223::aid-cm5>3.0.co;2-5

355. 355.

     Gundersen G.G., Bulinski J.C. Distribution of tyrosinated and nontyrosinated α-tubulin during mitosis. J. Cell Biol. 1986;102:1118-1126.

     Not in our library10.1083/jcb.102.3.1118

356. 356.

     Gundersen G.G., Kalnoski M.H., Bulinski J.C. Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo. Cell. 1984;38:779-789.

     Not in our library10.1016/0092-8674(84)90273-3

357. 357.

     Wilson P.J., Forer A. Effects of nanomolar taxol on crane-fly spermatocyte spindles indicate that acetylation of kinetochore microtubules can be used as a marker of poleward tubulin flux. Cell Motil. Cytoskeleton. 1997;37:20-32.

     Not in our library10.1002/(sici)1097-0169(1997)37:1<20::aid-cm3>3.0.co;2-l

358. 358.

     McKenney R.J., Huynh W., Vale R.D., Sirajuddin M. Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. 2016;35:1175-1185.

     Not in our library10.15252/embj.201593071

359. 359.
     α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons · 2016

     Not checked
360. 360.

     Peris L., Thery M., Faure J., Saoudi Y., Lafanechere L., Chilton J.K., Gordon-Weeks P., Galjart N., Bornens M., Wordeman L., et al. Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. J. Cell Biol. 2006;174:839-849.

     Not in our library10.1083/jcb.200512058

361. 361.

     Kubo T., Yanagisawa H.A., Yagi T., Hirono M., Kamiya R. Tubulin polyglutamylation regulates axonemal motility by modulating activities of inner-arm dyneins. Curr. Biol. 2010;20:441-445.

     Not in our library10.1016/j.cub.2009.12.058

362. 362.

     Wang Z., Sheetz M.P. The C-terminus of tubulin increases cytoplasmic dynein and kinesin processivity. Biophys. J. 2000;78:1955-1964.

     Not in our library10.1016/s0006-3495(00)76743-9

363. 363.

     Alper J.D., Decker F., Agana B., Howard J. The motility of axonemal dynein is regulated by the tubulin code. Biophys. J. 2014;107:2872-2880.

     Not in our library10.1016/j.bpj.2014.10.061

364. 364.

     Sardar H.S., Gilbert S.P. Microtubule capture by mitotic kinesin centromere protein E (CENP-E). J. Biol. Chem. 2012;287:24894-24904.

     Not in our library10.1074/jbc.m112.376830

365. 365.

     Belyy V., Schlager M.A., Foster H., Reimer A.E., Carter A.P., Yildiz A. The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition. Nat. Cell Biol. 2016;18:1018-1024.

     Not in our library10.1038/ncb3393

366. 366.

     Iniguez A., Allard J. Spatial pattern formation in microtubule post-translational modifications and the tight localization of motor-driven cargo. J. Math. Biol. 2016.

     Not in our library10.1007/s00285-016-1053-x

367. 367.

     Skiniotis G., Cochran J.C., Muller J., Mandelkow E., Gilbert S.P., Hoenger A. Modulation of kinesin binding by the C-termini of tubulin. EMBO J. 2004;23:989-999.

     Not in our library10.1038/sj.emboj.7600118

368. 368.

     Neumann E., Garcia-Saez I., DeBonis S., Wade R.H., Kozielski F., Conway J.F. Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bound to microtubules. J. Mol. Biol. 2006;362:203-211.

     Not in our library10.1016/j.jmb.2006.07.042

369. 369.

     Garcia-Saez I., Yen T., Wade R.H., Kozielski F. Crystal structure of the motor domain of the human kinetochore protein CENP-E. J. Mol. Biol. 2004;340:1107-1116.

     Not in our library10.1016/j.jmb.2004.05.053

370. 370.

     Musinipally V., Howes S., Alushin G.M., Nogales E. The microtubule binding properties of CENP-E’s C-terminus and CENP-F. J. Mol. Biol. 2013;425:4427-4441.

     Not in our library10.1016/j.jmb.2013.07.027

371. 371.

     Wang Q., Crevenna A.H., Kunze I., Mizuno N. Structural basis for the extended CAP-Gly domains of p150(glued) binding to microtubules and the implication for tubulin dynamics. Proc. Natl. Acad. Sci. USA. 2014;111:11347-11352.

     Not in our library10.1073/pnas.1403135111

372. 372.

     Yan S., Guo C., Hou G., Zhang H., Lu X., Williams J.C., Polenova T. Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy. Proc. Natl. Acad. Sci. USA. 2015;112:14611-14616.

     Not in our library10.1073/pnas.1509852112

373. 373.

     Pereira A.J., Matos I., Lince-Faria M., Maiato H. Dissecting mitosis with laser microsurgery and RNAi in Drosophila cells. Methods Mol. Biol. 2009;545:145-164.

     Not in our library10.1007/978-1-60327-993-2_9

374. 374.

     McIntosh J.R., Hepler P.K., Van Wie D.G. Model for mitosis. Nature. 1969;224:659-663.

     Not in our library10.1038/224659a0

375. 375.

     Goode D. Microtubule turnover as a mechanism of mitosis and its possible evolution. Biosystems. 1981;14:271-287.

     Not in our library10.1016/0303-2647(81)90034-4

376. 376.

     Margolis R.L., Wilson L., Keifer B.I. Mitotic mechanism based on intrinsic microtubule behaviour. Nature. 1978;272:450-452.

     Not in our library10.1038/272450a0

377. 377.

     Nicklas R.B., Kubai D.F., Hays T.S. Spindle microtubules and their mechanical associations after micromanipulation in anaphase. J. Cell Biol. 1982;95:91-104.

     Not in our library10.1083/jcb.95.1.91

378. 378.

     Mastronarde D.N., McDonald K.L., Ding R., McIntosh J.R. Interpolar spindle microtubules in PTK cells. J. Cell Biol. 1993;123:1475-1489.

     Not in our library10.1083/jcb.123.6.1475

379. 379.

     Shimamoto Y., Maeda Y.T., Ishiwata S., Libchaber A.J., Kapoor T.M. Insights into the micromechanical properties of the metaphase spindle. Cell. 2011;145:1062-1074.

