Vaccine Effectiveness against DS-1–Like Rotavirus Strains

To the Editor: Global emergence of reassortant rotavirus A (RVA) strains possessing the DS-1 backbone genes, such as DS-1-like G1P[8] strains (1-3), raises 2 key questions of public health importance. First, is the G1P[8] monovalent vaccine (RV1) effective against the DS-1-like G1P[8] strain? Second, does this strain cause more severe disease than the Wa-like G1P[8] strain?

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