Stem cell-based regenerative medicine in Huntington’s disease: is fetal striatal grafting passing the baton? A commentary on Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient, by Reddington AE et al. (2014). Front Cellular Neurosci 8, 398
Berardino ePorfirio, Annamaria eMorelli, Renato eConti and 2 more
Frontiers in Cellular Neuroscience · 2015
doi:10.3389/fncel.2015.00177 (opens in a new tab)
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Abstract
We comment on a review illustrating the shortcomings of targeting at just the MSN lineage when trying to produce stem cells for a substitutive therapy to HD patients. We document recent and important insights emerged from studies by us and others, encompassing fetal striatal grafting and normal striatal development.
Abstract licence: CC BY
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