     Not in our library10.1016/j.cell.2011.05.038

380. 380.

     Vladimirou E., McHedlishvili N., Gasic I., Armond J.W., Samora C.P., Meraldi P., McAinsh A.D. Nonautonomous Movement of Chromosomes in Mitosis. Dev. Cell. 2013;27:60-71.

     Not in our library10.1016/j.devcel.2013.08.004

381. 381.

     Pereira A.J., Maiato H. Maturation of the kinetochore-microtubule interface and the meaning of metaphase. Chromosome Res. 2012;20:563-577.

     Not in our library10.1007/s10577-012-9298-8

382. 382.

     Cross R.A., McAinsh A. Prime movers: The mechanochemistry of mitotic kinesins. Nat. Rev. Mol. Cell Biol. 2014;15:257-271.

     Not in our library10.1038/nrm3768

383. 383.

     Royle S.J. The role of clathrin in mitotic spindle organisation. J. Cell Sci. 2012;125:19-28.

     Not in our library10.1242/jcs.094607

384. 384.

     Maiato H., Sampaio P., Sunkel C.E. Microtubule-associated proteins and their essential roles during mitosis. Int. Rev. Cytol. 2004;241:53-153.

     Not in our library10.1016/s0074-7696(04)41002-x

385. 385.

     Hoffman D.B., Pearson C.G., Yen T.J., Howell B.J., Salmon E.D. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol. Biol. Cell. 2001;12:1995-2009.

     Not in our library10.1091/mbc.12.7.1995

386. 386.

     Ohashi A., Ohori M., Iwai K., Nambu T., Miyamoto M., Kawamoto T., Okaniwa M. A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity. PLoS ONE. 2015;10:e0144675.

     Not in our library10.1371/journal.pone.0144675

387. 387.

     Gorbsky G.J. Cohesion fatigue. Curr. Biol. 2013;23:R986-R988.

     Not in our library10.1016/j.cub.2013.08.017

388. 388.

     Daum J.R., Potapova T.A., Sivakumar S., Daniel J.J., Flynn J.N., Rankin S., Gorbsky G.J. Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr. Biol. 2011;21:1018-1024.

     Not in our library10.1016/j.cub.2011.05.032

389. 389.

     Bannigan A., Lizotte-Waniewski M., Riley M., Baskin T.I. Emerging molecular mechanisms that power and regulate the anastral mitotic spindle of flowering plants. Cell Motil. Cytoskelet. 2008;65:1-11.

     Not in our library10.1002/cm.20247

390. 390.

     Yamada M., Goshima G. Mitotic spindle assembly in land plants: Molecules and mechanisms. Biology. 2017;6:6.

     Not in our library10.3390/biology6010006

391. 391.

     Khodjakov A., Cole R.W., Bajer A.S., Rieder C.L. The force for poleward chromosome motion in Haemanthus cells acts along the length of the chromosome during metaphase but only at the kinetochore during anaphase. J. Cell Biol. 1996;132:1093-1104.

     Not in our library10.1083/jcb.132.6.1093

392. 392.

     Schuh M., Ellenberg J. Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes. Cell. 2007;130:484-498.

     Not in our library10.1016/j.cell.2007.06.025

393. 393.

     Dumont J., Desai A. Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis. Trends Cell Biol. 2012;22:241-249.

     Not in our library10.1016/j.tcb.2012.02.007

394. 394.

     Bennabi I., Terret M.E., Verlhac M.H. Meiotic spindle assembly and chromosome segregation in oocytes. J. Cell Biol. 2016;215:611-619.

     Not in our library10.1083/jcb.201607062

395. 395.

     Kitajima T.S., Ohsugi M., Ellenberg J. Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Cell. 2011;146:568-581.

     Not in our library10.1016/j.cell.2011.07.031

396. 396.

     Ohsugi M., Adachi K., Horai R., Kakuta S., Sudo K., Kotaki H., Tokai-Nishizumi N., Sagara H., Iwakura Y., Yamamoto T. Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell. 2008;132:771-782.

     Not in our library10.1016/j.cell.2008.01.029

397. 397.

     Gui L., Homer H. Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes. Development. 2012;139:1941-1946.

     Not in our library10.1242/dev.078352

398. 398.

     Radford S.J., Hoang T.L., Gluszek A.A., Ohkura H., McKim K.S. Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes. PLoS Genet. 2015;11:e1005605.

     Not in our library10.1371/journal.pgen.1005605

399. 399.

     Wignall S.M., Villeneuve A.M. Lateral microtubule bundles promote chromosome alignment during acentrosomal oocyte meiosis. Nat. Cell Biol. 2009;11:839-844.

     Not in our library10.1038/ncb1891

400. 400.

     Dumont J., Oegema K., Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat. Cell Biol. 2010;12:894-901.

     Not in our library10.1038/ncb2093

401. 401.
     Dyneins Across Eukaryotes: A Comparative Genomic Analysis · 2007

     No notice
402. 402.

     ten Hoopen R., Schleker T., Manteuffel R., Schubert I. Transient CENP-E-like kinetochore proteins in plants. Chromosome Res. 2002;10:561-570.

     Not in our library10.1023/a:1020962618696

403. 403.

     Naito H., Goshima G. NACK kinesin is required for metaphase chromosome alignment and cytokinesis in the moss Physcomitrella patens. Cell Struct. Funct. 2015;40:31-41.

     Not in our library10.1247/csf.14016

404. 404.

     Moutinho-Pereira S., Stuurman N., Afonso O., Hornsveld M., Aguiar P., Goshima G., Vale R.D., Maiato H. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. Proc. Natl. Acad. Sci. USA. 2013;110:19808-19813.

     Not in our library10.1073/pnas.1320013110

405. 405.

     Thompson S.L., Bakhoum S.F., Compton D.A. Mechanisms of chromosomal instability. Curr. Biol. 2010;20:R285-R295.

     Not in our library10.1016/j.cub.2010.01.034

406. 406.

     Carter S.L., Eklund A.C., Kohane I.S., Harris L.N., Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat. Genet. 2006;38:1043-1048.

