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Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Jing Gao, Kang Xu, Hongnan Liu and 5 more

Frontiers in Cellular and Infection Microbiology · 2018 · Review

doi:10.3389/fcimb.2018.00013

Abstract

The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. Recent discoveries have underscored that changes in the microbiota modulate the host immune system by modulating Trp metabolism. Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacterial Trp metabolites (indole, indolic acid, skatole, and tryptamine) have profound effects on gut microbial composition, microbial metabolism, the host's immune system, the host-microbiome interface, and host immune system-intestinal microbiota interactions. The aryl hydrocarbon receptor (AhR) mediates the regulation of intestinal immunity by Trp metabolites (as ligands of AhR), which is beneficial for immune homeostasis. Among Trp metabolites, AhR ligands consist of endogenous metabolites, including kynurenine, kynurenic acid, xanthurenic acid, and cinnabarinic acid, and bacterial metabolites, including indole, indole propionic acid, indole acetic acid, skatole, and tryptamine. Additional factors, such as aging, stress, probiotics, and diseases (spondyloarthritis, irritable bowel syndrome, inflammatory bowel disease, colorectal cancer), which are associated with variability in Trp metabolism, can influence Trp-microbiome-immune system interactions in the gut and also play roles in regulating gut immunity. This review clarifies how the gut microbiota regulates Trp metabolism and identifies the underlying molecular mechanisms of these interactions. Increased mechanistic insight into how the microbiota modulates the intestinal immune system through Trp metabolism may allow for the identification of innovative microbiota-based diagnostics, as well as appropriate nutritional supplementation of Trp to prevent or alleviate intestinal inflammation. Moreover, this review provides new insight regarding the influence of the gut microbiota on Trp metabolism. Additional comprehensive analyses of targeted Trp metabolites (including endogenous and bacterial metabolites) are essential for experimental preciseness, as the influence of the gut microbiota cannot be neglected, and may explain contradictory results in the literature.

References 214

1.
Anders H. J. Andersen K. Stecher B. (2013 ). The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney Int. 83, 1010–1016.
Not in our library10.1038/ki.2012.440
2.
Anderson G. Maes M. (2015 ). The gut–brain axis: the role of melatonin in linking psychiatric, inflammatory and neurodegenerative conditions. Adv. Integr. Med. 2, 31–37.
Not in our library10.1016/j.aimed.2014.12.007
3.
Anderson G. Seo M. Berk M. F. Carvalho A. Maes M. (2016 ). Gut permeability and microbiota in parkinson disease: role of depression, tryptophan catabolites, oxidative and nitrosative stress and melatonergic pathways. Curr. Pharm. Des. 22, 6142–6151.
Not in our library10.2174/1381612822666160906161513
4.
Arsenescu R. Arsenescu V. Zhong J. Nasser M. Melinte R. Dingle R. W. C.. (2011 ). Role of the xenobiotic receptor in inflammatory bowel disease. Inflamm. Bowel Dis. 17, 1149–1162.
Not in our library10.1002/ibd.21463
5.
Tryptophan metabolism, disposition and utilization in pregnancy · 2015
No notice
6.
Bai M. Liu H. Xu K. Oso A. O. Wu X. Liu G.. (2017 ). A review of the immunomodulatory role of dietary tryptophan in livestock and poultry. Amino Acids 49, 67–74.
Not in our library10.1007/s00726-016-2351-8
7.
Bailey M. T. (2014 ). Influence of stressor-induced nervous system activation on the intestinal microbiota and the importance for immunomodulation. Adv. Exp. Med. Biol. 817, 255–276.
Not in our library10.1007/978-1-4939-0897-4_12
8.
Balsari A. Ceccarelli A. Dubini F. Fesce E. Poli G. (1982 ). The fecal microbial population in the irritable bowel syndrome. Microbiologica 5, 185–194.
Not in our library
9.
Bansal T. Alaniz R. C. Wood T. K. Jayaraman A. (2010 ). The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc. Natl. Acad. Sci. U.S.A. 107, 228–233.
Not in our library10.1073/pnas.0906112107
10.
Behnsen J. Jellbauer S. Wong C. P. Edwards R. A. George M. D. Ouyang W.. (2014 ). The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria. Immunity 40, 262–273.
Not in our library10.1016/j.immuni.2014.01.003
11.
Benson J. M. Shepherd D. M. (2011 ). Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with crohn's disease. Toxicol. Sci. 120, 68–78.
Not in our library10.1093/toxsci/kfq360
12.
Bessede A. Gargaro M. Pallotta M. T. Matino D. Servillo G. Brunacci C.. (2014 ). Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature 511, 184–190.
Not in our library10.1038/nature13323
13.
Bhattarai Y. Muniz Pedrogo D. A. Kashyap P. C. (2017 ). Irritable bowel syndrome: a gut microbiota-related disorder? Am. J. Physiol. Gastrointest. Liver Physiol. 312, G52–G62.
Not in our library10.1152/ajpgi.00338.2016
14.
Biagi E. Candela M. Fairweather-Tait S. Franceschi C. Brigidi P. (2012 ). Aging of the human metaorganism: the microbial counterpart. Age 34, 247–267.
Not in our library10.1007/s11357-011-9217-5
15.
Biagi E. Candela M. Turroni S. Garagnani P. Franceschi C. Brigidi P. (2013 ). Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol. Res. 69, 11–20.
Not in our library10.1016/j.phrs.2012.10.005
16.
Bischoff S. C. Mailer R. Pabst O. Weier G. Sedlik W. Li Z.. (2009 ). Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G685–G695.
Not in our library10.1152/ajpgi.90685.2008
17.
Bittinger M. A. Nguyen L. P. Bradfield C. A. (2003 ). Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor. Mol. Pharmacol. 64, 550–556.
Not in our library10.1124/mol.64.3.550
18.
Blumberg R. Powrie F. (2012 ). Microbiota, disease, and back to health: a metastable journey. Sci. Transl. Med. 4:137rv137.
Not in our library10.1126/scitranslmed.3004184
19.
Bogdan C. (2001 ). Nitric oxide and the immune response. Nat. Immunol. 2:907.
