Editorial: Non-apoptotic cell death mechanisms and their therapeutic significance

Editorial on the Research Topic Non-apoptotic cell death mechanisms and their therapeutic significanceThe field of cell biology has progressed rapidly over the past few decades.From the basic understanding of apoptosis and necrosis in the early 90s, we now have a clearer picture of the different apoptotic and non-apoptotic mechanisms of cell death.With the emergence of advanced techniques and technologies, identifying unconventional cell death mechanisms has become easier in recent years.Apoptosis is a well-characterized cell death mechanism that helps shape the developing organism, fights infections, optimizes body composition, and prevents hyperproliferative diseases.Over the years, laboratories have noticed many alternative modes of cell death, some of which share features of apoptosis and others bearing little or no resemblance to it (Nirmala and Lopus, 2020).The ability of cancer cells to resist innately programmed or drug-induced apoptosis necessitates identification and targeting of non-apoptotic cell death for effective cancer treatment.Besides apoptosis, there exist several cell death mechanisms.Many of these mechanisms operate to maintain the homeostatic wellbeing of the host organism, while some can as well be detrimental to the host.Some of the wellstudied cell death mechanisms include the Ras-mediated, caspase-independent methuosis, characterized by the presence of single-membrane-bound large vacuoles; pathogen-and drug-induced necroptosis having features of both apoptosis and necrosis; Netosis, the classic strategy of neutrophils to trap pathogens by casting some of their content as a net; pyronecrosis, which is stimulated by pathogens such as Shigella, and involves inflammasome formation; the autophagy-associated autosis; the cannibalistic entosis, where a

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