     Not in our library10.1038/ng1861

407. 407.

     Choi C.-M., Seo K.W., Jang S.J., Oh Y.-M., Shim T.-S., Kim W.S., Lee D.-S., Lee S.-D. Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients. Lung Cancer. 2009;64:66-70.

     Not in our library10.1016/j.lungcan.2008.07.016

408. 408.

     Lee A.J.X., Endesfelder D., Rowan A.J., Walther A., Birkbak N.J., Futreal P.A., Downward J., Szallasi Z., Tomlinson I.P.M., Howell M., et al. Chromosomal instability confers intrinsic multidrug resistance. Cancer Res. 2011;71:1858-1870.

     Not in our library10.1158/0008-5472.can-10-3604

409. 409.

     McClelland S.E., Burrell R.A., Swanton C. Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy. Cell Cycle. 2009;8:3262-3266.

     Not in our library10.4161/cc.8.20.9690

410. 410.

     Swanton C., Nicke B., Schuett M., Eklund A.C., Ng C., Li Q., Hardcastle T., Lee A., Roy R., East P., et al. Chromosomal instability determines taxane response. Proc. Natl. Acad. Sci. USA. 2009;106:8671-8676.

     Not in our library10.1073/pnas.0811835106

411. 411.

     Birkbak N.J., Eklund A.C., Li Q., McClelland S.E., Endesfelder D., Tan P., Tan I.B., Richardson A.L., Szallasi Z., Swanton C. Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res. 2011;71:3447-3452.

     Not in our library10.1158/0008-5472.can-10-3667

412. 412.

     Burrell R.A., Juul N., Johnston S.R., Reis-Filho J.S., Szallasi Z., Swanton C. Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer. J. Cell. Biochem. 2010;111:782-790.

     Not in our library10.1002/jcb.22781

413. 413.

     Roschke A.V., Kirsch I.R. Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability. Cell Cycle. 2005;4:679-682.

     Not in our library10.4161/cc.4.5.1687

414. 414.

     Gordon D.J., Resio B., Pellman D. Causes and consequences of aneuploidy in cancer. Nat. Rev. Genet. 2012;13:189-203.

     Not in our library10.1038/nrg3123

415. 415.

     Maiato H., Logarinho E. Mitotic spindle multipolarity without centrosome amplification. Nat. Cell Biol. 2014;16:386-394.

     Not in our library10.1038/ncb2958

416. 416.

     Weaver B.A.A., Bonday Z.Q., Putkey F.R., Kops G.J.P.L., Silk A.D., Cleveland D.W. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J. Cell Biol. 2003;162:551-563.

     Not in our library10.1083/jcb.200303167

417. 417.

     Silk A.D., Zasadil L.M., Holland A.J., Vitre B., Cleveland D.W., Weaver B.A. Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc. Natl. Acad. Sci. USA. 2013;110:E4134-E4141.

     Not in our library10.1073/pnas.1317042110

418. 418.

     Weaver B.A.A., Silk A.D., Montagna C., Verdier-Pinard P., Cleveland D.W. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 2007;11:25-36.

     Not in our library10.1016/j.ccr.2006.12.003

419. 419.

     Zasadil L.M., Britigan E.M.C., Ryan S.D., Kaur C., Guckenberger D.J., Beebe D.J., Moser A.R., Weaver B.A. High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation. Mol. Biol. Cell. 2016;27:1981-1989.

     Not in our library10.1091/mbc.e15-10-0747

420. 420.

     Morais da Silva S., Moutinho-Santos T., Sunkel C.E. A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. J. Cell Biol. 2013;201:385-393.

     Not in our library10.1083/jcb.201210018

421. 421.

     Clemente-Ruiz M., Muzzopappa M., Milán M. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Cell Cycle. 2014;13:1450-1455.

     Not in our library10.4161/cc.28417

422. 422.
     Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts · 1999

     Not checked
423. 423.

     Kung P.-P., Martinez R., Zhu Z., Zager M., Blasina A., Rymer I., Hallin J., Xu M., Carroll C., Chionis J., et al. Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer. Mol. Cancer Ther. 2014;13:2104-2115.

     Not in our library10.1158/1535-7163.mct-14-0083-t

424. 424.
     Reduced expression of cenp-e in human hepatocellular carcinoma · 2009

     Not checked
425. 425.

     Kumar A., Purohit R. Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E. Mutat. Res. 2012;738–773:28-37.

     Not in our library10.1016/j.mrfmmm.2012.08.005

426. 426.

     Mirzaa G.M., Vitre B., Carpenter G., Abramowicz I., Gleeson J.G., Paciorkowski A.R., Cleveland D.W., Dobyns W.B., O’Driscoll M. Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Hum. Genet. 2014;133:1023-1039.

     Not in our library10.1007/s00439-014-1443-3

427. 427.

     Nagahara M., Nishida N., Iwatsuki M., Ishimaru S., Mimori K., Tanaka F., Nakagawa T., Sato T., Sugihara K., Hoon D.S.B., et al. Kinesin 18A expression: Clinical relevance to colorectal cancer progression. Int. J. Cancer. 2011;129:2543-2552.

     Not in our library10.1002/ijc.25916

428. 428.

     Zhang C., Zhu C., Chen H., Li L., Guo L., Jiang W., Lu S.H. Kif18A is involved in human breast carcinogenesis. Carcinogenesis. 2010;31:1676-1684.

     Not in our library10.1093/carcin/bgq134

429. 429.

     Rucksaken R., Khoontawad J., Roytrakul S., Pinlaor P., Hiraku Y., Wongkham C., Pairojkul C., Boonmars T., Pinlaor S. Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma. Cancer Biomark. 2012;12:81-95.

     Not in our library10.3233/cbm-130296

430. 430.

     Tooker B.C., Newman L.S., Bowler R.P., Karjalainen A., Oksa P., Vainio H., Pukkala E., Brandt-Rauf P.W. Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. Biomarkers. 2011;16:181-191.

     Not in our library10.3109/1354750x.2010.543289

431. 431.

     Zhu H., Xu W., Zhang H., Liu J., Xu H., Lu S., Dang S., Kuang Y., Jin X., Wang Z. Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation. Biochem. Biophys. Res. Commun. 2013;438:97-102.