Not in our library10.1038/ni1001-907
20.
Bouguen G. Dubuquoy L. Desreumaux P. Brunner T. Bertin B. (2015 ). Intestinal steroidogenesis. Steroids 103, 64–71.
Not in our library10.1016/j.steroids.2014.12.022
21.
Bubenik G. A. Brown G. M. Grota L. J. (1977 ). Immunohistological localization of melatonin in the rat digestive system. Experientia 33, 662–663.
Not in our library10.1007/bf01946561
22.
Kynurenines in CNS disease: regulation by inflammatory cytokines · 2014
No notice
23.
Cerf-Bensussan N. Eberl G. (2012 ). The dialog between microbiota and the immune system: shaping the partners through development and evolution. Semin. Immunol. 24, 1–2.
Not in our library10.1016/j.smim.2011.11.007
24.
Cheng J. Palva A. M. De Vos W. M. Satokari R. (2013 ). Contribution of the intestinal microbiota to human health: from birth to 100 years of age. Curr. Top. Microbiol. Immunol. 358, 323–346.
Not in our library10.1007/82_2011_189
25.
Cheng Y. Jin U.-H. Allred C. D. Jayaraman A. Chapkin R. S. Safe S. (2015 ). Aryl hydrocarbon receptor activity of tryptophan metabolites in young adult mouse colonocytes. Drug Metab. Disposit. 43, 1536–1543.
Not in our library10.1124/dmd.115.063677
26.
Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells · 2014
No notice
27.
Chung K. T. Gadupudi G. S. (2011 ). Possible roles of excess tryptophan metabolites in cancer. Environ. Mol. Mutagen. 52, 81–104.
Not in our library10.1002/em.20588
28.
Ciorba M. A. Bettonville E. E. Mcdonald K. G. Metz R. Prendergast G. C. Newberry R. D.. (2010 ). Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis. J. Immunol. 184, 3907–3916.
Not in our library10.4049/jimmunol.0900291
29.
Clarke G. Grenham S. Scully P. Fitzgerald P. Moloney R. D. Shanahan F.. (2013 ). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol. Psychiatry 18, 666–673.
Not in our library10.1038/mp.2012.77
30.
Clarke G. Mckernan D. P. Gaszner G. Quigley E. M. Cryan J. F. Dinan T. G. (2012 ). A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of toll-like receptor activation in irritable bowel syndrome. Front. Pharmacol. 3:90.
Not in our library10.3389/fphar.2012.00090
31.
Clarke G. O'mahony S. M. Hennessy A. A. Ross P. Stanton C. Cryan J. F.. (2009 ). Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood. Behav. Brain Res. 205, 319–321.
Not in our library10.1016/j.bbr.2009.07.008
32.
Clarke G. Stilling R. M. Kennedy P. J. Stanton C. Cryan J. F. Dinan T. G. (2014 ). Minireview: gut microbiota: the neglected endocrine organ. Mol. Endocrinol. 28, 1221–1238.
Not in our library10.1210/me.2014-1108
33.
Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism · 2013
Corrected
34.
Cook K. L. Rothrock M. J. Jr. Loughrin J. H. Doerner K. C. (2007 ). Characterization of skatole-producing microbial populations in enriched swine lagoon slurry. FEMS Microbiol. Ecol. 60, 329–340.
Not in our library10.1111/j.1574-6941.2007.00299.x
35.
Cooper H. S. Murthy S. Kido K. Yoshitake H. Flanigan A. (2000 ). Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation. Carcinogenesis 21, 757–768.
Not in our library10.1093/carcin/21.4.757
36.
Coste A. Dubuquoy L. Barnouin R. Annicotte J. S. Magnier B. Notti M.. (2007 ). LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc. Natl. Acad. Sci. U.S.A. 104, 13098–13103.
Not in our library10.1073/pnas.0702440104
37.
Costello M. E. Ciccia F. Willner D. Warrington N. Robinson P. C. Gardiner B.. (2014 ). Intestinal dysbiosis in ankylosing spondylitis. Arthritis Rheumatol. 67, 686–691.
Not in our library10.1002/art.38967
38.
Cox A. J. Pyne D. B. Saunders P. U. Fricker P. A. (2010 ). Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. Br. J. Sports Med. 44, 222–226.
Not in our library10.1136/bjsm.2007.044628
39.
Dai X. Zhu B. T. (2010 ). Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions. J. Histochem. Cytochem. 58, 17–28.
Not in our library10.1369/jhc.2009.953604
40.
Davis R. E. (2014 ). Exploring the Effects of Gut-Derived Microbial Metabolites on Expression of SPI-1 Genes and Antimicrobial Resistance in Salmonella Typhimurium[D]. College Station, TX: Texas A&M University.
Not in our library
41.
De Luca A. Zelante T. D'angelo C. Zagarella S. Fallarino F. Spreca A.. (2010 ). IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 3, 361–373.
Not in our library10.1038/mi.2010.22
42.
De Mello M. P. De Toledo S. M. Haun M. Cilento G. Duran N. (1980 ). Excited indole-3-aldehyde from the peroxidase-catalyzed aerobic oxidation of indole-3-acetic acid. Reaction with and energy transfer to transfer ribonucleic acid. Biochemistry 19, 5270–5275.
Not in our library10.1021/bi00564a019
43.
Desbonnet L. Garrett L. Clarke G. Bienenstock J. Dinan T. G. (2008 ). The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. J. Psychiatr. Res. 43, 164–174.
Not in our library10.1016/j.jpsychires.2008.03.009
44.
El Aidy S. Kunze W. Bienenstock J. Kleerebezem M. (2012 ). The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. Benef. Microbes 3, 251–259.
Not in our library10.3920/bm2012.0042
45.
Eliasson L. (2014 ). Melatonin heals the gut. Acta Physiol. 212, 120–121.
Not in our library10.1111/apha.12364
46.
Engberg R. M. Hedemann M. S. Leser T. D. Jensen B. B. (2000 ). Effect of zinc bacitracin and salinomycin on intestinal microflora and performance of broilers. Poult. Sci. 79, 1311–1319.
