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Control of Fluoroquinolone Resistance through Successful Regulation, Australia

Allen C. Cheng, John Turnidge, Peter Collignon and 3 more

Emerging Infectious Diseases · 2012 · Review

doi:10.3201/eid1809.111515

Abstract

Fluoroquinolone antimicrobial drugs are highly bioavailable, broad-spectrum agents with activity against gram-negative pathogens, especially those resistant to other classes of antimicrobial drugs. Australia has restricted the use of quinolones in humans through its national pharmaceutical subsidy scheme; and, through regulation, has not permitted the use of quinolones in food-producing animals. As a consequence, resistance to fluoroquinolones in the community has been slow to emerge and has remained at low levels in key pathogens, such as Escherichia coli. In contrast to policies in most other countries, this policy has successfully preserved the utility of this class of antimicrobial drugs for treatment of most infections.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 22, 2026. Paragraph numbers are ours, so an answer can point at one.

Medscape CME Activity

Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit.

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.

Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at www.medscape.org/journal/eid; (4) view/print certificate.

Release date: August 16, 2012; Expiration date: August 16, 2013

Learning Objectives

Upon completion of this activity, participants will be able to:

Describe restrictions in Australia regarding use of fluoroquinolones, based on a review

Describe development of fluoroquinolone resistance in Australia compared to that in other countries, based on a review

Describe potential harms of restricting fluoroquinolone use, and strategies to eliminate those harms, based on a review

CME Editor

Jean Michaels Jones, Technical Writer/Editor, Emerging Infectious Diseases. Disclosure: Jean Michaels Jones has disclosed no relevant financial relationships.

CME Author

Laurie Barclay, MD, freelance writer and reviewer, Medscape, LLC. Disclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.

Authors

Disclosures: Allen C. Cheng, PhD; Peter Collignon, FRACP; David Looke, FRACP; and Mary Barton, PhD, have disclosed no relevant financial relationships. John Turnidge, FRACP, has disclosed the following relevant financial relationships: served as an advisor or consultant for AstraZeneca Australia, BioMerieux. Thomas Gottlieb, FRACP, has disclosed the following relevant financial relationships: served as an advisor or consultant for AstraZeneca Australia, Janssen-Cilag, Novartis, Pfizer.

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