     Not in our library10.1016/j.bbrc.2013.07.032

432. 432.

     Kurasawa Y., Earnshaw W.C., Mochizuki Y., Dohmae N., Todokoro K. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J. 2004;23:3237-3248.

     Not in our library10.1038/sj.emboj.7600347

433. 433.

     Mazumdar M., Lee J.-H., Sengupta K., Ried T., Rane S., Misteli T. Tumor formation via loss of a molecular motor protein. Curr. Biol. 2006;16:1559-1564.

     Not in our library10.1016/j.cub.2006.06.029

434. 434.

     Gao J., Sai N., Wang C., Sheng X., Shao Q., Zhou C., Shi Y., Sun S., Qu X., Zhu C. Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo. Tumour Biol. 2011;32:53-61.

     Not in our library10.1007/s13277-010-0090-0

435. 435.

     Narayan G., Bourdon V., Chaganti S., Arias-Pulido H., Nandula S.V., Rao P.H., Gissmann L., Dürst M., Schneider A., Pothuri B., et al. Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: Identification of candidate amplified and overexpressed genes. Genes Chromosom. Cancer. 2007;46:373-384.

     Not in our library10.1002/gcc.20418

436. 436.

     Taniwaki M., Takano A., Ishikawa N., Yasui W., Inai K., Nishimura H., Tsuchiya E., Kohno N., Nakamura Y., Daigo Y. Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer. Clin. Cancer Res. 2007;13:6624-6631.

     Not in our library10.1158/1078-0432.ccr-07-1328

437. 437.

     Jordan M.A., Wilson L. Microtubules as a target for anticancer drugs. Nat. Rev. Cancer. 2004;4:253-265.

     Not in our library10.1038/nrc1317

438. 438.

     Gotaskie G.E., Andreassi B.F. Paclitaxel: A new antimitotic chemotherapeutic agent. Cancer Pract. 1994;2:27-33.

     Not in our library

439. 439.

     Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat. Rev. Cancer. 2010;10:194-204.

     Not in our library10.1038/nrc2803

440. 440.

     Zhou X.J., Rahmani R. Preclinical and clinical pharmacology of vinca alkaloids. Drugs. 1992;44:1-16.

     Not in our library10.2165/00003495-199200444-00002

441. 441.

     Jordan M.A., Toso R.J., Thrower D., Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc. Natl. Acad. Sci. USA. 1993;90:9552-9556.

     Not in our library10.1073/pnas.90.20.9552

442. 442.

     Jordan M.A., Wendell K., Gardiner S., Derry W.B., Copp H., Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res. 1996;56:816-825.

     Not in our library

443. 443.

     Jordan M.A., Thrower D., Wilson L. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. J. Cell Sci. 1992;102:401-416.

     Not in our library10.1242/jcs.102.3.401

444. 444.

     Yang Z., Kenny A.E., Brito D.A., Rieder C.L. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J. Cell Biol. 2009;186:675-684.

     Not in our library10.1083/jcb.200906150

445. 445.

     Zasadil L.M., Andersen K.A., Yeum D., Rocque G.B., Wilke L.G., Tevaarwerk A.J., Raines R.T., Burkard M.E., Weaver B.A. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci. Transl. Med. 2014;6:229ra43.

     Not in our library10.1126/scitranslmed.3007965

446. 446.

     Manchado E., Guillamot M., Malumbres M. Killing cells by targeting mitosis. Cell Death Differ. 2012;19:369-377.

     Not in our library10.1038/cdd.2011.197

447. 447.

     Miglarese M.R., Carlson R.O. Development of new cancer therapeutic agents targeting mitosis. Expert Opin. Investig. Drugs. 2006;15:1411-1425.

     Not in our library10.1517/13543784.15.11.1411

448. 448.

     Jackson J.R., Patrick D.R., Dar M.M., Huang P.S. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat. Rev. Cancer. 2007;7:107-117.

     Not in our library10.1038/nrc2049

449. 449.

     Wood K.W., Lad L., Luo L., Qian X., Knight S.D., Nevins N., Brejc K., Sutton D., Gilmartin A.G., Chua P.R., et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc. Natl. Acad. Sci. USA. 2010;107:5839-5844.

     Not in our library10.1073/pnas.0915068107

450. 450.

     Qian X., McDonald A., Zhou H.-J., Adams N.D., Parrish C.A., Duffy K.J., Fitch D.M., Tedesco R., Ashcraft L.W., Yao B., et al. Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295. ACS Med. Chem. Lett. 2010;1:30-34.

     Not in our library10.1021/ml900018m

451. 451.

     Balamuth N.J., Wood A., Wang Q., Jagannathan J., Mayes P., Zhang Z., Chen Z., Rappaport E., Courtright J., Pawel B., et al. Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target. Cancer Res. 2010;70:2749-2758.

     Not in our library10.1158/0008-5472.can-09-3844

452. 452.

     Hu Z., Kuo W.-l., Das D., Ziyad S., Gu S., Bhattacharya S., Wyrobek A., Wang N., Feiler H., Wooster R., et al. Abstract #5572: Small molecular inhibitor of centromere-associated protein E (CENP-E), GSK923295A inhibits cell growth in breast cancer cells. Cancer Res. 2009;69:5572.

     Not in our library

453. 453.

     Lock R.B., Carol H., Morton C.L., Keir S.T., Reynolds C.P., Kang M.H., Maris J.M., Wozniak A.W., Gorlick R., Kolb E.A., et al. Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program. Pediatr. Blood Cancer. 2012;58:916-923.

     Not in our library10.1002/pbc.23176

454. 454.

     Mayes P.A., Degenhardt Y.Y., Wood A., Toporovskya Y., Diskin S.J., Haglund E., Moy C., Wooster R., Maris J.M. Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition. Int. J. Cancer. 2013;132:E149-E157.

     Not in our library10.1002/ijc.27781

455. 455.

     Sutton D., Gilmartin A., Kusnierz A., Sung C.-M., Luo L., Carson J., Laquerre S., Cornwell W., King A., Knight S., et al. A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A), demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro. Am. Assoc. Cancer Res. 2007;6:A111.

