Editorial: Organellar dynamics in cell fate

Editorial on the Research Topic organellar dynamics in cell fateOne of the intriguing aspects of cell fate lies in the fact that multiple factors, or a myriad of interconnecting processes dictates life and death of the cell.Among the many different triggers of death versus promoters of survival, many originate from the inside of the cell itself, with organelles being the upstream source or acting as a downstream converging interacting point for these factors.The organelles constitute the sites of crucial processes to maintain life such as replication/proliferation, differentiation, metabolism and energy generation while also mediating cell death via processes ranging from disrupted calcium homeostasis to release of pro-death proteins.Although investigation is ongoing, there remains unknown facets to the role of the organelles in governing cell fate.In this Research Topic comprising of 3 original research articles and 2 reviews, we get a glimpse of some of the different studies focused on unraveling the mysteries regarding the organelles as gatekeepers of life and death of the host cell.Dai et al. from the group of Jian Wu and Yunzeng Zou demonstrated that cardiac hypertrophic preconditioning (HP) in mice preserved cardiac function, alleviated myocardial hypertrophy and fibrosis, provided that caspase-1 as a key member of the proinflammatory caspases known to mediate mitochondrial disassembly and its downstream cytokine targets IL-1β and IL-18 remain subdued.The authors found that HP abrogated the function of caspase-1 through attenuation of inflammation rather than pyroptosis.Genetic overexpression of caspase-1 in the myocardium prevented the benefit of HP in pressure overload mouse hearts via an aggravated activation of IL-1β and IL-18.

Abstract licence: CC BY

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