West Nile Virus Infection in the Golden Hamster ( Mesocricetus auratus ): A Model for West Nile Encephalitis

Abstract

This report describes a new hamster model for West Nile (WN) virus encephalitis. Following intraperitoneal inoculation of a New York isolate of WN virus, hamsters had moderate viremia of 5 to 6 days in duration, followed by the development of humoral antibodies. Encephalitic symptoms began 6 days after infection; about half the animals died between the seventh and 14th days. The appearance of viral antigen in the brain and neuronal degeneration also began on the sixth day. WN virus was cultured from the brains of convalescent hamsters up to 53 days after initial infection, suggesting that persistent virus infection occurs. Hamsters offer an inexpensive model for studying the pathogenesis and treatment of WN virus encephalitis.

References 31

1. 1.

   Asnis D. S., Conetta R., Teixeira A. A., Waldman G., Sampson B. A. The West Nile Virus outbreak of 1999 in New York: the Flushing Hospital experience. Clin Infect Dis. 2000;30(3):413-418.

   Not in our library10.1086/313737

2. 2.

   Centers for Disease Control and Prevention (CDC). Update: West Nile Virus activity--Eastern United States, 2000. MMWR Morb Mortal Wkly Rep. 2000;49(46):1044-1047.

   Not in our library

3. 3.

   Centers for Disease Control and Prevention (CDC). Update: West Nile-like viral encephalitis--New York, 1999. MMWR Morb Mortal Wkly Rep. 1999;48(39):890-892.

   Not in our library

4. 4.

   Desprès P., Frenkiel M. P., Ceccaldi P. E., Duarte Dos Santos C., Deubel V. Apoptosis in the mouse central nervous system in response to infection with mouse-neurovirulent dengue viruses. J Virol. 1998;72(1):823-829.

   Not in our library10.1128/jvi.72.1.823-829.1998

5. 5.

   Eldadah A. H., Nathanson N. Pathogenesis of West Nile Virus encepahlitis in mice and rats. II. Virus multiplication, evolution of immunofluorescence, and development of histological lesions in the brain. Am J Epidemiol. 1967;86(3):776-790.

   Not in our library10.1093/oxfordjournals.aje.a120786

6. 6.

   Eldadah A. H., Nathanson N., Sarsitis R. Pathogenesis of West Nile Virus encephalitis in mice and rats. 1. Influence of age and species on mortality and infection. Am J Epidemiol. 1967;86(3):765-775.

   Not in our library10.1093/oxfordjournals.aje.a120785

7. 7.

   HURLBUT H. S., RIZK F., TAYLOR R. M., WORK T. H. A study of the ecology of West Nile virus in Egypt. Am J Trop Med Hyg. 1956;5(4):579-620.

   Not in our library10.4269/ajtmh.1956.5.579

8. 8.

   Hubálek Z., Halouzka J. West Nile fever--a reemerging mosquito-borne viral disease in Europe. Emerg Infect Dis. 1999;5(5):643-650.

   Not in our library10.3201/eid0505.990505

9. 9.

   Igarashi A. Isolation of a Singh's Aedes albopictus cell clone sensitive to Dengue and Chikungunya viruses. J Gen Virol. 1978;40(3):531-544.

   Not in our library10.1099/0022-1317-40-3-531

10. 10.

    Komar N. West Nile viral encephalitis. Rev Sci Tech. 2000;19(1):166-176.

    Not in our library10.20506/rst.19.1.1201

11. 11.

    Lewis J., Wesselingh S. L., Griffin D. E., Hardwick J. M. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence. J Virol. 1996;70(3):1828-1835.

    Not in our library10.1128/jvi.70.3.1828-1835.1996

12. 12.

    Lustig S., Olshevsky U., Ben-Nathan D., Lachmi B. E., Malkinson M., Kobiler D., Halevy M. A live attenuated West Nile virus strain as a potential veterinary vaccine. Viral Immunol. 2000;13(4):401-410.

    Not in our library10.1089/vim.2000.13.401

13. 13.

    McMinn P. C., Dalgarno L., Weir R. C. A comparison of the spread of Murray Valley encephalitis viruses of high or low neuroinvasiveness in the tissues of Swiss mice after peripheral inoculation. Virology. 1996;220(2):414-423.

    Not in our library10.1006/viro.1996.0329

14. 14.

    Monath T. P., Cropp C. B., Harrison A. K. Mode of entry of a neurotropic arbovirus into the central nervous system. Reinvestigation of an old controversy. Lab Invest. 1983;48(4):399-410.

    Not in our library

15. 15.

    Pogodina V. V., Frolova M. P., Malenko G. V., Fokina G. I., Koreshkova G. V., Kiseleva L. L., Bochkova N. G., Ralph N. M. Study on West Nile virus persistence in monkeys. Arch Virol. 1983;75(1-2):71-86.