     Not in our library

456. 456.

     Bennett A., Bechi B., Tighe A., Thompson S., Procter D.J., Taylor S.S. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget. 2015;6:20921-20932.

     Not in our library10.18632/oncotarget.4879

457. 457.

     Tcherniuk S.O., Oleinikov A.V. Pgp efflux pump decreases the cytostatic effect of CENP-E inhibitor GSK923295. Cancer Lett. 2015;361:97-103.

     Not in our library10.1016/j.canlet.2015.02.040

458. 458.
     Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells · 2015

     No notice
459. 459.

     Kim J.-H., Lee H.-S., Lee N.C.O., Goncharov N.V., Kumeiko V., Masumoto H., Earnshaw W.C., Kouprina N., Larionov V. Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells. Oncotarget. 2016;7:14841-14856.

     Not in our library10.18632/oncotarget.7854

460. 460.

     Henderson M.C., Shaw Y.-J.Y., Wang H., Han H., Hurley L.H., Flynn G., Dorr R.T., Von Hoff D.D. UA62784, a novel inhibitor of centromere protein E kinesin-like protein. Mol. Cancer Ther. 2009;8:36-44.

     Not in our library10.1158/1535-7163.mct-08-0789

461. 461.

     Tcherniuk S., Deshayes S., Sarli V., Divita G., Abrieu A. UA62784 Is a cytotoxic inhibitor of microtubules, not CENP-E. Chem. Biol. 2011;18:631-641.

     Not in our library10.1016/j.chembiol.2011.03.006

462. 462.

     Maiato H., Logarinho E. Motor-dependent and -independent roles of CENP-E at kinetochores: The cautionary tale of UA62784. Chem. Biol. 2011;18:679-680.

     Not in our library10.1016/j.chembiol.2011.06.002

463. 463.

     Shaw A.Y., Henderson M.C., Flynn G., Samulitis B., Han H., Stratton S.P., Chow H.H.S., Hurley L.H., Dorr R.T. Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer. J. Pharmacol. Exp. Ther. 2009;331:636-647.

     Not in our library10.1124/jpet.109.156406

464. 464.

     Ding X., Yan F., Yao P., Yang Z., Wan W., Wang X., Liu J., Gao X., Abrieu A., Zhu T., et al. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 2010;20:1386-1389.

     Not in our library10.1038/cr.2010.167

465. 465.

     Chung V., Heath E.I., Schelman W.R., Johnson B.M., Kirby L.C., Lynch K.M., Botbyl J.D., Lampkin T.A., Holen K.D. First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer Chemother. Pharmacol. 2012;69:733-741.

     Not in our library10.1007/s00280-011-1756-z

466. 466.

     Capell B.C., Erdos M.R., Madigan J.P., Fiordalisi J.J., Varga R., Conneely K.N., Gordon L.B., Der C.J., Cox A.D., Collins F.S. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA. 2005;102:12879-12884.

     Not in our library10.1073/pnas.0506001102

467. 467.

     Buckner F.S., Eastman R.T., Yokoyama K., Gelb M.H., Van Voorhis W.C. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Curr. Opin. Investig. Drugs. 2005;6:791-797.

     Not in our library

468. 468.

     Gordon L.B., Kleinman M.E., Miller D.T., Neuberg D.S., Giobbie-Hurder A., Gerhard-Herman M., Smoot L.B., Gordon C.M., Cleveland R., Snyder B.D., et al. Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA. 2012;109:16666-16671.

     Not in our library10.1073/pnas.1202529109

469. 469.

     Nallan L., Bauer K.D., Bendale P., Rivas K., Yokoyama K., Horney C.P., Pendyala P.R., Floyd D., Lombardo L.J., Williams D.K., et al. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J. Med. Chem. 2005;48:3704-3713.

     Not in our library10.1021/jm0491039

470. 470.

     Wiesner J., Kettler K., Sakowski J., Ortmann R., Katzin A.M., Kimura E.A., Silber K., Klebe G., Jomaa H., Schlitzer M. Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo. Angew. Chem. Int. Ed. Engl. 2004;43:251-254.

     Not in our library10.1002/anie.200351169

471. 471.

     Shen M., Pan P., Li Y., Li D., Yu H., Hou T. Farnesyltransferase and geranylgeranyltransferase I: Structures, mechanism, inhibitors and molecular modeling. Drug Discov. Today. 2015;20:267-276.

     Not in our library10.1016/j.drudis.2014.10.002

472. 472.

     Moorthy N.S., Sousa S.F., Ramos M.J., Fernandes P.A. Farnesyltransferase inhibitors: A comprehensive review based on quantitative structural analysis. Curr. Med. Chem. 2013;20:4888-4923.

     Not in our library10.2174/09298673113206660262

473. 473.

     Agrawal A.G., Somani R.R. Farnesyltransferase inhibitor as anticancer agent. Mini Rev. Med. Chem. 2009;9:638-652.

     Not in our library10.2174/138955709788452702

474. 474.

     Kho Y., Kim S.C., Jiang C., Barma D., Kwon S.W., Cheng J., Jaunbergs J., Weinbaum C., Tamanoi F., Falck J., et al. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc. Natl. Acad. Sci. USA. 2004;101:12479-12484.

     Not in our library10.1073/pnas.0403413101

475. 475.

     Clark G.J., Kinch M.S., Rogers-Graham K., Sebti S.M., Hamilton A.D., Der C.J. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J. Biol. Chem. 1997;272:10608-10615.

     Not in our library10.1074/jbc.272.16.10608

476. 476.

     Holstein S.A., Hohl R.J. Is there a future for prenyltransferase inhibitors in cancer therapy? Curr. Opin. Pharmacol. 2012;12:704-709.

     Not in our library10.1016/j.coph.2012.06.013

477. 477.

     Kohl N.E., Mosser S.D., deSolms S.J., Giuliani E.A., Pompliano D.L., Graham S.L., Smith R.L., Scolnick E.M., Oliff A., Gibbs J.B. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science. 1993;260:1934-1937.

     Not in our library10.1126/science.8316833

478. 478.

