Commentary: Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates

da Silva et al provide data indicating that amino acid sequence of the factor H binding protein (FHbp) signal peptide (SP) impacts the biochemical processing of FHbp in transit to the cell surface of Neisseria meningitidis serogroup B (MenB). The authors suggest that this may impact interpretation of the breadth of coverage of Trumenba®, a vaccine licensed to prevent MenB infections. Though the results reported are mechanistically interesting, the findings are contrary to published data and licensure reports describing Trumenba® breadth of coverage.

Abstract licence: CC BY

8 more references, whose wording the paper’s licence keeps private.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.