Significance of Susceptible Gene Expression Profiles in Nasal Polyposis

An interesting observation is that NP is frequently found to run in families, suggesting a hereditary or shared environmental factor.In the study by Rugina et al. (5), more than half of 224 NP patients (52%) had a positive family history of NP.The presence of NP was considered when NP had been diagnosed by an ENT practitioner or the patients had undergone sinus surgery for NP.A lower percentage (14%) of familial occurrence of NP was reported earlier by Greisner and Settipane (6) in a smaller group (n=50) of adult patients with NP.Thus, these results strongly suggest the existence of a hereditary factor in the pathogenesis of NP.However, studies of monozygotic twins have not shown that Nasal polyposis (NP) is a common chronic inflammatory disease of the rhinosinus mucosa and a complex disease with strong genetic and environmental components.During the past 10 to 20 yr, many studies have been performed to determine differential gene expression profiles between NP and normal nasal tissues, in order to identify susceptible genes that are associated with NP-related traits.Despite achievement in the identification of candidate genes and their associated pathogenic pathways, the large challenges remain as the genetic and molecular alterations required for its development and progression are still unclear.Therefore, the development of novel, powerful tools for gene discovery, and a closer integration of genetics and medical biology would provide valuable insight into the pathogenesis of NP.

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