One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines
Aïcha Derdour, Michel Vaultier, Amar Saad
Molecules · 2004
doi:10.3390/90700527 (opens in a new tab)
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Abstract
The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.
Abstract licence: CC BY
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