Comprehensive bibliometric analysis of sirtuins: Focus on sirt1 and kidney disease

Sirtuins, as regulators of metabolism and energy, have been found to play an important role in health and disease. Sirt1, the most widely studied member of the sirtuin family, can ameliorate oxidative stress, immune inflammation, autophagy, and mitochondrial homeostasis by deacetylating regulatory histone and nonhistone proteins. Notably, sirt1 has gradually gained attention in kidney disease research. Therefore, an evaluation of the overall distribution of publications concerning sirt1 based on bibliometric analysis methods to understand the thematic evolution and emerging research trends is necessary to discover topics with potential implications for kidney disease research. We conducted a bibliometric analysis of publications derived from the Web of Science Core Collection and found that publications concerning sirt1 have grown dramatically over the past 2 decades, especially in the past 5 years. Among these, the proportion of publications regarding kidney diseases have increased annually. China and the United States are major contributors to the study of sirt1, and Japanese researchers have made important contributions to the study of sirt1 in kidney disease. Obesity, and Alzheimer’s disease are hotspots diseases for the study of sirt1, while diabetic nephropathy is regarded as a research hotspot in the study of sirt1 in kidney disease. NAD + , oxidative stress, and p53 are the focus of the sirt1 research field. Autophagy and NLRP3 inflammasome are emerging research trends have gradually attracted the interest of scholars in sirt1, as well as in kidney disease. Notably, we also identified several potential research topics that may link sirt1 and kidney disease, which require further study, including immune function, metabolic reprogramming, and fecal microbiota.

Abstract licence: CC BY

1. 2.

   Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation · 2013

2. 31.

   Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells · 2017

3. 44.

   Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury · 2018

4. 48.

   SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis · 2018

5. 53.

   The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer · 2019

6. 64.

   Sirtuins and their Biological Relevance in Aging and Age-Related Diseases · 2020

7. 76.

   SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation · 2021

8. 81.

   Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy · 2021

9. 84.

   p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy · 2021

10. 89.

    SIRT1: A Potential Therapeutic Target in Autoimmune Diseases · 2021

83 more references, whose wording the paper’s licence keeps private.

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