No retraction, correction or concern found when last checked on Oct 18, 2026.

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Rojita Mishra, Amrita Kumari Panda, Surajit De Mandal and 3 more

Frontiers in Microbiology · 2020 · Review · CC BY

doi:10.3389/fmicb.2020.566325

Abstract

Pathogenic microorganisms and their chronic pathogenicity are significant concerns in biomedical research. Biofilm-linked persistent infections are not easy to treat due to resident multidrug-resistant microbes. Low efficiency of various treatments and in-vivo toxicity of available antibiotics drives the researchers towards the discovery of many effective natural anti-biofilm agents. Natural extracts, natural product-based anti-biofilm agents are more efficient than the chemically synthesized counterparts with lesser side effects. The present review primarily focuses on various natural anti-biofilm agents, i.e. phytochemicals, biosurfactants, antimicrobial peptides and microbial enzymes along with their sources, mechanism of action via interfering in the quorum-sensing pathways, disruption of extracellular polymeric substance, adhesion mechanism and their inhibitory concentrations existing in literature so far. This study provides a better understanding that a particular natural anti-biofilm molecule exhibit different mode of actions and biofilm inhibitory activity against more than one pathogenic species. This information can be exploited further to improve the therapeutic strategy by a combination of more than one natural anti-biofilm compounds from diverse sources.

References 196

1.
In Vitro and Ex Vivo Antibiofilm Activity of a Lipopeptide Biosurfactant Produced by the Entomopathogenic Beauveria bassiana Strain against Microsporum canis · 2020
Not checked
2.
Abdelli F. Jardak M. Elloumi J. Stien D. Cherif S. Mnif S. (2019 ). Antibacterial, anti-adherent and cytotoxic activities of surfactin (s) from a lipolytic strain Bacillus safensis F4. Biodegradation 30 287–300.
Not in our library10.1007/s10532-018-09865-4
3.
Abdollahi S. Tofighi Z. Babaee T. Shamsi M. Rahimzadeh G. Rezvanifar H. (2020 ). Evaluation of anti-oxidant and anti-biofilm activities of biogenic surfactants derived from Bacillus amyloliquefaciens and Pseudomonas aeruginosa. Ira. J. Pharm. Res. 19 115-126.
Not in our library10.22037/ijpr.2020.1101033
4.
Effect of Adiantum philippense Extract on Biofilm Formation, Adhesion With Its Antibacterial Activities Against Foodborne Pathogens, and Characterization of Bioactive Metabolites: An in vitro-in silico Approach · 2020
Not checked
5.
Algburi A. Comito N. Kashtanov D. Dicks L. M. Chikindas M. L. (2017 ). Control of biofilm formation: antibiotics and beyond. Appl. Environ. Microbiol. 83 e2508–e2516.
Not in our library10.1128/aem.02508-16
6.
Alkawash M. A. Soothill J. S. Schiller N. L. (2006 ). Alginate lyase enhances the antibiotic killing of mucoid Pseudomonas aeruginosa in biofilms. Apmis 114 131–138.
Not in our library10.1111/j.1600-0463.2006.apm_356.x
7.
Arita-Morioka K. I. Yamanaka K. Mizunoe Y. Tanaka Y. Ogura T. Sugimoto S. (2018 ). Inhibitory effects of Myricetin derivatives on curli-dependent biofilm formation in Escherichia coli. Sci. Rep. 8:8452.
Not in our library10.1038/s41598-018-26748-z
8.
Ashitha A. Radhakrishnan E. K. Jyothis M. (2020 ). Characterization of biosurfactant produced by the endophyte Burkholderia sp. WYAT7 and evaluation of its antibacterial and anti-biofilm potentials. J. Biotechnol. 313 1–10.
Not in our library10.1016/j.jbiotec.2020.03.005
9.
Azman A. S. Mawang C. I. Khairat J. E. AbuBakar S. (2019 ). Actinobacteria—a promising natural source of anti-biofilm agents. Int. Microbiol. 22 403–409.
Not in our library10.1007/s10123-019-00066-4
10.
Balan S. S. Kumar C. G. Jayalakshmi S. (2016 ). Pontifactin, a new lipopeptide biosurfactant produced by a marine Pontibacter korlensis strain SBK-47: purification, characterization and it’s biological evaluation. Process Biochem. 51 2198–2207.
Not in our library10.1016/j.procbio.2016.09.009
11.
Banar M. Emaneini M. Satarzadeh M. Abdellahi N. Beigverdi R. van Leeuwen W. B. (2016 ). Evaluation of mannosidase and trypsin enzymes effects on biofilm production of Pseudomonas aeruginosa isolated from burn wound infections. PLoS One 11:e0164622.
Not in our library10.1371/journal.pone.0164622
12.
Başaran T. I. Berber D. Gökalsın B. Tramice A. Tommonaro G. Abbamondi G. R. (2020 ). Extremophilic Natrinema versiforme against Pseudomonas aeruginosa quorum sensing and biofilm. Front. Microbiol. 11:79.
Not in our library10.3389/fmicb.2020.00079
13.
Basso V. Tran D. Q. Schaal J. B. Tran P. Eriguchi Y. Ngole D. (2019 ). Rhesus Theta Defensin 1 promotes long term survival in Systemic Candidiasis by host directed mechanisms. Sci Rep. 9:16905.
Not in our library10.1038/s41598-019-53402-z
14.
Blower R. J. Barksdale S. M. Van Hoek M. L. (2015 ). Snake cathelicidin NA-CATH and smaller helical antimicrobial peptides are effective against Burkholderia thailandensis. PLoS Negl. Trop. Dis. 9:e0003862.
Not in our library10.1371/journal.pntd.0003862
15.
agr-Mediated Dispersal of Staphylococcus aureus Biofilms · 2008
No notice
16.
Borghi E. Borgo F. Morace G. (2016 ). Fungal biofilms: Update on resistance. Adv. Exp. Med. Biol. 931 37–47.
Not in our library10.1007/5584_2016_7
17.
Branco-de-Almeida L. S. Murata R. M. Franco E. M. dos Santos M. H. de Alencar S. M. Koo H. (2011 ). Effects of 7-epiclusianone on Streptococcus mutans and caries development in rats. Planta Med. 77 40–45.
Not in our library10.1055/s-0030-1250121
18.
Branda S. S. Vik S. Friedman L. Kolter R. (2005 ). Biofilms: the matrix revisited. Trends Microbiol. 13 20–26.
Not in our library10.1016/j.tim.2004.11.006
19.
Caceres M. Hidalgo W. Stashenko E. Torres R. Ortiz C. (2020 ). Essential oils of aromatic plants with antibacterial, anti-biofilm and anti-quorum sensing activities against pathogenic bacteria. Antibiotics 9:147.
Not in our library10.3390/antibiotics9040147
20.
Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections · 2010
Not checked
21.