Not in our library10.1093/ps/79.9.1311
47.
Engin A. B. Karahalil B. Karakaya A. E. Engin A. (2015 ). Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer. World J. Gastroenterol. 21, 3636–3643.
Not in our library10.3748/wjg.v21.i12.3636
48.
Essien B. E. Grasberger H. Romain R. D. Law D. J. Veniaminova N. A. Saqui–Salces M.. (2013 ). ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against salmonella typhimurium in mice. Gastroenterology 144, 1466.e1469–1477.e1469.
Not in our library10.1053/j.gastro.2013.01.057
49.
Etienne-Mesmin L. Chassaing B. Gewirtz A. T. (2017 ). Tryptophan: a gut microbiota-derived metabolites regulating inflammation. World J. Gastrointest. Pharmacol. Ther. 8, 7–9.
Not in our library10.4292/wjgpt.v8.i1.7
50.
Fantini M.-C. (2009 ). Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies. World J. Gastroenterol. 15:2472.
Not in our library10.3748/wjg.15.2472
51.
Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer · 2011
No notice
52.
Fitzgerald P. Cassidy Eugene M. Clarke G. Scully P. Barry S. Quigley Eamonn M. M.. (2008 ). Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity. Neurogastroenterol. Motil. 20, 1291–1297.
Not in our library10.1111/j.1365-2982.2008.01195.x
53.
Flint H. J. Scott K. P. Louis P. Duncan S. H. (2012 ). The role of the gut microbiota in nutrition and health. Nat. Rev. Gastroenterol. Hepatol. 9, 577–589.
Not in our library10.1038/nrgastro.2012.156
54.
Forrest C. M. Gould S. R. Darlington L. G. Stone T. W. (2003 ). Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease, in Developments in Tryptophan and Serotonin Metabolism, eds Allegri G. Costa C. V. L. Ragazzi E. Steinhart H. Varesio L. (Boston, MA: Springer), 395–400.
Not in our library10.1007/978-1-4615-0135-0_46
55.
Forsythe P. Sudo N. Dinan T. Taylor V. H. Bienenstock J. (2010 ). Mood and gut feelings. Brain Behav. Immun. 24, 9–16.
Not in our library10.1016/j.bbi.2009.05.058
56.
Franceschi C. Bonafe M. Valensin S. Olivieri F. De Luca M. Ottaviani E.. (2000 ). Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908, 244–254.
Not in our library10.1111/j.1749-6632.2000.tb06651.x
57.
Frank D. N. St. Amand A. L. Feldman R. A. Boedeker E. C. Harpaz N. Pace N. R. (2007 ). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl. Acad. Sci.U.S.A. 104, 13780–13785.
Not in our library10.1073/pnas.0706625104
58.
Freewan M. Rees M. D. Plaza T. S. Glaros E. Lim Y. J. Wang X. S.. (2013 ). Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide. J. Biol. Chem. 288, 1548–1567.
Not in our library10.1074/jbc.m112.410993
59.
Galley H. F. Lowes D. A. Allen L. Cameron G. Aucott L. S. Webster N. R. (2014 ). Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis. J. Pineal Res. 56, 427–438.
Not in our library10.1111/jpi.12134
60.
García-Lara L. Perez-Severiano F. Gonzalez-Esquivel D. Elizondo G. Segovia J. (2015 ). Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress. J. Neurosci. Res. 93, 1423–1433.
Not in our library10.1002/jnr.23595
61.
Genestet C. Le Gouellec A. Chaker H. Polack B. Guery B. Toussaint B.. (2014 ). Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing. Free Radic. Biol. Med. 73, 400–410.
Not in our library10.1016/j.freeradbiomed.2014.06.003
62.
Gershon M. D. Tack J. (2007 ). The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132, 397–414.
Not in our library10.1053/j.gastro.2006.11.002
63.
The gut microbiota in mouse models of inflammatory bowel disease · 2014
No notice
64.
Glenister R. Mcdaniel K. Francis H. Venter J. Jensen K. Dusio G.. (2013 ). Therapeutic actions of melatonin on gastrointestinal cancer development and progression. Transl. Gastrointest. Cancer 2, 11–20.
Not in our library10.3978/j.issn.2224-4778.2012.08.03
65.
Gordon J. I. (2012 ). Honor thy gut symbionts redux. Science 336, 1251–1253.
Not in our library10.1126/science.1224686
66.
Grant R. S. Passey R. Matanovic G. Smythe G. Kapoor V. (1999 ). Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism? Arch. Biochem. Biophys. 372, 1–7.
Not in our library10.1006/abbi.1999.1381
67.
Grivennikov S. I. Wang K. Mucida D. Stewart C. A. Schnabl B. Jauch D.. (2012 ). Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 491, 254–258.
Not in our library10.1038/nature11465
68.
Gupta N. K. Thaker A. I. Kanuri N. Riehl T. E. Rowley C. W. Stenson W. F.. (2012 ). Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity. Inflamm. Bowel Dis. 18, 1214–1220.
Not in our library10.1002/ibd.21849
69.
Gurkar A. U. Niedernhofer L. J. (2015 ). Comparison of mice with accelerated aging caused by distinct mechanisms. Exp. Gerontol. 68, 43–50.
Not in our library10.1016/j.exger.2015.01.045
70.
Hamard A. Seve B. Le Floc'h N. (2007 ). Intestinal development and growth performance of early-weaned piglets fed a low-threonine diet. Animal 1, 1134–1142.
Not in our library10.1017/s1751731107000560
71.
Hansen L. L. Mikkelsen L. L. Agerhem H. Laue A. Jensen M. T. Jensen B. B. (2000 ). Effect of fermented liquid food and zinc bacitracin on microbial metabolism in the gut and sensoric profile of m. longissimus dorsi from entire male and female pigs. Anim. Sci. 71, 65–80.
Not in our library10.1017/s1357729800054904
72.
Hashimoto T. Perlot T. Rehman A. Trichereau J. Ishiguro H. Paolino M.. (2012 ). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487, 477–481.
Not in our library10.1038/nature11228
73.
