The Relationships between West Nile and Kunjin Viruses

Abstract

Until recently, West Nile (WN) and Kunjin (KUN) viruses were classified as distinct types in the Flavivirus genus. However, genetic and antigenic studies on isolates of these two viruses indicate that the relationship between them is more complex. To better define this relationship, we performed sequence analyses on 32 isolates of KUN virus and 28 isolates of WN virus from different geographic areas, including a WN isolate from the recent outbreak in New York. Sequence comparisons showed that the KUN virus isolates from Australia were tightly grouped but that the WN virus isolates exhibited substantial divergence and could be differentiated into four distinct groups. KUN virus isolates from Australia were antigenically homologous and distinct from the WN isolates and a Malaysian KUN virus. Our results suggest that KUN and WN viruses comprise a group of closely related viruses that can be differentiated into subgroups on the basis of genetic and antigenic analyses.

References 39

1. 1.

   Adams S. C., Broom A. K., Sammels L. M., Hartnett A. C., Howard M. J., Coelen R. J., Mackenzie J. S., Hall R. A. Glycosylation and antigenic variation among Kunjin virus isolates. Virology. 1995;206(1):49-56.

   Not in our library10.1016/s0042-6822(95)80018-2

2. 2.

   Berthet F. X., Zeller H. G., Drouet M. T., Rauzier J., Digoutte J. P., Deubel V. Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses. J Gen Virol. 1997;78(Pt 9):2293-2297.

   Not in our library10.1099/0022-1317-78-9-2293

3. 3.

   Besselaar T. G., Blackburn N. K. Antigenic analysis of West Nile virus strains using monoclonal antibodies. Arch Virol. 1988;99(1-2):75-88.

   Not in our library10.1007/bf01311025

4. 4.

   Briese T., Jia X. Y., Huang C., Grady L. J., Lipkin W. I. Identification of a Kunjin/West Nile-like flavivirus in brains of patients with New York encephalitis. Lancet. 1999;354(9186):1261-1262.

   Not in our library10.1016/s0140-6736(99)04576-6

5. 5.

   Brinton M. A., Fernandez A. V., Dispoto J. H. The 3'-nucleotides of flavivirus genomic RNA form a conserved secondary structure. Virology. 1986;153(1):113-121.

   Not in our library10.1016/0042-6822(86)90012-7

6. 6.

   Calisher C. H., Karabatsos N., Dalrymple J. M., Shope R. E., Porterfield J. S., Westaway E. G., Brandt W. E. Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J Gen Virol. 1989;70(Pt 1):37-43.

   Not in our library10.1099/0022-1317-70-1-37

7. 7.

   Castle E., Leidner U., Nowak T., Wengler G., Wengler G. Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins. Virology. 1986;149(1):10-26.

   Not in our library10.1016/0042-6822(86)90082-6

8. 8.

   Castle E., Nowak T., Leidner U., Wengler G., Wengler G. Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins. Virology. 1985;145(2):227-236.

   Not in our library10.1016/0042-6822(85)90156-4

9. 9.

   Chambers T. J., Hahn C. S., Galler R., Rice C. M. Flavivirus genome organization, expression, and replication. Annu Rev Microbiol. 1990;44:649-688.

   Not in our library10.1146/annurev.mi.44.100190.003245

10. 10.

    Chambers T. J., Halevy M., Nestorowicz A., Rice C. M., Lustig S. West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness. J Gen Virol. 1998;79(Pt 10):2375-2380.

    Not in our library10.1099/0022-1317-79-10-2375

11. 11.

    Coia G., Parker M. D., Speight G., Byrne M. E., Westaway E. G. Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins. J Gen Virol. 1988;69(Pt 1):1-21.

    Not in our library10.1099/0022-1317-69-1-1

12. 12.

    Damle R. G., Yeolekar L. R., Rao B. L. Strain analysis and epitope mapping of West Nile virus using monoclonal antibodies. Acta Virol. 1998;42(6):389-395.