Cappiello F. Ranieri D. Carnicelli V. Casciaro B. Chen H. T. Ferrera L. (2019 ). Bronchial epithelium repair by Esculentin-1a-derived antimicrobial peptides: involvement of metalloproteinase-9 and interleukin-8, and evaluation of peptides’ immunogenicity. Sci Rep. 9:18988.
Not in our library10.1038/s41598-019-55426-x
22.
Casciaro B. Cappiello F. Loffredo M. R. Ghirg F. Mangoni M. L. (2019 ). The Potential of frog skin peptides for anti-Infective therapies: the Case of Esculentin-1a (1-21) NH2. Curr. Med. Chem. 27 1405–1419.
Not in our library10.2174/0929867326666190722095408
23.
Cegelski L. Pinkner J. S. Hammer N. D. Cusumano C. K. Hung C. S. Chorell E. (2009 ). Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nat. Chem. Biol. 5 913–919.
Not in our library10.1038/nchembio.242
24.
Ceresa C. Rinaldi M. Chiono V. Carmagnola I. Allegrone G. Fracchia L. (2016 ). Lipopeptides from Bacillus subtilis AC7 inhibit adhesion and biofilm formation of Candida albicans on silicone. Anton. Van Leeuw. 109 1375–1388.
Not in our library10.1007/s10482-016-0736-z
25.
Characklis W. G. (1973 ). Attached microbial growths – I. Attachment and growth. Water Res. 7 1113–1127.
Not in our library10.1016/0043-1354(73)90066-3
26.
Development and Challenges of Antimicrobial Peptides for Therapeutic Applications · 2020
No notice
27.
Chen X. Zhang L. Wu Y. Wang L. Ma C. Xi X. (2018 ). Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogs designed through targeted engineering. Int. J. Biol. Sci. 14 599–607.
Not in our library10.7150/ijbs.23419
28.
Chi M. Qi M. A. L. Wang P. Weir M. D. Melo M. A. Sun X. (2019 ). Novel bioactive and therapeutic dental polymeric materials to inhibit periodontal pathogens and biofilms. Int. J. Mol. Sci. 20:278.
Not in our library10.3390/ijms20020278
29.
Ch’ng J.-H. Chong K. K. Lam L. N. Wong J. J. Kline K. A. (2019 ). Biofilm-associated infection by Enterococci. Nat. Rev. Microbiol. 17 82–94.
Not in our library10.1038/s41579-018-0107-z
30.
Choi J. H. Jang A. Y. Lin S. Lim S. Kim D. Park K. (2015 ). Melittin, a honeybee venom-derived antimicrobial peptide, may target methicillin-resistant Staphylococcus aureus. Mol. Med. Rep. 12 6483–6490.
Not in our library10.3892/mmr.2015.4275
31.
Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics · 2019
No notice
32.
Ciric A. D. Petrovic J. D. Glamoclija J. M. Smiljkovic M. S. Nikolic M. M. Stojkovic D. S. (2019 ). Natural products as biofilm formation antagonists and regulators of quorum sensing functions: a comprehensive review update and future trends. South Afr J Bot 120 65–80.
Not in our library10.1016/j.sajb.2018.09.010
33.
Costa B. Mota R. Tamagnini P. Martins M. C. L. Costa F. (2020 ). Natural cyanobacterial polymer-based coating as a preventive strategy to avoid catheter-associated urinary tract infections. Mar. Drugs 18:279.
Not in our library10.3390/md18060279
34.
Costerton J. W. Stewart P. S. Greenberg E. P. (1999 ). Bacterial biofilms: a common cause of persistent infections. Science 284 1318–1322.
Not in our library10.1126/science.284.5418.1318
35.
Cowan M. M. (1999 ). Plant products as antimicrobial agents. Clin. Microbiol. Rev. 12 564–582.
Not in our library10.1128/cmr.12.4.564
36.
Cui T. Bai F. Sun M. Lv X. Li X. Zhang D. (2020 ). Lactobacillus crustorum ZHG 2-1 as novel quorum-quenching bacteria reducing virulence factors and biofilms formation of Pseudomonas aeruginosa. LWT 117:108696
Not in our library10.1016/j.lwt.2019.108696
37.
Bio-inspired strategies for designing antifouling biomaterials · 2016
No notice
38.
Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin · 2016
No notice
39.
Dawson C. C. Intapa C. Jabra-Rizk M. A. (2011 ). “Persisters”: survival at the cellular level. PLoS Pathog. 7:e1002121.
Not in our library10.1371/journal.ppat.1002121
40.
Snake Venom Cathelicidins as Natural Antimicrobial Peptides · 2019
Not checked
41.
De Vos W. M. (2015 ). Microbial biofilms and the human intestinal microbiome. NPJ Biofilms Microb. 1:15005.
Not in our library10.1038/npjbiofilms.2015.5
42.
Deokar S. Kadam D. (2020 ). An Update on the Management of Urinary Tract Infections in An Era of Drug Resistance: Anti-Biofilm Strategy. Available at SSRN: https://ssrn.com/abstract=3533744 (accessed February 7, 2020).
Not in our library
43.
Dey P. Parai D. Banerjee M. Hossain S. T. Mukherjee S. K. (2020 ). Naringin sensitizes the anti-biofilm effect of ciprofloxacin and tetracycline against Pseudomonas aeruginosa biofilm. Int. J Med. Microbiol. 310:151410.
Not in our library10.1016/j.ijmm.2020.151410
44.
Antimicrobial and Antibiofilm Peptides · 2020
No notice
45.
Diamond G. Beckloff N. Weinberg A. Kisich K. O. (2009 ). The roles of antimicrobial peptides in innate host defense. Curr. Pharm. Des. 15 2377–2392.
Not in our library10.2174/138161209788682325
46.
Diaz De Rienzo M. A. Stevenson P. S. Marchant R. Banat I. M. (2016 ). Effect of biosurfactants on Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a bioFlux channel. Appl. Microbiol. Biotechnol. 100 5773–5779.
Not in our library10.1007/s00253-016-7310-5
47.
Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy · 2020
No notice
48.
Ding X. Yin B. Qian L. Zeng Z. Yang Z. Li H. (2011 ). Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm. J. Med. Microbiol. 60 1827–1834.
Not in our library10.1099/jmm.0.024166-0
49.
Dominguez E. Zarnowski R. Sanchez H. Covelli A. S. Westler W. M. Azadi P. (2018 ). Conservation and divergence in the Candida species biofilm matrix mannan-glucan complex structure, function, and genetic control. mBio. 9:e00451-18.
Not in our library10.1128/mbio.00451-18
50.
Eckhart L. Fischer H. Barken K. B. Tolker-Nielsen T. Tschachler E. (2007 ). DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus. Br. J. Dermat 156 1342–1345.
Not in our library10.1111/j.1365-2133.2007.07886.x
51.
