Stress and pluripotency

Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al., 2014a,b). The findings were controver-sial, and the authors have now retracted the papers, citing multiple critical errors within the reports that impaired the cred-ibility of the findings as a whole. The central notion of this stimulus-triggered acquisition of pluripotency (STAP), and how the idea might have evolved from other notions, is nonetheless worth a moment of thought. In view of the fact that generation of STAP cells beyond the authors ’ labs have not yet been definitely reported thus far

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