The role of long non-coding RNAs in genome formatting and expression
Pierre-Olivier eAngrand, Constance eVennin, Xuefen eLe Bourhis and 1 more
Frontiers in Genetics · 2015
doi:10.3389/fgene.2015.00165 (opens in a new tab)
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Abstract
Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA.
Abstract licence: CC BY
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