Elshikh M. Funston S. Chebbi A. Ahmed S. Marchant R. Banat I. M. (2017 ). Rhamnolipids from non-pathogenic Burkholderia thailandensis E264: physicochemical characterization, antimicrobial and anti-biofilm efficacy against oral hygiene related pathogens. New Biotechnol. 36 26–36.
Not in our library10.1016/j.nbt.2016.12.009
52.
Fenton M. Keary R. Mcauliffe O. O’Mahony J. Coffey A. (2013 ). Bacteriophage-Derived Peptidase CHAPK eliminates and prevents Staphylococcal Biofilms. Int. J. Microbiol. 2013:625341.
Not in our library10.1155/2013/625341
53.
Flemming H.-C. (2011 ). Biofilm Highlights. Hoboken, NJ: Springer, 81–109.
Not in our library
54.
Flemming H. C. Neu T. R. Wingender J. (eds) (2016a ). The Perfect Slime: Microbial Extracellular Polymeric Substances (EPS). London: IWA publishing.
Not in our library
55.
Flemming H. C. Wingender J. (2010 ). The biofilm matrix. Nat. Rev. Microbiol. 8 623–633.
Not in our library10.1038/nrmicro2415
56.
Flemming H.-C. Wingender J. Szewzyk U. Steinberg P. Rice S. A. Kjelleberg S. (2016b ). Biofilms: an emergent form of bacterial life. Nat. Rev. Microbiol. 14 563–575.
Not in our library10.1038/nrmicro.2016.94
57.
Flemming H. C. Wuertz S. (2019 ). Bacteria and archaea on Earth and their abundance in biofilms. Nat. Rev. Microbiol. 17 247–260.
Not in our library10.1038/s41579-019-0158-9
58.
Fletcher M. M. Floodgate G. D. (1973 ). An electron microscopic demonstration of an acidic polysaccharide involved in the adhesion of a marine bacterium to solid surfaces. J. Gen. Microbiol. 74 325–334.
Not in our library10.1099/00221287-74-2-325
59.
Fox E. P. Nobile C. J. (2012 ). A sticky situation: untangling the transcriptional network controlling biofilm development in Candida albicans. Transcription 3 315–322.
Not in our library10.4161/trns.22281
60.
Fux A. Costerton W. Stewart P. Stoodley P. (2005 ). Survival strategies of infectious biofilms. Trends Microbiol. 13 34–40.
Not in our library10.1016/j.tim.2004.11.010
61.
Gartika M. Pramesti H. T. Kurnia D. Satari M. H. (2018 ). A terpenoid isolated from sarang semut (Myrmecodia pendans) bulb and its potential for the inhibition and eradication of Streptococcus mutans biofilm. BMC Compl. Alt. Med. 18:151.
Not in our library10.1186/s12906-018-2213-x
62.
Geesey G. G. Mutch R. Costerton J. W. (1978 ). Sessile bacteria: an important component of the microbial population in small mountain streams. Limnol. Oceanogr. 23 1214–1224.
Not in our library10.4319/lo.1978.23.6.1214
63.
Gharieb R. M. A. Saad M. F. Mohamed A. S. Tartor Y. H. (2020 ). Characterization of two novel lytic bacteriophages for reducing biofilms of zoonotic multidrug-resistant Staphylococcus aureus and controlling their growth in milk. LWT 124:109145
Not in our library10.1016/j.lwt.2020.109145
64.
Giordani B. Costantini P. E. Fedi S. Cappelletti M. Abruzzo A. Parolin C. (2019 ). Liposomes containing biosurfactants isolated from Lactobacillus gasseri exert anti-biofilm activity against methicillin-resistant Staphylococcus aureus strains. Eur. J. Pharm. Biopharm. 139 246–252.
Not in our library10.1016/j.ejpb.2019.04.011
65.
Guilhelmelli F. Vilela N. Smidt K. S. de Oliveira M. A. da Cunha Morales Álvares A. Rigonatto M. C. (2016 ). Activity of scorpion venom-derived antifungal peptides against planktonic cells of Candida spp. and Cryptococcus neoformans and Candida albicans biofilms. Front. Microbiol. 7:1844.
Not in our library10.3389/fmicb.2016.01844
66.
Gunn J. S. Bakaletz L. O. Wozniak D. J. (2016 ). What’s on the outside matters: the role of the extracellular polymeric substance of gram-negative biofilms in evading host immunity and as a target for therapeutic intervention. J. Biol. Chem. 291 12538–12546.
Not in our library10.1074/jbc.r115.707547
67.
Guo L. Mclean J. S. Yang Y. Eckert R. Kaplan C. W. Kyme P. (2015 ). Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology. Proc. Natl. Acad. Sci. U.S.A. 112 7569–7574.
Not in our library10.1073/pnas.1506207112
68.
Effective Removal of Staphylococcal Biofilms by the Endolysin LysH5 · 2014
No notice
69.
Hall-Stoodley L. Costerton J. W. Stoodley P. (2004 ). Bacterial biofilms: from the natural environment to infectious diseases. Nat. Rev. Microbiol. 2 95–108.
Not in our library10.1038/nrmicro821
70.
Inhibitory Effect of Sophorolipid on Candida albicans Biofilm Formation and Hyphal Growth · 2016
No notice
71.
Harjai K. Kumar R. Singh S. (2010 ). Garlic blocks quorum sensing and attenuates the virulence of Pseudomonas aeruginosa. FEMS Immunol. Med. Microbiol. 58 161–168.
Not in our library10.1111/j.1574-695x.2009.00614.x
72.
Harms A. Maisonneuve E. Gerdes K. (2016 ). Mechanisms of bacterial persistence during stress and antibiotic exposure. Science 354 42–68.
Not in our library10.1126/science.aaf4268
73.
Hell E. Giske C. G. Nelson A. Römling U. Marchini G. (2010 ). Human cathelicidin peptide LL37 inhibits both attachment capability and biofilm formation of Staphylococcus epidermidis. Lett. Appl. Microbiol. 50 211–215.
Not in our library10.1111/j.1472-765x.2009.02778.x
74.
Hirt H. Hall J. W. Larson E. Gorr S. U. (2018 ). A D-enantiomer of the antimicrobial peptide GL13K evades antimicrobial resistance in the gram-positive bacteria Enterococcus faecalis and Streptococcus gordonii. PLoS One 13:e0194900.
Not in our library10.1371/journal.pone.0194900
75.
Hogan S. Zapotoczna M. Stevens N. T. Humphreys H. O’Gara J. P. O’Neill E. (2017 ). Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm-related infections. J. Hosp. Infect. 96 177–182.
Not in our library10.1016/j.jhin.2017.02.008
76.
Ibberson C. B. Parlet C. P. Kwiecinski J. Crosby H. A. Meyerholz D. K. Horswill A. R. (2016 ). Hyaluronan modulation impacts Staphylococcus aureus biofilm infection. Inf. Immun. 84 1917–1929.
