Hepatitis E Virus and Neurologic Disorders
Nassim Kamar, Richard P. Bendall, Jean Marie Peron and 8 more
Emerging Infectious Diseases · 2011 · Case report
doi:10.3201/eid1702.100856 (opens in a new tab)
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Abstract
Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%): inflammatory polyradiculopathy (n = 3), Guillain-Barre syndrome (n = 1), bilateral brachial neuritis (n = 1), encephalitis (n = 1), and ataxia/proximal myopathy (n = 1). Three cases occurred in nonimmunocompromised patients with acute HEV infection, and 4 were in immunocompromised patients with chronic HEV infection. HEV RNA was detected in cerebrospinal fluid of all 4 patients with chronic HEV infection but not in that of 2 patients with acute HEV infection. Neurologic outcomes were complete resolution (n = 3), improvement with residual neurologic deficit (n = 3), and no improvement (n = 1). Neurologic disorders are an emerging extrahepatic manifestation of HEV infection.
Abstract licence: CC BY
Full text
From PubMed Central, U.S. National Library of Medicine, as current on Nov 12, 2026. Paragraph numbers are ours, so an answer can point at one.
MEDSCAPE CME
Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit.
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.
Medscape, LLC designates this Journal-based CME for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with their participation in the activity.
All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test and/or complete the evaluation at www.medscapecme.com/journal/eid; (4) view/print certificate.
Release date: January 25, 2011; Expiration date: January 25, 2012
Learning Objectives
Upon completion of this activity, participants will be able to:
Describe the overall spectrum of neurological manifestations of hepatitis E virus (HEV) infection, based on a case series
Describe diagnosis of HEV infection in patients who present with neurological symptoms and liver function test abnormalities
Describe peripheral nerve involvement associated with HEV infection.
Editor
P. Lynne Stockton, VMD, MS, ELS(D), Technical Writer-Editor, Emerging Infectious Diseases. Disclosure: P. Lynne Stockton, VMD, MS, ELS(D), has disclosed no relevant financial relationships.
CME AUTHOR
Laurie Barclay, MD, freelance writer and reviewer, Medscape, LLC. Disclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.
AUTHORS
Disclosures: Nassim Kamar, MD, PhD; Richard P. Bendall, FRCP; Jean Marie Peron, MD; Pascal Cintas, MD;Laurent Prudhomme, MD; Jean Michel Mansuy, MD; Lionel Rostaing, MD, PhD; Frances Keane, MD, FRCP; Samreen Ijaz, PhD; and Jacques Izopet, PharmD, have disclosed no relevant financial relationships. Harry R. Dalton, FRCP, has disclosed the following relevant financial relationships: served as an advisor or consultant for Beijing Wantai Biological Pharmacy Enterprises Co., Ltd.; GlaxoSmithKline
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