No retraction, correction or concern found when last checked on Oct 16, 2026.
Age-Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population
Efraim Jaul, Jeremy Barron
Frontiers in Public Health · 2017 · Review
Abstract
By 2050, the American 85 years old and over population will triple. Clinicians and the public health community need to develop a culture of sensitivity to the needs of this population and its subgroups. Sensory changes, cognitive changes, and weakness may be subtle or may be severe in the heterogeneous population of people over age 85. Falls, cardiovascular disease, and difficulty with activities of daily living are common but not universal. This paper reviews relevant changes of normal aging, diseases, and syndromes common in people over age 85, cognitive and psychological changes, social and environmental changes, and then reviews common discussions which clinicians routinely have with these patients and their families. Some hearing and vision loss are a part of normal aging as is decline in immune function. Cardiovascular disease and osteoporosis and dementia are common chronic conditions at age 85. Osteoarthritis, diabetes, and related mobility disability will increase in prevalence as the population ages and becomes more overweight. These population changes have considerable public health importance. Caregiver support, services in the home, assistive technologies, and promotion of home exercise programs as well as consideration of transportation and housing policies are recommended. For clinicians, judicious prescribing and ordering of tests includes a consideration of life expectancy, lag time to benefit, and patient goals. Furthermore, healthy behaviors starting in early childhood can optimize quality of life among the oldest-old.
References 70
- 1.
United Nations, Department of Economic and Social Affairs, Population Division. World Population Ageing 2015. (ST/ESA/SER.A/390). New York: United Nations (2015 ).
Not in our library
- 2.
Snider EL. Young-old versus old-old and the use of health services. Does the difference make a difference? J Am Geriatr Soc (1981 ) 29:354–8.
Not in our library10.1111/j.1532-5415.1981.tb01241.x
- 3.
Gavazzi G Mallaret MR Couturier P Iffenecker A Franco A. Bloodstream infection: differences between young-old, old, and old-old patients. J Am Geriatr Soc (2002 ) 50:1667–73.
Not in our library10.1046/j.1532-5415.2002.50458.x
- 4.
Suzman R Riley MW Introducing the “oldest old”. Milbank Mem Fund Q Health Soc (1985 ) 63:177–86.
Not in our library10.2307/3349879
- 5.
Davis A McMahon CM Pichora-Fuller KM Russ S Lin F Olusanya BO Aging and hearing health: the life-course approach. Gerontologist (2016 ) 56(Suppl 2):S256–67.
Not in our library10.1093/geront/gnw033
- 6.
Desai M Pratt LA Lentzner H Robinson KN Trends in Vision and Hearing Among Older Americans. Aging Trends. Hyattsville, MD: National Center for Health Statistics (2001 ).
Not in our library10.1037/e620682007-001
- 7.
Amieva H Ouvrard C Giulioli C Meillon C Rullier L Dartigues JF. Self-reported hearing loss, hearing aids, and cognitive decline in elderly adults: a 25-year study. J Am Geriatr Soc (2015 ) 63:2099–104.
Not in our library10.1111/jgs.13649
- 8.
Popelka MM Cruickshanks KJ Wiley TL Tweed TS Klein BE Klein R. Low prevalence of hearing aid use among older adults with hearing loss: the epidemiology of hearing loss study. J Am Geriatr Soc (1998 ) 46:1075–8.
Not in our library10.1111/j.1532-5415.1998.tb06643.x
- 9.
Evans JR Fletcher AE Wormald RP Ng ES Stirling S Smeeth L Prevalence of visual impairment in people aged 75 years and older in Britain: results from the MRC trial of assessment and management of older people in the community. Br J Ophthalmol (2002 ) 86:795–800.
Not in our library10.1136/bjo.86.7.795
- 10.
Zalewski CK. Aging of the human vestibular system. Semin Hear (2015 ) 36:175–96.
Not in our library10.1055/s-0035-1555120
- 11.
- 12.
Walston JD. Sarcopenia in older adults. Curr Opin Rheumatol (2012 ) 24:623–7.
Not in our library10.1097/bor.0b013e328358d59b
- 13.
Newman AB Kupelian V Visser M Simonsick EM Goodpaster BH Kritchevsky SB Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci (2006 ) 61:72–7.
Not in our library10.1093/gerona/61.1.72
- 14.
Xue QL Beamer BA Chaves PH Guralnik JM Fried LP Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the women’s health and aging study II. J Am Geriatr Soc (2010 ) 58:2076–84.
Not in our library10.1111/j.1532-5415.2010.03154.x
- 15.
Bandaranayake T Shaw AC. Host resistance and immune aging. Clin Geriatr Med (2016 ) 32:415–32.