Not in our library10.1128/iai.01418-15
77.
Izano E. A. Shah S. M. Kaplan J. B. (2009 ). Intercellular adhesion and biocide resistance in nontypeable Haemophilus influenzae biofilms. Microb. Pathog. 46 207–213.
Not in our library10.1016/j.micpath.2009.01.004
78.
Jakobsen T. H. van Gennip M. Phipps R. K. Shanmugham M. S. Christensen L. D. Alhede M. (2012 ). Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob. Agents Chemother. 56 2314–2325.
Not in our library10.1128/aac.05919-11
79.
Jakobsen T. H. Warming A. N. Vejborg R. M. Moscoso J. A. Stegger M. Lorenzen F. (2017 ). A broad range of quorum sensing inhibitor working through sRNA inhibition. Sci. Rep. 7:9857.
Not in our library10.1038/s41598-017-09886-8
80.
Janeczko M. Masłyk M. Kubiński K. Golczyk H. (2017 ). Emodin, a natural inhibitor of protein kinase CK2, suppresses growth, hyphal development, and biofilm formation of Candida albicans. Yeast 34 253–265.
Not in our library10.1002/yea.3230
81.
Janek T. Drzymała K. Dobrowolski A. (2020 ). In vitro efficacy of the lipopeptide biosurfactant surfactin-C15 and its complexes with divalent counterions to inhibit Candida albicans biofilm and hyphal formation. Biofouling 36 210–221.
Not in our library10.1080/08927014.2020.1752370
82.
Johari N. A. Amran S. S. D. Kamaruzzaman A. N. A. Man C. A. I. C. Yahya M. F. Z. R. (2020 ). Anti-biofilm potential and mode of action of malaysian plant species: a review. Sci. Lett. 14 34–46.
Not in our library
83.
Jones E. A. McGillivary G. Bakaletz L. O. (2013 ). Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human defensin-3 and reduces its antimicrobial activity. J. Innate Immun. 5 24–38.
Not in our library10.1159/000339961
84.
Junter G. A. Thebault P. Lebrun L. (2016 ). Polysaccharide-based antibiofilm surfaces. Acta Biomater. 30 13–25.
Not in our library10.1016/j.actbio.2015.11.010
85.
Kalia V. C. (2013 ). Quorum sensing inhibitors: an overview. Biotechnol. Adv. 31 224–245.
Not in our library10.1016/j.biotechadv.2012.10.004
86.
Kalpana B. J. Aarthy S. Pandian S. K. (2012 ). Anti-biofilm activity of α-amylase from Bacillus subtilis S8-18 against biofilm-forming human bacterial pathogens. Appl. Biochem. Biotechnol. 167 1778–1794.
Not in our library10.1007/s12010-011-9526-2
87.
Extracellular polymeric substance (EPS)-degrading enzymes reduce staphylococcal surface attachment and biocide resistance on pig skin in vivo. · 2018
Not checked
88.
Karlapudi A. P. Venkateswarulu T. C. Krupanidhi S. Rohini K. K. Indira M. Vidya P. K. (2020 ). Evaluation of anti-cancer, anti-microbial and anti-biofilm potential of biosurfactant extracted from an Acinetobacter M6 strain. J. King Saud. Univ. Sci. 32 223–227.
Not in our library10.1016/j.jksus.2018.04.007
89.
Karygianni L. Attin T. Thurnheer T. (2020 ). Combined DNase and proteinase treatment interferes with composition and structural integrity of multispecies oral biofilms. J. Clin. Med. 9:983.
Not in our library10.3390/jcm9040983
90.
Kerenga B. K. McKenna J. A. Harvey P. J. Quimbar P. Garcia D. Lay F. T. (2019 ). Salt-tolerant antifungal and antibacterial activities of the corn defensin ZmD32. Front. Microbiol. 10:795.
Not in our library10.3389/fmicb.2019.00795
91.
Kerkoub N. Panda S. K. Yang M.-R. Lu J.-G. Jiang Z.-H. Nasri H. (2018 ). Bioassay-Guided isolation of anti-Candida biofilm compounds from methanol extracts of the aerial parts of Salvia officinalis (Annaba. Algeria). Front. Pharmacol. 9:1418phar. 2
Not in our library10.3389/fphar.2018.01418
92.
Khan F. Oloketuyi S. F. Kim Y. M. (2019 ). Diversity of bacteria and bacterial products as anti-biofilm and antiquorum sensing drugs against pathogenic bacteria. Curr. Drug Targets 20 1156–1179.
Not in our library10.2174/1389450120666190423161249
93.
Khozani R. S. Shahbazzadeh D. Harzandi N. Feizabadi M. M. Bagheri K. P. (2019 ). Kinetics study of an antimicrobial peptide, melittin, in simultaneous biofilm degradation and eradication of potent biofilm-producing MDR Pseudomonas aeruginosa isolates. Int. J. Pept. Res. Ther. 25 329–338.
Not in our library10.1007/s10989-018-9675-z
94.
Kipanga P. N. Liu M. Panda S. K. Mai A. H. Veryser C. Van Puyvelde L. (2020 ). Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. J. Ethnopharmacol. 248:112352.
Not in our library10.1016/j.jep.2019.112352
95.
Koo H. Allan R. N. Howlin R. P. Stoodley P. Hall-Stoodley L. (2017 ). Targeting microbial biofilms: current and prospective therapeutic strategies. Nat. Rev. Microbiol. 15 740–755.
Not in our library10.1038/nrmicro.2017.99
96.
Kouakou K. Panda S. K. Yang M.-R. Lu J.-G. Jiang Z.-H. Van Puyvelde L. (2019 ). Isolation of antimicrobial compounds from Cnestis ferruginea Vahl ex. DC (Connaraceae) leaves through bioassay-guided fractionation. Front. Microbiol. 10:705.
Not in our library10.3389/fmicb.2019.00705
97.
Kumar L. Chhibber S. Kumar R. Kumar M. Harjai K. (2015 ). Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa. Fitoterapia 102 84–95.
Not in our library10.1016/j.fitote.2015.02.002
98.
LaSarre B. Federle M. J. (2013 ). Exploiting quorum sensing to confuse bacterial pathogens. Microbiol. Mol. Biol. Rev. 77 73–111.
Not in our library10.1128/mmbr.00046-12
99.
Lee J.-H. Kim Y.-G. Ryu S. Y. Cho M. H. Lee J. (2014a ). Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157: H7 and Staphylococcus aureus biofilm formation. Int. J. Food Microbiol. 174 47–55.
Not in our library10.1016/j.ijfoodmicro.2013.12.030
100.
Lee J.-H. Kim Y.-G. Ryu S. Y. Cho M. H. Lee J. (2014b ). Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157: H7 and Pseudomonas aeruginosa. J. Nat. Prod. 77 168–172.