    Not in our library

13. 13.

    De Madrid A. T., Porterfield J. S. The flaviviruses (group B arboviruses): a cross-neutralization study. J Gen Virol. 1974;23(1):91-96.

    Not in our library10.1099/0022-1317-23-1-91

14. 14.

    Deubel V., Kinney R. M., Trent D. W. Nucleotide sequence and deduced amino acid sequence of the nonstructural proteins of dengue type 2 virus, Jamaica genotype: comparative analysis of the full-length genome. Virology. 1988;165(1):234-244.

    Not in our library10.1016/0042-6822(88)90677-0

15. 15.

    Flynn L. M., Coelen R. J., Mackenzie J. S. Kunjin virus isolates of Australia are genetically homogeneous. J Gen Virol. 1989;70(Pt 10):2819-2824.

    Not in our library10.1099/0022-1317-70-10-2819

16. 16.

    Hahn C. S., Hahn Y. S., Rice C. M., Lee E., Dalgarno L., Strauss E. G., Strauss J. H. Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences. J Mol Biol. 1987;198(1):33-41.

    Not in our library10.1016/0022-2836(87)90455-4

17. 17.

    Halevy M., Akov Y., Ben-Nathan D., Kobiler D., Lachmi B., Lustig S. Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID mice. Arch Virol. 1994;137(3-4):355-370.

    Not in our library10.1007/bf01309481

18. 18.

    Hall R. A., Burgess G. W., Kay B. H., Clancy P. Monoclonal antibodies to Kunjin and Kokobera viruses. Immunol Cell Biol. 1991;69(Pt 1):47-49.

    Not in our library10.1038/icb.1991.7

19. 19.

    Hammam H. M., Price W. H. Further observations on geographic variation in the antigenic character of West Nile and Japanese B viruses. Am J Epidemiol. 1966;83(1):113-122.

    Not in our library10.1093/oxfordjournals.aje.a120559

20. 20.

    Jia X. Y., Briese T., Jordan I., Rambaut A., Chi H. C., Mackenzie J. S., Hall R. A., Scherret J., Lipkin W. I. Genetic analysis of West Nile New York 1999 encephalitis virus. Lancet. 1999;354(9194):1971-1972.

    Not in our library10.1016/s0140-6736(99)05384-2

21. 21.

    Khromykh A. A., Westaway E. G. Completion of Kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA. J Virol. 1994;68(7):4580-4588.

    Not in our library10.1128/jvi.68.7.4580-4588.1994

22. 22.

    Kuno G., Chang G. J., Tsuchiya K. R., Karabatsos N., Cropp C. B. Phylogeny of the genus Flavivirus. J Virol. 1998;72(1):73-83.

    Not in our library10.1128/jvi.72.1.73-83.1998

23. 23.

    Lanciotti R. S., Roehrig J. T., Deubel V., Smith J., Parker M., Steele K., Crise B., Volpe K. E., Crabtree M. B., Scherret J. H. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science. 1999;286(5448):2333-2337.

    Not in our library10.1126/science.286.5448.2333

24. 24.

    Lobigs M., Weir R. C., Dalgarno L. Genetic analysis of Kunjin virus isolates using HaeIII and TaqI restriction digests of single-stranded cDNA to virion RNA. Aust J Exp Biol Med Sci. 1986;64(Pt 2):185-196.

    Not in our library10.1038/icb.1986.20

25. 25.

    Men R., Bray M., Clark D., Chanock R. M., Lai C. J. Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys. J Virol. 1996;70(6):3930-3937.

    Not in our library10.1128/jvi.70.6.3930-3937.1996

26. 26.

    Ng M. L., Howe J., Sreenivasan V., Mulders J. J. Flavivirus West Nile (Sarafend) egress at the plasma membrane. Arch Virol. 1994;137(3-4):303-313.

    Not in our library10.1007/bf01309477

27. 27.

