Oseltamivir-Resistant Influenza Virus A (H1N1), Europe, 2007–08 Season

Abstract

In Europe, the 2007-08 winter season was dominated by infl uenza virus A (H1N1) circulation through week 7, followed by infl uenza B virus from week 8 onward.Oseltamivir-resistant infl uenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use.By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway.The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%).Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive infl uenza viruses A (H1N1).Minor variants of ORVs emerged independently, indicating multiclonal ORVs.Overall, the clinical effect of ORVs in Europe, measured by infl uenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.

Cited by papers we hold 3

• Influenza Virus Neuraminidase Structure and Functions · 2019
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• Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013–2014 · 2015
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• Clinical Implications of Antiviral Resistance in Influenza · 2015
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