Not in our library10.1021/np400756g
101.
Lee J.-H. Regmi S. C. Kim J.-A. Cho M. H. Yun H. Lee C.-S. (2011 ). Apple flavonoid phloretin inhibits Escherichia coli O157: H7 biofilm formation and ameliorates colon inflammation in rats. Infect. Immun. 79 4819–4827.
Not in our library10.1128/iai.05580-11
102.
Lewis K. (2005 ). Persister cells and the riddle of biofilm survival. Biochemistry 70 267–274.
Not in our library10.1007/s10541-005-0111-6
103.
Lewis K. (2010 ). Persister cells. Annu. Rev. Microbiol. 64 357–372.
Not in our library10.1146/annurev.micro.112408.134306
104.
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities · 2019
Not checked
105.
ClpV3 of the H3-Type VI Secretion System (H3-T6SS) Affects Multiple Virulence Factors in Pseudomonas aeruginosa · 2020
Not checked
106.
Little B. J. Lee J. S. (2015 ). Microbiologically influenced corrosion: an update. Int. Mat. Rev. 59 384–393.
Not in our library10.1179/1743280414y.3840000000035
107.
Liu J. Wu Q. Li L. Xi X. Wu D. Zhou M. (2017 ). Discovery of phylloseptins that defense against gram-positive bacteria and inhibit the proliferation of the non-small cell lung cancer cell line, from the skin secretions of Phyllomedusa frogs. Molecules 22:1428.
Not in our library10.3390/molecules22091428
108.
Loiselle M. Anderson K. W. (2003 ). The use of cellulase in inhibiting biofilm formation from organisms commonly found on medical implants. Biofouling 19 77–85.
Not in our library10.1080/0892701021000030142
109.
Long L. Chiang H. Y. Qian P. Y. (2020 ). A potent anti-biofilm agent inhibits and eradicates mono-and multi-species biofilms. bioRxiv[Preprint].
Not in our library10.1101/2020.03.25.009126
110.
Developing natural products as potential anti-biofilm agents · 2019
No notice
111.
Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model · 2017
No notice
112.
Lyles J. T. Kim A. Nelson K. Bullard-Roberts A. L. Hajdari A. Mustafa B. (2017 ). The chemical and antibacterial Evaluation of St. John’s Wort Oil Macerates Used in Kosovar Traditional Medicine. Front. Microbiol. 8:1639.
Not in our library10.3389/fmicb.2017.01639
113.
MacKenzie K. D. Palmer M. B. Köster W. L. White A. P. (2017 ). Examining the link between biofilm formation and the ability of pathogenic Salmonella strains to colonize multiple host species. Front. Vet. Sci. 25:138.
Not in our library10.3389/fvets.2017.00138
114.
Majik M. S. Naik D. Bhat C. Tilve S. Tilvi S. D’Souza L. (2013 ). Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa. Bioorg. Med. Chem. Lett. 23 2353–2356.
Not in our library10.1016/j.bmcl.2013.02.051
115.
Marshall K. C. Stout R. Mitchell R. (1971 ). Mechanisms of the initial events in the sorption of marine bacteria to surfaces. J. Gen. Microbiol. 68 337–348.
Not in our library10.1099/00221287-68-3-337
116.
Mitchell K. F. Zarnowski R. Sanchez H. Edward J. A. Reinicke E. L. Nett J. E. (2015 ). Community participation in biofilm matrix assembly and function. Proc. Natl. Acad. Sci. U.S.A. 112 4092–4097.
Not in our library10.1073/pnas.1421437112
117.
Mohammadi M. Taheri B. Momenzadeh N. Salarinia R. Nabipour I. Farshadzadeh Z. (2018 ). Identification and characterization of novel antimicrobial peptide from hippocampus comes by In Silico and experimental studies. Mar. Biotechnol. 20 718–728.
Not in our library10.1007/s10126-018-9843-3
118.
Mookherjee N. Brown K. L. Bowdish D. M. Doria S. Falsafi R. Hokamp K. (2006 ). Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J. Immunol. 176 2455–2464.
Not in our library10.4049/jimmunol.176.4.2455
119.
Murata R. M. Branco-de-Almeida L. S. Franco E. M. Yatsuda R. dos Santos M. H. de Alencar S. M. (2010 ). Inhibition of Streptococcus mutans biofilm accumulation and development of dental caries in vivo by 7-epiclusianone and fluoride. Biofouling 26 865–872.
Not in our library10.1080/08927014.2010.527435
120.
Nahar S. Mizan M. F. R. Ha A. J. W. Ha S. D. (2018 ). Advances and future prospects of enzyme-based biofilm prevention approaches in the food industry. Compr. Rev. Food Sci. Food Saf. 17 1484–1502.
Not in our library10.1111/1541-4337.12382
121.
Nguyen B. V. Nagakubo T. Toyofuku M. Nomura N. Utada A. S. (2020 ). Synergy between Sophorolipid biosurfactant and SDS increases the efficiency of P. aeruginosa biofilm disruption. Langmuir 36 6411–6420.
Not in our library10.1021/acs.langmuir.0c00643
122.
Ohadi M. Forootanfar H. Dehghannoudeh G. Eslaminejad T. Ameri A. Shakibaie M. (2020 ). Antimicrobial, anti-biofilm, and anti-proliferative activities of lipopeptide biosurfactant produced by Acinetobacter junii B6. Microb. Pathog. 138:103806.
Not in our library10.1016/j.micpath.2019.103806
123.
Olwal C. O. Ang’ienda P. O. Ochiel D. O. (2019 ). Alternative sigma factor B (σB) and catalase enzyme contribute to Staphylococcus epidermidis biofilm’s tolerance against physico-chemical disinfection. Sci. Rep. 9:5355.
Not in our library10.1038/s41598-019-41797-8
124.
Padhi A. Naik S. K. Sengupta S. Ganguli G. Sonawane A. (2016 ). Expression of Mycobacterium tuberculosis NLPC/p60 family protein Rv0024 induce biofilm formation and resistance against cell wall acting anti-tuberculosis drugs in Mycobacterium smegmatis. Microbe Infect. 18 224–236.
Not in our library10.1016/j.micinf.2015.11.007
125.
Prevention of biofilm formation by quorum quenching · 2020
No notice
126.
Pan C. Zubin Z. Xiaowei Y. (2018 ). Coatings as the useful drug delivery system for the prevention of implant-related infections. J Orthop. Sur. Res. 13:220.
Not in our library10.1186/s13018-018-0930-y
127.
Panda S. K. Das R. Lavigne R. Luyten W. (2020 ). Indian medicinal plant extracts to control multidrug-resistant S. aureus, including in biofilms. South Afr. J. Bot. 128 283–291.
Not in our library10.1016/j.sajb.2019.11.019
128.