Not in our library10.1016/j.cger.2016.02.007
- 16.
Raviotta JM Smith KJ DePasse J Brown ST Shim E Nowalk MP Cost-effectiveness and public health effect of influenza vaccine strategies for U.S. elderly adults. J Am Geriatr Soc (2016 ) 64:2126–31.
Not in our library10.1111/jgs.14323
- 17.
Gould L Abadir P Brem H Carter M Conner-Kerr T Davidson J Chronic wound repair and healing in older adults: current status and future research. J Am Geriatr Soc (2015 ) 63:427–38.
Not in our library10.1111/jgs.13332
- 18.
Ariathianto Y. Asymptomatic bacteriuria – prevalence in the elderly population. Aust Fam Physician (2011 ) 40:805–9.
Not in our library
- 19.
Zalmanovici Trestioreanu A Lador A Sauerbrun-Cutler MT Leibovici L. Antibiotics for asymptomatic bacteriuria. Cochrane Database Syst Rev (2015 ) 4:CD009534.
Not in our library10.1002/14651858.cd009534.pub2
- 20.
Collerton J Davies K Jagger C Kingston A Bond J Eccles MP Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ (2009 ) 339:b4904.
Not in our library10.1136/bmj.b4904
- 21.
Wang JC Bennett M. Aging and atherosclerosis mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res (2012 ) 111:245–59.
Not in our library10.1161/circresaha.111.261388
- 22.
Alexander RW Hypertension and the pathogenesis of atherosclerosis. Hypertension (1995 ) 25:155–61.
Not in our library10.1161/01.hyp.25.2.155
- 23.
Federal Interagency Forum on Aging-related Statistics. Older Americans 2016: Key Indicators of Well-Being. (2016 ). Available from: https://agingstats.gov/docs/LatestReport/Older-Americans-2016-Key-Indicators-of-WellBeing.pdf
Not in our library
- 24.
SPRINT Research GroupWright JT Jr Williamson JD Whelton PK Snyder JK Sink KM A randomized trial of intensive versus standard blood-pressure control. N Engl J Med (2015 ) 373:2103–16.
Not in our library10.1056/nejmoa1511939
- 25.
Gorina Y Hoyert D Lentzner H Goulding M Trends in Causes of Death among Older Persons in the United States. Aging Trends. Hyattsville, MD: National Center for Health Statistics (2006 ).
Not in our library
- 26.
Siu AL U.S. Preventive Services Task Force. Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med (2016 ) 164:279–96.
Not in our library10.7326/m15-2886
- 27.
Lee SJ Boscardin WJ Stijacic-Cenzer I Conell-Price J O’Brien S Walter LC. Time lag to benefit after screening for breast and colorectal cancer: meta-analysis of survival data from the United States, Sweden, United Kingdom, and Denmark. BMJ (2013 ) 346:e8441.
Not in our library10.1136/bmj.e8441
- 28.
Lin JS Piper MA Perdue LA Rutter C Webber EM O’Connor E Screening for colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA (2016 ) 315:2576–94.
Not in our library10.1001/jama.2016.3332
- 29.
Walter LC Covinsky KE. Cancer screening in elderly patients: a framework for individualized decision making. JAMA (2001 ) 285:2750–6.
Not in our library10.1001/jama.285.21.2750
- 30.
Moyer VA U.S. Preventive Services Task Force. Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med (2012 ) 157:120–34.
Not in our library10.7326/0003-4819-157-2-201207170-00459
- 31.
Kirkman MS Briscoe VJ Clark N Florez H Haas LB Halter JB Diabetes in older adults. Diabetes Care (2012 ) 35:2650–64.
Not in our library10.2337/dc12-1801
- 32.
Odden MC Shlipak MG Whitson HE Katz R Kearney PM defilippi C Risk factors for cardiovascular disease across the spectrum of older age: the cardiovascular health study. Atherosclerosis (2014 ) 237:336–42.
Not in our library10.1016/j.atherosclerosis.2014.09.012
- 33.
Evidence Summary: Osteoporosis: Screening. U.S. Preventive Services Task Force (2014 ). Available from: https://www.uspreventiveservicestaskforce.org/Page/Document/evidence-summary6/osteoporosis-screening
Not in our library
- 34.
- 35.
Hayek S Ifrah A Enav T Shohat T Presence correlates and time trends of multiple chronic conditions among Israeli adults: estimates from the Israeli National Health Interview Survey. Prev Chronic Dis (2017 ) 14:E64
Not in our library10.5888/pcd14.170038
- 36.