    Not in our library10.1007/bf01314128

16. 16.

    Pogodina V. V., Frolova M. P., Malenko G. V., Fokina G. I., Levina L. S., Mamonenko L. L., Koreshkova G. V., Ralf N. M. Persistence of tick-borne encephalitis virus in monkeys. I. Features of experimental infection. Acta Virol. 1981;25(6):337-343.

    Not in our library

17. 17.

    Pogodina V. V., Levina L. S., Fokina G. I., Koreshkova G. V., Malenko G. V., Bochkova N. G., Rzhakhova O. E. Persistence of tic-borne encephalitis virus in monkeys. III. Phenotypes of the persisting virus. Acta Virol. 1981;25(6):352-360.

    Not in our library

18. 18.

    Pogodina V. V., Malenko G. V., Fokina G. I., Levina L. S., Koreshkova G. V., Rzhakhova O. E., Bochkova N. G., Mamonenko L. L. Persistence of tick-borne encephalitis virus in monkeys. II. Effectiveness of methods used for virus detection. Acta Virol. 1981;25(6):344-351.

    Not in our library

19. 19.

    Rajcáni J., Ciampor F., Sabó A., Líbiková H., Rosenbergová M. Activation of latent herpesvirus hominis in explants of rabbit trigeminal ganglia: the influence of immune serum. Arch Virol. 1977;53(1-2):55-69.

    Not in our library10.1007/bf01314847

20. 20.

    Sampson B. A., Ambrosi C., Charlot A., Reiber K., Veress J. F., Armbrustmacher V. The pathology of human West Nile Virus infection. Hum Pathol. 2000;31(5):527-531.

    Not in our library10.1053/hp.2000.8047

21. 21.

    Shope T. C., Klein-Robbenhaar J., Miller G. Fatal encephalitis due to Herpesvirus hominis: use of intact brain cells for isolation of virus. J Infect Dis. 1972;125(5):542-544.

    Not in our library10.1093/infdis/125.5.542

22. 22.

    Slonim D., Závadová H., Simon J. Pathogenicity of tick-borne encephalitis virus. VI. Relation between infective and pathogenic activity for golden hamsters. Acta Virol. 1966;10(4):336-342.

    Not in our library

23. 23.

    Steele K. E., Linn M. J., Schoepp R. J., Komar N., Geisbert T. W., Manduca R. M., Calle P. P., Raphael B. L., Clippinger T. L., Larsen T. Pathology of fatal West Nile virus infections in native and exotic birds during the 1999 outbreak in New York City, New York. Vet Pathol. 2000;37(3):208-224.

    Not in our library10.1354/vp.37-3-208

24. 24.

    Tesh R. B. A method for the isolation and identification of dengue viruses, using mosquito cell cultures. Am J Trop Med Hyg. 1979;28(6):1053-1059.

    Not in our library10.4269/ajtmh.1979.28.1053

25. 25.

    Tesh R. B., Guzman H., da Rosa A. P., Vasconcelos P. F., Dias L. B., Bunnell J. E., Zhang H., Xiao S. Y. Experimental yellow fever virus infection in the Golden Hamster (Mesocricetus auratus). I. Virologic, biochemical, and immunologic studies. J Infect Dis. 2001;183(10):1431-1436.

    Not in our library10.1086/320199

26. 26.

    Tesh R. B., Peters C. J., Meegan J. M. Studies on the antigenic relationship among phleboviruses. Am J Trop Med Hyg. 1982;31(1):149-155.

    Not in our library10.4269/ajtmh.1982.31.149

27. 27.

    Tsai T. F., Popovici F., Cernescu C., Campbell G. L., Nedelcu N. I. West Nile encephalitis epidemic in southeastern Romania. Lancet. 1998;352(9130):767-771.

    Not in our library10.1016/s0140-6736(98)03538-7

28. 28.

    Weiner L. P., Cole G. A., Nathanson N. Experimental encephalitis following peripheral inoculation of West Nile virus in mice of different ages. J Hyg (Lond). 1970;68(3):435-446.

    Not in our library10.1017/s0022172400042339

29. 29.

    Xiao S. Y., Zhang H., Guzman H., Tesh R. B. Experimental yellow fever virus infection in the Golden hamster (Mesocricetus auratus). II. Pathology. J Infect Dis. 2001;183(10):1437-1444.

    Not in our library10.1086/320200

30. 30.

    Zlontnik I., Grant D. P., Carter G. B. Experimental infection of monkeys with viruses of the tick-borne encephalitis complex: degenerative cerebellar lesions following inapparent forms of the disease or recovery from clinical encephalitis. Br J Exp Pathol. 1976;57(2):200-210.

    Not in our library

31. 31.

    Zlotnik I., Carter G. B., Grant D. P. The persistence of louping ill virus in immunosuppressed guinea-pigs. Br J Exp Pathol. 1971;52(4):395-407.

    Not in our library

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