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A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone

John Butler, Alan T. McGown, John A. Hadfield

Molecules · 2000

doi:10.3390/50100082 (opens in a new tab)

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Abstract

A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy’s salt oxidation of phenol (7).

Abstract licence: CC BY

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