Hasnain S. Z. Tauro S. Das I. Tong H. Chen A. C. H. Jeffery P. L.. (2013 ). IL-10 Promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology 144, 357.e359–368.e359.
Not in our library10.1053/j.gastro.2012.10.043
74.
Haverback B. J. Dyce B. Thomas H. V. (1960 ). Indole metabolism in the malabsorption syndrome. N. Engl. J. Med. 262, 754–757.
Not in our library10.1056/nejm196004142621504
75.
Hold G. L. (2016 ). Gastrointestinal microbiota and colon cancer. Dig. Dis. 34, 244–250.
Not in our library10.1159/000443358
76.
Hold G. L. Smith M. Grange C. Watt E. R. El-Omar E. M. Mukhopadhya I. (2014 ). Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World J. Gastroenterol. 20, 1192–1210.
Not in our library10.3748/wjg.v20.i5.1192
77.
Hong S. N. Rhee P. L. (2014 ). Unraveling the ties between irritable bowel syndrome and intestinal microbiota. World J. Gastroenterol. 20, 2470–2481.
Not in our library10.3748/wjg.v20.i10.2470
78.
Honneffer J. Guard B. Steiner J. M. Suchodolski J. S. (2015 ). Mo1805 untargeted metabolomics reveals disruption within bile acid, cholesterol, and tryptophan metabolic pathways in dogs with idiopathic inflammatory bowel disease. Gastroenterology 148, S-715
Not in our library10.1016/s0016-5085(15)32435-5
79.
Hooper L. V. Littman D. R. Macpherson A. J. (2012 ). Interactions between the microbiota and the immune system. Science 336, 1268–1273.
Not in our library10.1126/science.1223490
80.
Høverstad T. Midtvedt T. (1986 ). Short-chain fatty acids in germfree mice and rats. J. Nutr. 116, 1772–1776.
Not in our library10.1093/jn/116.9.1772
81.
Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer · 2002
No notice
82.
Huang S.-C. Lee C.-T. Chung B.-C. (2014 ). Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis. Sci. Signal. 7, ra20.
Not in our library10.1126/scisignal.2004786
83.
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles · 2015
No notice
84.
Hubbard T. D. Murray I. A. Perdew G. H. (2015b ). Indole and tryptophan metabolism: endogenous and dietary routes to ah receptor activation. Drug Metab. Disposit. 43, 1522–1535.
Not in our library10.1124/dmd.115.064246
85.
Islam J. Sato S. Watanabe K. Watanabe T. Ardiansyah Hirahara K. Aoyama Y.. (2017 ). Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice. J. Nutr. Biochem. 42, 43–50.
Not in our library10.1016/j.jnutbio.2016.12.019
86.
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis · 2016
No notice
87.
Jensen M. T. Cox R. P. Jensen B. B. (1995 ). 3-Methylindole (skatole) and indole production by mixed populations of pig fecal bacteria. Appl. Environ. Microbiol. 61, 3180–3184.
Not in our library10.1128/aem.61.8.3180-3184.1995
88.
Jia W. Whitehead R. N. Griffiths L. Dawson C. Bai H. Waring R. H.. (2012 ). Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease. FEMS Immunol. Med. Microbiol. 65, 55–68.
Not in our library10.1111/j.1574-695x.2012.00935.x
89.
Kang K. Y. Lee S. H. Jung S. M. Park S. H. Jung B. H. Ju J. H. (2015 ). Downregulation of tryptophan-related metabolomic profile in rheumatoid arthritis synovial fluid. J. Rheumatol. 42, 2003–2011.
Not in our library10.3899/jrheum.141505
90.
Kashyap P. C. Marcobal A. Ursell L. K. Larauche M. Duboc H. Earle K. A.. (2013 ). Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice. Gastroenterology 144, 967–977.
Not in our library10.1053/j.gastro.2013.01.047
91.
Kaszaki J. Palasthy Z. Erczes D. Racz A. Torday C. Varga G.. (2008 ). Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs. Neurogastroenterol. Motil. 20, 53–62.
Not in our library10.1111/j.1365-2982.2007.00989.x
92.
Katz J. B. Muller A. J. Prendergast G. C. (2008 ). Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol. Rev. 222, 206–221.
Not in our library10.1111/j.1600-065x.2008.00610.x
93.
Kawai T. Akira S. (2010 ). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373–384.
Not in our library10.1038/ni.1863
94.
Keszthelyi D. Troost F. J. Masclee A. A. (2009 ). Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function. Neurogastroenterol. Motil. 21, 1239–1249.
Not in our library10.1111/j.1365-2982.2009.01370.x
95.
Kilkens T. O. C. Honig A. Van Nieuwenhoven M. A. Riedel W. J. Brummer R. J. M. (2004 ). Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls. Gut 53, 1794–1800.
Not in our library10.1136/gut.2004.041657
96.
Kim C. J. Kovacs-Nolan J. A. Yang C. Archbold T. Fan M. Z. Mine Y. (2010 ). l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis. J. Nutr. Biochem. 21, 468–475.
Not in our library10.1016/j.jnutbio.2009.01.019
97.
Kim T. H. Kim S. J. Lee S. M. (2014 ). Stimulation of the alpha7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation. J. Infect. Dis. 209, 1668–1677.
Not in our library10.1093/infdis/jit669
98.
Knarreborg A. Beck J. Jensen M. T. Laue A. Agergaard N. Jensen B. B. (2002 ). Effect of non-starch polysaccharides on production and absorption of indolic compounds in entire male pigs. Anim. Sci. 74, 445–453.
Not in our library10.1017/s1357729800052590
99.
Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism · 2016
No notice
100.
Kostic A. D. Xavier R. J. Gevers D. (2014 ). The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146, 1489–1499.
Not in our library10.1053/j.gastro.2014.02.009
101.
Lamas B. Richard M. L. Sokol H. (2017 ). Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases. Curr. Opin. Clin. Nutr. Metab. Care 20, 243–247.
Not in our library10.1097/mco.0000000000000382
102.
Lamas B. Richard M. L. Leducq V. Pham H. P. Michel M. L. Da Costa G.. (2016 ). CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat. Med. 22, 598–605.