     Lee K.H., Koh M., Moon A. Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation. Oncol. Lett. 2016;12:2222-2226.

     Not in our library10.3892/ol.2016.4837

479. 479.

     Cox A.D., Der C.J. Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras? Biochim. Biophys. Acta. 1997;1333:F51-F71.

     Not in our library10.1016/s0304-419x(97)00011-5

480. 480.

     Sepp-Lorenzino L., Ma Z., Rands E., Kohl N.E., Gibbs J.B., Oliff A., Rosen N. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 1995;55:5302-5309.

     Not in our library

481. 481.

     Karp J.E., Lancet J.E., Kaufmann S.H., End D.W., Wright J.J., Bol K., Horak I., Tidwell M.L., Liesveld J., Kottke T.J., et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial. Blood. 2001;97:3361-3369.

     Not in our library10.1182/blood.v97.11.3361

482. 482.

     Rolland D., Camara-Clayette V., Barbarat A., Salles G., Coiffier B., Ribrag V., Thieblemont C. Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma. Cancer Chemother. Pharmacol. 2008;61:855-863.

     Not in our library10.1007/s00280-007-0543-3

483. 483.

     Adjei A.A., Davis J.N., Bruzek L.M., Erlichman C., Kaufmann S.H. Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines. Clin. Cancer Res. 2001;7:1438-1445.

     Not in our library

484. 484.

     Russo P., Malacarne D., Falugi C., Trombino S., O’Connor P.M. RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53. Int. J. Cancer. 2002;100:266-275.

     Not in our library10.1002/ijc.10461

485. 485.

     Brassard D.L., English J.M., Malkowski M., Kirschmeier P., Nagabhushan T.L., Bishop W.R. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras. Exp. Cell Res. 2002;273:138-146.

     Not in our library10.1006/excr.2001.5440

486. 486.

     Edamatsu H., Gau C.L., Nemoto T., Guo L., Tamanoi F. Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene. 2000;19:3059-3068.

     Not in our library10.1038/sj.onc.1203625

487. 487.

     Nagai T., Ohmine K., Fujiwara S., Uesawa M., Sakurai C., Ozawa K. Combination of tipifarnib and rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling pathways. Leuk. Res. 2010;34:1057-1063.

     Not in our library10.1016/j.leukres.2009.12.011

488. 488.
     Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones · 1998

     Not checked
489. 489.

     Karp J.E., Kaufmann S.H., Adjei A.A., Lancet J.E., Wright J.J., End D.W. Current status of clinical trials of farnesyltransferase inhibitors. Curr. Opin. Oncol. 2001;13:470-476.

     Not in our library10.1097/00001622-200111000-00009

490. 490.

     Santos E.S., Rosenblatt J.D., Goodman M. Role of farnesyltransferase inhibitors in hematologic malignancies. Expert Rev. Anticancer Ther. 2004;4:843-856.

     Not in our library10.1586/14737140.4.5.843

491. 491.

     Sebti S.M., Adjei A.A. Farnesyltransferase inhibitors. Semin. Oncol. 2004;31:28-39.

     Not in our library10.1053/j.seminoncol.2003.12.012

492. 492.

     Karp J.E., Lancet J.E. Targeting the process of farynesylation for therapy of hematologic malignancies. Curr. Mol. Med. 2005;5:643-652.

     Not in our library10.2174/156652405774641052

493. 493.

     Epling-Burnette P.K., Loughran T.P. Suppression of farnesyltransferase activity in acute myeloid leukemia and myelodysplastic syndrome: Current understanding and recommended use of tipifarnib. Expert Opin. Investig. Drugs. 2010;19:689-698.

     Not in our library10.1517/13543781003801076

494. 494.

     Rao S., Cunningham D., de Gramont A., Scheithauer W., Smakal M., Humblet Y., Kourteva G., Iveson T., Andre T., Dostalova J., et al. Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer. J. Clin. Oncol. 2004;22:3950-3957.

     Not in our library10.1200/jco.2004.10.037

495. 495.

     Van Cutsem E., van de Velde H., Karasek P., Oettle H., Vervenne W.L., Szawlowski A., Schoffski P., Post S., Verslype C., Neumann H., et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J. Clin. Oncol. 2004;22:1430-1438.

     Not in our library10.1200/jco.2004.10.112

496. 496.

     Macdonald J.S., McCoy S., Whitehead R.P., Iqbal S., Wade J.L., Giguere J.K., Abbruzzese J.L. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest oncology group (SWOG 9924) study. Investig. New Drugs. 2005;23:485-487.

     Not in our library10.1007/s10637-005-2908-y

497. 497.

     Harousseau J.L., Martinelli G., Jedrzejczak W.W., Brandwein J.M., Bordessoule D., Masszi T., Ossenkoppele G.J., Alexeeva J.A., Beutel G., Maertens J., et al. A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older. Blood. 2009;114:1166-1173.

     Not in our library10.1182/blood-2009-01-198093

498. 498.

     Stieglitz E., Ward A.F., Gerbing R.B., Alonzo T.A., Arceci R.J., Liu Y.L., Emanuel P.D., Widemann B.C., Cheng J.W., Jayaprakash N., et al. Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: A report from the Children’s Oncology Group. Pediatr. Blood Cancer. 2015;62:629-636.

     Not in our library10.1002/pbc.25342

499. 499.
     Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104) · 2012

     Not checked
500. 500.

     Burnett A.K., Russell N.H., Culligan D., Cavanagh J., Kell J., Wheatley K., Virchis A., Hills R.K., Milligan D., AML Working Group of the UK National Cancer Research Institute. The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML. Br. J. Haematol. 2012;158:519-522.

     Not in our library10.1111/j.1365-2141.2012.09165.x

501. 501.

     Meier W., du Bois A., Rau J., Gropp-Meier M., Baumann K., Huober J., Wollschlaeger K., Kreienberg R., Canzler U., Schmalfeldt B., et al. Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV. Gynecol. Oncol. 2012;126:236-240.

     Not in our library10.1016/j.ygyno.2012.04.050

502. 502.