Gerteis J Izrael D Deitz D LeRoy L Ricciardi R Miller T Multiple Chronic Conditions Chartbook. Rockville, MD: Agency for Healthcare Research and Quality (2014 ). AHRQ Publications No, Q14-0038.
Not in our library
- 37.
Guralnik JM Ferrucci L Pieper CF Leveille SG Markides KS Ostir GV Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci (2000 ) 55:M221–31.
Not in our library10.1093/gerona/55.4.m221
- 38.
Middleton A Fritz SL Lusardi M. Walking speed: the functional vital sign. J Aging Phys Act (2015 ) 23:314–22.
Not in our library10.1123/japa.2013-0236
- 39.
Butler AA Menant JC Tiedemann AC Lord SR. Age and gender differences in seven tests of functional mobility. J Neuroeng Rehabil (2009 ) 6:31.
Not in our library10.1186/1743-0003-6-31
- 40.
He W Larsen LJ U.S. Census Bureau, American Community Survey Reports, ACS-29, Older Americans with a Disability: 2008–2012. Washington, DC: U.S. Government Printing Office (2014 ).
Not in our library
- 41.
Jagger C Arthur AJ Spiers NA Clarke M. Patterns of onset of disability in activities of daily living with age. J Am Geriatr Soc (2001 ) 49:404–9.
Not in our library10.1046/j.1532-5415.2001.49083.x
- 42.
Connolly D Garvey J McKee G. Factors associated with ADL/IADL disability in community dwelling older adults in the Irish longitudinal study on ageing (TILDA). Disabil Rehabil (2017 ) 39:809–16.
Not in our library10.3109/09638288.2016.1161848
- 43.
WHO Global Report on Falls Prevention in Old Age. Geneva, Switzerland: World Health Organization (2007 ). Available from: http://apps.who.int/iris/handle/10665/43811
Not in our library
- 44.
Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society. Summary of the Updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons. J Am Geriatr Soc (2011 ) 59:148–57.
Not in our library10.1111/j.1532-5415.2010.03234.x
- 45.
NICE. The Assessment and Prevention of Falls in Older People. (2013 ). Available from: http://www.nice.org.uk/CG161
Not in our library
- 46.
Fried LP Tangen CM Walston J Newman AB Hirsch C Gottdiener J Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci (2001 ) 56:M146–56.
Not in our library10.1093/gerona/56.3.m146
- 47.
Bandeen-Roche K Seplaki CL Huang J Buta B Kalyani RR Varadhan R Frailty in older adults: a nationally representative profile in the United States. J Gerontol A Biol Sci Med Sci (2015 ) 70:1427–34.
Not in our library10.1093/gerona/glv133
- 48.
Puts MTE Toubasi S Andrew MK Ashe MC Ploeg J Atkinson E Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing (2017 ) 46:383–92.
Not in our library10.1093/ageing/afw247
- 49.
Shah D Badlani G. Treatment of overactive bladder and incontinence in the elderly. Rev Urol (2002 ) 4(Suppl 4):S38–43.
Not in our library
- 50.
Sims J Browning C Lundgren-Lindquist B Kendig H. Urinary incontinence in a community sample of older adults: prevalence and impact on quality of life. Disabil Rehabil (2011 ) 33:1389–98.
Not in our library10.3109/09638288.2010.532284
- 51.
Blazer DG Yaffe K Karlawish J Cognitive aging: a report from the Institute of Medicine. JAMA (2015 ) 313:2121–2.
Not in our library10.1001/jama.2015.4380
- 52.
Rosen JB Brand M Kalbe E. Empathy mediates the effects of age and sex on altruistic moral decision making. Front Behav Neurosci (2016 ) 10:67.
Not in our library10.3389/fnbeh.2016.00067
- 53.
ADI. World Alzheimer Report 2015: The Global Impact of Dementia. London: Alzheimer’s Disease International (ADI) (2015 ).
Not in our library
- 54.
Amjad H Roth DL Samus QM Yasar S Wolff JL. Potentially unsafe activities and living conditions of older adults with dementia. J Am Geriatr Soc (2016 ) 64:1223–32.
Not in our library10.1111/jgs.14164
- 55.
Kenny RA Coen RF Frewen J Donoghue OA Cronin H Savva GM. Normative values of cognitive and physical function in older adults: findings from the Irish longitudinal study on ageing. J Am Geriatr Soc (2013 ) 61(Suppl 2):S279–90.
Not in our library10.1111/jgs.12195
- 56.
Stek ML Vinkers DJ Gussekloo J van der Mast RC Beekman AT Westendorp RG. Natural history of depression in the oldest old: population-based prospective study. Br J Psychiatry (2006 ) 188:65–9.