Paraszkiewicz K. Moryl M. Płaza G. Bhagat D. K. Satpute S. Bernat P. (2019 ). Surfactants of microbial origin as anti-biofilm agents. Int. J. Environ. Health Res. 11 1–20.
Not in our library10.1080/09603123.2019.1664729
129.
Parducho K. R. Beadell B. Ybarra T. Bush M. Escalera E. Mendez M. (2020 ). The antimicrobial peptide human beta-defensin 2 inhibits biofilm production of Pseudomonas aeruginosa without compromising metabolic activity. Front. Immunol. 11:805.
Not in our library10.3389/fimmu.2020.00805
130.
Payne D. E. Martin N. R. Parzych K. R. Rickard A. H. Underwood A. Boles B. R. (2013 ). Tannic acid inhibits Staphylococcus aureus surface colonization in an IsaA-dependent manner. Infect. Immun. 81 496–504.
Not in our library10.1128/iai.00877-12
131.
Peng X. Zhu L. Wang Z. Zhan X. (2020 ). Enhanced stability of the bactericidal activity of nisin through conjugation with gellan gum. Int. J. Biol. Macromol. 148 525–532.
Not in our library10.1016/j.ijbiomac.2020.01.164
132.
Pires D. P. Costa A. R. Pinto G. Meneses L. Azeredo J. (2020 ). Current challenges and future opportunities of phage therapy. FEMS Microbiol. Rev. fuaa017.
Not in our library10.1093/femsre/fuaa017
133.
Pletzer D. Coleman S. R. Hancock R. E. (2016 ). Anti-biofilm peptides as a new weapon in antimicrobial warfare. Curr. Opin. Microbiol. 33 35–40.
Not in our library10.1016/j.mib.2016.05.016
134.
Qian W. Zhang J. Wang W. Liu M. Fu Y. Li X. (2020 ). Efficacy of chelerythrine against mono- and dual-species biofilms of Candida albicans and Staphylococcus aureus and its properties of inducing hypha-to-yeast transition of C. albicans. J. Fungi 6:45.
Not in our library10.3390/jof6020045
135.
Qvortrup K. Hultqvist L. Nilsson M. Jakobsen T. H. Jansen C. U. Uhd J. (2019 ). Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation. Front. Chem. 7:742.
Not in our library10.3389/fchem.2019.00742
136.
Rajasekharan S. K. Ramesh S. (2013 ). Cellulase inhibits Burkholderia cepacia biofilms on diverse prosthetic materials. Pol. J. Microbiol. 62 327–330.
Not in our library
137.
Rajput A. Kumar M. (2018 ). Anti-Biofilm Peptides: A New Class of Quorum Quenchers and Their Prospective Therapeutic Applications: Biotechnological Applications of Quorum Sensing Inhibitors. Singapore: Springer, 87–110.
Not in our library10.1007/978-981-10-9026-4_5
138.
Raorane C. J. Lee J. H. Kim Y. G. Rajasekharan S. K. Garcia-Contreras R. Lee J. (2019 ). Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin Against Acinetobacter baumannii. Front. Microbiol. 10:990.
Not in our library10.3389/fmicb.2019.00990
139.
Razak F. A. Rahim Z. H. (2003 ). The anti-adherence effect of Piper betle and Psidium guajava extracts on the adhesion of early settlers in dental plaque to saliva-coated glass surfaces. J. Oral Sci. 45 201–206.
Not in our library10.2334/josnusd.45.201
140.
Reuter M. Kruger D. H. (2020 ). Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections. Virus Genes 56 136–149.
Not in our library10.1007/s11262-020-01735-7
141.
Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action · 2018
No notice
142.
Sacco L. P. Castellane T. C. L. Polachini T. C. de Macedo Lemos E. G. Alves L. M. C. (2019 ). Exopolysaccharides produced by Pandoraea shows emulsifying and anti-biofilm activities. J. Polym. Res. 26 91
Not in our library10.1007/s10965-019-1737-1
143.
Samoilova Z. Smirnova G. Oktyabrsky O. (2019a ). The effect of catechin, tannic and gallic acids on biofilm formation in Escherichia coli depends on medium composition. Asian J. Microbiol. Biotechnol. 4 16–23.
Not in our library
144.
Samoilova Z. Tyulenev A. Muzyka N. Smirnova G. Oktyabrsky O. (2019b ). Tannic and gallic acids alter redox-parameters of the medium and modulate biofilm formation. AIMS Microbiol. 5 379–392.
Not in our library10.3934/microbiol.2019.4.379
145.
Sandasi M. Leonard C. M. Viljoen A. M. (2010 ). The in-vitro anti-biofilm activity of selected culinary herbs and medicinal plants against Listeria monocytogenes. Lett. Appl. Microbiol. 50 30–35.
Not in our library10.1111/j.1472-765x.2009.02747.xlam2747
146.
Sardi J. C. Freires I. A. Lazarini J. G. Infante J. de Alencar S. M. Rosalen P. L. (2017 ). Unexplored endemic fruit species from Brazil: anti-biofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp. Microb. Pathog. 105 280–287.
Not in our library10.1016/j.micpath.2017.02.044
147.
Satpute S. K. Banpurkar A. G. Banat I. M. Sangshetti J. N. Patil R. H. Gade W. N. (2016 ). Multiple roles of biosurfactants in biofilms. Curr. Pharm. Des. 22 1429–1448.
Not in our library10.2174/1381612822666160120152704
148.
Satpute S. K. Mone N. S. Das P. Banat I. M. Banpurkar A. G. (2019 ). Inhibition of pathogenic bacterial biofilms on PDMS based implants by L. acidophilus derived biosurfactant. BMC Microbiol. 19:39.
Not in our library10.1186/s12866-019-1412-z
149.
Scoffone V. C. Trespidi G. Chiarelli L. R. Barbieri G. Buroni S. (2019 ). Quorum sensing as antivirulence target in cystic fibrosis pathogens. Int. J. Mol. Sci. 20:1838.
Not in our library10.3390/ijms20081838
150.
Seneviratne C. J. Suriyanarayanan T. Swarup S. Chia K. H. B. Nagarajan N. Zhang C. (2017 ). Transcriptomics analysis reveals putative genes involved in biofilm formation and biofilm-associated drug resistance of Enterococcus faecalis. J. Endodont. 43 949–955.
Not in our library10.1016/j.joen.2017.01.020
151.
Shahrour H. Ferrer-Espada R. Dandache I. Barcena-Varela S. Sanchez-Gomez S. Chokr A. (2019 ). AMPs as anti-biofilm agents for human therapy and prophylaxis. Adv. Exp. Med. Biol. 1117 257–279.
Not in our library10.1007/978-981-13-3588-4_14
152.
Sharahi J. Y. Azimi T. Shariati A. Safari H. Tehrani M. K. Hashemi A. (2019 ). Advanced strategies for combating bacterial biofilms. J. Cell Physiol. 234 14689–14708.