     Adjei A.A., Croghan G.A., Erlichman C., Marks R.S., Reid J.M., Sloan J.A., Pitot H.C., Alberts S.R., Goldberg R.M., Hanson L.J., et al. A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin. Cancer Res. 2003;9:2520-2526.

     Not in our library

503. 503.

     Siegel-Lakhai W.S., Crul M., Zhang S., Sparidans R.W., Pluim D., Howes A., Solanki B., Beijnen J.H., Schellens J.H. Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours. Br. J. Cancer. 2005;93:1222-1229.

     Not in our library10.1038/sj.bjc.6602850

504. 504.

     Sparano J.A., Moulder S., Kazi A., Vahdat L., Li T., Pellegrino C., Munster P., Malafa M., Lee D., Hoschander S., et al. Targeted inhibition of farnesyltransferase in locally advanced breast cancer: A phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide. J. Clin. Oncol. 2006;24:3013-3018.

     Not in our library10.1200/jco.2005.04.9114

505. 505.

     Medeiros B.C., Landau H.J., Morrow M., Lockerbie R.O., Pitts T., Eckhardt S.G. The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia. 2007;21:739-746.

     Not in our library10.1038/sj.leu.2404539

506. 506.

     Jabbour E., Kantarjian H., Ravandi F., Garcia-Manero G., Estrov Z., Verstovsek S., O’Brien S., Faderl S., Thomas D.A., Wright J.J., et al. A phase 1–2 study of a farnesyltransferase inhibitor, tipifarnib, combined with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndrome. Cancer. 2011;117:1236-1244.

     Not in our library10.1002/cncr.25575

507. 507.

     Li T., Guo M., Gradishar W.J., Sparano J.A., Perez E.A., Wang M., Sledge G.W. A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: An Eastern Cooperative Oncology Group Study (E1103). Breast Cancer Res. Treat. 2012;134:345-352.

     Not in our library10.1007/s10549-012-2071-z

508. 508.

     Kim E.S., Kies M.S., Fossella F.V., Glisson B.S., Zaknoen S., Statkevich P., Munden R.F., Summey C., Pisters K.M., Papadimitrakopoulou V., et al. Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma. Cancer. 2005;104:561-569.

     Not in our library10.1002/cncr.21188

509. 509.

     Karp J.E., Smith B.D., Gojo I., Lancet J.E., Greer J., Klein M., Morris L., Levis M.J., Gore S.D., Wright J.J., et al. Phase II trial of tipifarnib as maintenance therapy in first complete remission in adults with acute myelogenous leukemia and poor-risk features. Clin. Cancer Res. 2008;14:3077-3082.

     Not in our library10.1158/1078-0432.ccr-07-4743

510. 510.

     Castro-Castro A., Janke C., Montagnac G., Paul-Gilloteaux P., Chavrier P. ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion. Eur. J. Cell Biol. 2012;91:950-960.

     Not in our library10.1016/j.ejcb.2012.07.001

511. 511.

     Boggs A.E., Vitolo M.I., Whipple R.A., Charpentier M.S., Goloubeva O.G., Ioffe O.B., Tuttle K.C., Slovic J., Lu Y., Mills G.B., et al. α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration. Cancer Res. 2015;75:203-215.

     Not in our library10.1158/0008-5472.can-13-3563

512. 512.

     Kashiwaya K., Nakagawa H., Hosokawa M., Mochizuki Y., Ueda K., Piao L., Chung S., Hamamoto R., Eguchi H., Ohigashi H., et al. Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. Cancer Res. 2010;70:4024-4033.

     Not in our library10.1158/0008-5472.can-09-4444

513. 513.

     Wasylyk C., Zambrano A., Zhao C., Brants J., Abecassis J., Schalken J.A., Rogatsch H., Schaefer G., Pycha A., Klocker H., et al. Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy. Int. J. Cancer. 2010;127:2542-2553.

     Not in our library10.1002/ijc.25261

514. 514.
     Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. · 2012

     Not checked
515. 515.

     Rocha C., Papon L., Cacheux W., Marques Sousa P., Lascano V., Tort O., Giordano T., Vacher S., Lemmers B., Mariani P., et al. Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. EMBO J. 2014;33:2247-2260.

     Not in our library10.15252/embj.201488466

516. 516.

     Lafanechere L., Courtay-Cahen C., Kawakami T., Jacrot M., Rudiger M., Wehland J., Job D., Margolis R.L. Suppression of tubulin tyrosine ligase during tumor growth. J. Cell Sci. 1998;111:171-181.

     Not in our library10.1242/jcs.111.2.171

517. 517.

     Mialhe A., Lafanechere L., Treilleux I., Peloux N., Dumontet C., Bremond A., Panh M.H., Payan R., Wehland J., Margolis R.L., et al. Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Res. 2001;61:5024-5027.

     Not in our library

518. 518.

     Kato C., Miyazaki K., Nakagawa A., Ohira M., Nakamura Y., Ozaki T., Imai T., Nakagawara A. Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis. Int. J. Cancer. 2004;112:365-375.

     Not in our library10.1002/ijc.20431

519. 519.

     Soucek K., Kamaid A., Phung A.D., Kubala L., Bulinski J.C., Harper R.W., Eiserich J.P. Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications. Prostate. 2006;66:954-965.

     Not in our library10.1002/pros.20416

520. 520.

     Kuroda H., Saito K., Kuroda M., Suzuki Y. Differential expression of glu-tubulin in relation to mammary gland disease. Virchows Arch. 2010;457:477-482.

     Not in our library10.1007/s00428-010-0955-z

521. 521.

     Whipple R.A., Matrone M.A., Cho E.H., Balzer E.M., Vitolo M.I., Yoon J.R., Ioffe O.B., Tuttle K.C., Yang J., Martin S.S. Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement. Cancer Res. 2010;70:8127-8137.

     Not in our library10.1158/0008-5472.can-09-4613

522. 522.

     Kreuger M.R., Grootjans S., Biavatti M.W., Vandenabeele P., D’Herde K. Sesquiterpene lactones as drugs with multiple targets in cancer treatment: Focus on parthenolide. Anticancer Drugs. 2012;23:883-896.

