Editorial: Implications of Ferroptosis-Related Genes to the Genetics of Cancer Development

Implications of Ferroptosis-Related Genes for the Genetics of Cancer DevelopmentFerroptosis is a unique type of cell death, distinct from apoptosis, which refers to an iron-dependent cell death caused by the overload of lipid peroxides on cell membranes (Dixon et al., 2012).Current cancer treatment strategies selectively eliminate cancer cells without harming normal cells.Targeting ferroptosis may provide an alternative strategy for cancer therapy to inhibit tumor growth (Chen et al., 2021;Lei et al., 2022).Studies have shown that multiple cancer-related signaling pathways control ferroptosis in cancer cells, and ferroptosis is also involved in the activity of multiple tumor suppressors (Lei et al., 2022).In addition, some cancer cells rely on ferroptosis defense systems and oxidative stress conditions to survive, and disrupting these ferroptosis defenses can be fatal to cancer cells while leaving normal cells unharmed (Mao et al., 2021).At the same time, the unique metabolism of cancer cells, the high load of reactive oxygen species (ROS), and their specific mutations make cells inherently susceptible to ferroptosis, thus exposing the therapeutic vulnerability of some cancers (Wu et al., 2019).Furthermore, it has been found that oncogeneinduced ferroptosis resistance can be mediated by downstream effectors, which can be targeted to reverse ferroptosis resistance and play a strong tumor inhibition effect (Yi et al., 2020).Recent research also suggests that EMT is thought to call into being cancer stem cells, leading to transfer diffusion (Yang et al., 2020), and EMT signaling can promote ferroptosis.Increased CD44dependent iron endocytosis promotes iron-dependent demethylase activity, which promotes the expression of EMT signaling-related genes, thus making breast cancer cells sensitive to ferroptosis (Müller et al., 2020).Ferroptosis has a wide range of effects on cell metabolism and has many targets in cancer.In addition, various clinical drugs and herbal extracts can induce ferroptosis in cancer cells (Xu et al., 2021).Similarly, ferroptosis-related genes and lncRNA may become potential biomarkers that provide new anti-cancer treatment strategies.Our Research Topic included one review and fifteen original research articles related to Ferroptosis-related genes, lncRNA, and drugs, which may be potential targets for reversing cancer drug resistance and targeted therapy.LncRNAs are considered to be major regulators of various cellular processes, and their dysregulation is implicated in all features of cancer (Balihodzic et al., 2021).More and more evidence confirmed the importance of lncRNA in regulating ferroptosis (Balihodzic et al., 2022).LncRNAs can regulate the expression of GPX4 and induce lipid peroxidation of the cell membrane through sponge miRNAs, resulting in the ferroptosis of cancer cells (Zuo et al., 2022).We included four ferroptosis-related long non-coding RNA articles.Jiang et al. explored the critical role of ferroptosis-related long non-coding RNAs in the prognosis of head and neck squamous cell carcinoma (HNSCC).They identified ferroptosis-related lncRNAs as independent risk factors for

Abstract licence: CC BY

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   Guidelines and definitions for research on epithelial–mesenchymal transition · 2020

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   Ferroptosis in Cancer Progression: Role of Noncoding RNAs · 2022

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   Non-coding RNAs and ferroptosis: potential implications for cancer therapy · 2022

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