Lipid domains in HIV-1 assembly
Naresh eYandrapalli, Delphine eMuriaux, Cyril eFavard
Frontiers in Microbiology · 2014
doi:10.3389/fmicb.2014.00220 (opens in a new tab)
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Abstract
In CD4+ T cells, HIV-1 buds from the host cell plasma membrane. The viral Gagpolyprotein is mainly responsible for this process. However, the intimate interaction of Gag andlipids at the plasma membrane as well as its consequences, in terms of lipids lateral organizationand virus assembly, is still under debate. In this review we propose to revisit the role of plasmamembrane lipids in HIV-1 Gag targeting and assembly, at the light of lipid membranes biophysics andliterature dealing with Gag-lipid interactions.
Abstract licence: CC BY
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