Not in our library10.1192/bjp.188.1.65
- 57.
Conwell Y Thompson C. Suicidal behavior in elders. Psychiatr Clin North Am (2008 ) 31:333–56.
Not in our library10.1016/j.psc.2008.01.004
- 58.
Steptoe A Shankar A Demakakos P Wardle J. Social isolation, loneliness, and all-cause mortality in older men and women. Proc Natl Acad Sci U S A (2013 ) 110:5797–801.
Not in our library10.1073/pnas.1219686110
- 59.
Ornstein KA Leff B Covinsky KE Ritchie CS Federman AD Roberts L Epidemiology of the homebound population in the United States. JAMA Intern Med (2015 ) 175:1180–6.
Not in our library10.1001/jamainternmed.2015.1849
- 60.
Dostal PJ. Vulnerability of urban homebound older adults in disasters: a survey of evacuation preparedness. Disaster Med Public Health Prep (2015 ) 9:301–6.
Not in our library10.1017/dmp.2015.50
- 61.
Joint Center for Housing Studies of Harvard University. Projections and Implications for Housing a Growing Population: Older Households 2015-2035. Cambridge, MA: Harvard University (2016 ).
Not in our library
- 62.
Pew Research Center. Smaller Share of Women Ages 65 and Over Are Living Alone. Pew Research Center Social and Demographic Trends (2016 ). Available from: http://www.pewsocialtrends.org/2016/02/18/2-living-arrangements-of-older-americans-by-gender/
Not in our library
- 63.
National Academies of Sciences, Engineering, and Medicine. Families Caring for an Aging America. Washington, DC: The National Academies Press (2016 ).
Not in our library
- 64.
Carmeli E The invisibles: unpaid caregivers of the elderly. Front Public Health (2014 ) 2:91
Not in our library10.3389/fpubh.2014.00091
- 65.
Schoenborn NL Lee K Pollack CE Armacost K Dy SM Bridges JFP Older adults’ views and communication preferences about cancer screening cessation. JAMA Intern Med (2017 ) 177:1121–8.
Not in our library10.1001/jamainternmed.2017.1778
- 66.
Wang R Chen L Fan L Gao D Liang Z He J Incidence and effects of polypharmacy on clinical outcome among patients aged 80+: a five-year follow-up study. PLoS One (2015 ) 10:e0142123.
Not in our library10.1371/journal.pone.0142123
- 67.
Holmes HM Hayley DC Alexander GC Sachs GA Reconsidering medication appropriateness for patients late in life. Arch Intern Med (2006 ) 166:605–9.
Not in our library10.1001/archinte.166.6.605
- 68.
Levant S Chari K DeFrances CJ Hospitalizations for Patients Aged 85 and over in the United States, 2000–2010. Hyattsville, MD: National Center for Health Statistics (2015 ). NCHS Data Brief No. 182.
Not in our library
- 69.
Boyd CM Xue QL Guralnik JM Fried LP. Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: the Women’s Health and Aging Study I. J Gerontol A Biol Sci Med Sci (2005 ) 60:888–93.
Not in our library10.1093/gerona/60.7.888
- 70.
Szanton SL Wolff JL Leff B Roberts L Thorpe RJ Tanner EK Preliminary data from community aging in place, advancing better living for elders, a patient-directed, team-based intervention to improve physical function and decrease nursing home utilization: the first 100 individuals to complete a Centers for Medicare and Medicaid Services Innovation Project. J Am Geriatr Soc (2015 ) 63:371–4.
Not in our library10.1111/jgs.13245
Cited by papers we hold 13
- Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement · 2023No notice
- Dynamic lipidome alterations associated with human health, disease and ageing · 2023No notice
- Napping and cognitive decline: a systematic review and meta-analysis of observational studies · 2022Not checked
- Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity · 2022No notice
- Telomerase activator-65 and pomegranate peel improved the health status of the liver in aged rats; multi-targets involved · 2021Not checked
- What is the Prevalence of Low Health Literacy in European Union Member States? A Systematic Review and Meta-analysis · 2021No notice
- Design and Feasibility of a Randomized Controlled Pilot Trial to Reduce Exposure and Cognitive Risk Associated With Advanced Glycation End Products in Older Adults With Type 2 Diabetes · 2021Not checked
- Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases · 2021No notice
- DNA Methylation Biomarkers in Aging and Age-Related Diseases · 2020No notice
- Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols · 2020No notice
- Heterochromatin: an epigenetic point of view in aging · 2020No notice
- Hallmarks of senescence and aging · 2019No notice
- Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis · 2019No notice
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.