Not in our library10.1002/jcp.28225
153.
Sharma D. Bisht G. S. (2020 ). Recent updates on antifungal peptides. Mini Rev. Med. Chem. 20 260–268.
Not in our library10.2174/1389557519666190926112423
154.
Shastry R. P. Rekha P. D. Rai V. R. (2019 ). Biofilm inhibitory activity of metalloprotein AHL-lactonase from the cell-free lysate of endophytic Enterobacter species isolated from Coscinium fenestratum Gaertn. Biocat. Agri. Biotechnol. 18:101009
Not in our library10.1016/j.bcab.2019.01.047
155.
Shehabeldine A. M. Ashour R. M. Okba M. M. Saber F. R. (2020 ). Callistemon citrinus bioactive metabolites as new inhibitors of methicillin-resistant Staphylococcus aureus biofilm formation. J. Ethnopharmacol. 254 112669.
Not in our library10.1016/j.jep.2020.112669
156.
Shin J. M. Gwak J. W. Kamarajan P. Fenno J. C. Rickard A. H. Kapila Y. L. (2016 ). Biomedical applications of Nisin. J. Appl. Microbiol. 120 1449–1465.
Not in our library10.1111/jam.13033
157.
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents · 2017
No notice
158.
Soares A. Roussel V. Pestel-Caron M. Barreau M. Caron F. Bouffartigues E. (2019 ). Understanding ciprofloxacin failure in Pseudomonas aeruginosa biofilm: persister cells survive matrix disruption. Front. Microbiol. 10:2603.
Not in our library10.3389/fmicb.2019.02603
159.
Spormann A. M. (2008 ). Physiology of microbes in biofilms. Curr. Top. Microbiol. Immunol. 322 17–36.
Not in our library10.1007/978-3-540-75418-3_2
160.
Srinivasan R. Devi K. R. Kannappan A. Pandian S. K. Ravi A. V. (2016 ). Piper betle and its bioactive metabolite phytol mitigates quorum sensing mediated virulence factors and biofilm of nosocomial pathogen Serratia marcescens in vitro. J. Ethnopharmacol. 193 592–603.
Not in our library10.1016/j.jep.2016.10.017
161.
Steinstraesser L. Tack B. F. Waring A. J. Hong T. Boo L. M. Fan M. H. (2002 ). Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and infected burns. Antimicrob. Agents Chemother. 46 1837–1844.
Not in our library10.1128/aac.46.6.1837-1844.2002
162.
Stewart P. S. Franklin M. J. (2008 ). Physiological heterogeneity in biofilms. Nat. Rev. Microbiol. 6 199–210.
Not in our library10.1038/nrmicro1838
163.
Sugimoto S. Iwamoto T. Takada K. Okuda K. I. Tajima A. Iwase T. (2013 ). Staphylococcus epidermidis Esp degrades specific proteins associated with Staphylococcus aureus biofilm formation and host-pathogen interaction. J. Bacteriol. 195 1645–1655.
Not in our library10.1128/jb.01672-12
164.
Sztukowska M. N. Roky M. Demuth D. R. (2019 ). Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms. Mol. Oral Microbiol. 34 169–182.
Not in our library10.1111/omi.12267
165.
Tabak M. Scher K. Chikindas M. L. Yaron S. (2009 ). The synergistic activity of triclosan and ciprofloxacin on biofilms of Salmonella Typhimurium. FEMS Microbiol. Lett. 301 69–76.
Not in our library10.1111/j.1574-6968.2009.01804.x
166.
Tahrioui A. Ortiz S. Azuama O. C. Bouffartigues E. Benalia N. Tortuel D. (2020 ). Membrane-Interactive Compounds From Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence. Front. Microbiol. 11:1068.
Not in our library10.3389/fmicb.2020.01068
167.
Tan Y. Leonhard M. Moser D. Schneider-Stickler B. (2017 ). Inhibition activity of Lactobacilli supernatant against fungal-bacterial multispecies biofilms on silicone. Microb Pathog. 113 197–201.
Not in our library10.1016/j.micpath.2017.10.051
168.
Tapia-Rodriguez M. R. Bernal-Mercado A. T. Gutierrez-Pacheco M. M. Vazquez-Armenta F. J. Hernandez-Mendoza A. Gonzalez-Aguilar G. A. (2019 ). Virulence of Pseudomonas aeruginosa exposed to carvacrol: alterations of the Quorum sensing at enzymatic and gene levels. J. Cell Commun. Signal. 13 531–537.
Not in our library10.1007/s12079-019-00516-8
169.
Tjabringa G. S. Ninaber D. K. Drijfhout J. W. Rabe K. F. Hiemstra P. S. (2006 ). Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors. Int. Arch. Allergy Immunol. 140 103–112.
Not in our library10.1159/000092305
170.
Trentin D. S. Giordani R. B. Zimmer K. R. da Silva A. G. da Silva M. V. dos Santos (2011 ). Potential of medicinal plants from the Brazilian semi-arid region Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles. J. Ethnopharmacol. 137 327–335.
Not in our library10.1016/j.jep.2011.05.030
171.
Tseng B. S. Zhang W. Harrison J. J. Quach T. P. Song J. L. Penterman J. (2013 ). The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin. Environ. Microbiol. 15 2865–2878.
Not in our library10.1111/1462-2920.12155
172.
Tursi S. A. Puligedda R. D. Szabo P. Nicastro L. K. Miller A. L. Qiu C. (2020 ). Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli. Nat. Commun. 11 1–13.
Not in our library10.1038/s41467-020-14685-3
173.
Uppuluri P. Zaldivar M. A. Anderson M. Z. Dunn M. J. Berman J. Ribot J. L. L. (2018 ). Candida albicans dispersed cells are developmentally distinct from the biofilm and planktonic cells. mBio 9:e001338-18.
Not in our library10.1128/mbio.01338-18
174.
Van der Veen S. Abee T. (2011 ). Mixed species biofilms of Listeria monocytogenes and Lactobacillus plantarum show enhanced resistance to benzalkonium chloride and peracetic acid. Int. J. Food Microbiol. 144 421–431.
Not in our library10.1016/j.ijfoodmicro.2010.10.029
175.
Vasilchenko A. S. Rogozhin E. A. (2019 ). Sub-Inhibitory effects of antimicrobial peptides. Front. Microbiol. 10:1160.
Not in our library10.3389/fmicb.2019.01160
176.
Vijayakumar K. Ramanathan T. (2020 ). Musa acuminata and its bioactive metabolite 5-Hydroxymethylfurfural mitigates quorum sensing (las and rhl) mediated biofilm and virulence production of nosocomial pathogen Pseudomonas aeruginosa in vitro. J. Ethnopharmacol. 246:112242.
Not in our library10.1016/j.jep.2019.112242
177.
