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Correlation of Pandemic (H1N1) 2009 Viral Load with Disease Severity and Prolonged Viral Shedding in Children
Chung-Chen Li, Lin Wang, Hock-Liew Eng and 9 more
Emerging Infectious Diseases · 2010
Abstract
Pandemic (H1N1) 2009 virus causes severe illness, including pneumonia, which leads to hospitalization and even death.To characterize the kinetic changes in viral load and identify factors of infl uence, we analyzed variables that could potentially infl uence the viral shedding time in a hospitalbased cohort of 1,052 patients.Viral load was inversely correlated with number of days after the onset of fever and was maintained at a high level over the fi rst 3 days.Patients with pneumonia had higher viral loads than those with bronchitis or upper respiratory tract infection.Median viral shedding time after the onset of symptoms was 9 days.Patients 13 years of age (11 days vs. 7 days).These results suggest that younger children may require a longer isolation period and that patients with pneumonia may require treatment that is more aggressive than standard therapy for pandemic (H1N1) 2009 virus.T he infl uenza A pandemic (H1N1) 2009 virus, initially identifi ed in Mexico and the United States in April 2009, has been reported in >213 countries (1).Severe ill-Correlation of Pandemic (H1N1) 2009 Viral Load with Disease Severity and Prolonged Viral Shedding in Children
Full text
From PubMed Central, U.S. National Library of Medicine, as current on Oct 27, 2026. Paragraph numbers are ours, so an answer can point at one.
MEDSCAPE CME
Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit. This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians. Medscape, LLC designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test and/or complete the evaluation at http://cme.medscape.com/viewpublication/30063; (4) view/print certificate.
Learning Objectives
Identify the most common clinical manifestations associated with pandemic (H1N1) 2009 infection.
Recognize different diagnostic tests for pandemic (H1N1) 2009 infection.
Identify independent predictors of viral shedding in pandemic (H1N1) 2009 infection, including impact of age and comorbidities.
Editor
Carol Snarey, MA, Copyeditor, Emerging Infectious Diseases. Disclosure: Carol Snarey, MA, has disclosed no relevant financial relationships.
CME AUTHOR
Desiree Lie, MD, MSED, Clinical Professor of Family Medicine, Director of Research and Faculty Development, University of California, Irvine at Orange, California. Disclosure: Désirée Lie, MD, MSEd, has disclosed the following relevant financial relationship: served as a nonproduct speaker for "Topics in Health" for Merck Speaker Services.
AUTHORS
Disclosures: Chung-Chen Li, MD; Lin Wang, MD; Hock-Liew Eng, MD; Huey-Ling You, MD; Ling-Sai Chang, MD; Kuo-Shu Tang, MD; Ying-Jui Lin, MD; Hsuan-Chang Kuo, MD; Ing-Kit Lee, MD; Jien-Wei Liu, MD; Eng-Yen Huang, MD; and Kuender D. Yang, MD, have disclosed no relevant financial relationships.
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