Potency Syzygium cumini L as adjuvant therapy on mice model malaria

The objective of the study was to prove the potential extract of <em>Syzygium cumini</em> L leaf and stem bark as an adjuvant to malaria modelling mice. Antimalarial effects were assessed by the percentage of parasitemia, growth inhibition, 50% dose level (ED50), Parasite Clearance Time (PCT), Recrudescence Time (RT) of Plasmodium berghei. Male albino Swiss mice infected with 1x10⁵ <em>P. berghei</em> parasite in 0.2 ml intraperitoneally. Treatment with chloroquine 25 mg/kg body weight, chloroquine combination 25 mg/kg body weight with leaf and stem bark extract of <em>Syzygium cumini</em> L dose 600 mg / kg body weight for 4 days and 24 hours after infection, and then its activity as antimalarial and adjuvant therapy were observed. The results showed that the extract of <em>Syzygium</em> <em>cumini</em> L leaf combined with chloroquine gives highly significant result in inhibiting the growth of parasites than the chloroquine alone and the extract of <em>Syzygium cumini</em> L leaf combined with chloroquine gives the Parasite Clearance Time faster and Recrudescence Time (RT) longer than the other treatment.

Abstract licence: CC BY

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