Sequencing-Based Measurable Residual Disease Testing in Acute Myeloid Leukemia

Next generation sequencing (NGS) methods have allowed for unprecedented genomic characterization of acute myeloid leukemia (AML) over the last several years. Further advances in NGS-based methods including error correction using unique molecular identifiers (UMIs) have more recently enabled the use of NGS-based measurable residual disease (MRD) detection. This review focuses on the use of NGS-based MRD detection in AML, including basic methodologies and clinical applications.

Abstract licence: CC BY

1. 22.

   Subclonal variant calling with multiple samples and prior knowledge · 2014

2. 35.

   Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults · 2016

38 more references, whose wording the paper’s licence keeps private.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.