Not in our library10.1038/nm.4102
103.
Lawrence R. C. Felson D. T. Helmick C. G. Arnold L. M. Choi H. Deyo R. A.. (2008 ). Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II. Arthritis Rheumat. 58, 26–35.
Not in our library10.1002/art.23176
104.
Le Floc'h N. Otten W. Merlot E. (2011 ). Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 41, 1195–1205.
Not in our library10.1007/s00726-010-0752-7
105.
Lee J. S. Cella M. Mcdonald K. G. Garlanda C. Kennedy G. D. Nukaya M.. (2012 ). AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat. Immunol. 13, 144–151.
Not in our library10.1038/ni.2187
106.
Lesurtel M. Soll C. Graf R. Clavien P. A. (2008 ). Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives. Cell. Mol. Life Sci. 65, 940–952.
Not in our library10.1007/s00018-007-7377-3
107.
Levin A. D. Van Den Brink G. R. (2014 ). Selective inhibition of mucosal serotonin as treatment for IBD? Gut 63, 866–867.
Not in our library10.1136/gutjnl-2013-305283
108.
Levy M. Blacher E. Elinav E. (2016 ). Microbiome, metabolites and host immunity. Curr. Opin. Microbiol. 35, 8–15.
Not in our library10.1016/j.mib.2016.10.003
109.
Li G. Young K. D. (2013 ). Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan. Microbiology 159, 402–410.
Not in our library10.1099/mic.0.064139-0
110.
Linden D. R. Chen J. X. Gershon M. D. Sharkey K. A. Mawe G. M. (2003 ). Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G207–G216.
Not in our library10.1152/ajpgi.00488.2002
111.
Linden D. R. Foley K. F. Mcquoid C. Simpson J. Sharkey K. A. Mawe G. M. (2005 ). Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastroenterol. Motil. 17, 565–574.
Not in our library10.1111/j.1365-2982.2005.00673.x
112.
Liu X. Shin N. Koblish H. K. Yang G. Wang Q. Wang K.. (2010 ). Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood 115, 3520–3530.
Not in our library10.1182/blood-2009-09-246124
113.
Liu Y. Wang X. Hou Y. Yin Y. Qiu Y. Wu G.. (2017 ). Roles of amino acids in preventing and treating intestinal diseases: recent studies with pig models. Amino Acids 49, 1277–1291.
Not in our library10.1007/s00726-017-2450-1
114.
Llopis M. Antolin M. Carol M. Borruel N. Casellas F. Martinez C.. (2009 ). Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa. Inflamm. Bowel Dis. 15, 275–283.
Not in our library10.1002/ibd.20736
115.
Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production · 2014
No notice
116.
Lundgren O. (1998 ). 5-Hydroxytryptamine, enterotoxins, and intestinal fluid secretion. Gastroenterology 115, 1009–1012.
Not in our library10.1016/s0016-5085(98)70275-6
117.
Maes M. Mihaylova I. Ruyter M. D. Kubera M. Bosmans E. (2007 ). The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation. Neuro Endocrinol. Lett. 28, 826–831.
Not in our library
118.
Marcobal A. Kashyap P. C. Nelson T. A. Aronov P. A. Donia M. S. Spormann A.. (2013 ). A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice. ISME J. 7, 1933–1943.
Not in our library10.1038/ismej.2013.89
119.
The gut microbiota modulates host amino acid and glutathione metabolism in mice · 2015
No notice
120.
Margolis K. G. Stevanovic K. Li Z. Yang Q. M. Oravecz T. Zambrowicz B. (2013 ). Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut 63, 928–937.
Not in our library10.1136/gutjnl-2013-304901
121.
Markus R. P. Silva C. L. M. Franco D. G. Barbosa E. M. Jr. Ferreira Z. S. (2010 ). Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs? Pharmacol. Ther. 126, 251–262.
Not in our library10.1016/j.pharmthera.2010.02.009
122.
Marsland B. J. (2016 ). Regulating inflammation with microbial metabolites. Nat. Med. 22, 581–583.
Not in our library10.1038/nm.4117
123.
Martin-Subero M. Anderson G. Kanchanatawan B. Berk M. Maes M. (2015 ). Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut–brain pathways. CNS Spectr. 21, 184–198.
Not in our library10.1017/s1092852915000449
124.
Maslowski K. M. Vieira A. T. Ng A. Kranich J. Sierro F. Yu D.. (2009 ). Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461, 1282–1286.
Not in our library10.1038/nature08530
125.
The gut microbiota and inflammatory bowel disease · 2014
No notice
126.
Mosa A. Gerber A. Neunzig J. Bernhardt R. (2016 ). Products of gut-microbial tryptophan metabolism inhibit the steroid hormone-synthesizing cytochrome P450 11A1. Endocrine 53, 610–614.
Not in our library10.1007/s12020-016-0874-0
127.
Muller A. J. Scherle P. A. (2006 ). Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors. Nat. Rev. Cancer 6, 613–625.
Not in our library10.1038/nrc1929
128.
Muller A. J. Duhadaway J. B. Donover P. S. Sutanto-Ward E. Prendergast G. C. (2005 ). Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. 11, 312.
Not in our library10.1038/nm1196
129.
Munn D. H. Mellor A. L. (2007 ). Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Investig. 117, 1147–1154.
Not in our library10.1172/jci31178
130.
Nagata S. Asahara T. Wang C. Suyama Y. Chonan O. Takano K.. (2016 ). The effectiveness of lactobacillus beverages in controlling infections among the residents of an aged care facility: a randomized placebo-controlled double-blind trial. Ann. Nutr. Metab. 68, 51–59.
Not in our library10.1159/000442305
131.
Nakai A. Kumakura Y. Boivin M. Rosa P. Diksic M. D'souza D.. (2003 ). Sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using alpha-[11C]methyl-L-tryptophan, positron emission tomography and statistical parametric mapping. Can. J. Gastroenterol. 17, 191–196.
Not in our library10.1155/2003/572127
132.
Nemoto H. Kataoka K. Ishikawa H. Ikata K. Arimochi H. Iwasaki T.. (2012 ). Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis. Dig. Dis. Sci. 57, 2955–2964.
