Latest Trend of Milk Derived Exosomes: Cargos, Functions, and Applications

Exosomes are nanosized phospholipid bilayer vesicles released to the extracellular environment. Exosomes from various tissues or cells are being studied and there has been a growing interest in milk exosomes research due to their emerging role as messengers between cells and the fact that it can be produced in large quantities with rich source of milk. Milk derived exosomes (MDEs) contain lipids, microRNAs, proteins, mRNAs as well as DNA. Studies of exosome cargo have been conducted widely in many research areas, especially exosomal miRNAs. In this paper, we reviewed the current knowledge in isolation and identification, cargos, functions mainly in intestinal tract and immunity system of MDEs. Its application as drug carriers and diseases biomarker are also discussed. Furthermore, we also consider critical challenges of MDEs application and provide possible directions for future research.

Abstract licence: CC BY

1. 9.

   Commercial Cow Milk Contains Physically Stable Extracellular Vesicles Expressing Immunoregulatory TGF-β · 2015

2. 11.

   Exploration of microRNAs in porcine milk exosomes · 2014

3. 13.

   Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes · 2012

4. 26.

   microRNA as a new immune-regulatory agent in breast milk · 2010

5. 27.

   Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth · 2013

6. 29.

   MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection · 2015

7. 40.

   Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease · 2016

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