    Pierre V., Drouet M. T., Deubel V. Identification of mosquito-borne flavivirus sequences using universal primers and reverse transcription/polymerase chain reaction. Res Virol. 1994;145(2):93-104.

    Not in our library10.1016/s0923-2516(07)80011-2

28. 28.

    Poidinger M., Hall R. A., Mackenzie J. S. Molecular characterization of the Japanese encephalitis serocomplex of the flavivirus genus. Virology. 1996;218(2):417-421.

    Not in our library10.1006/viro.1996.0213

29. 29.

    Proutski V., Gaunt M. W., Gould E. A., Holmes E. C. Secondary structure of the 3'-untranslated region of yellow fever virus: implications for virulence, attenuation and vaccine development. J Gen Virol. 1997;78(Pt 7):1543-1549.

    Not in our library10.1099/0022-1317-78-7-1543

30. 30.

    Rice C. M., Lenches E. M., Eddy S. R., Shin S. J., Sheets R. L., Strauss J. H. Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science. 1985;229(4715):726-733.

    Not in our library10.1126/science.4023707

31. 31.

    Savage H. M., Ceianu C., Nicolescu G., Karabatsos N., Lanciotti R., Vladimirescu A., Laiv L., Ungureanu A., Romanca C., Tsai T. F. Entomologic and avian investigations of an epidemic of West Nile fever in Romania in 1996, with serologic and molecular characterization of a virus isolate from mosquitoes. Am J Trop Med Hyg. 1999;61(4):600-611.

    Not in our library10.4269/ajtmh.1999.61.600

32. 32.

    Sellner L. N., Coelen R. J., Mackenzie J. S. A one-tube, one manipulation RT-PCR reaction for detection of Ross River virus. J Virol Methods. 1992;40(3):255-263.

    Not in our library10.1016/0166-0934(92)90084-q

33. 33.

    Sumiyoshi H., Mori C., Fuke I., Morita K., Kuhara S., Kondou J., Kikuchi Y., Nagamatu H., Igarashi A. Complete nucleotide sequence of the Japanese encephalitis virus genome RNA. Virology. 1987;161(2):497-510.

    Not in our library10.1016/0042-6822(87)90144-9

34. 34.

    Takegami T., Washizu M., Yasui K. Nucleotide sequence at the 3' end of Japanese encephalitis virus genomic RNA. Virology. 1986;152(2):483-486.

    Not in our library10.1016/0042-6822(86)90152-2

35. 35.

    Thompson J. D., Higgins D. G., Gibson T. J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994;22(22):4673-4680.

    Not in our library10.1093/nar/22.22.4673

36. 36.

    Tsai T. F., Popovici F., Cernescu C., Campbell G. L., Nedelcu N. I. West Nile encephalitis epidemic in southeastern Romania. Lancet. 1998;352(9130):767-771.

    Not in our library10.1016/s0140-6736(98)03538-7

37. 37.

    Wengler G., Castle E. Analysis of structural properties which possibly are characteristic for the 3'-terminal sequence of the genome RNA of flaviviruses. J Gen Virol. 1986;67(Pt 6):1183-1188.

    Not in our library10.1099/0022-1317-67-6-1183

38. 38.

    Wengler G., Castle E., Leidner U., Nowak T., Wengler G. Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene. Virology. 1985;147(2):264-274.

    Not in our library10.1016/0042-6822(85)90129-1

39. 39.

    Westaway E. G. The neutralization of arboviruses. II. Neutralization in heterologous virus-serum mixtures with four group B arboviruses. Virology. 1965;26(4):528-537.

    Not in our library10.1016/0042-6822(65)90314-4

Cited by papers we hold 4

• The Global Ecology and Epidemiology of West Nile Virus · 2015
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• Vector-Virus Interactions and Transmission Dynamics of West Nile Virus · 2013
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• Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011 · 2012
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• Introduction of West Nile Virus in the Middle East by Migrating White Storks · 2002
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