Not in our library10.1007/s10620-012-2236-y
133.
Nicholson J. K. Wilson I. D. (2003 ). Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2, 668–676.
Not in our library10.1038/nrd1157
134.
Niño-Castro A. Abdullah Z. Popov A. Thabet Y. Beyer M. Knolle P.. (2014 ). The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes. Innate Immun. 20, 401–411.
Not in our library10.1177/1753425913496442
135.
Notarangelo F. M. Wilson E. H. Horning K. J. Thomas M. A. Harris T. H. Fang Q.. (2014 ). Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia. Schizophr. Res. 152, 261–267.
Not in our library10.1016/j.schres.2013.11.011
136.
Nowak A. Libudzisz Z. (2006 ). Influence of phenol, p-cresol and indole on growth and survival of intestinal lactic acid bacteria. Anaerobe 12, 80–84.
Not in our library10.1016/j.anaerobe.2005.10.003
137.
O'mahony S. M. Clarke G. Borre Y. E. Dinan T. G. Cryan J. F. (2015 ). Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav. Brain Res. 277, 32–48.
Not in our library10.1016/j.bbr.2014.07.027
138.
Opitz C. A. Litzenburger U. M. Sahm F. Ott M. Tritschler I. Trump S.. (2011 ). An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197–203.
Not in our library10.1038/nature10491
139.
Oxenkrug G. F. (2010 ). Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism. Ann. N. Y. Acad. Sci. 1199, 1–14.
Not in our library10.1111/j.1749-6632.2009.05356.x
140.
Peters J. C. (1991 ). Tryptophan nutrition and metabolism: an overview. Adv. Exp. Med. Biol. 294, 345–358.
Not in our library10.1007/978-1-4684-5952-4_32
141.
Pillai S. (2013 ). Rethinking mechanisms of autoimmune pathogenesis. J. Autoimmun. 45, 97–103.
Not in our library10.1016/j.jaut.2013.05.003
142.
Png C. W. Linden S. K. Gilshenan K. S. Zoetendal E. G. Mcsweeney C. S. Sly L. I.. (2010 ). Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am. J. Gastroenterol. 105, 2420–2428.
Not in our library10.1038/ajg.2010.281
143.
Puel A. Döffinger R. Natividad A. Chrabieh M. Barcenas-Morales G. Picard C.. (2010 ). Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. 207, 291–297.
Not in our library10.1084/jem.20091983
144.
Qiu J. Heller J. J. Guo X. Chen Z. M. Fish K. Fu Y. X.. (2012 ). The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 36, 92–104.
Not in our library10.1016/j.immuni.2011.11.011
145.
Radogna F. Diederich M. Ghibelli L. (2010 ). Melatonin: a pleiotropic molecule regulating inflammation. Biochem. Pharmacol. 80, 1844–1852.
Not in our library10.1016/j.bcp.2010.07.041
146.
Raman M. Ambalam P. Kondepudi K. K. Pithva S. Kothari C. Patel A. T.. (2013 ). Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer. Gut Microbes 4, 181-192.
Not in our library10.4161/gmic.23919
147.
Functional metagenomic profiling of intestinal microbiome in extreme ageing · 2013
No notice
148.
Reigstad C. S. Salmonson C. E. Rainey J. F. III. Szurszewski J. H. Linden D. R. Sonnenburg J. L.. (2015 ). Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J. 29, 1395–1403.
Not in our library10.1096/fj.14-259598
149.
Ridaura V. Belkaid Y. (2015 ). Gut microbiota: the link to your second brain. Cell 161, 193–194.
Not in our library10.1016/j.cell.2015.03.033
150.
Romani L. Zelante T. Luca A. D. Iannitti R. G. Moretti S. Bartoli A.. (2014 ). Microbiota control of a tryptophan–AhR pathway in disease tolerance to fungi. Eur. J. Immunol. 44, 3192–3200.
Not in our library10.1002/eji.201344406
151.
Rooks M. G. Garrett W. S. (2016 ). Gut microbiota, metabolites and host immunity. Nat. Rev. Immunol. 16, 341–352.
Not in our library10.1038/nri.2016.42
152.
Rowan F. Docherty N. G. Murphy M. Murphy B. Calvin Coffey J. O'connell P. R. (2010 ). Desulfovibrio bacterial species are increased in ulcerative colitis. Dis. Colon Rectum 53, 1530–1536.
Not in our library10.1007/dcr.0b013e3181f1e620
153.
Ruddick J. P. Evans A. K. Nutt D. J. Lightman S. L. Rook G. A. W. Lowry C. A. (2006 ). Tryptophan metabolism in the central nervous system: medical implications. Expert Rev. Mol. Med. 8, 1–27.
Not in our library10.1017/s1462399406000068
154.
The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations · 2014
Not checked
155.
Salazar N. Valdes-Varela L. Gonzalez S. Gueimonde M. De Los Reyes-Gavilan C. G. (2016 ). Nutrition and the gut microbiome in the elderly. Gut Microbes 8, 82–97.
Not in our library10.1080/19490976.2016.1256525
156.
Santhanam S. Alvarado D. M. Ciorba M. A. (2016 ). Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer. Transl. Res. 167, 67–79.
Not in our library10.1016/j.trsl.2015.07.003
157.
Sartor R. B. (2004 ). Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology 126, 1620–1633.
Not in our library10.1053/j.gastro.2004.03.024
158.
Sartor R. B. (2008 ). Microbial influences in inflammatory bowel diseases. Gastroenterology 134, 577–594.
Not in our library10.1053/j.gastro.2007.11.059
159.
Scher J. U. Ubeda C. Artacho A. Attur M. Isaac S. Reddy S. M.. (2015 ). Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol. 67, 128–139.
Not in our library10.1002/art.38892
160.
Schiering C. Wincent E. Metidji A. Iseppon A. Li Y. Potocnik A. J.. (2017 ). Feedback control of AHR signalling regulates intestinal immunity. Nature 542, 242–245.
Not in our library10.1038/nature21080
161.