Vikram A. Jayaprakasha G. K. Uckoo R. M. Patil B. S. (2013 ). Inhibition of Escherichia coli O157: H7 motility and biofilm by β-sitosterol glucoside. Biochim. Biophys. Acta Gen. Subj. 1830 5219–5228.
Not in our library10.1016/j.bbagen.2013.07.022
178.
Vikram A. Jesudhasan P. Pillai S. Patil B. (2012 ). Isolimonic acid interferes with Escherichia coli O157: H7 biofilm and TTSS in QseBC and QseA dependent fashion. BMC Microbiol. 12:261.
Not in our library10.1186/1471-2180-12-261
179.
Vikram A. Jesudhasan P. R. Jayaprakasha G. K. Pillai S. D. Patil B. S. (2011 ). Citrus limonoids interfere with Vibrio harveyi cell-cell signalling and biofilm formation by modulating the response regulator LuxO. Microbiol. 157(Pt. 1), 99–110.
Not in our library10.1099/mic.0.041228-0
180.
Von Borowski R. G. Sophie C. H. A. T. Schneider R. Giudice E. Zimmer A. R. Gnoatto S. C. B. (2020 ). Capsicumine: a new peptide from red peppers turns out to be a powerful anti-biofilm agent and displays a new mechanism of action, matrix anti-assembly. bioRxiv[Preprint]
Not in our library10.1101/2020.04.03.022020
181.
Wang T. Huang W. Duan Q. Wang J. Cheng H. Shao J. (2019 ). Sodium houttuyfonate in vitro inhibits biofilm dispersion and expression of bdlA in Pseudomonas aeruginosa. Mol. Biol. Rep. 46 471–477.
Not in our library10.1007/s11033-018-4497-9
182.
Wilkins M. Hall-Stoodley L. Allan R. N. Faust S. N. (2014 ). New approaches to the treatment of biofilm-related infections. J. Infect. 69 S47–S52.
Not in our library10.1016/j.jinf.2014.07.014
183.
Wingender J. Flemming H.-C. (2011 ). Biofilms in drinking water and their role as a reservoir for pathogens. Int. J. Hyg. Environ. Health 214 417–423.
Not in our library10.1016/j.ijheh.2011.05.009
184.
Xiang H. Cao F. Ming D. Zheng Y. Dong X. Zhong X. (2017 ). Aloe-emodin inhibits Staphylococcus aureus biofilms and extracellular protein production at the initial adhesion stage of biofilm development. Appl. Microbiol. Biotechnol. 101 6671–6681.
Not in our library10.1007/s00253-017-8403-5
185.
Xu L. Shao C. Li G. Shan A. Chou S. Wang J. (2020 ). Conversion of broad-spectrum antimicrobial peptides into species-specific antimicrobials capable of precisely targeting pathogenic bacteria. Sci. Rep. 10:944.
Not in our library10.1038/s41598-020-58014-6
186.
Xu Z. Zhang H. Yu H. Dai Q. Xiong J. Sheng H. (2019 ). Allicin inhibits Pseudomonas aeruginosa virulence by suppressing the rhl and pqs quorum-sensing systems. Can. J. Microbiol. 65 563–574.
Not in our library10.1139/cjm-2019-0055
187.
Yan X. Gu S. Cui X. Shi Y. Wen S. Chen H. (2019 ). Antimicrobial, anti-adhesive and anti-biofilm potential of biosurfactants isolated from Pediococcus acidilactici and Lactobacillus plantarum against Staphylococcus aureus CMCC26003. Microb. Pathog. 127 12–20.
Not in our library10.1016/j.micpath.2018.11.039
188.
Yan X. Gu S. Shi Y. Cui X. Wen S. Ge J. (2017 ). The effect of emodin on Staphylococcus aureus strains in planktonic form and biofilm formation in vitro. Arch. Microbiol. 199 1267–1275.
Not in our library10.1007/s00203-017-1396-8
189.
Yang Y. B. Wang S. Wang C. Huang Q. Y. Bai J. W. Chen J. Q. (2015 ). Emodin affects biofilm formation and expression of virulence factors in Streptococcus suis ATCC700794. Arch. Microbiol. 197 1173–1180.
Not in our library10.1007/s00203-015-1158-4
190.
Yong Y. Y. Dykes G. A. Choo W. S. (2019 ). Biofilm formation by staphylococci in health-related environments and recent reports on their control using natural compounds. Crit. Rev. Microbiol. 45 201–222.
Not in our library10.1080/1040841x.2019.1573802
191.
Yuan L. Hansen M. F. Roder H. L. Wang N. Burmolle M. He G. (2020 ). Mixed-species biofilms in the food industry: current knowledge and novel control strategies. Crit. Rev. Food Sci. Nutr. 60 2277–2293.
Not in our library10.1080/10408398.2019.1632790
192.
Yuan Y. Zai Y. Xi X. Ma C. Wang L. Zhou M. (2019 ). A novel membrane-disruptive antimicrobial peptide from frog skin secretion against cystic fibrosis isolates and evaluation of anti-MRSA effect using Galleria mellonella model. Biochim. Biophys. Acta Gen. Subj. 1863 849–856.
Not in our library10.1016/j.bbagen.2019.02.013
193.
Candida albicans biofilm–induced vesicles confer drug resistance through matrix biogenesis · 2018
No notice
194.
Zhang L. Liang E. Cheng Y. Mahmood T. Ge F. Zhou K. (2020 ). Is combined medication with natural medicine a promising therapy for bacterial biofilm infection? Biomed. Pharmacother. 128:110184.
Not in our library10.1016/j.biopha.2020.110184
195.
Zhong L. Ravichandran V. Zhang N. Wang H. Bian X. Zhang Y. (2020 ). Attenuation of Pseudomonas aeruginosa quorum sensing by natural products: virtual screening, evaluation and biomolecular interactions. Int. J. Mol. Sci. 21:2190.
Not in our library10.3390/ijms21062190
196.
Zhou J. W. Luo H. Z. Jiang H. Jian T. K. Chen Z. Q. Jia A. Q. (2018 ). Hordenine: a novel quorum sensing inhibitor and antibiofilm agent against Pseudomonas aeruginosa. J Agri. Food Chem. 66 1620–1628.
Not in our library10.1021/acs.jafc.7b05035

Cited by papers we hold 6

Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review · 2025
No notice
Biofilm and wound healing: from bench to bedside · 2023
No notice
Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria · 2022
No notice
The Fusaric Acid Derivative qy17 Inhibits Staphylococcus haemolyticus by Disrupting Biofilm Formation and the Stress Response via Altered Gene Expression · 2022
Not checked
Polymicrobial Infections and Biofilms: Clinical Significance and Eradication Strategies · 2022
No notice
Phenolic-Rich Plant Extracts With Antimicrobial Activity: An Alternative to Food Preservatives and Biocides? · 2022
No notice

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.