Perspective: Of Mice and Men – How Widespread Is Adult Neurogenesis?

These are exciting times for research on adult hippocampal neurogenesis (AHN). Debate and controversy regarding the existence of generation of new neurons in the adult, and even diseased human brain flourishes as articles against and in favor accumulate. Adult neurogenesis in the human brain is a phenomenon that does not share the qualities of quantum mechanics. The scientific community should agree that human AHN exists or does not, but not both at the same time. In this commentary, we discuss the latest research articles about hAHN and what their findings imply for the neurogenesis field.

Abstract licence: CC BY

1. 16.

   Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates · 2011

2. 20.

   Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years · 2010

3. 37.

   Practical considerations for choosing a mouse model of Alzheimer’s disease · 2017

47 more references, whose wording the paper’s licence keeps private.

• The Role of Neurod Genes in Brain Development, Function, and Disease · 2021

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