Shi L. Z. Faith N. G. Nakayama Y. Suresh M. Steinberg H. Czuprynski C. J. (2007 ). The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice. J. Immunol. 179, 6952–6962.
Not in our library10.4049/jimmunol.179.10.6952
162.
Shi Z. C. Devasagayaraj A. Gu K. Jin H. Marinelli B. Samala L.. (2008 ). Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J. Med. Chem. 51, 3684–3687.
Not in our library10.1021/jm800338j
163.
Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon · 2013
No notice
164.
Shufflebotham J. Hood S. Hendry J. Hince D. A. Morris K. Nutt D.. (2006 ). Acute tryptophan depletion alters gastrointestinal and anxiety symptoms in irritable bowel syndrome. Am. J. Gastroenterol. 101, 2582.
Not in our library10.1111/j.1572-0241.2006.00811.x
165.
Smith E. A. Macfarlane G. T. (1997 ). Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine. Microb. Ecol. 33, 180–188.
Not in our library10.1007/s002489900020
166.
Soares R. L. (2014 ). Irritable bowel syndrome: a clinical review. World J. Gastroenterol. 20, 12144–12160.
Not in our library10.3748/wjg.v20.i34.12144
167.
Sokol H. Pigneur B. Watterlot L. Lakhdari O. Bermúdez-Humarán L. G. Gratadoux J.-J.. (2008 ). Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl. Acad. Sci. U.S.A. 105, 16731–16736.
Not in our library10.1073/pnas.0804812105
168.
Sommansson A. Nylander O. Sjöblom M. (2013 ). Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receptor–dependent pathway in rats in vivo. J. Pineal Res. 54, 282–291.
Not in our library10.1111/jpi.12013
169.
Spiller R. (2008 ). Serotonin and GI clinical disorders. Neuropharmacology 55, 1072–1080.
Not in our library10.1016/j.neuropharm.2008.07.016
170.
Stoll M. L. Kumar R. Lefkowitz E. J. Cron R. Q. Morrow C. D. Barnes S. (2016 ). Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors. Genes Immun. 17, 400–405.
Not in our library10.1038/gene.2016.38
171.
Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis · 2014
No notice
172.
Strauss J. Kaplan G. G. Beck P. L. Rioux K. Panaccione R. Devinney R.. (2011 ). Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host. Inflamm. Bowel Dis. 17, 1971–1978.
Not in our library10.1002/ibd.21606
173.
Sudo N. Chida Y. Aiba Y. Sonoda J. Oyama N. Yu X. N.. (2004 ). Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol. 558, 263–275.
Not in our library10.1113/jphysiol.2004.063388
174.
Sun X. Shao Y. Jin Y. Huai J. Zhou Q. Huang Z.. (2013 ). Melatonin reduces bacterial translocation by preventing damage to the intestinal mucosa in an experimental severe acute pancreatitis rat model. Exp. Ther. Med. 6, 1343–1349.
Not in our library10.3892/etm.2013.1338
175.
Sutter C. H. Bodreddigari S. Campion C. Wible R. S. Sutter T. R. (2011 ). 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation. Toxicol. Sci. 124, 128–137.
Not in our library10.1093/toxsci/kfr205
176.
Takaki M. Mawe G. M. Barasch J. M. Gershon M. D. Gershon M. D. (1985 ). Physiological responses of guinea-pig myenteric neurons secondary to the release of endogenous serotonin by tryptamine. Neuroscience 16, 223–240.
Not in our library10.1016/0306-4522(85)90059-4
177.
Takamura T. Harama D. Matsuoka S. Shimokawa N. Nakamura Y. Okumura K.. (2010 ). Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. Immunol. Cell Biol. 88, 685–689.
Not in our library10.1038/icb.2010.35
178.
Thaiss C. A. Zmora N. Levy M. Elinav E. (2016 ). The microbiome and innate immunity. Nature 535, 65–74.
Not in our library10.1038/nature18847
179.
Thaker A. I. Rao M. S. Bishnupuri K. S. Kerr T. A. Foster L. Marinshaw J. M.. (2013 ). IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. Gastroenterology 145, 416.e414–425.e414.
Not in our library10.1053/j.gastro.2013.05.002
180.
Théate I. Van Baren N. Pilotte L. Moulin P. Larrieu P. Renauld J. C.. (2015 ). Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues. Cancer Immunol. Res. 3, 161–172.
Not in our library10.1158/2326-6066.cir-14-0137
181.
Thorburn A. N. Macia L. Mackay C. R. (2014 ). Diet, metabolites, and “western-lifestyle” inflammatory diseases. Immunity 40, 833–842.
Not in our library10.1016/j.immuni.2014.05.014
182.
Tilg H. Moschen A. R. (2015 ). Food, immunity, and the microbiome. Gastroenterology 148, 1107–1119.
Not in our library10.1053/j.gastro.2014.12.036
183.
Tourino M. C. De Oliveira E. M. Belle L. P. Knebel F. H. Albuquerque R. C. Dorr F. A.. (2013 ). Tryptamine and dimethyltryptamine inhibit indoleamine 2,3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells. Cell Biochem. Funct. 31, 361–364.
Not in our library10.1002/cbf.2980
184.
Turvill J. L. Connor P. Farthing M. J. (2000 ). The inhibition of cholera toxin-induced 5-HT release by the 5-HT(3) receptor antagonist, granisetron, in the rat. Br. J. Pharmacol. 130, 1031–1036.
Not in our library10.1038/sj.bjp.0703414
185.
Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility · 2009
No notice
186.
Uyttenhove C. Pilotte L. Theate I. Stroobant V. Colau D. Parmentier N.. (2003 ). Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9, 1269–1274.
Not in our library10.1038/nm934
187.
Valladares R. Bojilova L. Potts A. H. Cameron E. Gardner C. Lorca G.. (2013 ). Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats. FASEB J. 27, 1711–1720.
Not in our library10.1096/fj.12-223339
188.
Van Beek A. A. Hugenholtz F. Meijer B. Sovran B. Perdijk O. Vermeij W. P.. (2016 ). Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Delta7 mice. J. Leukoc. Biol. 101, 811–821.
