Glutamine metabolism in cancers: Targeting the oxidative homeostasis

Glutamine is the most abundant amino acid in blood and tissues, and the most important nutrient except for glucose in cancer cells. Over the past years, most studies have focused on the role of Gln metabolism in supporting energy metabolism rather than maintaining oxidative homeostasis. In fact, Gln is an important factor in maintaining oxidative homeostasis of cancer cells, especially in “Glutamine addicted” cancer cells. Here, this paper will review the recent scientific literature about the link between Gln metabolism and oxidative homeostasis, with an emphasis on the potential role of Gln metabolism in different cancers. Given that oxidative homeostasis is of critical importance in cancer, understanding the impacts of a Gln metabolism on oxidative homeostasis, gaining great insights into underlying molecular mechanisms, and developing effective therapeutic strategies are of great importance.

Abstract licence: CC BY

1. 41.

   Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone · 2015

2. 56.

   The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy · 2016

3. 57.

   ROS homeostasis and metabolism: a dangerous liason in cancer cells · 2016

4. 61.

   Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes · 2016

5. 69.

   Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells · 2017

6. 73.

   The emerging role and targetability of the TCA cycle in cancer metabolism · 2017

7. 84.

   Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer · 2018

8. 110.

   Role of Glutathione in Cancer: From Mechanisms to Therapies · 2020

9. 111.

   The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies · 2020

10. 117.

    GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy · 2021

11. 121.

    Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells · 2021

12. 125.

    Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response · 2022

114 more references, whose wording the paper’s licence keeps private.

• Energy metabolism in health and diseases · 2025

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.