Molecular Model of Prion Transmission to Humans
Michael Jones, Darren Wight, Rona Barron and 5 more
Emerging Infectious Diseases · 2009
doi:10.3201/eid1512.090194 (opens in a new tab)
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Abstract
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
Abstract licence: CC BY
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