Not in our library10.1189/jlb.1hi0216-062rr
189.
Venkatesh M. Mukherjee S. Wang H. Li H. Sun K. Benechet A. P.. (2014 ). Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and toll-like receptor 4. Immunity 41, 296–310.
Not in our library10.1016/j.immuni.2014.06.014
190.
Vereecke L. Elewaut D. (2017 ). Spondyloarthropathies: ruminococcus on the horizon in arthritic disease. Nat. Rev. Rheumatol. 13, 574–576.
Not in our library10.1038/nrrheum.2017.130
191.
Vikström Bergander L. Cai W. Klocke B. Seifert M. Pongratz I. (2012 ). Tryptamine serves as a proligand of the AhR transcriptional pathway whose activation is dependent of monoamine oxidases. Mol. Endocrinol. 26, 1542–1551.
Not in our library10.1210/me.2011-1351
192.
Walczak K. Dabrowski W. Langner E. Zgrajka W. Pilat J. Kocki T.. (2011 ). Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells. Scand. J. Gastroenterol. 46, 903–912.
Not in our library10.3109/00365521.2011.579159
193.
Wang J. Simonavicius N. Wu X. Swaminath G. Reagan J. Tian H.. (2006 ). Kynurenic acid as a ligand for orphan G Protein-coupled Receptor GPR35. J. Biol. Chem. 281, 22021–22028.
Not in our library10.1074/jbc.m603503200
194.
Wang Y. Devkota S. Musch M. W. Jabri B. Nagler C. Antonopoulos D. A.. (2010 ). Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS ONE 5:e13607.
Not in our library10.1371/journal.pone.0013607
195.
Weinlich G. Murr C. Richardsen L. Winkler C. Fuchs D. (2007 ). Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 214, 8–14.
Not in our library10.1159/000096906
196.
Whitehead T. R. Price N. P. Drake H. L. Cotta M. A. (2008 ). Catabolic pathway for the production of skatole and indoleacetic acid by the acetogen Clostridium drakei, Clostridium scatologenes, and swine manure. Appl. Environ. Microbiol. 74, 1950–1953.
Not in our library10.1128/aem.02458-07
197.
Whiteside T. L. (2006 ). Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention. Semin. Cancer Biol. 16, 3–15.
Not in our library10.1016/j.semcancer.2005.07.008
198.
Whitfield-Cargile C. M. Cohen N. D. Chapkin R. S. Weeks B. R. Davidson L. A. Goldsby J. S.. (2016 ). The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy. Gut Microbes 7, 246–261.
Not in our library10.1080/19490976.2016.1156827
199.
Wikoff W. R. Anfora A. T. Liu J. Schultz P. G. Lesley S. A. Peters E. C.. (2009 ). Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc. Natl. Acad. Sci. U.S.A. 106, 3698–3703.
Not in our library10.1073/pnas.0812874106
200.
Williams B. B. Van Benschoten A. H. Cimermancic P. Donia M. S. Zimmermann M. Taketani M.. (2014 ). Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe 16, 495–503.
Not in our library10.1016/j.chom.2014.09.001
201.
Wilson B. A. Kleiman S. C. Bulik-Sullivan E. C. Glenny E. M. Zerwas S. C. Huh E. Y. (2017 ). The gut-brain axis in healthy females: lack of significant association between microbial composition and diversity with psychiatric measures. PLoS ONE 12:e0170208
Not in our library10.1371/journal.pone.0170208
202.
Wlodarska M. Kostic A. D. Xavier R. J. (2015 ). An integrative view of microbiome-host interactions in inflammatory bowel diseases. Cell Host Microbe 17, 577–591.
Not in our library10.1016/j.chom.2015.04.008
203.
Wlodarska M. Luo C. Kolde R. D'hennezel E. Annand J. W. Heim C. E.. (2017 ). Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation. Cell Host Microbe 22, 25.e26–37.e26.
Not in our library10.1016/j.chom.2017.06.007
204.
Wolf A. M. Wolf D. Rumpold H. Moschen A. R. Kaser A. Obrist P.. (2004 ). Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease. Clin. Immunol. 113, 47–55.
Not in our library10.1016/j.clim.2004.05.004
205.
Xavier R. J. Podolsky D. K. (2007 ). Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427–434.
Not in our library10.1038/nature06005
206.
Xu K. Liu H. Bai M. Gao J. Wu X. Yin Y. (2017 ). Redox properties of tryptophan metabolism and the concept of tryptophan use in pregnancy. Int. J. Mol. Sci. 18:1595.
Not in our library10.3390/ijms18071595
207.
Yano J. M. Yu K. Donaldson G. P. Shastri G. G. Ann P. Ma L.. (2015 ). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161, 264–276.
Not in our library10.1016/j.cell.2015.02.047
208.
Yokoyama M. T. Carlson J. R. (1979 ). Microbial metabolites of tryptophan in the intestinal tract with special reference to skatole. Am. J. Clin. Nutr. 32, 173–178.
Not in our library10.1093/ajcn/32.1.173
209.
Yoshihara I. Maruta K. (1977 ). Gas Chromatographic microdetermination of indole and skatole in gastrointestinal contents of domestic animals. Agric. Biol. Chem. 41, 2083–2085.
Not in our library
210.
Zambetti L. P. Mortellaro A. (2014 ). NLRPs, microbiota, and gut homeostasis: unravelling the connection. J. Pathol. 233, 321–330.
Not in our library10.1002/path.4357
211.
Tryptophan feeding of the IDO1-AhR axis in host-microbial symbioses · 2014
Not checked
212.
Zelante T. Iannitti R. G. Cunha C. De luca A. Giovannini G. Pieraccini G.. (2013 ). Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39, 372–385.
Not in our library10.1016/j.immuni.2013.08.003
213.
Zenewicz L. A. Yin X. Wang G. Elinav E. Hao L. Zhao L.. (2013 ). IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J.Immunol. 190, 5306–5312.
Not in our library10.4049/jimmunol.1300016
214.
Zucchi R. Chiellini G. Scanlan T. S. Grandy D. K. (2006 ). Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149, 967–978.
Not in our library10.1038/sj.bjp.0706948

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