     Not in our library10.1097/cad.0b013e328356cad9

523. 523.

     Curry E.A., Murry D.J., Yoder C., Fife K., Armstrong V., Nakshatri H., O’Connell M., Sweeney C.J. Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Investig. New Drugs. 2004;22:299-305.

     Not in our library10.1023/b:drug.0000026256.38560.be

524. 524.

     Ghantous A., Sinjab A., Herceg Z., Darwiche N. Parthenolide: From plant shoots to cancer roots. Drug Discov. Today. 2013;18:894-905.

     Not in our library10.1016/j.drudis.2013.05.005

525. 525.

     Bork P.M., Schmitz M.L., Kuhnt M., Escher C., Heinrich M. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB. FEBS Lett. 1997;402:85-90.

     Not in our library10.1016/s0014-5793(96)01502-5

526. 526.

     Hehner S.P., Hofmann T.G., Droge W., Schmitz M.L. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex. J. Immunol. 1999;163:5617-5623.

     Not in our library

527. 527.

     Kwok B.H., Koh B., Ndubuisi M.I., Elofsson M., Crews C.M. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase. Chem. Biol. 2001;8:759-766.

     Not in our library10.1016/s1074-5521(01)00049-7

528. 528.

     Garcia-Pineres A.J., Castro V., Mora G., Schmidt T.J., Strunck E., Pahl H.L., Merfort I. Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 2001;276:39713-39720.

     Not in our library10.1074/jbc.m101985200

529. 529.

     Fonrose X., Ausseil F., Soleilhac E., Masson V., David B., Pouny I., Cintrat J.C., Rousseau B., Barette C., Massiot G., et al. Parthenolide inhibits tubulin carboxypeptidase activity. Cancer Res. 2007;67:3371-3378.

     Not in our library10.1158/0008-5472.can-06-3732

530. 530.

     Whipple R.A., Vitolo M.I., Boggs A.E., Charpentier M.S., Thompson K., Martin S.S. Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition. Breast Cancer Res. 2013;15:R83.

     Not in our library10.1186/bcr3477

531. 531.

     Shanmugam R., Kusumanchi P., Appaiah H., Cheng L., Crooks P., Neelakantan S., Peat T., Klaunig J., Matthews W., Nakshatri H., et al. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. Int. J. Cancer. 2011;128:2481-2494.

     Not in our library10.1002/ijc.25587

532. 532.

     Shanmugam R., Kusumanchi P., Appaiah H., Cheng L., Crooks P., Neelakantan S., Peat T., Klaunig J., Matthews W., Nakshatri H., et al. Naturally occurring asteriscunolide A induces apoptosis and activation of mitogen-activated protein kinase pathway in human tumor cell lines. Mol. Carcinog. 2010;49:488-499.

     Not in our library10.1002/mc.20629

533. 533.

     Rozenblat S., Grossman S., Bergman M., Gottlieb H., Cohen Y., Dovrat S. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines. Biochem. Pharmacol. 2008;75:369-382.

     Not in our library10.1016/j.bcp.2007.08.024

534. 534.

     Guzman M.L., Rossi R.M., Karnischky L., Li X., Peterson D.R., Howard D.S., Jordan C.T. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005;105:4163-4169.

     Not in our library10.1182/blood-2004-10-4135

535. 535.

     Carnero A., Garcia-Mayea Y., Mir C., Lorente J., Rubio I.T., ME L.L. The cancer stem-cell signaling network and resistance to therapy. Cancer Treat. Rev. 2016;49:25-36.

     Not in our library10.1016/j.ctrv.2016.07.001

536. 536.

     Valent P., Bonnet D., De Maria R., Lapidot T., Copland M., Melo J.V., Chomienne C., Ishikawa F., Schuringa J.J., Stassi G., et al. Cancer stem cell definitions and terminology: The devil is in the details. Nat. Rev. Cancer. 2012;12:767-775.

     Not in our library10.1038/nrc3368

537. 537.

     Kawasaki B.T., Hurt E.M., Kalathur M., Duhagon M.A., Milner J.A., Kim Y.S., Farrar W.L. Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach. Prostate. 2009;69:827-837.

     Not in our library10.1002/pros.20931

538. 538.

     Guzman M.L., Rossi R.M., Neelakantan S., Li X., Corbett C.A., Hassane D.C., Becker M.W., Bennett J.M., Sullivan E., Lachowicz J.L., et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 2007;110:4427-4435.

     Not in our library10.1182/blood-2007-05-090621

539. 539.

     Carlisi D., Buttitta G., Di Fiore R., Scerri C., Drago-Ferrante R., Vento R., Tesoriere G. Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis. Cell Death Dis. 2016;7:e2194.

     Not in our library10.1038/cddis.2016.94

540. 540.

     Shanmugam R., Kusumanchi P., Cheng L., Crooks P., Neelakantan S., Matthews W., Nakshatri H., Sweeney C.J. A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species. Prostate. 2010;70:1074-1086.

     Not in our library10.1002/pros.21141

541. 541.

     Sweeney C.J., Mehrotra S., Sadaria M.R., Kumar S., Shortle N.H., Roman Y., Sheridan C., Campbell R.A., Murry D.J., Badve S., et al. The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer. Mol. Cancer Ther. 2005;4:1004-1012.

     Not in our library10.1158/1535-7163.mct-05-0030

542. 542.

     Zhang D., Qiu L., Jin X., Guo Z., Guo C. Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo. Mol. Cancer Res. 2009;7:1139-1149.

     Not in our library10.1158/1541-7786.mcr-08-0410

543. 543.

     Liu Y., Lu W.L., Guo J., Du J., Li T., Wu J.W., Wang G.L., Wang J.C., Zhang X., Zhang Q. A potential target associated with both cancer and cancer stem cells: A combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes. J. Control. Release. 2008;129:18-25.

     Not in our library10.1016/j.jconrel.2008.03.022

Cited by papers we hold 3

• A mitotic chromatin phase transition prevents perforation by microtubules · 2022
  No notice
• The mitotic spindle is chiral due to torques within microtubule bundles · 2018
  Not checked
• A Molecular View of Kinetochore Assembly and Function · 2017
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.